LOCUS       NM_001330723            6441 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens sorting nexin 27 (SNX27), transcript variant 1, mRNA.
ACCESSION   NM_001330723 XM_005245509
VERSION     NM_001330723.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6441)
  AUTHORS   Broniarczyk,J., Trejo-Cerro,O., Massimi,P., Kavcic,N., Myers,M.P.
            and Banks,L.
  TITLE     HPV-18 E6 enhances the interaction between EMILIN2 and SNX27 to
            promote WNT signaling
  JOURNAL   J Virol 98 (7), e0073524 (2024)
   PUBMED   38874360
  REMARK    GeneRIF: HPV-18 E6 enhances the interaction between EMILIN2 and
            SNX27 to promote WNT signaling.
REFERENCE   2  (bases 1 to 6441)
  AUTHORS   Xi,Y., Gai,Y., Zhang,W., Wang,M., Liu,Q. and Bi,Y.
  TITLE     Circular RNA SNX27 Facilitates Gastric Cancer Progression By
            Sponging miR-638
  JOURNAL   Turk J Gastroenterol 35 (4), 280-287 (2024)
   PUBMED   39128090
  REMARK    GeneRIF: Circular RNA SNX27 Facilitates Gastric Cancer Progression
            By Sponging miR-638.
REFERENCE   3  (bases 1 to 6441)
  AUTHORS   Li,H., Liu,B., Xu,X., Li,S., Zhang,D. and Liu,Q.
  TITLE     Circ_SNX27 regulates hepatocellular carcinoma development via
            miR-637/FGFR1 axis
  JOURNAL   Environ Toxicol 37 (12), 2832-2843 (2022)
   PUBMED   36029209
  REMARK    GeneRIF: Circ_SNX27 regulates hepatocellular carcinoma development
            via miR-637/FGFR1 axis.
REFERENCE   4  (bases 1 to 6441)
  AUTHORS   Broniarczyk,J.K., Massimi,P., Trejo-Cerro,O., Myers,M.P. and
            Banks,L.
  TITLE     HPV-18E6 Inhibits Interactions between TANC2 and SNX27 in a
            PBM-Dependent Manner and Promotes Increased Cell Proliferation
  JOURNAL   J Virol 96 (22), e0136522 (2022)
   PUBMED   36326272
  REMARK    GeneRIF: HPV-18E6 Inhibits Interactions between TANC2 and SNX27 in
            a PBM-Dependent Manner and Promotes Increased Cell Proliferation.
REFERENCE   5  (bases 1 to 6441)
  AUTHORS   Gonzalez-Mancha,N., Rodriguez-Rodriguez,C., Alcover,A. and
            Merida,I.
  TITLE     Sorting Nexin 27 Enables MTOC and Secretory Machinery Translocation
            to the Immune Synapse
  JOURNAL   Front Immunol 12, 814570 (2022)
   PUBMED   35095913
  REMARK    GeneRIF: Sorting Nexin 27 Enables MTOC and Secretory Machinery
            Translocation to the Immune Synapse.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6441)
  AUTHORS   MacNeil,A.J., Mansour,M. and Pohajdak,B.
  TITLE     Sorting nexin 27 interacts with the Cytohesin associated
            scaffolding protein (CASP) in lymphocytes
  JOURNAL   Biochem Biophys Res Commun 359 (4), 848-853 (2007)
   PUBMED   17577583
  REMARK    GeneRIF: These results suggest that endosomal SNX27 may recruit
            CASP to orchestrate intracellular trafficking and/or signaling
            complexes.
REFERENCE   7  (bases 1 to 6441)
  AUTHORS   Rincon,E., Santos,T., Avila-Flores,A., Albar,J.P., Lalioti,V.,
            Lei,C., Hong,W. and Merida,I.
  TITLE     Proteomics identification of sorting nexin 27 as a diacylglycerol
            kinase zeta-associated protein: new diacylglycerol kinase roles in
            endocytic recycling
  JOURNAL   Mol Cell Proteomics 6 (6), 1073-1087 (2007)
   PUBMED   17351151
  REMARK    GeneRIF: These data support a previously unreported role for
            diacylglycerol kinase zeta in the modulation of membrane
            trafficking, which may also help to define SNX27 function.
REFERENCE   8  (bases 1 to 6441)
  AUTHORS   Joubert,L., Hanson,B., Barthet,G., Sebben,M., Claeysen,S., Hong,W.,
            Marin,P., Dumuis,A. and Bockaert,J.
