LOCUS       NM_024798               3600 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens sorting nexin 22 (SNX22), transcript variant 1, mRNA.
ACCESSION   NM_024798 XM_001133540
VERSION     NM_024798.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3600)
  AUTHORS   Batty,M.B., Schittenhelm,R.B., Dorin-Semblat,D., Doerig,C. and
            Garcia-Bustos,J.F.
  TITLE     Interaction of Plasmodium falciparum casein kinase 1 with
            components of host cell protein trafficking machinery
  JOURNAL   IUBMB Life 72 (6), 1243-1249 (2020)
   PUBMED   32356940
REFERENCE   2  (bases 1 to 3600)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3600)
  AUTHORS   Song,J., Zhao,K.Q., Newman,C.L., Vinarov,D.A. and Markley,J.L.
  TITLE     Solution structure of human sorting nexin 22
  JOURNAL   Protein Sci 16 (5), 807-814 (2007)
   PUBMED   17400918
REFERENCE   4  (bases 1 to 3600)
  AUTHORS   Worby,C.A. and Dixon,J.E.
  TITLE     Sorting out the cellular functions of sorting nexins
  JOURNAL   Nat Rev Mol Cell Biol 3 (12), 919-931 (2002)
   PUBMED   12461558
  REMARK    Review article
            Erratum:[Nat Rev Mol Cell Biol. 2003 Feb;4(2):156.]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK024014.1 and AC100840.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_024798.2.
            
            Summary: The protein encoded by this gene is a sorting nexin that
            is found in the cytoplasm, where it interacts with membrane-bound
            phosphatidylinositol 3-phosphate. The encoded protein may play a
            role in intracellular trafficking. Two transcript variants, one
            protein-coding and the other not protein-coding, have been found
            for this gene. [provided by RefSeq, Dec 2012].
            
            Transcript Variant: This variant (1) represents the protein-coding
            transcript.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA958012.1, AK024014.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000325881.9/ ENSP00000323435.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-616               AK024014.1         15-630
            617-3600            AC100840.2         19612-22595         c
FEATURES             Location/Qualifiers
     source          1..3600
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q22.31"
     gene            1..3600
                     /gene="SNX22"
                     /note="sorting nexin 22"
                     /db_xref="GeneID:79856"
                     /db_xref="HGNC:HGNC:16315"
     exon            1..120
                     /gene="SNX22"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..627
                     /gene="SNX22"
                     /codon_start=1
                     /product="sorting nexin-22"
                     /protein_id="NP_079074.2"
                     /db_xref="CCDS:CCDS10190.1"
                     /db_xref="GeneID:79856"
                     /db_xref="HGNC:HGNC:16315"
                     /translation="MLEVHIPSVGPEAEGPRQSPEKSHMVFRVEVLCSGRRHTVPRRY
                     SEFHALHKRIKKLYKVPDFPSKRLPNWRTRGLEQRRQGLEAYIQGILYLNQEVPKELL
                     EFLRLRHFPTDPKASNWGTLREFLPGDSSSQQHQRPVLSFHVDPYVCNPSPESLPNVV
                     VNGVLQGLYSFSISPDKAQPKAACHPAPLPPMP"
     exon            121..204
                     /gene="SNX22"
                     /inference="alignment:Splign:2.1.0"
     exon            205..309
                     /gene="SNX22"
                     /inference="alignment:Splign:2.1.0"
     exon            310..404
                     /gene="SNX22"
                     /inference="alignment:Splign:2.1.0"
     exon            405..437
                     /gene="SNX22"
                     /inference="alignment:Splign:2.1.0"
     exon            438..505
                     /gene="SNX22"
                     /inference="alignment:Splign:2.1.0"
     exon            506..3600
                     /gene="SNX22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3578..3583
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNX22"
                     /note="hexamer: AATAAA"
     polyA_site      3600
                     /gene="SNX22"
                     /note="major polyA site"
ORIGIN      
        1 agggctccga gccgagcgcg cggagcagct ggggccgggg cgcggatgct ggaagttcac
       61 atcccgtcgg tggggcccga ggccgagggg cccaggcaga gcccggagaa aagccacatg
