LOCUS       NM_001317781            3318 bp    mRNA    linear   PRI 04-OCT-2024
DEFINITION  Homo sapiens sorting nexin 25 (SNX25), transcript variant 6, mRNA.
ACCESSION   NM_001317781 XM_011532309
VERSION     NM_001317781.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3318)
  AUTHORS   Lauzier,A., Bossanyi,M.F., Larcher,R., Nassari,S., Ugrankar,R.,
            Henne,W.M. and Jean,S.
  TITLE     Snazarus and its human ortholog SNX25 modulate autophagic flux
  JOURNAL   J Cell Sci 135 (5) (2022)
   PUBMED   34821359
REFERENCE   2  (bases 1 to 3318)
  AUTHORS   Zhang,Y., Zheng,L., Xu,B.M., Tang,W.H., Ye,Z.D., Huang,C., Ma,X.,
            Zhao,J.J., Guo,F.X., Kang,C.M., Lu,J.B., Xiu,J.C., Li,P., Xu,Y.J.,
            Xiao,L., Wu,Q., Hu,Y.W. and Wang,Q.
  TITLE     LncRNA-RP11-714G18.1 suppresses vascular cell migration via
            directly targeting LRP2BP
  JOURNAL   Immunol Cell Biol 96 (2), 175-189 (2018)
   PUBMED   29363163
  REMARK    GeneRIF: RP11-714G18.1 may play an athero-protective role by
            inhibiting vascular cell migration via RP11-714G18.1/LRP2BP/MMP1
            signaling pathway.
REFERENCE   3  (bases 1 to 3318)
  AUTHORS   Lee,J.H., Cheng,R., Vardarajan,B., Lantigua,R., Reyes-Dumeyer,D.,
            Ortmann,W., Graham,R.R., Bhangale,T., Behrens,T.W., Medrano,M.,
            Jimenez-Velazquez,I.Z. and Mayeux,R.
  TITLE     Genetic Modifiers of Age at Onset in Carriers of the G206A Mutation
            in PSEN1 With Familial Alzheimer Disease Among Caribbean Hispanics
  JOURNAL   JAMA Neurol 72 (9), 1043-1051 (2015)
   PUBMED   26214276
  REMARK    GeneRIF: This study confirmed that SNX25 as genetic modifiers of
            age at onset of Alzheimer disease.
REFERENCE   4  (bases 1 to 3318)
  AUTHORS   Du,Y., Zou,Y., Yu,W., Shi,R., Zhang,M., Yang,W., Duan,J., Deng,Y.,
            Wang,X. and Lu,Y.
  TITLE     Expression pattern of sorting Nexin 25 in temporal lobe epilepsy: a
            study on patients and pilocarpine-induced rats
  JOURNAL   Brain Res 1509, 79-85 (2013)
   PUBMED   23518199
  REMARK    GeneRIF: upregulation of SNX25 might be involved in the development
            of temporal lobe epilepsy.
REFERENCE   5  (bases 1 to 3318)
  AUTHORS   Hao,X., Wang,Y., Ren,F., Zhu,S., Ren,Y., Jia,B., Li,Y.P., Shi,Y.
            and Chang,Z.
  TITLE     SNX25 regulates TGF-beta signaling by enhancing the receptor
            degradation
  JOURNAL   Cell Signal 23 (5), 935-946 (2011)
   PUBMED   21266196
  REMARK    GeneRIF: SNX25 negatively regulates TGF-beta signaling by enhancing
            the receptor degradation through lysosome pathway.
REFERENCE   6  (bases 1 to 3318)
  AUTHORS   Worby,C.A. and Dixon,J.E.
