LOCUS       NM_014758              15691 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens sorting nexin 19 (SNX19), transcript variant 1, mRNA.
ACCESSION   NM_014758 NR_125382 XM_374949
VERSION     NM_014758.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 15691)
  AUTHORS   Saric,A., Freeman,S.A., Williamson,C.D., Jarnik,M., Guardia,C.M.,
            Fernandopulle,M.S., Gershlick,D.C. and Bonifacino,J.S.
  TITLE     SNX19 restricts endolysosome motility through contacts with the
            endoplasmic reticulum
  JOURNAL   Nat Commun 12 (1), 4552 (2021)
   PUBMED   34315878
  REMARK    GeneRIF: SNX19 restricts endolysosome motility through contacts
            with the endoplasmic reticulum.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 15691)
  AUTHORS   Takahashi,Y., Maynard,K.R., Tippani,M., Jaffe,A.E., Martinowich,K.,
            Kleinman,J.E., Weinberger,D.R. and Hyde,T.M.
  TITLE     Single molecule in situ hybridization reveals distinct
            localizations of schizophrenia risk-related transcripts SNX19 and
            AS3MT in human brain
  JOURNAL   Mol Psychiatry 26 (7), 3536-3547 (2021)
   PUBMED   33649454
  REMARK    GeneRIF: Single molecule in situ hybridization reveals distinct
            localizations of schizophrenia risk-related transcripts SNX19 and
            AS3MT in human brain.
REFERENCE   3  (bases 1 to 15691)
  AUTHORS   Ma,L., Semick,S.A., Chen,Q., Li,C., Tao,R., Price,A.J., Shin,J.H.,
            Jia,Y., Brandon,N.J., Cross,A.J., Hyde,T.M., Kleinman,J.E.,
            Jaffe,A.E., Weinberger,D.R. and Straub,R.E.
  CONSRTM   BrainSeq Consortium
  TITLE     Schizophrenia risk variants influence multiple classes of
            transcripts of sorting nexin 19 (SNX19)
  JOURNAL   Mol Psychiatry 25 (4), 831-843 (2020)
   PUBMED   30635639
  REMARK    GeneRIF: Schizophrenia risk variants influence multiple classes of
            transcripts of sorting nexin 19 (SNX19).
REFERENCE   4  (bases 1 to 15691)
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Biological insights from 108 schizophrenia-associated genetic loci
  JOURNAL   Nature 511 (7510), 421-427 (2014)
   PUBMED   25056061
REFERENCE   5  (bases 1 to 15691)
  AUTHORS   Harashima,S., Horiuchi,T., Wang,Y., Notkins,A.L., Seino,Y. and
            Inagaki,N.
  TITLE     Sorting nexin 19 regulates the number of dense core vesicles in
            pancreatic beta-cells
  JOURNAL   J Diabetes Investig 3 (1), 52-61 (2012)
   PUBMED   24843546
REFERENCE   6  (bases 1 to 15691)
  AUTHORS   Shiffman,D., O'Meara,E.S., Bare,L.A., Rowland,C.M., Louie,J.Z.,
            Arellano,A.R., Lumley,T., Rice,K., Iakoubova,O., Luke,M.M.,
            Young,B.A., Malloy,M.J., Kane,J.P., Ellis,S.G., Tracy,R.P.,
            Devlin,J.J. and Psaty,B.M.
  TITLE     Association of gene variants with incident myocardial infarction in
            the Cardiovascular Health Study
  JOURNAL   Arterioscler Thromb Vasc Biol 28 (1), 173-179 (2008)
   PUBMED   17975119
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 15691)
  AUTHORS   Bare,L.A., Morrison,A.C., Rowland,C.M., Shiffman,D., Luke,M.M.,
            Iakoubova,O.A., Kane,J.P., Malloy,M.J., Ellis,S.G., Pankow,J.S.,
            Willerson,J.T., Devlin,J.J. and Boerwinkle,E.
  TITLE     Five common gene variants identify elevated genetic risk for
            coronary heart disease
  JOURNAL   Genet Med 9 (10), 682-689 (2007)
   PUBMED   18073581
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-gene interaction. (HuGE Navigator)
REFERENCE   8  (bases 1 to 15691)
  AUTHORS   Hu,Y.F., Zhang,H.L., Cai,T., Harashima,S. and Notkins,A.L.
