LOCUS       NM_003100               6479 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens sorting nexin 2 (SNX2), transcript variant 1, mRNA.
ACCESSION   NM_003100
VERSION     NM_003100.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6479)
  AUTHORS   Garcia Delgado,L., Derome,A., Longpre,S., Giroux-Dansereau,M.,
            Basbous,G., Lavoie,C., Saucier,C. and Denault,J.B.
  TITLE     Spatiotemporal regulation of the hepatocyte growth factor receptor
            MET activity by sorting nexins 1/2 in HCT116 colorectal cancer
            cells
  JOURNAL   Biosci Rep 44 (6) (2024)
   PUBMED   38836326
  REMARK    GeneRIF: Spatiotemporal regulation of the hepatocyte growth factor
            receptor MET activity by sorting nexins 1/2 in HCT116 colorectal
            cancer cells.
REFERENCE   2  (bases 1 to 6479)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 6479)
  AUTHORS   Kocmar,T., Caglayan,E., Rayaman,E., Nagata,K. and Turan,K.
  TITLE     Human sorting nexin 2 protein interacts with Influenza A virus PA
            protein and has a negative regulatory effect on the virus
            replication
  JOURNAL   Mol Biol Rep 49 (1), 497-510 (2022)
   PUBMED   34817777
  REMARK    GeneRIF: Human sorting nexin 2 protein interacts with Influenza A
            virus PA protein and has a negative regulatory effect on the virus
            replication.
REFERENCE   4  (bases 1 to 6479)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 6479)
  AUTHORS   Cardoso,R.S., Tavares,L.A., Jesus,B.L.S., Criado,M.F., de
            Carvalho,A.N., Souza,J.P., Bedi,S., de Souza,M.M., Silva,M.L.,
            Lanfredi,G.P., Vitti,B.C., Scudero,O.B., Faca,V.M., Ono,A.,
            Ventura,A.M., daSilva,L.L.P. and Arruda,E.
  TITLE     Host Retromer Protein Sorting Nexin 2 Interacts with Human
            Respiratory Syncytial Virus Structural Proteins and is Required for
            Efficient Viral Production
  JOURNAL   mBio 11 (5), e01869-20 (2020)
   PUBMED   32994321
  REMARK    GeneRIF: Host Retromer Protein Sorting Nexin 2 Interacts with Human
            Respiratory Syncytial Virus Structural Proteins and is Required for
            Efficient Viral Production.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6479)
  AUTHORS   Fuchs,U., Rehkamp,G., Haas,O.A., Slany,R., Konig,M., Bojesen,S.,
            Bohle,R.M., Damm-Welk,C., Ludwig,W.D., Harbott,J. and Borkhardt,A.
  TITLE     The human formin-binding protein 17 (FBP17) interacts with sorting
            nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous
            leukemia
  JOURNAL   Proc Natl Acad Sci U S A 98 (15), 8756-8761 (2001)
   PUBMED   11438682
REFERENCE   7  (bases 1 to 6479)
  AUTHORS   Parks,W.T., Frank,D.B., Huff,C., Renfrew Haft,C., Martin,J.,
            Meng,X., de Caestecker,M.P., McNally,J.G., Reddi,A., Taylor,S.I.,
            Roberts,A.B., Wang,T. and Lechleider,R.J.
  TITLE     Sorting nexin 6, a novel SNX, interacts with the transforming
            growth factor-beta family of receptor serine-threonine kinases
  JOURNAL   J Biol Chem 276 (22), 19332-19339 (2001)
   PUBMED   11279102
REFERENCE   8  (bases 1 to 6479)
  AUTHORS   Wurthner,J.U., Frank,D.B., Felici,A., Green,H.M., Cao,Z.,
            Schneider,M.D., McNally,J.G., Lechleider,R.J. and Roberts,A.B.
  TITLE     Transforming growth factor-beta receptor-associated protein 1 is a
            Smad4 chaperone
  JOURNAL   J Biol Chem 276 (22), 19495-19502 (2001)
   PUBMED   11278302
REFERENCE   9  (bases 1 to 6479)
  AUTHORS   Haft,C.R., de la Luz Sierra,M., Bafford,R., Lesniak,M.A., Barr,V.A.
            and Taylor,S.I.
  TITLE     Human orthologs of yeast vacuolar protein sorting proteins Vps26,
            29, and 35: assembly into multimeric complexes
  JOURNAL   Mol Biol Cell 11 (12), 4105-4116 (2000)
   PUBMED   11102511
REFERENCE   10 (bases 1 to 6479)
  AUTHORS   Haft,C.R., de la Luz Sierra,M., Barr,V.A., Haft,D.H. and
            Taylor,S.I.