  TITLE     Sorting out the cellular functions of sorting nexins
  JOURNAL   Nat Rev Mol Cell Biol 3 (12), 919-931 (2002)
   PUBMED   12461558
  REMARK    Review article
            Erratum:[Nat Rev Mol Cell Biol. 2003 Feb;4(2):156.]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY601647.1, AC073344.7, AF113223.1 and AA626308.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001317781.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY601647.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148874, SAMEA2151119
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AY601647.1         1-18
            19-19               AC073344.7         14854-14854
            20-96               AY601647.1         20-96
            97-97               AC073344.7         14932-14932
            98-1460             AY601647.1         98-1460
            1461-3058           AF113223.1         346-1943
            3059-3318           AA626308.1         14-273              c
FEATURES             Location/Qualifiers
     source          1..3318
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q35.1"
     gene            1..3318
                     /gene="SNX25"
                     /gene_synonym="LRP2BP-AS1; MSTP043; SBBI31"
                     /note="sorting nexin 25"
                     /db_xref="GeneID:83891"
                     /db_xref="HGNC:HGNC:21883"
                     /db_xref="MIM:620961"
     exon            1..231
                     /gene="SNX25"
                     /gene_synonym="LRP2BP-AS1; MSTP043; SBBI31"
                     /inference="alignment:Splign:2.1.0"
     exon            232..316
                     /gene="SNX25"
                     /gene_synonym="LRP2BP-AS1; MSTP043; SBBI31"
                     /inference="alignment:Splign:2.1.0"
     CDS             295..2817
                     /gene="SNX25"
                     /gene_synonym="LRP2BP-AS1; MSTP043; SBBI31"
                     /note="isoform 6 is encoded by transcript variant 6;
                     LRP2BP antisense RNA 1; RP11-714G18.1"
                     /codon_start=1
                     /product="sorting nexin-25 isoform 6"
                     /protein_id="NP_001304710.1"
                     /db_xref="CCDS:CCDS34116.1"
                     /db_xref="GeneID:83891"
                     /db_xref="HGNC:HGNC:21883"
                     /db_xref="MIM:620961"
                     /translation="MDKALKEVFDYSYRDYILSWYGNLSRDEGQLYHLLLEDFWEIAR
                     QLHHRLSHVDVVKVVCNDVVRTLLTHFCDLKAANARHEEQPRPFVLHACLRNSDDEVR
                     FLQTCSRVLVFCLLPSKDVQSLSLRIMLAEILTTKVLKPVVELLSNPDYINQMLLAQL
                     AYREQMNEHHKRAYTYAPSYEDFIKLINSNSDVEFLKQLRYQIVVEIIQATTISSFPQ
                     LKRHKGKETAAMKADLLRARNMKRYINQLTVAKKQCEKRIRILGGPAYDQQEDGALDE
                     GEGPQSQKILQFEDILANTFYREHFGMYMERMDKRALISFWESVEHLKNANKNEIPQL
                     VGEIYQNFFVESKEISVEKSLYKEIQQCLVGNKGIEVFYKIQEDVYETLKDRYYPSFI
                     VSDLYEKLLIKEEEKHASQMISNKDEMGPRDEAGEEAVDDGTNQINEQASFAVNKLRE
                     LNEKLEYKRQALNSIQNAPKPDKKIVSKLKDEIILIEKERTDLQLHMARTDWWCENLG
                     MWKASITSGEVTEENGEQLPCYFVMVSLQEVGGVETKNWTVPRRLSEFQNLHRKLSEC
                     VPSLKKVQLPSLSKLPFKSIDQKFMEKSKNQLNKFLQNLLSDERLCQSEALYAFLSPS
                     PDYLKVIDVQGKKNSFSLSSFLERLPRDFFSHQEEETEEDSDLSDYGDDVDGRKDALA
                     EPCFMLIGEIFELRGMFKWVRRTLIALVQVTFGRTINKQIRDTVSWIFSEQMLVYYIN
                     IFRDAFWPNGKLAPPTTIRSKEQSQETKQRAQQKLLENIPDMLQSLVGQQNARHGIIK
                     IFNALQETRANKHLLYALMELLLIELCPELRVHLDQLKAGQV"
     exon            317..533
                     /gene="SNX25"
                     /gene_synonym="LRP2BP-AS1; MSTP043; SBBI31"