  TITLE     The IA-2 interactome
  JOURNAL   Diabetologia 48 (12), 2576-2581 (2005)
   PUBMED   16273344
REFERENCE   9  (bases 1 to 15691)
  AUTHORS   Worby,C.A. and Dixon,J.E.
  TITLE     Sorting out the cellular functions of sorting nexins
  JOURNAL   Nat Rev Mol Cell Biol 3 (12), 919-931 (2002)
   PUBMED   12461558
  REMARK    Review article
            Erratum:[Nat Rev Mol Cell Biol. 2003 Feb;4(2):156.]
REFERENCE   10 (bases 1 to 15691)
  AUTHORS   Weinmann,A.S., Bartley,S.M., Zhang,T., Zhang,M.Q. and Farnham,P.J.
  TITLE     Use of chromatin immunoprecipitation to clone novel E2F target
            promoters
  JOURNAL   Mol Cell Biol 21 (20), 6820-6832 (2001)
   PUBMED   11564866
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP001093.5, AP000824.5 and
            AP003486.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On or before May 21, 2020 this sequence version replaced
            NR_125382.1, NM_014758.2.
            
            Summary: Islet antigen-2 (IA-2) is an autoantigen in type 1
            diabetes and plays a role in insulin secretion. IA-2 is found in
            dense-core secretory vesicles and interacts with the product of
            this gene, a sorting nexin. In mouse pancreatic beta-cells, the
            encoded protein influenced insulin secretion by stabilizing the
            number of dense-core secretory vesicles. [provided by RefSeq, Dec
            2016].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853567.6392.1,
                                           SRR11853563.6594.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265909.9/ ENSP00000265909.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2214              AP001093.5         2650-4863           c
            2215-2353           AP001093.5         17-155              c
            2354-2454           AP000824.5         182568-182668       c
            2455-2574           AP000824.5         182316-182435       c
            2575-2705           AP000824.5         180251-180381       c
            2706-2802           AP000824.5         178923-179019       c
            2803-2983           AP000824.5         178251-178431       c
            2984-3113           AP000824.5         175553-175682       c
            3114-3298           AP000824.5         152920-153104       c
            3299-3386           AP000824.5         151922-152009       c
            3387-7423           AP000824.5         146816-150852       c
            7424-15691          AP003486.3         209212-217479       c
FEATURES             Location/Qualifiers
     source          1..15691
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.3-q25"
     gene            1..15691
                     /gene="SNX19"
                     /gene_synonym="CHET8"
                     /note="sorting nexin 19"
                     /db_xref="GeneID:399979"
                     /db_xref="HGNC:HGNC:21532"
     exon            1..2214
                     /gene="SNX19"
                     /gene_synonym="CHET8"
                     /inference="alignment:Splign:2.1.0"
     CDS             541..3519
                     /gene="SNX19"
                     /gene_synonym="CHET8"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="sorting nexin-19 isoform 1"
