LOCUS       NM_001378036            3210 bp    mRNA    linear   PRI 04-OCT-2024
DEFINITION  Homo sapiens sorting nexin 25 (SNX25), transcript variant 4, mRNA.
ACCESSION   NM_001378036
VERSION     NM_001378036.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3210)
  AUTHORS   Lauzier,A., Bossanyi,M.F., Larcher,R., Nassari,S., Ugrankar,R.,
            Henne,W.M. and Jean,S.
  TITLE     Snazarus and its human ortholog SNX25 modulate autophagic flux
  JOURNAL   J Cell Sci 135 (5) (2022)
   PUBMED   34821359
REFERENCE   2  (bases 1 to 3210)
  AUTHORS   Zhang,Y., Zheng,L., Xu,B.M., Tang,W.H., Ye,Z.D., Huang,C., Ma,X.,
            Zhao,J.J., Guo,F.X., Kang,C.M., Lu,J.B., Xiu,J.C., Li,P., Xu,Y.J.,
            Xiao,L., Wu,Q., Hu,Y.W. and Wang,Q.
  TITLE     LncRNA-RP11-714G18.1 suppresses vascular cell migration via
            directly targeting LRP2BP
  JOURNAL   Immunol Cell Biol 96 (2), 175-189 (2018)
   PUBMED   29363163
  REMARK    GeneRIF: RP11-714G18.1 may play an athero-protective role by
            inhibiting vascular cell migration via RP11-714G18.1/LRP2BP/MMP1
            signaling pathway.
REFERENCE   3  (bases 1 to 3210)
  AUTHORS   Lee,J.H., Cheng,R., Vardarajan,B., Lantigua,R., Reyes-Dumeyer,D.,
            Ortmann,W., Graham,R.R., Bhangale,T., Behrens,T.W., Medrano,M.,
            Jimenez-Velazquez,I.Z. and Mayeux,R.
  TITLE     Genetic Modifiers of Age at Onset in Carriers of the G206A Mutation
            in PSEN1 With Familial Alzheimer Disease Among Caribbean Hispanics
  JOURNAL   JAMA Neurol 72 (9), 1043-1051 (2015)
   PUBMED   26214276
  REMARK    GeneRIF: This study confirmed that SNX25 as genetic modifiers of
            age at onset of Alzheimer disease.
REFERENCE   4  (bases 1 to 3210)
  AUTHORS   Du,Y., Zou,Y., Yu,W., Shi,R., Zhang,M., Yang,W., Duan,J., Deng,Y.,
            Wang,X. and Lu,Y.
  TITLE     Expression pattern of sorting Nexin 25 in temporal lobe epilepsy: a
            study on patients and pilocarpine-induced rats
  JOURNAL   Brain Res 1509, 79-85 (2013)
   PUBMED   23518199
  REMARK    GeneRIF: upregulation of SNX25 might be involved in the development
            of temporal lobe epilepsy.
REFERENCE   5  (bases 1 to 3210)
  AUTHORS   Hao,X., Wang,Y., Ren,F., Zhu,S., Ren,Y., Jia,B., Li,Y.P., Shi,Y.
            and Chang,Z.
  TITLE     SNX25 regulates TGF-beta signaling by enhancing the receptor
            degradation
  JOURNAL   Cell Signal 23 (5), 935-946 (2011)
   PUBMED   21266196
  REMARK    GeneRIF: SNX25 negatively regulates TGF-beta signaling by enhancing
            the receptor degradation through lysosome pathway.
REFERENCE   6  (bases 1 to 3210)
  AUTHORS   Worby,C.A. and Dixon,J.E.
  TITLE     Sorting out the cellular functions of sorting nexins
  JOURNAL   Nat Rev Mol Cell Biol 3 (12), 919-931 (2002)
   PUBMED   12461558
  REMARK    Review article
            Erratum:[Nat Rev Mol Cell Biol. 2003 Feb;4(2):156.]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC073344.7.