                     /inference="alignment:Splign:2.1.0"
     exon            534..706
                     /gene="SNX25"
                     /gene_synonym="LRP2BP-AS1; MSTP043; SBBI31"
                     /inference="alignment:Splign:2.1.0"
     exon            707..893
                     /gene="SNX25"
                     /gene_synonym="LRP2BP-AS1; MSTP043; SBBI31"
                     /inference="alignment:Splign:2.1.0"
     exon            894..964
                     /gene="SNX25"
                     /gene_synonym="LRP2BP-AS1; MSTP043; SBBI31"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1146
                     /gene="SNX25"
                     /gene_synonym="LRP2BP-AS1; MSTP043; SBBI31"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1278
                     /gene="SNX25"
                     /gene_synonym="LRP2BP-AS1; MSTP043; SBBI31"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1551
                     /gene="SNX25"
                     /gene_synonym="LRP2BP-AS1; MSTP043; SBBI31"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1716
                     /gene="SNX25"
                     /gene_synonym="LRP2BP-AS1; MSTP043; SBBI31"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1848
                     /gene="SNX25"
                     /gene_synonym="LRP2BP-AS1; MSTP043; SBBI31"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..1989
                     /gene="SNX25"
                     /gene_synonym="LRP2BP-AS1; MSTP043; SBBI31"
                     /inference="alignment:Splign:2.1.0"
     exon            1990..2103
                     /gene="SNX25"
                     /gene_synonym="LRP2BP-AS1; MSTP043; SBBI31"
                     /inference="alignment:Splign:2.1.0"
     exon            2104..2268
                     /gene="SNX25"
                     /gene_synonym="LRP2BP-AS1; MSTP043; SBBI31"
                     /inference="alignment:Splign:2.1.0"
     exon            2269..2386
                     /gene="SNX25"
                     /gene_synonym="LRP2BP-AS1; MSTP043; SBBI31"
                     /inference="alignment:Splign:2.1.0"
     exon            2387..2453
                     /gene="SNX25"
                     /gene_synonym="LRP2BP-AS1; MSTP043; SBBI31"
                     /inference="alignment:Splign:2.1.0"
     exon            2454..2635
                     /gene="SNX25"
                     /gene_synonym="LRP2BP-AS1; MSTP043; SBBI31"
                     /inference="alignment:Splign:2.1.0"
     exon            2636..2736
                     /gene="SNX25"
                     /gene_synonym="LRP2BP-AS1; MSTP043; SBBI31"
                     /inference="alignment:Splign:2.1.0"
     exon            2737..3318
                     /gene="SNX25"
                     /gene_synonym="LRP2BP-AS1; MSTP043; SBBI31"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3300..3305
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNX25"
                     /gene_synonym="LRP2BP-AS1; MSTP043; SBBI31"
                     /note="hexamer: AATAAA"
     polyA_site      3318
                     /gene="SNX25"
                     /gene_synonym="LRP2BP-AS1; MSTP043; SBBI31"
                     /note="major polyA site"
ORIGIN      
        1 ctgctcccgg ctgcctaggg cggcgcgggt aggccccgtt gttctcgtgc gttaataggg
       61 aaagctgcct tgattatctt gtaattctct accaaaccaa gaataaaaaa gaacggcggc
      121 tgtgtgtttg tgatattttc tatcagcaaa tttcagttca taccactagt tagttctgtg
      181 gaccagaggc tggtttcaga atggaaagac ctttgccgag tggtaaacga gagtcctgtg
      241 tatggaaact cacatgagtc agctcagtct agaagggtag taatttctca taatatggat
      301 aaagctctga aagaagtgtt cgactacagt tatagagatt acattctgtc ctggtatgga