                     /protein_id="NP_055573.3"
                     /db_xref="CCDS:CCDS31721.1"
                     /db_xref="GeneID:399979"
                     /db_xref="HGNC:HGNC:21532"
                     /translation="MKTETVPPFQETPAGSSCHLNNLLSSRKLMAVGVLLGWLLVIHL
                     LVNVWLLCLLSALLVVLGGWLGSSLAGVASGRLHLERFIPLATCPPCPEAERQLEREI
                     NRTIQMIIRDFVLSWYRSVSQEPAFEEEMEAAMKGLVQELRRRMSVMDSHAVAQSVLT
                     LCGCHLQSYIQAKEATAGKNGPVEPSHLWEAYCRATAPHPAVHSPSAEVTYTRGVVNL
                     LLQGLVPKPHLETRTGRHVVVELITCNVILPLISRLSDPDWIHLVLVGIFSKARDPAP
                     CPASAPEQPSVPTSLPLIAEVEQLPEGRASPVAAPVFLSYSEPEGSAGPSPEVEEGHE
                     AVEGDLGGMCEERKVGNNSSHFLQPNVRGPLFLCEDSELESPLSELGKETIMLMTPGS
                     FLSDRIQDALCALESSQALEPKDGEASEGAEAEEGPGTETETGLPVSTLNSCPEIHID
                     TADKEIEQGDVTASVTALLEGPEKTCPSRPSCLEKDLTNDVSSLDPTLPPVLLSSSPP
                     GPLSSATFSFEPLSSPDGPVIIQNLRITGTITAREHSGTGFHPYTLYTVKYETALDGE
                     NSSGLQQLAYHTVNRRYREFLNLQTRLEEKPDLRKFIKNVKGPKKLFPDLPLGNMDSD
                     RVEARKSLLESFLKQLCAIPEIANSEEVQEFLALNTDARIAFVKKPFMVSRIDKMVVS
                     AIVDTLKTAFPRSEPQSPTEELSEAETESKPQTEGKKASKSRLRFSSSKISPALSVTE
                     AQDKILYCLQEGNVESETLSMSAMESFIEKQTKLLEMQPTKAPEKDPEQPPKGRVDSC
                     VSDAAVPAQDPSNSDPGTETELADTALDLLLLLLTEQWKWLCTENMQKFLRLIFGTLV
                     QRWLEVQVANLTSPQRWVQYLLLLQESIWPGGVLPKFPRPVRTQEQKLAAEKQALQSL
                     MGVLPDLVVEILGVNKCRLSWGLVLESLQQPLINRHLIYCLGDIILEFLDLSASVEES
                     AATTSASDTPGNSKRMGVSS"
     exon            2215..2353
                     /gene="SNX19"
                     /gene_synonym="CHET8"
                     /inference="alignment:Splign:2.1.0"
     exon            2354..2454
                     /gene="SNX19"
                     /gene_synonym="CHET8"
                     /inference="alignment:Splign:2.1.0"
     exon            2455..2574
                     /gene="SNX19"
                     /gene_synonym="CHET8"
                     /inference="alignment:Splign:2.1.0"
     exon            2575..2705
                     /gene="SNX19"
                     /gene_synonym="CHET8"
                     /inference="alignment:Splign:2.1.0"
     exon            2706..2802
                     /gene="SNX19"
                     /gene_synonym="CHET8"
                     /inference="alignment:Splign:2.1.0"
     exon            2803..2983
                     /gene="SNX19"
                     /gene_synonym="CHET8"
                     /inference="alignment:Splign:2.1.0"
     exon            2984..3113
                     /gene="SNX19"
                     /gene_synonym="CHET8"
                     /inference="alignment:Splign:2.1.0"
     exon            3114..3298
                     /gene="SNX19"
                     /gene_synonym="CHET8"
                     /inference="alignment:Splign:2.1.0"
     exon            3299..3386
                     /gene="SNX19"
                     /gene_synonym="CHET8"
                     /inference="alignment:Splign:2.1.0"
     exon            3387..15691
                     /gene="SNX19"