  TITLE     Identification of a family of sorting nexin molecules and
            characterization of their association with receptors
  JOURNAL   Mol Cell Biol 18 (12), 7278-7287 (1998)
   PUBMED   9819414
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC003382.1 and AC008669.7.
            
            On Nov 23, 2018 this sequence version replaced NM_003100.3.
            
            Summary: This gene belongs to the sorting nexin family whose
            members contain the phosphoinositide-binding phox (PX) domain. The
            encoded protein is a component of the retromer complex which plays
            a role in protein sorting in the endocytic pathway. This protein
            may form oligomeric complexes with other family members. Alternate
            splicing results in multiple transcript variants of this gene.
            Pseudogenes associated with this gene are located on chromosomes 1
            and 7. [provided by RefSeq, May 2013].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK222968.1, SRR3476690.902636.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379516.7/ ENSP00000368831.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2044              BC003382.1         9-2052
            2045-6479           AC008669.7         44630-49064
FEATURES             Location/Qualifiers
     source          1..6479
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q23.2"
     gene            1..6479
                     /gene="SNX2"
                     /gene_synonym="TRG-9"
                     /note="sorting nexin 2"
                     /db_xref="GeneID:6643"
                     /db_xref="HGNC:HGNC:11173"
                     /db_xref="MIM:605929"
     exon            1..132
                     /gene="SNX2"
                     /gene_synonym="TRG-9"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..1584
                     /gene="SNX2"
                     /gene_synonym="TRG-9"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transformation-related gene 9 protein; CTB-36H16.2"
                     /codon_start=1
                     /product="sorting nexin-2 isoform 1"
                     /protein_id="NP_003091.2"
                     /db_xref="CCDS:CCDS34217.1"
                     /db_xref="GeneID:6643"
                     /db_xref="HGNC:HGNC:11173"
                     /db_xref="MIM:605929"
                     /translation="MAAEREPPPLGDGKPTDFEDLEDGEDLFTSTVSTLESSPSSPEP
                     ASLPAEDISANSNGPKPTEVVLDDDREDLFAEATEEVSLDSPEREPILSSEPSPAVTP
                     VTPTTLIAPRIESKSMSAPVIFDRSREEIEEEANGDIFDIEIGVSDPEKVGDGMNAYM
                     AYRVTTKTSLSMFSKSEFSVKRRFSDFLGLHSKLASKYLHVGYIVPPAPEKSIVGMTK
                     VKVGKEDSSSTEFVEKRRAALERYLQRTVKHPTLLQDPDLRQFLESSELPRAVNTQAL
                     SGAGILRMVNKAADAVNKMTIKMNESDAWFEEKQQQFENLDQQLRKLHVSVEALVCHR
                     KELSANTAAFAKSAAMLGNSEDHTALSRALSQLAEVEEKIDQLHQEQAFADFYMFSEL
                     LSDYIRLIAAVKGVFDHRMKCWQKWEDAQITLLKKREAEAKMMVANKPDKIQQAKNEI
                     REWEAKVQQGERDFEQISKTIRKEVGRFEKERVKDFKTVIIKYLESLVQTQQQLIKYW
                     EAFLPEAKAIA"
     exon            133..250
                     /gene="SNX2"
                     /gene_synonym="TRG-9"
                     /inference="alignment:Splign:2.1.0"
     exon            251..414
                     /gene="SNX2"
                     /gene_synonym="TRG-9"
                     /inference="alignment:Splign:2.1.0"
     exon            415..481
                     /gene="SNX2"
                     /gene_synonym="TRG-9"
