LOCUS       NP_003786                162 aa            linear   PRI 04-APR-2024
DEFINITION  sorting nexin-3 isoform a [Homo sapiens].
ACCESSION   NP_003786
VERSION     NP_003786.1
DBSOURCE    REFSEQ: accession NM_003795.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 162)
  AUTHORS   Lu,J., Xu,S., Huo,Y., Sun,D., Hu,Y., Wang,J., Zhang,X., Wang,P.,
            Li,Z., Liang,M., Wu,Z. and Liu,P.
  TITLE     Sorting nexin 3 induces heart failure via promoting
            retromer-dependent nuclear trafficking of STAT3
  JOURNAL   Cell Death Differ 28 (10), 2871-2887 (2021)
   PUBMED   33947971
  REMARK    GeneRIF: Sorting nexin 3 induces heart failure via promoting
            retromer-dependent nuclear trafficking of STAT3.
REFERENCE   2  (residues 1 to 162)
  AUTHORS   Cai,Q., Zhao,X., Wang,Y., Li,S., Wang,J., Xin,Z. and Li,F.
  TITLE     LINC01614 promotes osteosarcoma progression via miR-520a-3p/SNX3
            axis
  JOURNAL   Cell Signal 83, 109985 (2021)
   PUBMED   33753211
  REMARK    GeneRIF: LINC01614 promotes osteosarcoma progression via
            miR-520a-3p/SNX3 axis.
REFERENCE   3  (residues 1 to 162)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (residues 1 to 162)
  AUTHORS   Klose,M., Salloum,J.E., Gonschior,H. and Linder,S.
  TITLE     SNX3 drives maturation of Borrelia phagosomes by forming a hub for
            PI(3)P, Rab5a, and galectin-9
  JOURNAL   J Cell Biol 218 (9), 3039-3059 (2019)
   PUBMED   31337623
  REMARK    GeneRIF: sorting nexin SNX3 is transported with Rab5a vesicles and
            that its PX domain enables vesicle-phagosome contact by binding to
            PI(3)P in the phagosomal coat. Moreover, the C-terminal region of
            SNX3 recruits galectin-9, a lectin implicated in protein and
            membrane recycling, which we identify as a further regulator of
            phagosome compaction.
REFERENCE   5  (residues 1 to 162)
  AUTHORS   McGough,I.J., de Groot,R.E.A., Jellett,A.P., Betist,M.C.,
            Varandas,K.C., Danson,C.M., Heesom,K.J., Korswagen,H.C. and
            Cullen,P.J.
  TITLE     SNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A
            complex to mediate Wntless sorting and Wnt secretion
  JOURNAL   Nat Commun 9 (1), 3737 (2018)
   PUBMED   30213940
  REMARK    GeneRIF: an evolutionary conserved MON2:DOPEY2:ATP9A complex is
            required for SNX3 retromer mediation of Wntless sorting and Wnt
            secretion
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 162)
  AUTHORS   Gevaert,K., Goethals,M., Martens,L., Van Damme,J., Staes,A.,
            Thomas,G.R. and Vandekerckhove,J.
  TITLE     Exploring proteomes and analyzing protein processing by mass
            spectrometric identification of sorted N-terminal peptides
  JOURNAL   Nat Biotechnol 21 (5), 566-569 (2003)
   PUBMED   12665801
REFERENCE   7  (residues 1 to 162)
  AUTHORS   Vervoort,V.S., Viljoen,D., Smart,R., Suthers,G., DuPont,B.R.,
            Abbott,A. and Schwartz,C.E.
  TITLE     Sorting nexin 3 (SNX3) is disrupted in a patient with a
            translocation t(6;13)(q21;q12) and microcephaly, microphthalmia,
            ectrodactyly, prognathism (MMEP) phenotype
  JOURNAL   J Med Genet 39 (12), 893-899 (2002)
   PUBMED   12471201
  REMARK    GeneRIF: Sorting nexin 3 (SNX3) is disrupted in a patient with a
            translocation t(6;13)(q21;q12) and microcephaly, microphthalmia,
            ectrodactyly, prognathism (MMEP) phenotype
REFERENCE   8  (residues 1 to 162)
  AUTHORS   Xu,Y., Hortsman,H., Seet,L., Wong,S.H. and Hong,W.