                     /gene_synonym="CHET8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4939..4944
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNX19"
                     /gene_synonym="CHET8"
                     /note="hexamer: ATTAAA"
     polyA_site      4961
                     /gene="SNX19"
                     /gene_synonym="CHET8"
                     /note="major polyA site"
     regulatory      6044..6049
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNX19"
                     /gene_synonym="CHET8"
                     /note="hexamer: AATAAA"
     polyA_site      6062
                     /gene="SNX19"
                     /gene_synonym="CHET8"
                     /note="major polyA site"
     regulatory      15656..15661
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNX19"
                     /gene_synonym="CHET8"
                     /note="hexamer: CATAAA"
     regulatory      15670..15675
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNX19"
                     /gene_synonym="CHET8"
                     /note="hexamer: AGTAAA"
     polyA_site      15681
                     /gene="SNX19"
                     /gene_synonym="CHET8"
     polyA_site      15691
                     /gene="SNX19"
                     /gene_synonym="CHET8"
ORIGIN      
        1 agctgtcgcc ggcggccggc cggcggtcag ccttcacaca ggcccggctg cggagcgcag
       61 tcgcccaggt ttacggcggc agagggccga ggctcccgga gaggaccgcg atgagtccac
      121 ttcaggtcgg ggctgagtgt gggcgcgcgg ttcccggcgg cgtgtgaccc agtcttcgcc
      181 ggccgctgcc cgctgcgtgt gtaagtgtcc gtgggcccca gggccttgca gcgcccgccc
      241 cgaggccccg aagaggcctt ccgcctgggg cagtgtgaag gccacagagt tttcctccaa
      301 agccacacct cagctggaag gggcgagttg gagggctctg ttagtggtag ccatggggag
      361 acgcggagct gcagctgtcg ctttgcagtg cctgtaggac tttgagggcc tggagccccg
      421 gttccctgaa cagcacccag atcgccccat atctgagaca cagttcatgc cccccttccc
      481 taactctgaa gtaaaatctt gagggctgtc atctggggaa gccaccttgt ccgttcagcc
      541 atgaagacag aaacagtgcc accgttccag gaaactccag ctggatcgag ctgtcacctc
      601 aataacctgt tgagtagccg gaagctgatg gctgtggggg tcttgcttgg ctggctcctg
      661 gtcatacacc ttctggtcaa cgtgtggctg ctgtgccttc tgtcggcatt gctagtggtg
      721 ctgggaggat ggctgggctc cagcctcgct ggagtggctt caggtcgact gcatctggaa
      781 cgcttcatcc cgttggccac ctgtcctcca tgccctgagg cagaaaggca gctggaacgg
      841 gagatcaacc gcaccatcca gatgattatt cgagattttg tgttatcttg gtaccgttcc
      901 gtgagccagg agccagcctt tgaggaagaa atggaggcag ccatgaaagg gttggtccag
      961 gagcttcgga gaaggatgag cgtgatggac agtcatgctg ttgcccagag tgttctgact
     1021 ctctgcggtt gtcacctgca gagctacatt caggcaaagg aggccactgc agggaagaat
     1081 ggtccagttg agccttccca cctctgggag gcttactgcc gggcgactgc cccacatcct
     1141 gctgtgcaca gccccagtgc tgaagtcacc tatacgcgtg gcgttgtgaa tttgttgctt
     1201 caagggctgg tgcccaagcc ccacttggag actcgtaccg gacgccatgt agtggtcgaa
     1261 ctcatcacat gcaatgtaat cttaccactg atcagcaggc tgtcagatcc tgactggatc
     1321 caccttgtac tcgtgggtat cttttccaag gccagagatc cagcaccctg cccagccagt
     1381 gcccccgaac agccctcagt gccgacatct ctgccactga ttgctgaggt agagcagctt
     1441 ccagaaggga gagcttctcc agtagcagcc ccagtattcc taagttacag tgagccagag
     1501 ggttctgcag gcccctctcc agaggttgaa gaaggccacg aagctgtaga gggagatttg