                     /inference="alignment:Splign:2.1.0"
     exon            482..525
                     /gene="SNX2"
                     /gene_synonym="TRG-9"
                     /inference="alignment:Splign:2.1.0"
     exon            526..667
                     /gene="SNX2"
                     /gene_synonym="TRG-9"
                     /inference="alignment:Splign:2.1.0"
     exon            668..746
                     /gene="SNX2"
                     /gene_synonym="TRG-9"
                     /inference="alignment:Splign:2.1.0"
     exon            747..822
                     /gene="SNX2"
                     /gene_synonym="TRG-9"
                     /inference="alignment:Splign:2.1.0"
     exon            823..936
                     /gene="SNX2"
                     /gene_synonym="TRG-9"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1030
                     /gene="SNX2"
                     /gene_synonym="TRG-9"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1236
                     /gene="SNX2"
                     /gene_synonym="TRG-9"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1380
                     /gene="SNX2"
                     /gene_synonym="TRG-9"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1461
                     /gene="SNX2"
                     /gene_synonym="TRG-9"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1533
                     /gene="SNX2"
                     /gene_synonym="TRG-9"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..6479
                     /gene="SNX2"
                     /gene_synonym="TRG-9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1669..1674
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNX2"
                     /gene_synonym="TRG-9"
                     /note="hexamer: AATAAA"
     polyA_site      1693
                     /gene="SNX2"
                     /gene_synonym="TRG-9"
                     /note="major polyA site"
     regulatory      2021..2026
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNX2"
                     /gene_synonym="TRG-9"
                     /note="hexamer: AATAAA"
     polyA_site      2044
                     /gene="SNX2"
                     /gene_synonym="TRG-9"
                     /note="major polyA site"
     regulatory      6447..6452
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNX2"
                     /gene_synonym="TRG-9"
                     /note="hexamer: AATAAA"
     polyA_site      6479
                     /gene="SNX2"
                     /gene_synonym="TRG-9"
ORIGIN      
        1 gcgcagtcgt tcgggtgagc gaagatggcg gccgagaggg aacctcctcc gctgggggac
       61 gggaagccca ccgactttga ggatctggag gacggagagg acctgttcac cagcactgtc
      121 tccaccctag agtcaagtcc atcatctcca gaaccagcta gtcttcctgc agaagatatt
      181 agtgcaaact ccaatggccc aaaacccaca gaagttgtat tagatgatga cagagaagat
      241 ctttttgcag aagccacaga agaagtttct ttggacagcc ctgaaaggga acctatccta
      301 tcctcggaac cttctcctgc agtcacacct gtcactccta ctacactcat tgctcctaga
      361 attgaatcaa agagtatgtc tgctcccgtg atctttgata gatccaggga agagattgaa
      421 gaagaagcaa atggagacat ttttgacata gaaattggtg tatcagatcc agaaaaagtt
      481 ggtgatggca tgaatgccta tatggcatat agagtaacaa caaagacatc tctttccatg
      541 ttcagtaaga gtgaattttc agtgaaaaga agattcagcg actttcttgg tttgcacagc
      601 aaattagcaa gcaaatattt acatgttggt tatattgtgc caccagctcc agaaaagagt
      661 atagtaggga tgaccaaggt caaagtgggt aaagaagact catcatccac tgagtttgta
      721 gaaaaacgga gagcagctct tgaaaggtat cttcaaagaa cagtaaaaca tccaacttta
