LOCUS       NM_014035               1987 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens sorting nexin 24 (SNX24), transcript variant 1, mRNA.
ACCESSION   NM_014035
VERSION     NM_014035.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1987)
  AUTHORS   Lacey,J., Webster,S.J., Heath,P.R., Hill,C.J., Nicholson-Goult,L.,
            Wagner,B.E., Khan,A.O., Morgan,N.V., Makris,M. and Daly,M.E.
  TITLE     Sorting nexin 24 is required for alpha-granule biogenesis and cargo
            delivery in megakaryocytes
  JOURNAL   Haematologica 107 (8), 1902-1913 (2022)
   PUBMED   35021601
  REMARK    GeneRIF: Sorting nexin 24 is required for alpha-granule biogenesis
            and cargo delivery in megakaryocytes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1987)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1987)
  AUTHORS   Anttila,V., Winsvold,B.S., Gormley,P., Kurth,T., Bettella,F.,
            McMahon,G., Kallela,M., Malik,R., de Vries,B., Terwindt,G.,
            Medland,S.E., Todt,U., McArdle,W.L., Quaye,L., Koiranen,M.,
            Ikram,M.A., Lehtimaki,T., Stam,A.H., Ligthart,L., Wedenoja,J.,
            Dunham,I., Neale,B.M., Palta,P., Hamalainen,E., Schurks,M.,
            Rose,L.M., Buring,J.E., Ridker,P.M., Steinberg,S., Stefansson,H.,
            Jakobsson,F., Lawlor,D.A., Evans,D.M., Ring,S.M., Farkkila,M.,
            Artto,V., Kaunisto,M.A., Freilinger,T., Schoenen,J., Frants,R.R.,
            Pelzer,N., Weller,C.M., Zielman,R., Heath,A.C., Madden,P.A.F.,
            Montgomery,G.W., Martin,N.G., Borck,G., Gobel,H., Heinze,A.,
            Heinze-Kuhn,K., Williams,F.M.K., Hartikainen,A.L., Pouta,A., van
            den Ende,J., Uitterlinden,A.G., Hofman,A., Amin,N., Hottenga,J.J.,
            Vink,J.M., Heikkila,K., Alexander,M., Muller-Myhsok,B.,
            Schreiber,S., Meitinger,T., Wichmann,H.E., Aromaa,A.,
            Eriksson,J.G., Traynor,B., Trabzuni,D., Rossin,E., Lage,K.,
            Jacobs,S.B.R., Gibbs,J.R., Birney,E., Kaprio,J., Penninx,B.W.,
            Boomsma,D.I., van Duijn,C., Raitakari,O., Jarvelin,M.R.,
            Zwart,J.A., Cherkas,L., Strachan,D.P., Kubisch,C., Ferrari,M.D.,
            van den Maagdenberg,A.M.J.M., Dichgans,M., Wessman,M., Smith,G.D.,
            Stefansson,K., Daly,M.J., Nyholt,D.R., Chasman,D. and Palotie,A.
  CONSRTM   North American Brain Expression Consortium; UK Brain Expression
            Consortium
  TITLE     Genome-wide meta-analysis identifies new susceptibility loci for
            migraine
  JOURNAL   Nat Genet 45 (8), 912-917 (2013)
   PUBMED   23793025
REFERENCE   4  (bases 1 to 1987)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   5  (bases 1 to 1987)
  AUTHORS   Worby,C.A. and Dixon,J.E.
  TITLE     Sorting out the cellular functions of sorting nexins
  JOURNAL   Nat Rev Mol Cell Biol 3 (12), 919-931 (2002)
   PUBMED   12461558
  REMARK    Review article
            Erratum:[Nat Rev Mol Cell Biol. 2003 Feb;4(2):156.]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ278046.1, BC010886.1, AF139461.1 and BU623609.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014035.3.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes a protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.282706.1,
                                           SRR1660807.231209.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261369.9/ ENSP00000261369.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-463               BQ278046.1         121-583
            464-1356            BC010886.1         572-1464
            1357-1477           AF139461.1         1386-1506
            1478-1987           BU623609.1         25-534              c
FEATURES             Location/Qualifiers
     source          1..1987
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q23.2"
     gene            1..1987
                     /gene="SNX24"
                     /gene_synonym="PRO1284; SBBI31"
                     /note="sorting nexin 24"
                     /db_xref="GeneID:28966"
                     /db_xref="HGNC:HGNC:21533"
     exon            1..81
                     /gene="SNX24"
                     /gene_synonym="PRO1284; SBBI31"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..531
                     /gene="SNX24"
                     /gene_synonym="PRO1284; SBBI31"
                     /note="sorting nexing 24"
                     /codon_start=1