     1561 ggtgggatgt gtgaagaaag aaaagtagga aacaactcat ctcatttcct acagccaaat
     1621 gttcgaggtc ccctgttctt atgtgaagac tcagagctgg agtctccgct gtctgaactg
     1681 ggcaaagaaa ccatcatgct catgactcca ggcagctttc tctctgacag gattcaggat
     1741 gccctgtgtg ccctagagag ttcccaggct ctggaaccca aagatggtga ggcatctgaa
     1801 ggagcagagg ctgaggaggg tccagggaca gaaacagaga caggcctgcc ggtctccaca
     1861 ctgaattcct gcccagagat ccatattgac acagcagaca aggagataga acaaggagat
     1921 gttaccgcct ctgttacagc tttgctggag gggccagaaa agacctgccc ctcacggccg
     1981 tcatgcttag agaaggatct caccaatgat gtgagctccc ttgatcctac tctgccacca
     2041 gttctgcttt cctcctctcc acctggtcct ctcagctcag ccaccttcag ctttgagccc
     2101 ctaagcagtc ccgatggtcc agttatcatc cagaaccttc gtatcactgg caccattaca
     2161 gcccgagagc acagtggcac tggattccac ccatacacac tctatactgt gaagtacgag
     2221 acagcccttg acggtgaaaa cagcagcggc ctgcagcagc tggcctacca cactgtgaat
     2281 cgtcgctatc gggagttctt gaatctgcag acccgtctgg aggagaaacc agatctacga
     2341 aagttcatca aaaatgtgaa gggtcctaaa aagctctttc cagatcttcc attgggaaac
     2401 atggacagtg acagagtaga agcccgtaag agcctcctag aatcattcct aaagcaactc
     2461 tgtgccattc cggagatcgc taacagtgag gaggtgcagg agttccttgc tctgaacaca
     2521 gatgctcgta ttgcctttgt caagaaacca tttatggtct ctagaataga caagatggtg
     2581 gtgagtgcca ttgtggacac cttgaagaca gcgtttcctc gctctgaacc ccagagcccc
     2641 acagaggagc tgagtgaggc cgagaccgaa agcaagcccc agacagaagg caagaaggct
     2701 agcaagtcta ggctgaggtt ctcatccagt aaaatttctc cagcactaag tgtgactgaa
     2761 gcacaagaca agattcttta ttgtctccag gaaggcaatg tggagtctga gactctatcc
     2821 atgtctgcga tggaatcttt tattgaaaaa cagacaaagt tactggaaat gcagccaaca
     2881 aaagccccag aaaaagatcc tgaacaacct cccaaaggac gtgtggacag ttgcgtgtca
     2941 gatgcagccg tgccagccca agaccccagc aacagcgatc caggaacaga gacagagtta
     3001 gctgacacag ccctggatct gctcctcttg ctactaacag aacagtggaa atggctatgt
     3061 accgaaaaca tgcaaaagtt tcttcgtctt atctttggga ccctagttca aaggtggcta
     3121 gaggtgcagg tagctaattt aacaagtcca cagcgctggg tgcagtacct cctgcttctt
     3181 caggagtcca tctggcctgg tggagttttg cctaagtttc cacggcccgt aaggacccaa
     3241 gagcagaaac tggctgctga gaaacaggct ttgcagagcc tgatgggagt cctcccagat
     3301 ctcgtagtag aaattcttgg ggtgaacaaa tgccggctga gctggggtct agtcctggag
     3361 tcactacaac aacccctcat caacaggcat ttgatttact gccttgggga catcatcctg
     3421 gaattcttgg atctcagtgc ctctgttgag gagtctgctg ctaccacctc tgcctcagat
     3481 accccaggca actctaagag gatgggtgtc tcctcttagc tggttattca cgccttcttc
     3541 ccaggtcagg gaagtagagt tactcggcca ccagagacca gtcaggaagc ccgtgccctc
     3601 ttcaagtagg ctacagctaa gaaggcctag gttctcggtg gctcacttct ctcccacttc
     3661 tgctccattt gtagcaggtg acaggggtct gtgtgtccca gttgtatgca cgtttatttc
     3721 cctgttcctt ttgtgatgtt gggattgttg ctggtgagta gatcctgttt cctttgggaa
     3781 aagaagctgt gaggtagagg aatgaacccc ttttgcttct ccttttgcca tcctccctga
     3841 gattgtttgc cagaatcctg gccctgtgca cacatgtgct taatccacca gcacacaagc
     3901 tctagataga acaggaaaaa aactgtggcc agatttcctt ggaggagaaa acaaccttct
     3961 cagctctctg ttcctacccg gaaactaaaa attcattcag ggccattctc aaaaaccaga
     4021 ctcctgggtc taatctagtt tcccaacagt tccagaagaa gaaggaggga agaaaatttt