      361 aacctcagca gagatgaggg acaactttac catctgctct tggaagactt ttgggaaatt
      421 gccagacagc tgcaccacag actgagtcac gtggatgtgg ttaaagttgt ctgcaatgat
      481 gttgtgagga ctttactcac tcatttctgt gacctgaaag ctgccaatgc cagacatgaa
      541 gaacagccaa gaccttttgt gttgcacgca tgcttgagga actcagatga tgaagtaaga
      601 tttctacaaa cgtgttctcg ggttctggtg ttttgtctcc tcccctcaaa ggatgtgcag
      661 tctctcagct tacgtataat gcttgcagaa attctcacaa caaaagtctt gaagccggta
      721 gtggagttac tgagtaatcc agattacatt aaccaaatgc tgcttgccca gctggcgtac
      781 agagagcaaa tgaatgagca tcacaagaga gcctacacct atgccccctc ttacgaggac
      841 ttcatcaagc tcattaacag caactctgat gtggagttct tgaagcaact aaggtatcaa
      901 attgtagtgg aaataatcca ggcgactaca attagcagct ttccccaact gaagaggcac
      961 aaaggtaaag aaactgcggc aatgaaagct gatctcctga gggccaggaa catgaagagg
     1021 tacatcaacc aactgactgt ggcaaagaag cagtgtgaga agagaatccg aatcctggga
     1081 ggccctgcct atgaccagca agaggatggg gccctggatg agggggaagg gcctcaaagc
     1141 cagaagattc ttcagtttga agatatcttg gccaatacgt tctaccgaga gcactttgga
     1201 atgtacatgg aaaggatgga caaaagagct ctgattagtt tttgggaatc tgtggaacat
     1261 ttaaagaatg ctaacaagaa tgaaattcca caattagttg gtgaaattta tcagaatttc
     1321 tttgtggaga gcaaagaaat atctgtggaa aaatcacttt acaaagaaat tcagcagtgt
     1381 cttgtaggaa ataaaggtat tgaagtattc tacaaaatcc aggaagatgt ttatgagacc
     1441 ctaaaggata ggtattaccc ttcatttatt gtcagtgacc tgtatgagaa attgttgata
     1501 aaagaggaag aaaaacatgc ctcacagatg atttccaaca aggatgagat gggcccaaga
     1561 gatgaggctg gtgaggaagc cgtggatgat ggtaccaatc agatcaatga acaagccagt
     1621 tttgctgtaa acaaactgcg agaactaaat gagaaacttg aatataaaag gcaagctcta
     1681 aattctattc aaaatgcacc aaaacctgac aagaagattg tttccaagtt gaaggatgaa
     1741 ataatcctaa tagagaaaga acgcacagac cttcagctgc acatggcaag aacggattgg
     1801 tggtgtgaaa accttggcat gtggaaagcc tccatcacca gtggagaggt tacagaagag
     1861 aatggtgagc aattgccatg ttactttgtc atggtaagcc tacaagaagt tggaggagtt
     1921 gaaactaaga actggacggt ccccagaagg ctcagcgagt ttcagaattt acaccggaaa
     1981 ctcagtgagt gcgtcccttc tttaaaaaaa gtccagttgc cttctcttag caagctgcct
     2041 ttcaaatcta tagatcaaaa gtttatggaa aagtcgaaga atcaattaaa taagttttta
     2101 cagaatctgc tttcagatga aagactgtgt cagagtgaag cactttatgc cttcttgagc
     2161 ccttctcctg actacctcaa ggttatcgac gtgcagggga aaaaaaattc tttttcatta
     2221 tcctcatttt tggaaagact tcctcgcgac ttcttctccc accaggagga ggagacagag
     2281 gaggacagtg acctgtcaga ttatggtgat gatgtggatg ggaggaaaga cgccttggct
     2341 gaaccatgtt tcatgttgat tggggagatt tttgaacttc gaggaatgtt taaatgggtg
     2401 agaagaacat taattgccct cgttcaggtc acttttggaa gaaccatcaa caaacaaatc
     2461 cgggacacag tcagctggat tttcagtgag caaatgttgg tttactacat caatattttc
     2521 cgggatgctt tttggccaaa tgggaagttg gcaccaccga ccacaatcag aagcaaagag
     2581 caaagtcagg aaacaaaaca gagagcacag caaaagctgc ttgaaaacat tccagatatg
     2641 cttcagagcc ttgttggaca gcaaaatgcc cgccacggta taataaaaat attcaatgca
     2701 ctgcaagaaa caagagccaa caagcatctg ttatatgcgc tgatggaact gctgctaatt
     2761 gaactgtgtc ctgagctgag agttcattta gatcaactta aagctggcca agtttgagac
     2821 tacacaaata aaccaccaga aaaatgtctg tgtaataata gacatgaaac attttcctct
     2881 tttccacaga gggcttaact gagaaccgta ttgattttta ttttagttac ctccctctag
     2941 ttttatgtga aattagtaga atcagggagg acgggactta tgctgtggta ggcaacagaa
     3001 aaaaacttct attgatttta atttaatatg aatactttaa agatcaacat accgattgaa
     3061 atacaaatgt taatatgtga gaacctagga agtattttaa atatttatga aaatattttg
     3121 ttttaaaatg aactatgaat attgtacagt taatttcctc actgaggact gtgaacattc
     3181 ttatattatt tcatgtatat tgaagaacat tgttatgcaa tgctttgtgt aaagttattg
     3241 tgaagatttt attgtcttta tttttaccaa agatttccca tagtttgagc attcaaagca
     3301 ataaaatata aaaatgaa
//