  TITLE     New sorting nexin (SNX27) and NHERF specifically interact with the
            5-HT4a receptor splice variant: roles in receptor targeting
  JOURNAL   J Cell Sci 117 (Pt 22), 5367-5379 (2004)
   PUBMED   15466885
  REMARK    GeneRIF: SNX27a redirects part of the 5-HT4(a)R to early endosomes.
REFERENCE   9  (bases 1 to 6441)
  AUTHORS   Worby,C.A. and Dixon,J.E.
  TITLE     Sorting out the cellular functions of sorting nexins
  JOURNAL   Nat Rev Mol Cell Biol 3 (12), 919-931 (2002)
   PUBMED   12461558
  REMARK    Review article
            Erratum:[Nat Rev Mol Cell Biol. 2003 Feb;4(2):156.]
REFERENCE   10 (bases 1 to 6441)
  AUTHORS   Teasdale,R.D., Loci,D., Houghton,F., Karlsson,L. and Gleeson,P.A.
  TITLE     A large family of endosome-localized proteins related to sorting
            nexin 1
  JOURNAL   Biochem J 358 (Pt 1), 7-16 (2001)
   PUBMED   11485546
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL391335.32 and AL589765.19.
            
            On Nov 23, 2018 this sequence version replaced NM_001330723.1.
            
            Summary: This gene encodes a member of the sorting nexin family, a
            diverse group of cytoplasmic and membrane-associated proteins
            involved in endocytosis of plasma membrane receptors and protein
            trafficking through these compartments. All members of this protein
            family contain a phosphoinositide binding domain (PX domain). A
            highly similar protein in mouse is responsible for the specific
            recruitment of an isoform of serotonin 5-hydroxytryptamine 4
            receptor into early endosomes, suggesting the analogous role for
            the human protein. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB054888.1, SRR14038193.1860186.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000458013.7/ ENSP00000400333.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-463               AL391335.32        15327-15789
            464-695             AL391335.32        42165-42396
            696-888             AL391335.32        61512-61704
            889-953             AL391335.32        64075-64139
            954-1058            AL391335.32        65443-65547
            1059-1137           AL391335.32        69210-69288
            1138-1301           AL391335.32        71749-71912
            1302-1391           AL589765.19        5731-5820
            1392-1541           AL589765.19        14810-14959
            1542-1670           AL589765.19        15286-15414
            1671-1730           AL589765.19        15799-15858
            1731-6441           AL589765.19        16745-21455
FEATURES             Location/Qualifiers
     source          1..6441
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..6441
                     /gene="SNX27"
                     /gene_synonym="MRT1; MY014"
                     /note="sorting nexin 27"
                     /db_xref="GeneID:81609"
                     /db_xref="HGNC:HGNC:20073"
                     /db_xref="MIM:611541"
     exon            1..463
                     /gene="SNX27"
                     /gene_synonym="MRT1; MY014"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..1778
                     /gene="SNX27"
                     /gene_synonym="MRT1; MY014"
                     /note="isoform 1 is encoded by transcript variant 1;
                     methamphetamine-responsive transcript 1; sorting nexin
                     family member 27"
                     /codon_start=1
                     /product="sorting nexin-27 isoform 1"
                     /protein_id="NP_001317652.1"
                     /db_xref="CCDS:CCDS81377.1"