      121 gtgttccgag tggaggtgct gtgcagcggg cgcagacaca cggtgccaag gcgctacagc
      181 gagttccacg cgctgcacaa gcggatcaag aagctgtaca aagtgcccga cttcccctcg
      241 aaacgcctgc ccaactggag gaccagaggg ttggaacagc gccggcaggg cttggaggct
      301 tacatccagg gcatcctgta cctgaaccag gaggtgccca aggagttact ggaattcctg
      361 agacttcggc acttccccac agaccccaag gctagcaact ggggcaccct gagggagttc
      421 ctgcctggcg acagcagctc ccagcagcac cagcggcctg tcctgagctt ccatgtggat
      481 ccctatgttt gcaacccctc cccagagtcg ctgcccaacg tggtggtgaa tggtgtgctc
      541 cagggcctct acagcttcag catcagccca gataaagccc agccaaaggc ggcctgtcac
      601 cctgctcctc tgccaccgat gccctgatca gtccagaggc ctttggctgc ctcctaagaa
      661 agtcatgtgc ctctgtccta tgaactccat ataaggctgg gtcctccttt ggcctggacc
      721 caggacttaa ttacccagtg cccagttgtg ccacattccc actcaaggct cagaacttgg
      781 ctcgcattgg tagctggagg tggtagaatt tgtatgctct tagagcccaa cagccaaggc
      841 agggtcaaga agataagtaa taaaagagga agtcagccag gcgcggtggc tcatgcctgt
      901 aatcccagca ctttgggagg ccaagatggg tggatcacct gaagtcagga gttcgagacc
      961 agcctgacca ccatggagaa accccgtctc tactaaaaat acaaaattag ccgggcattg
     1021 tggtggtgca tgcctgtaat cccagctact cgggaagctg aggtaggaga atctcttttt
     1081 tttttttttt tttttttttg agacggagtt tcactcttgt tgcccaggct ggaatgcaat
     1141 ggcacgatct cggctcacgg caacccccgc ttcccgggtt caagcaattc tcctgcctca
     1201 gcctctcgag tagctgggat tacaggcatc cgccaccatg cccggctaat ttttgtattt
     1261 ttaatagaga tgggtttcac cacgttggcc aggctggtct tgtactcctg acgtcaggtg
     1321 atccacccgc ctcggcttcc caaagtgctg ggattacggg cgtgagccac cgtgctcggc
     1381 ccaaggcagg agaatctctt gaagccagga ggcggaagtt gtggtgagcc gagatcgcgc
     1441 cactgcactc cagcctgggc aacaagagtg aaactccgtc tcaaaataaa taaataataa
     1501 aggaagaagt cagctgggtg cagaggctca tgcctgtaat cccaatactt taggaggcca
     1561 aggcaggagg atgcttgggt ctggaagttt gagaccagcc agcgcaacat agtgagacct
     1621 gtctctacca aaaaaaaaaa aaaaaaaaaa aaatcaattt agaggtaggc tatgaaaaag
     1681 tacagataca tcccttaaca tagactggag ggtggtggca aggggagcaa atgtggaggc
     1741 ccagtagctg gcaaagttta gaagcagggg gcaaaagctc ctgcctgact tttcctgggt
     1801 agctcctggg tcaaaatttc aggcaggatc ccagggaagg ggcaggcacc cattgccaca
     1861 ggagagttgc aggcatgttg ggatgtaggc ctaggggagg tgctgcaggc tcaagaacca
     1921 ggcccacaca ttatatatta aaaaaaaaaa aacccacatt tttttttatt ggtcagtgtt
     1981 ggtaggagtt tgttacaaaa gtgagtccat gggcctgtgg aatgtgaggg gagtgggtcc
     2041 gctccaccag atgccagcac cggggccagt gcagctcaga gccctgtggc ggactacagg
     2101 gcctgcacag acggtcactc aaagaaagat gtccctgtgc cctactcctt ggcgatggca
     2161 aagggcttct ccacctcgat cttgccgcag tctgcgatga tcacatcctt caggggttta
     2221 tcccggctgt ctgtcttggt gctctccacc ttccgcacca cctcctggaa aagaaaggtg
     2281 gaagcaggag ggcatggtgg atcaggaggt ccaccgctca ggagaaaggc cccagcgtat
     2341 ggctcaggag ggctaagacc cacaagtgat caacagcaca caaaactgga ggcaccaaaa
     2401 ttctaacaga ctcctggcca gagcagggag aatgcagatt tgacgagggg gtacaggaat
     2461 tttgttcctt tgaagtaaga cccaggttgg gccaagggtg aggaggagga agagggtgac
     2521 cagggcatgt ggcttctcag ggacattgcg ttcagctgca ctctgtatac ctcaggggtg
     2581 ggaccagcac gtcactgagt gaaggagggg agggaggctc tggcagttgt gcagccttcc
     2641 tggctgggct ctgagggggc tggaagaatt tagaaccttg gaggcatgga ggtacagggt
     2701 ttattctgga caggagcact gggctgcatc tgtgggttgg gtccttttgg gaaagggatg
     2761 gacacatgga gctcctgccc tggggtctgt gttgaatccc cggtgaggat tgcccagtag
     2821 tagcccttgc ttccacaact caccatgccc tctagaactt tgccaaacac cacatgcttg
     2881 ccatctagcc aggctgtctt gactgtcgtg atgaagaact gggagccgtt ggtgtctttg
     2941 cctgcgttgg ccatgctcac ccagccaggc ccgtagtgct tcagtttgaa gttctcatcg
     3001 gggaagcgct caccgtagat gctctttcct gggaaaaaag acagagcagg tcaggggcgc
     3061 tggattgcgc caaaccaagc agacattcgg ggccaggact gagggggctt aacctgtcct
     3121 ctgtgccagg ctaggctgga gtggactaca aggacataaa agcagcgtcc ttcctatctt
     3181 ctggcctcag agccaagcca tgctgactga ggccaagtgg ggcatcaggc caggctgatg
     3241 tggtgaacag ctcacagaag gattactttg agaagatagt tttgtggctt ttaaataagg
     3301 cgcatgttat cagctcccct tagctatggc ccaggcctgc cacggaggga ctttggtgga
     3361 gggaagtgcc gtgcaggatg caggggagtc aacagggtcg gaactctcca gaaaaggagg
     3421 actgctgtgg ctgaccagcc tgttttccta tgagcacaaa agacacaggc atagctgcag
     3481 aggagaaagc agccagagat gtgtggggag gggcagaaaa gaggggctgc cccttggatt
     3541 ctggagagtc aaagcctctt aacaaggaat gaacaggaat aaaagacagc tgtgagtgtg
//