  TITLE     SNX3 regulates endosomal function through its PX-domain-mediated
            interaction with PtdIns(3)P
  JOURNAL   Nat Cell Biol 3 (7), 658-666 (2001)
   PUBMED   11433298
REFERENCE   9  (residues 1 to 162)
  AUTHORS   Parks,W.T., Frank,D.B., Huff,C., Renfrew Haft,C., Martin,J.,
            Meng,X., de Caestecker,M.P., McNally,J.G., Reddi,A., Taylor,S.I.,
            Roberts,A.B., Wang,T. and Lechleider,R.J.
  TITLE     Sorting nexin 6, a novel SNX, interacts with the transforming
            growth factor-beta family of receptor serine-threonine kinases
  JOURNAL   J Biol Chem 276 (22), 19332-19339 (2001)
   PUBMED   11279102
REFERENCE   10 (residues 1 to 162)
  AUTHORS   Haft,C.R., de la Luz Sierra,M., Barr,V.A., Haft,D.H. and
            Taylor,S.I.
  TITLE     Identification of a family of sorting nexin molecules and
            characterization of their association with receptors
  JOURNAL   Mol Cell Biol 18 (12), 7278-7287 (1998)
   PUBMED   9819414
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY023148.1, AF034546.1,
            BQ432490.1 and CA442762.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene encodes a member of the sorting nexin family.
            Members of this family contain a phox (PX) domain, which is a
            phosphoinositide binding domain, and are involved in intracellular
            trafficking. This protein does not contain a coiled coil region,
            like most family members. This protein interacts with
            phosphatidylinositol-3-phosphate, and is involved in protein
            trafficking. A pseudogene of this gene is present on the sex
            chromosomes. Alternative splicing results in multiple transcript
            variants encoding distinct isoforms. [provided by RefSeq, Jul
            2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.156253.1,
                                           SRR3476690.827852.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000230085.13/ ENSP00000230085.8
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..162
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q21"
     Protein         1..162
                     /product="sorting nexin-3 isoform a"
                     /note="sorting nexin 3A"
                     /calculated_mol_wt=18631
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000269|PubMed:12665801,
                     ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:25944712;
                     propagated from UniProtKB/Swiss-Prot (O60493.3)"
     Region          28..150
                     /region_name="PX_SNX3"
                     /note="The phosphoinositide binding Phox Homology domain
                     of Sorting Nexin 3; cd07293"
                     /db_xref="CDD:132826"
     Site            43
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (O60493.3)"
     Site            order(70,72,75,95..96,109,118)
                     /site_type="other"
                     /note="phosphoinositide binding site [chemical binding]"
                     /db_xref="CDD:132826"
     Site            72
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163;
                     propagated from UniProtKB/Swiss-Prot (O60493.3)"
     Region          147..162
                     /region_name="Binds predominantly to PtdIns(P5) and weaker
                     to PtdIns(P3) abd PtdIns(P4), involved in neurite
                     outgrowth regulation.
                     /evidence=ECO:0000250|UniProtKB:O70492"
                     /note="propagated from UniProtKB/Swiss-Prot (O60493.3)"
     CDS             1..162
                     /gene="SNX3"
                     /gene_synonym="Grd19; MCOPS8; SDP3"
                     /coded_by="NM_003795.6:120..608"
                     /note="isoform a is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS5064.1"
                     /db_xref="GeneID:8724"
                     /db_xref="HGNC:HGNC:11174"
                     /db_xref="MIM:605930"
ORIGIN      
        1 maetvadtrr litkpqnlnd aygppsnfle idvsnpqtvg vgrgrfttye irvktnlpif
       61 klkestvrrr ysdfewlrse lereskvvvp plpgkaflrq lpfrgddgif ddnfieerkq
      121 gleqfinkva ghplaqnerc lhmflqdeii dksytpskir ha
//