                     /db_xref="GeneID:81609"
                     /db_xref="HGNC:HGNC:20073"
                     /db_xref="MIM:611541"
                     /translation="MADEDGEGIHPSAPHRNGGGGGGGGSGLHCAGNGGGGGGGPRVV
                     RIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAGVRKGDRIL
                     EVNHVNVEGATHKQVVDLIRAGEKELILTVLSVPPHEADNLDPSDDSLGQSFYDYTEK
                     QAVPISVPRYKHVEQNGEKFVVYNVYMAGRQLCSKRYREFAILHQNLKREFANFTFPR
                     LPGKWPFSLSEQQLDARRRGLEEYLEKVCSIRVIGESDIMQEFLSESDENYNGVSDVE
                     LRVALPDGTTVTVRVKKNSTTDQVYQAIAAKVGMDSTTVNYFALFEVISHSFVRKLAP
                     NEFPHKLYIQNYTSAVPGTCLTIRKWLFTTEEEILLNDNDLAVTYFFHQAVDDVKKGY
                     IKAEEKSYQLQKLYEQRKMVMYLNMLRTCEGYNEIIFPHCACDSRRKGHVITAISITH
                     FKLHACTEEGQLENQVIAFEWDEMQRWDTDEEGMAFCFEYARGEKKPRWVKIFTPYFN
                     YMHECFERVFCELKWRKENIFQMARSQQRDVAT"
     exon            464..695
                     /gene="SNX27"
                     /gene_synonym="MRT1; MY014"
                     /inference="alignment:Splign:2.1.0"
     exon            696..888
                     /gene="SNX27"
                     /gene_synonym="MRT1; MY014"
                     /inference="alignment:Splign:2.1.0"
     exon            889..953
                     /gene="SNX27"
                     /gene_synonym="MRT1; MY014"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1058
                     /gene="SNX27"
                     /gene_synonym="MRT1; MY014"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1137
                     /gene="SNX27"
                     /gene_synonym="MRT1; MY014"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1301
                     /gene="SNX27"
                     /gene_synonym="MRT1; MY014"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1391
                     /gene="SNX27"
                     /gene_synonym="MRT1; MY014"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1541
                     /gene="SNX27"
                     /gene_synonym="MRT1; MY014"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1670
                     /gene="SNX27"
                     /gene_synonym="MRT1; MY014"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..1730
                     /gene="SNX27"
                     /gene_synonym="MRT1; MY014"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..6441
                     /gene="SNX27"
                     /gene_synonym="MRT1; MY014"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6417..6422
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNX27"
                     /gene_synonym="MRT1; MY014"
                     /note="hexamer: AATAAA"
     polyA_site      6441
                     /gene="SNX27"
                     /gene_synonym="MRT1; MY014"
                     /note="major polyA site"
ORIGIN      
        1 accccgcgcc agcagctcgg tggccgagtc ggtcccgcgg ccggcggatc gggcgcgcgc
       61 gtcgggggtc gtccggctgc caggcagggc gagcacgcgc cgggaggcct tggaggcgta
      121 gggggcgggg gtacggctcg cctgctcgca agatggcgga cgaggacggg gaagggattc
      181 atccctcagc ccctcacagg aacggaggtg gcggcggcgg cggggggtct gggctccact
      241 gcgccgggaa cggcggcggg ggaggcggcg gcccgcgggt cgtgcgcatc gtcaagtccg
      301 agtccggcta cggcttcaac gtgcggggcc aagtgagcga gggcgggcaa ctgcggagca
      361 tcaacgggga gctgtacgcg ccgctgcagc atgtgagcgc cgtgctgccc gggggggcgg
      421 ccgatcgggc cggggtgcgc aagggggacc gcatcctgga ggtgaaccac gtgaatgttg
      481 agggggcgac acacaagcag gtggtggacc tgattcgagc aggcgagaag gaattgatct
      541 tgacagtgtt atctgtacct cctcatgagg cagataacct agatcccagt gacgactcgt