      781 ctacaggatc ctgatttaag gcagttcttg gaaagttcag agctgcctag agcagttaat
      841 acacaggctc tgagtggagc aggaatattg aggatggtga acaaggctgc cgacgctgtc
      901 aacaaaatga caatcaagat gaatgaatcg gatgcatggt ttgaagaaaa gcagcagcaa
      961 tttgagaatc tggatcagca acttaggaaa cttcatgtca gtgttgaagc cttggtctgt
     1021 catagaaaag aactttcagc caacacagct gcctttgcta aaagtgctgc catgttaggt
     1081 aattctgagg atcatactgc tttatctaga gctttgtctc agcttgcaga ggttgaggag
     1141 aagatagacc agttacatca agaacaagct tttgctgact tttatatgtt ttcagaacta
     1201 cttagtgact acattcgtct tattgctgca gtgaaaggtg tgtttgacca tcgaatgaag
     1261 tgctggcaga aatgggaaga tgctcaaatt actttgctca aaaaacgtga agctgaagca
     1321 aaaatgatgg ttgctaacaa accagataaa atacagcaag ctaaaaatga aataagagag
     1381 tgggaggcga aagtgcaaca aggggaaaga gattttgaac agatatctaa aacgattcga
     1441 aaagaagtgg gaagatttga gaaagaacga gtgaaggatt ttaaaaccgt tatcatcaag
     1501 tacttagaat cactagttca aacacaacaa cagctgataa aatactggga agcattccta
     1561 cctgaagcca aagccattgc ctagcaataa gattgttgcc gttaagaaga ccttggatgt
     1621 tgttccagtt atgctggatt ccacagtgaa atcatttaaa accatctaaa taaaccacta
     1681 tatattttat gaattacatg tggttttata tacacacaca cacacacaca cacacacaca
     1741 cacacactct gacattttat tacaagctgc atgtcctgac cctctttgaa ttaagtggac
     1801 tgtggcatga cattctgcaa tactttgctg aattgaacac tattgtgtct taaatacttg
     1861 cactaaatag tgcactgcaa gaccagaaaa ttttacaata ttttttcttt acaatatgtt
     1921 ctgtagtatg tttaccctct ttatgaagtg aattaccaat gctttgaata atgttcactt
     1981 atacattcct gtacagaaat tacgattttg tgattacagt aataaaatga tattccttgt
     2041 gaaatattag taacaaatta tttgggtatt taaacattag gaatcttttc aaagcatttt
     2101 taataggaag aaatttttct tctagatgta tataggtgat gccatgattc cttaattatt
     2161 ttaattgaca aagctgaact cattaaatga ctaaatgaag cttaagtttt cttatgaaac
     2221 catcataaat caaagaacat ttgactcttg attgtcttgg gtaaagaaga gaataattgt
     2281 ctttgcttgt ttttaaccat ctctattaca agtgcccaat ttaagaatta ggaaaaaaat
     2341 gtatttatat acttttacaa gtcccatgga ttttgttcat cttctcgtta tcttcagaat
     2401 ctcgtacttt gcatatattt aatttattct tgtcttttgg ttttttttct tttaaactaa
     2461 aagtatatca tctgtgctca cagttgacaa ggaatggtac catgttaaaa tataccatga
     2521 tttgatgaat aagcaagcac aacacaaagc aaatttgaag taaactgaaa tttagtttgc
     2581 cttgggcaat gtttttaccc attctgtatg ctacttagac agctgttatc taatccttaa
     2641 tgctgatgaa aatttaagtc atggctgggt gtggtggctc acgcctgtaa tcctagcact
     2701 ttgggaggct gaggtgggtg gatcacctga ggtcaggagt tcaagactag cctggccaac
     2761 atggtaaaac tccatctcta ctaaaaatac aaaaattcgc ctggtgtggt ggggtgtgct
     2821 tgtggtccca gctacttggg aggctgaggc acaagaatcg cttgaaccag gaaggtggag
     2881 gttgcagtga gccaagatca tgccgttgca cgccagccta ggcaacaaaa gcaaaactcc
     2941 atctcaaaaa aaaaaaaaaa aaaaaaaaag atgactggtg tcagagctat ttttgttttt
     3001 taaaaaatat tcttacaaac acccctcttc ttgagcttaa ccaccacata tcccttccat
     3061 aggaacaaga tatggtatgt gtaactaagt catctctagt gagtcactgg atacaattta
     3121 tatatcgaag tatccttagc atgtgtttgc ttctgcttta gttgaaatgt taagccttct
     3181 ataggtgtta ttcatattta tactcccaca gcccagaaga gtggctgata cataataggt
     3241 taataataag ggcttgatgg gccaggcaca gtgactcaca tgcctgtagt cccagcttct
     3301 tgggaggctg aggcaggagg atctcttgag cccaggagtt tgaggctata gtacactatg
     3361 atcgtgcctg tgaataccca ctaacctaca gccagcctgg acaacatagt gagaccctgt
     3421 ctctaaaaaa aatgaagact tgatgagttg aacagggaaa acaaaagttt gctcttctaa
     3481 aaagaaactg aagcagaaat agtacaatca tcttttgttg cttctgggaa tacttttcag
     3541 aaacgaataa ttcatagtaa tatatatcag atgctatctt gttgctccat taatattgag
     3601 caaaagatag gcttaccaag aatagtttca ctataatgat gtcctagtgt tatatccaca