     4081 tcaaggaact tcttgctcat gtgttgctgt ttcccaacac atcagcctta tggaagatgt
     4141 catgaggctg cttgcctggg aggctacact ttcctttcca gaagacttca aagctgactg
     4201 ccaaagcttc tggtaaatcc accccaccct tcacaccctt tcctgaaagg catttatacc
     4261 acccatttta tttattggct ttgctcccaa ccccctgccc tagagcaatt gagtttttga
     4321 atttttgacc ctctctctgt cttcagcaaa actgcatgac aagctgcata ttcagcctca
     4381 gtttttccaa ggagaatgga aagcacttgc ctcctgtctt aagaatgcac aaagagtagg
     4441 actagcaagg ctgggggatg aaatctccct tcctaagtct ttgacagaga acttttatta
     4501 ttctgaacag ataagattag caaacttaca aggaatagct tcttatttcc cattccttac
     4561 ggttataatc agtcctttaa caacaccagc atgaaggcaa aggtgttttg tcagactgca
     4621 acatctatta gaaaggcaag gcaactggga attgctggag aaggataaat caggaggaat
     4681 tgctggtaga aaaggctgca gacagtcaca gggaagtgct gtatattaaa tgcatgtgaa
     4741 tagctggcaa aaagatgtca aggatgtcac tgggagccct ttggcttcac actcgcctgt
     4801 tagcgccttg ctttcgctga attaccagag cctaccactc ggaggaaggt cttggagtta
     4861 gactgatgag aaggcaatgg ggtgtcaaaa acaagtgtca aagttctctt agattctgaa
     4921 gtcggtgatg agcacacaat taaagtggtt tgtggaagaa agttgtaaaa tctttttact
     4981 tttttgcccc tctggaggct tttaacccta aattgtgtct gatgtattcg ggaggcttag
     5041 gtgtgcaatt cttgcccaaa ggcaaggaga tgaatgagat gtctcatggc ctcttctagc
     5101 cttaaaagtt gaccattaca gtgactttat ggctccaaag ttcttgaagc atctccagcc
     5161 ctagactttg acaagaaaag gtagctcagc atctctactt tccgtgagta cctgcaggag
     5221 tccagccaat gtattagagc tgatcattaa gctccttcag tgagggctaa gatcctattc
     5281 tcgatgagca tagggggaca gccttgtttt atgccacttt tctctcccca tacctacctt
     5341 cccctcatgt gtacttagcc acctgtgttg ctttgaatct gctgccagtt ctggctcaaa
     5401 tgtggcacaa aatcagtaca tcagacacac catgaaatcc ctgtggctat aaattctaag
     5461 gaatcttttg acacttccag cccaaagaac ttatttttat ttcgtattat ataagagtcc
     5521 ccacctctac tccacgtacc ccaaaaagat aagctgtcct cagatcctcc ttctacccag
     5581 gagggaaata atggatattg ccaagggaac aatcagaact catctggctt tgaaaacgac
     5641 ctgccaagtt tggctagcag gttcagacaa caagagagta acaattggta gagagccaca
     5701 ggtagaaaag atactcccag ctgacagggt gataaaaggc agggaagaat tgggcctgtg
     5761 ctgatccagg aaggttttat tgtttgcttg ttttttgtat ttactcgtga ctaaatttta
     5821 ttcatttaag tcagaatttt gatatttgaa ataagactac tttccctttt cttactatct
     5881 ataaaaaaga cgaggcaggg atgctgtgtt ctttctgtca aattctaaat gtgatctttg
     5941 ccattgctta tttgaattca agaaagctat actttttcat cacatataac tcacagtttc
     6001 atttttgcat tgttggatta gacttaataa aacctaaatg gaaaataaat tcctaaatct
     6061 gagcctagga gcatgtataa attttatttt tattattatt atacattaag ttctagggaa
     6121 catgtgcaca acatgcaggt ttgttgcata tgtatacatg tgccgtgttg gtgtgctgca
     6181 cccgttaact cgtcatttac attaggtata tctcctgatg ctatcccttc cccctccccc
     6241 gacctcacaa caggccccag tgtgtgatgt tcaccttcct gtgtccaagt gttctcattg
     6301 ttcaattccc acctatgagt gagagcatgt ataaatttta aaatcaatac aagctactcc
     6361 aatttccatt ttggaaattt ccagtttaca aggtgatttt cttattgttg taaagaaaca
     6421 cataatgtga gatctaccct cttaagtgta cagtacatta tttatttatt ttgagacggt
     6481 acattattaa ctagaagcag cacagtgctt tgtagcagac tgctacaagt ttttcatctt
     6541 gcataaccaa aagtttatac ccattgaaca gccactcctc gtttcccctc ccaccagcct
     6601 ctggcaatca ctgttctact ttctgcttct gtgagtttga ctactttgaa cgcctcatat