      601 tgggacaatc attttatgat tacacagaaa agcaagcagt gcccatatcg gtccccagat
      661 acaaacatgt ggagcagaat ggtgagaagt ttgtggtata taatgtttac atggcaggga
      721 ggcagctgtg ttctaagcgg taccgggagt ttgctatcct acaccagaac ctgaagagag
      781 agtttgccaa ctttacattt cctcgactcc cagggaagtg gccattttca ttatcagaac
      841 aacaattaga tgcccgacgt cggggattgg aagaatatct agaaaaagtg tgttcaatac
      901 gagtaattgg tgagagtgac atcatgcagg aattcctatc agaatccgat gagaactaca
      961 atggtgtgtc cgacgtagag ctgagagtag cattaccaga tggaacaacg gttacagtca
     1021 gggttaaaaa gaacagtact acagaccaag tatatcaggc tatcgcagca aaggttggca
     1081 tggacagtac gacagtgaat tactttgcct tatttgaagt gatcagtcac tcctttgtac
     1141 gtaaattggc acctaatgag tttcctcaca aactctacat tcagaattat acatcagctg
     1201 tgccaggcac ctgcttgacc attcgaaagt ggctttttac aacagaagaa gaaattctct
     1261 taaatgacaa tgaccttgct gttacctact tctttcatca ggcagtcgat gatgtgaaga
     1321 aaggttacat caaagcagaa gaaaagtcct atcaattaca gaagctatac gaacaaagaa
     1381 aaatggtcat gtacctcaac atgctaagga cttgtgaggg ctacaatgaa atcatctttc
     1441 cccactgtgc ctgtgactcc aggaggaagg ggcacgttat cacagccatc agcatcacgc
     1501 actttaaact gcatgcctgc actgaagaag gacagctgga gaaccaggta attgcatttg
     1561 aatgggatga gatgcagcga tgggacacag atgaagaagg gatggccttc tgtttcgaat
     1621 atgcacgagg agagaagaag ccccgatggg ttaaaatctt cacgccatat ttcaattaca
     1681 tgcatgagtg cttcgagagg gtgttctgcg agctcaagtg gagaaaagag aacattttcc
     1741 agatggcgag gtcacagcag agagatgtgg ccacctagcc tttccttatc cccttccctt
     1801 cccttcaccc ccatcctctt actcctttca tgtcccattt cagacagagt aaccattaac
     1861 aaaaaagaag agaaaaagtt aaagtcgtta tattcaaaag ccctaaacta aatattatta
     1921 ataaccccct ctgaatttca tgtctctgga attgaggtgg tagtgaacag cagatcggtc
     1981 agcaccagaa gtcaactgag ttaaggcagg aaaagaaata agcccaacca acttgccaaa
     2041 ggtatctttg tcctttcacc tgggcctcat accaacagcc tctccttgta ctatattttt
     2101 aaaactggaa ctatgaactt catccatttg cactgttcag acatatatat gtatgtatgt
     2161 aaaaattata tatacacaaa ttagctgcac gtatatacat atatatattt ctttttaaat
     2221 ttcatattga tggcagtacc ttttttagct tgtgttttta cacacctttc actagaatcc
     2281 atgacctccc tcgtgctctc tttcttttga aacaaacttt aaaaaggaaa aaaaagcatt
     2341 ttacagggaa aaatacctct cctcatgaag gacttgaaaa gtttacaacc tgcttggatt
     2401 tttgcccctt tttttgtatt gagtatagat tccggctcat gggttgccat agagtctagg
     2461 aacaaggagt atagtttctt tatcttccaa gagggtgctg gggaggagaa agaggtgtgt
     2521 ttctcaaggt taacaggctg tagttctgca gggagagcct gaagtcctgg tatgggctct
     2581 tgattctgtg acaatttttt tgatccatct atttctctca ctcctggctt tctagccaca
     2641 ttctgcacct ccttcctgct ttcctagagc ctcggtatgc tttccctcaa ccgaccctgg
     2701 ctcaggaggt tgatgccatg ggaacctgaa cctgaaacac ttcatggtag taatttcctg
     2761 ttttccttgc cttttttttt tttttttttt tttttttctg agacagggtc ttactctgtc
     2821 gcccagactg gaatgtggtg gcatgaacat agctcactgt taccttgaat tctgggctca
     2881 ggtgatcctt ccgcctcacc ctcctgagta gctgggacta caggtgtgca ccaccacacc
     2941 tggctaattc ttcttaaaat ttttttgtag agacagggtc tcactatgtt gcccaggctg
     3001 gtctcaaact cctggcctca ggtgatcctc ttgtctcagc ctcccaaagt gctgggatta
     3061 caggcatgag ccactgtgtc cttccctgcc ttttttgcag cagggatagt actcaggacc
     3121 agagttaagc tgatacctta ggcacacagg ttggacttac atagaggaaa gaaagcaaga
     3181 aatgccctat gtacatgagg ttttacctcc tccattcctg accaataacc acccataact
     3241 acggcattct ctgtgacttc cttaaacagc agtgatggga agggatccaa tagtatcttc
     3301 aaggccttgg ggaaacttgc agtgggtcag tggtctgtgc caaccaaacg atagccccat
     3361 ccaagccagc tgagaaccta ggaaggagta gtaggaatat ggttgattag attggatctc
     3421 ccaagtttta attgaaagga gactgaacga aaacctttct gctttctgtc cgttaaagag
     3481 ctcctcatct gatcttgcag ctagaccctt tgagacttaa gagctgcatc ccaggatcag