            
            On Apr 8, 2021 this sequence version replaced NM_001378036.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR12514507.436134.1,
                                           SRR14038191.1390947.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA2142670
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-658               AC073344.7         20197-20854
            659-743             AC073344.7         57893-57977
            744-960             AC073344.7         69447-69663
            961-1133            AC073344.7         75037-75209
            1134-1320           AC073344.7         77568-77754
            1321-1391           AC073344.7         98611-98681
            1392-1573           AC073344.7         121234-121415
            1574-1705           AC073344.7         131332-131463
            1706-1978           AC073344.7         134127-134399
            1979-2143           AC073344.7         143194-143358
            2144-2275           AC073344.7         149978-150109
            2276-2416           AC073344.7         152575-152715
            2417-2530           AC073344.7         157136-157249
            2531-2695           AC073344.7         162044-162208
            2696-2813           AC073344.7         164084-164201
            2814-2880           AC073344.7         168270-168336
            2881-3062           AC073344.7         172523-172704
            3063-3210           AC073344.7         172791-172938
FEATURES             Location/Qualifiers
     source          1..3210
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q35.1"
     gene            1..3210
                     /gene="SNX25"
                     /gene_synonym="LRP2BP-AS1; MSTP043; SBBI31"
                     /note="sorting nexin 25"
                     /db_xref="GeneID:83891"
                     /db_xref="HGNC:HGNC:21883"
                     /db_xref="MIM:620961"
     exon            1..658
                     /gene="SNX25"
                     /gene_synonym="LRP2BP-AS1; MSTP043; SBBI31"
                     /inference="alignment:Splign:2.1.0"
     CDS             230..3142
                     /gene="SNX25"
                     /gene_synonym="LRP2BP-AS1; MSTP043; SBBI31"
                     /note="isoform 4 is encoded by transcript variant 4;
                     LRP2BP antisense RNA 1; RP11-714G18.1"
                     /codon_start=1
                     /product="sorting nexin-25 isoform 4"
                     /protein_id="NP_001364965.1"
                     /db_xref="GeneID:83891"
                     /db_xref="HGNC:HGNC:21883"
                     /db_xref="MIM:620961"
                     /translation="MHPDATDSGGAGPSPARAAGAGGRPVSGFRGERRPESPGDAEAA
                     AAAAPGAPGGRSWWKPVAVAALAAVALSFLGPGSGEAAGAAGLSSVLFRLSLYLSCAA
                     AAFLLGILFALVCRSPRAQPPDFAAAWSRLAATSAARRPPGSPVYGNSHESAQSRRVV
                     ISHNMDKALKEVFDYSYRDYILSWYGNLSRDEGQLYHLLLEDFWEIARQLHHRLSHVD
                     VVKVVCNDVVRTLLTHFCDLKAANARHEEQPRPFVLHACLRNSDDEVRFLQTCSRVLV
                     FCLLPSKDVQSLSLRIMLAEILTTKVLKPVVELLSNPDYINQMLLAQLAYREQMNEHH
                     KRAYTYAPSYEDFIKLINSNSDVEFLKQLRYQIVVEIIQATTISSFPQLKRHKGKETA
                     AMKADLLRARNMKRYINQLTVAKKQCEKRIRILGGPAYDQQEDGALDEGEGPQSQKIL
                     QFEDILANTFYREHFGMYMERMDKRALISFWESVEHLKNANKNEIPQLVGEIYQNFFV
                     ESKEISVEKSLYKEIQQCLVGNKGIEVFYKIQEDVYETLKDRYYPSFIVSDLYEKLLI
                     KEEEKHASQMISNKDEMGPRDEAGEEAVDDGTNQINEQASFAVNKLRELNEKLEYKRQ
                     ALNSIQNAPKPDKKIVSKLKDEIILIEKERTDLQLHMARTDWWCENLGMWKASITSGE
                     VTEENGEQLPCYFVMVSLQEVGGVETKNWTVPRRLSEFQNLHRKLSECVPSLKKVQLP
                     SLSKLPFKSIDQKFMEKSKNQLNKFLQNLLSDERLCQSEALYAFLSPSPDYLKVIDVQ
                     GKKNSFSLSSFLERLPRDFFSHQEEETEEDSDLSDYGDDVDGRKDALAEPCFMLIGEI