     3661 ggtatattac ttaacaaagg tatagtttac acataggatg gttattcaag ttattattaa
     3721 aatcttccat tcagatgtgg tacattagaa tattcagtac ctccaagtaa aataataaat
     3781 attttcagcc ttgattaaac tctagactcc cttccagact tccatttccc ttgcccacat
     3841 ttactaaaag atgagtgtgc tggaaatttc aagtattata tgagcctctg atacctacca
     3901 gtatttaaac aggatttaat tatttcaaca cttcacccat caatcttcac ttctcctgtt
     3961 cagataaaaa tgctttcatc ccaaataagt aaaacaagaa cattaatagt gctaataata
     4021 taatcttttc attggatagg tctgagttta gcgtttgttt gttttcttaa tgagatcaaa
     4081 agttaaagac caaggcagca aaatattgtg aaacaagctg aacttgggat cagcatacat
     4141 ttgttcagtc ttgtttcatt tagtatgact ttgggcatat cacttaaatc tcttatctat
     4201 aaaacaagta cataaaagtc ttgattcctg aagtgccttt ctactttaaa atattttgtt
     4261 taaaatatca aacttcaata taaatatgtt ggaaaacaat tctaatcaaa gaacttctat
     4321 taagtaaaac aagacaaaat gtgtgtaaaa atatgcctaa cacatagatt tccttgattg
     4381 tattttctac tgaactattt tcaagtattc agctttatac taatatatta atctcaaaat
     4441 acctttgttt cattgttgct actccttaaa cttttttctt tattatctag atctagtaaa
     4501 gttttctgca ttcattgtat taatgttggt tcaaaagtaa ttgcgtcctt tgtcgttata
     4561 taaattgttt tataaatggc tttaactatg acataagcct tttaacataa tcagctttct
     4621 ttaaaggagg aagtcagatg agtagagaag gaaagttata ttcctttaca aatgctctta
     4681 attttaatgt cttaagggaa ttatagagac ttccattatt ctgccttaaa taagggatgt
     4741 tacttcagtt ttcttgtcat ggctccctgc atgggcagtc atgttaacaa gagtcaggga
     4801 gatagcagat attccataat agtgactgca gataggccag tcaaagtcat tttgttttaa
     4861 aggaagggag gttgctggta gttaggtggg aaaataacac ctgtgaaaag gaagtccaag
     4921 tcactggctc agggactttg gaggcatttt catatcatat tcactagtca agaaacgtgt
     4981 agattatatg tgtgagtgac atagtctgtt tcaaagtatt agaaaagaga caatagaatc
     5041 acccaccctc ccttcgacac acacttcctt atgtaaaatc agaatcaaat aattatcatt
     5101 cctaaccctc acagtgaagg atttggtttc atgtaacaat gaaagtagat aatgggtcag
     5161 acatggaaat agcaataaaa gggaattaca acaagataaa tgtgagtaat agttcatttt
     5221 cctgcatttt tgatgagggc catgaagata ggtcatggta atctatggag aaggtcctta
     5281 agagcataga acaatataaa tataatatgg gccatatata taattttaaa attttctaca
     5341 gccaaatgtt aaaaagtaaa aaacaatttt aataatccag tagctccaaa atattatttt
     5401 aatatgtaat ccaatatatt gaagttataa gatattttac attctttttt tgatatctga
     5461 tgtatatttt acactttcat cacatctcca ttcagaccgg ctacaatttg atcagttgtc
     5521 acatgtggat gactagtggc tatgataatg gacagcatag gtttagacaa tgcctattca
     5581 actattcaac ttgttttaca tttataaatc tcaaaatgcc tttatttcat tgttggtact
     5641 cttttttatt acccagatac aataaagttt tccaagtttc attgtacaca tgaaatgagt
     5701 ttactgtgga aatgaaaatg cagagtaagt ccaacagcta gtttatcatc ctgaacccag
     5761 tgaagaaatc aaagctgaat aaaagcgact cctagttgtt actctcaagg gcaggtataa
     5821 tttatgtgca agactttgta gcataatgtt ttgcaagtag tggatgttca atatctacaa
     5881 taaatgaatt gtagtactat attgcttgaa ggaagtttat aacctgtcta gaacaacttt
     5941 ctcaatttta caactaaact aggagatcca gggcttaaat catgattgaa ctgattattc
     6001 ctgttaaatt tatgtgtgaa ccatatgtga acattctttg aaaatgtatg ataagcattt
     6061 caagatttct gttttaatta ttaacattta gaattctagg aaatcttttg ggatacagag
     6121 aacttatttc ttccaactgt tgcttcagac gctgataaga ttgtagaaga tagggaagct
     6181 gtagtttact atctagtttt ttaatgcaca tgaagtaatt taaaatgctc ttcttccttt
     6241 cttgtcacat acttttaaaa aattctctaa agattgaata attttaagta tttcttaact
     6301 gggcaaaatg gaaactttgt aactgaagcc agtcaaggtg aatacacaga aaatcatttt
     6361 cttattaagg tcagttaatg ggataaaccg ttttaagaga gttgagaaaa aataaagttc
     6421 tattttaaat ttatacatgt aactttaata aaaactaagt cagacaaaat ttaacaaaa
//