     3541 aagccagggc taattggggt aggacaatat tcccagcccc taagctctgt agataatgca
     3601 taagaagcac caagtcaggc tcagatgcaa ctaaaacaca tctttgagcc ttttcttttt
     3661 cccttctccc ctttctaaac aaaaaccttc ctaggatggc atcttttgct ctaactggga
     3721 gacagtcata attggttgta gtcaattcta ctaagcagtg ttggggtggt tggaaagtct
     3781 cttttttgta atttgttttt gcaaatcatt gtgaggccac tttttctttc tttctttctt
     3841 tctttctttc tttctttctt tctttcgttc tttcgttctt tcgttctttc tttctttctt
     3901 tctttctctt tctttctttt gctttccttc tttcatctct tttttgtaat ttgttgttgc
     3961 aaatcattgt gaggccactt ttctttcccc ttccttcctt cctttttttc tgtttttttt
     4021 tttttttttt cccagagtct tgctctgtcg cccaggttgg agtgcagtgg cacgatctcg
     4081 gctcactgca ccctctgcct cttgggttca agcgattctc ctgcctcagc ctcccaagta
     4141 gctgggatta caggcataca ccaccacgcc ccactaattt tttgtatttt tggtagggcg
     4201 gggtttcacc atgatggcca ggttggtttt gaactcctga cctcaagtaa tctgcccacc
     4261 tcggcctccc aaagtgctag gattacagga gtgagccact gcgcctggcc cacttttctt
     4321 tctttccttc ttattttgtt atgctggcag ccatttgccc ctgcatggta tgggatcaaa
     4381 gaggacagcc tttcctccct caccttctcc aaatctaggt gaaatcacag agtacaaaac
     4441 gtgagaatgc tgaatgtgta aagttgcaga gggatcccta atttgaagac tttgacacag
     4501 aactaacttc ttttgactta aatgaattta aaatgagcca aaggaccctg aaaagaagac
     4561 atgttgattt cccactccta gatgctaaag agacttggca ccagctttgt tcaaactgta
     4621 aaaatagcaa tttgccccta ctcgctcaga gtgggacagt agtgaacaga gctgggattc
     4681 catgcgacag cttgaatgct gaccttcaga catgagacat agggatttgg aggcccctta
     4741 gaatgggtag atggtgttat gttccctttc tggcatagca ttcacttggt gctttggaga
     4801 ttaggtgagg gccctatagg tagttggcct gttggcagaa tttatttagg aacagccctt
     4861 ttgaaagtgt cccagtaaca acgcacccag ctgcagcaag gaggtgggga aggagggcac
     4921 cccaaaggac agcgccttct tctcttccac ccatgcacgg ccttgggtga tggaggcggg
     4981 ttccctgtgg ctgcgtggat cccataggat caagcccttc tttgcatgaa gcagtgttgt
     5041 gactcttctc tctccccttc ctctgcactt cctttctgta atccctactg ttcttcttag
     5101 tcccagcttc tgcccaggga ggcttctacc cagacttctt ttgcaatttg tccctgggaa
     5161 gagggggtct cccagtgccc ccagcttcat cccagcagaa ccagcaggat cctcctggtc
     5221 tctcactggc cttcctccac acttggtttc tatcctcagg ggtagaagct cagagctttt
     5281 tatggcccag gagaaaatgt agaccctgag aaacctgtcc ctgcagaaag gttcccttgg
     5341 gccatgcttt gggccctctg ctctttatat gtttattcta ttctccattt ttccaccccg
     5401 tccttaccct aggcctaaac acaggtacag atatgtgcat gctcagggca gctcctaggc
     5461 ctggactgag ctctcagggg ggaattagat aaatattcca acatcctcat gcctggccca
     5521 tttagtttca tcctttagtt acccaggcca gtagctttgg gttatccctt cctgtagctc
     5581 caaacccagc acttggagca gcaaaatagg gcactgacag gagatgaaac tctctcctat
     5641 ctcagaattt gccaacttct gggctgggct cctaggaggt agttttcttg aaggggactg
     5701 catcctagtt gacctgaatt ttccagacca ggagggactg ctgtgctctc ccttctcgcc
     5761 atcatactgt ttggctagat tcattcagca gtagaagctg tttgatctgt tgaccccagc
     5821 atactgctgt ttcttcacca gcttcattgt gtcacagtag cttcctttgg gaggatgatg
     5881 tgatagaaca ctcagagaga gggagggaga agagagatag tgggtatgct tctctagctc
     5941 cccatcttcc aggtccacct cttgacttcc tgttccccta aacctgagca catcacgcca
     6001 ggcctctttg ctgccaggac agcatcagct cactcctcag caataatcta gggtatgtgg
     6061 gaaggtcagg gctgtggtaa ggaatagaat caaagagggg agtgatacgg ggtgggggca
     6121 cttggccgcc tgctaaactt ggacattaat tttatatcat gacccccttt taagccagtg
     6181 agctgggctt cagtttttcc caggccatgc acatttaatt tatttcagag aaactctaat
     6241 tgtattttca ctgcagtatc ttgtattttt tatttgtgat ttaagaaatg tgaagagaaa
     6301 atacacagac acaataatgg ctaacattgt ttctttcatt ccttgttcta gagctaacca
     6361 ctctaaaatt gtttggtaat gtcacttagt gtaattaatt gtaacatatt cttttaaata
     6421 aattgattta ttgatcaaac a
//