                     FELRGMFKWVRRTLIALVQVTFGRTINKQIRDTVSWIFSEQMLVYYINIFRDAFWPNG
                     KLAPPTTIRSKEQSQETKQRAQQKLLENIPGNILYNEKKKDHTLLSHFLSLAKKLY"
     exon            659..743
                     /gene="SNX25"
                     /gene_synonym="LRP2BP-AS1; MSTP043; SBBI31"
                     /inference="alignment:Splign:2.1.0"
     exon            744..960
                     /gene="SNX25"
                     /gene_synonym="LRP2BP-AS1; MSTP043; SBBI31"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1133
                     /gene="SNX25"
                     /gene_synonym="LRP2BP-AS1; MSTP043; SBBI31"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1320
                     /gene="SNX25"
                     /gene_synonym="LRP2BP-AS1; MSTP043; SBBI31"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1391
                     /gene="SNX25"
                     /gene_synonym="LRP2BP-AS1; MSTP043; SBBI31"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1573
                     /gene="SNX25"
                     /gene_synonym="LRP2BP-AS1; MSTP043; SBBI31"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1705
                     /gene="SNX25"
                     /gene_synonym="LRP2BP-AS1; MSTP043; SBBI31"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1978
                     /gene="SNX25"
                     /gene_synonym="LRP2BP-AS1; MSTP043; SBBI31"
                     /inference="alignment:Splign:2.1.0"
     exon            1979..2143
                     /gene="SNX25"
                     /gene_synonym="LRP2BP-AS1; MSTP043; SBBI31"
                     /inference="alignment:Splign:2.1.0"
     exon            2144..2275
                     /gene="SNX25"
                     /gene_synonym="LRP2BP-AS1; MSTP043; SBBI31"
                     /inference="alignment:Splign:2.1.0"
     exon            2276..2416
                     /gene="SNX25"
                     /gene_synonym="LRP2BP-AS1; MSTP043; SBBI31"
                     /inference="alignment:Splign:2.1.0"
     exon            2417..2530
                     /gene="SNX25"
                     /gene_synonym="LRP2BP-AS1; MSTP043; SBBI31"
                     /inference="alignment:Splign:2.1.0"
     exon            2531..2695
                     /gene="SNX25"
                     /gene_synonym="LRP2BP-AS1; MSTP043; SBBI31"
                     /inference="alignment:Splign:2.1.0"
     exon            2696..2813
                     /gene="SNX25"
                     /gene_synonym="LRP2BP-AS1; MSTP043; SBBI31"
                     /inference="alignment:Splign:2.1.0"
     exon            2814..2880
                     /gene="SNX25"
                     /gene_synonym="LRP2BP-AS1; MSTP043; SBBI31"
                     /inference="alignment:Splign:2.1.0"
     exon            2881..3062
                     /gene="SNX25"
                     /gene_synonym="LRP2BP-AS1; MSTP043; SBBI31"
                     /inference="alignment:Splign:2.1.0"
     exon            3063..3210
                     /gene="SNX25"
                     /gene_synonym="LRP2BP-AS1; MSTP043; SBBI31"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3179..3184
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNX25"
                     /gene_synonym="LRP2BP-AS1; MSTP043; SBBI31"
                     /note="hexamer: AATAAA"
     polyA_site      3210
                     /gene="SNX25"
                     /gene_synonym="LRP2BP-AS1; MSTP043; SBBI31"
                     /note="major polyA site"
ORIGIN      
        1 agtcacaaca cggtggggct ccctggctgc gcccggcccg gcagctacgg gcccagcgcc
       61 tggtggcggc gctgaggggt cgccgagagg ggcccggcgg cgtctgcggg ggccgctccc
      121 tcggtgggcc gcgggcgagg catgagcgcg ggctccccct gcctccggag cgccggcggg