                     /product="sorting nexin-24"
                     /protein_id="NP_054754.1"
                     /db_xref="CCDS:CCDS4132.1"
                     /db_xref="GeneID:28966"
                     /db_xref="HGNC:HGNC:21533"
                     /translation="MEVYIPSFRYEESDLERGYTVFKIEVLMNGRKHFVEKRYSEFHA
                     LHKKLKKCIKTPEIPSKHVRNWVPKVLEQRRQGLETYLQAVILENEELPKLFLDFLNV
                     RHLPSLPKAESCGSFDETESEESSKLSHQPVLLFLRDPYVLPAASDFPNVVIEGVLHG
                     IFYPHLQPR"
     exon            82..165
                     /gene="SNX24"
                     /gene_synonym="PRO1284; SBBI31"
                     /inference="alignment:Splign:2.1.0"
     exon            166..270
                     /gene="SNX24"
                     /gene_synonym="PRO1284; SBBI31"
                     /inference="alignment:Splign:2.1.0"
     exon            271..365
                     /gene="SNX24"
                     /gene_synonym="PRO1284; SBBI31"
                     /inference="alignment:Splign:2.1.0"
     exon            366..398
                     /gene="SNX24"
                     /gene_synonym="PRO1284; SBBI31"
                     /inference="alignment:Splign:2.1.0"
     exon            399..463
                     /gene="SNX24"
                     /gene_synonym="PRO1284; SBBI31"
                     /inference="alignment:Splign:2.1.0"
     exon            464..1987
                     /gene="SNX24"
                     /gene_synonym="PRO1284; SBBI31"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1967..1972
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNX24"
                     /gene_synonym="PRO1284; SBBI31"
                     /note="hexamer: AATAAA"
     polyA_site      1987
                     /gene="SNX24"
                     /gene_synonym="PRO1284; SBBI31"
                     /note="major polyA site"
ORIGIN      
        1 agccggctgg ccggcgcggc catggaggtc tacatcccgt cctttcgcta tgaagagagc
       61 gacctggagc ggggatacac ggtgtttaag atagaagtgc taatgaatgg aagaaaacat
      121 tttgttgaaa agagatacag cgaatttcat gctttgcaca aaaagcttaa gaaatgtata
      181 aaaactccag aaatcccttc taaacatgtt aggaactggg tccccaaagt cttggaacag
      241 cgacgacaag gcttggaaac atacttacag gctgtcattt tagaaaatga agaacttccc
      301 aaactgtttc ttgatttcct aaatgtgcga cacttgccct ctctaccaaa ggcagaaagt
      361 tgtggatctt ttgatgaaac agagtctgaa gagtcaagca aactgtccca ccagcctgtg
      421 ctgctgttcc tcagggatcc atatgtcttg cctgcagcca gcgattttcc aaatgtggtt
      481 attgaaggag tcctccatgg gatattttac cctcatctac agcccaggta gaaatcctac
      541 atggctaaaa gaagcagaag caagtttcga agtcacagtc aaggaaatca atacctacca
      601 atttaaccta aacgctatga tatataacag ctctagctag tggtaaagtg cacagtccca
      661 gcttaattca gggcagggac atttccatta gaatggtgct cttaaaaata gaaactgaac
      721 cggggcggtg gtcaggctaa ggccaagtgt ttaagaagta gagtgtagct gccagcgtag
      781 aaacccatga aaaggaggcc acaggagatt cctgggagca ctgggtgtag caaaacaaag
      841 ccactctctg cttcagtcgc accatttgct aattgaaaat catatcctga atcatactga
      901 gactgatcaa ctttggtagc ttttttgttc agatcttatg acacactact cttctcaccg
      961 tgagattttc tcagccagtg atagtacatt ctgaaatgct ggcaccagga gacggccaca
     1021 gacacacact gctaaatgtg aagatggaac taaactggaa attaaattat actgacaata
     1081 ttatggcatt tttaagatca tggcatttta atttacatta gagtggagtt gcatcatact
     1141 caggggttag cttccaaggt cagtacatag gtaaaatggg ctattaggat gatccttgaa
     1201 agccctttag aagggtgcca tgttggaaac ctgtacatcc acaacaagta gcttttcctc
     1261 ctatgttgga aaaaaagact gtttctttgt ttgaagacca agtgaagttg ttggtgtttg
     1321 tttaggggcc attttgttaa aaaaaaaaaa aaaaaagcac ataactttta acactagaat
     1381 cagcccgcaa gatgcttgcc ccgctagtgg cagatgtgaa ctgacaagga gtgaagcgcc
     1441 cacccagcgg atggacagca cccacctggg tttactcaag ggtgtgcatt cattttaggt
     1501 gggatcgcca caggatttca tgttattttc cttacggctt ccttttcact gacctcattt
     1561 gttgagttaa tgtaagttaa atgtgtttat gatataactc cactgtacat catcctttga
     1621 gtagtaaagg ataaaagcat atatactacc tatatgtatg tgctgtatgt gggcatttca
     1681 ttgagatcta attaatagct agcctattta tggttattcg ttttagtaag ttctgtggga
     1741 gcaaggtatt taaaatcaaa actaataact acatcatggt ttttgattag gatctaaata
     1801 ttcaggtttt aagcctgctg caaactttta aaatattatg atagattctg tactacatgt
     1861 gggaaacaag caagaactaa ataatcaaat gttgtcaacc aaaagtaata gttgggtatt
     1921 ggagattttt ttaaaatgtt tttatgttat tagctatttg gagttaaata aaaacagaac
     1981 aaggaaa
//