      181 ggaccggggg gcaggagatg tgcctgtcct tagcggccca ggaagcagca tgcaccccga
      241 tgcgaccgac agtggcggcg ccggccccag ccccgcgcgg gccgcaggcg ccggcggccg
      301 tcctgtctcg ggcttcaggg gcgagcggcg gccggagtcc ccgggggacg cggaggcagc
      361 agcagcggcg gcgccggggg ccccgggcgg ccggagctgg tggaagcccg tggcggtggc
      421 cgcactcgcc gccgtggccc tctccttcct ggggcccggc agcggggagg cggcgggggc
      481 cgcggggctg agctccgtcc tgttcaggct cagcctgtac ctgagctgcg cggcggccgc
      541 cttcctgctg gggatcctgt ttgccctcgt ctgccggagc ccgcgcgccc agccgcccga
      601 cttcgccgcc gcctggagcc ggctggccgc gacctcagcc gcccgccgcc cgccggggag
      661 tcctgtgtat ggaaactcac atgagtcagc tcagtctaga agggtagtaa tttctcataa
      721 tatggataaa gctctgaaag aagtgttcga ctacagttat agagattaca ttctgtcctg
      781 gtatggaaac ctcagcagag atgagggaca actttaccat ctgctcttgg aagacttttg
      841 ggaaattgcc agacagctgc accacagact gagtcacgtg gatgtggtta aagttgtctg
      901 caatgatgtt gtgaggactt tactcactca tttctgtgac ctgaaagctg ccaatgccag
      961 acatgaagaa cagccaagac cttttgtgtt gcacgcatgc ttgaggaact cagatgatga
     1021 agtaagattt ctacaaacgt gttctcgggt tctggtgttt tgtctcctcc cctcaaagga
     1081 tgtgcagtct ctcagcttac gtataatgct tgcagaaatt ctcacaacaa aagtcttgaa
     1141 gccggtagtg gagttactga gtaatccaga ttacattaac caaatgctgc ttgcccagct
     1201 ggcgtacaga gagcaaatga atgagcatca caagagagcc tacacctatg ccccctctta
     1261 cgaggacttc atcaagctca ttaacagcaa ctctgatgtg gagttcttga agcaactaag
     1321 gtatcaaatt gtagtggaaa taatccaggc gactacaatt agcagctttc cccaactgaa
     1381 gaggcacaaa ggtaaagaaa ctgcggcaat gaaagctgat ctcctgaggg ccaggaacat
     1441 gaagaggtac atcaaccaac tgactgtggc aaagaagcag tgtgagaaga gaatccgaat
     1501 cctgggaggc cctgcctatg accagcaaga ggatggggcc ctggatgagg gggaagggcc
     1561 tcaaagccag aagattcttc agtttgaaga tatcttggcc aatacgttct accgagagca
     1621 ctttggaatg tacatggaaa ggatggacaa aagagctctg attagttttt gggaatctgt
     1681 ggaacattta aagaatgcta acaagaatga aattccacaa ttagttggtg aaatttatca
     1741 gaatttcttt gtggagagca aagaaatatc tgtggaaaaa tcactttaca aagaaattca
     1801 gcagtgtctt gtaggaaata aaggtattga agtattctac aaaatccagg aagatgttta
     1861 tgagacccta aaggataggt attacccttc atttattgtc agtgacctgt atgagaaatt
     1921 gttgataaaa gaggaagaaa aacatgcctc acagatgatt tccaacaagg atgagatggg
     1981 cccaagagat gaggctggtg aggaagccgt ggatgatggt accaatcaga tcaatgaaca
     2041 agccagtttt gctgtaaaca aactgcgaga actaaatgag aaacttgaat ataaaaggca
     2101 agctctaaat tctattcaaa atgcaccaaa acctgacaag aagattgttt ccaagttgaa
     2161 ggatgaaata atcctaatag agaaagaacg cacagacctt cagctgcaca tggcaagaac
     2221 ggattggtgg tgtgaaaacc ttggcatgtg gaaagcctcc atcaccagtg gagaggttac
     2281 agaagagaat ggtgagcaat tgccatgtta ctttgtcatg gtaagcctac aagaagttgg
     2341 aggagttgaa actaagaact ggacggtccc cagaaggctc agcgagtttc agaatttaca
     2401 ccggaaactc agtgagtgcg tcccttcttt aaaaaaagtc cagttgcctt ctcttagcaa
     2461 gctgcctttc aaatctatag atcaaaagtt tatggaaaag tcgaagaatc aattaaataa
     2521 gtttttacag aatctgcttt cagatgaaag actgtgtcag agtgaagcac tttatgcctt
     2581 cttgagccct tctcctgact acctcaaggt tatcgacgtg caggggaaaa aaaattcttt
     2641 ttcattatcc tcatttttgg aaagacttcc tcgcgacttc ttctcccacc aggaggagga
     2701 gacagaggag gacagtgacc tgtcagatta tggtgatgat gtggatggga ggaaagacgc
     2761 cttggctgaa ccatgtttca tgttgattgg ggagattttt gaacttcgag gaatgtttaa
     2821 atgggtgaga agaacattaa ttgccctcgt tcaggtcact tttggaagaa ccatcaacaa
     2881 acaaatccgg gacacagtca gctggatttt cagtgagcaa atgttggttt actacatcaa
     2941 tattttccgg gatgcttttt ggccaaatgg gaagttggca ccaccgacca caatcagaag
     3001 caaagagcaa agtcaggaaa caaaacagag agcacagcaa aagctgcttg aaaacattcc
     3061 aggaaacatt ctttacaatg aaaaaaaaaa ggatcatact cttttaagcc attttttgtc
     3121 acttgctaag aagttatact gagaatgtta agaacttgaa aaatgtttta gaacagataa
     3181 taaactttgt gttttggaaa tcctgctaaa
//