     6661 aagtggaatc atgcagtgtt tgtcctttga ctggcttatt tcacttagca taatgtcctc
     6721 caggttcatc cacgttacag catgtgacag aattttcttt ttaaggctga aaacattcca
     6781 ttgtatggct atgccacatt ttctttgttc attcattgag ggacatttag gttggctccg
     6841 cgccttgatt gttgaaaaca atgctgcagt gaacatggga gtgtgactgt ttcttcgagg
     6901 ccctgctttt aattatttta gataaatacc cagaagtagg attgctggat catatattgt
     6961 tctgttttta attctttgaa gaccttcata ctgttttcca tagtgactag accattttac
     7021 attcccacca acaatgtaca agggttccag tttctccaca tcctctccaa cacttgtaat
     7081 gttttgtttt ttcataatgg catcttaaaa ggtattaggt gatattacta tctcatggtt
     7141 ttgatttgca tagcctagaa catttttgag tcttcctgtg tcctacccag gttattcatt
     7201 tccagctact gctcttcctt tgctcatagc acacaacacc agttgttagg tcctggagga
     7261 agtaaaaata tgtgtaacta tggtccctgg ctatatgaat caggatgctc tggacaagaa
     7321 ttaaattatg aggaaaattt attttatttc ataacattag tacgtgagta ggtaagccca
     7381 ggagtttggt gattcagcaa ctctgagacc tcttaagggg cctgaattct ttccatcttt
     7441 cttccttgcc attctaatta ggtcagctgt gctctcagac tgcctgcctt cctgctgctg
     7501 cagtttcagg catcacaccc agagataaca ttcataaaag aacaggagca tctcttctgt
     7561 gttttcttct aaggaatgaa ggaaccattt cccagaagtc cttcaagaat cctcttctag
     7621 gccgggcaca gcggctcaca cctataatct caacactttg ggaggccaag gttgggggat
     7681 tgtttgagtc caggagttta agaccagcct ggaacatagc aagaccctgt ctctacaaaa
     7741 aatataaaaa atgagcgggg catggtggct ctcgcctgtg gttccaccta ctagggaggc
     7801 tgaggcagga ggatcacttg agcccaggaa tttgaggctg cagtgagcta cgatcacacc
     7861 actgcattct agccttaagt gacagagtga gaccccaaat aaaaaaaaaa aaaacaaaaa
     7921 acctcttatg actcattggc tagaaccacc cacctcatgc caatccactg acactgagaa
     7981 tggcattgtg attggctttc aatagtattt tcccccagag atgaggtcat cttccatgaa
     8041 ggtcagatat ctacagaaat aattgatgtt agcaaggaag aagcagagaa tgggtattga
     8101 tagacaatgt ctgctctagg gatgggtcat tctgccaaca ttcagcagat cccctatcta
     8161 ctcccaaaat gcctggtacc agctaatagt taacatcttc tgagagcatt acttaaagtc
     8221 tttacatatc ttcacttatt taacccacaa atcaaccctt aaaggtaggt tctgatgtag
     8281 tgggttggtg caaaagtaat tggagttttg ccattttaat gcaattactt ttgcaccaat
     8341 ctaatatatc cccattttct aggtggggaa catgaggcac agagtggtta tgtcttaccc
     8401 acagtcattt gcaagggagt ggcagagcct agatacaaac catgtcaatc tgcctctgag
     8461 tctacgtagt atatccacta tactaaactg cccttctacc ttacaaagca gaacaagatc
     8521 aggttctcac ttttaaggag tctacagtct agtataggag ccagcaaact ttctctgtaa
     8581 aggtctggag actaaatact aggttttgca gcagtatggt ctctgttgta actactcagc
     8641 ttttccactg tagcgtaaaa acagttgtag acaattcata aacaagtgtg gctgtgttcc
     8701 aataaaactt gatttacaaa aataggcagc tggccgggtt tgtcccatga gtcagtttgt
     8761 ggacctgcgg tctagtgagt tagaatactg cttaccaaat tttaatgtgt gtgtgattca
     8821 cgtgggatcg ggttaaaatg caaattttga ttcaataggt ccggagtgag gcctagtaaa
     8881 agtgtaagtg ctatgctcta aaaatgttga cagcatgatt atcacactcc tctgctgttt
     8941 gaggggcagg gagcatttgg agatgccttg tttcaggaac ccattcagcc aagttgtcct
     9001 ggcaagccgt acctcccaca gccccctcca caccggctgt ttgtccaatc taactttgca
     9061 ctggagcaag atgtgttttc ccaggatgag gaaaggaagg ttagcccaca ctgctggatg
     9121 tggaagggga tgggaaccag ggaaagaatg gtaactgggg aggaagggaa accatgatac
     9181 ttttgtagtc gaaggcctaa ctgggcgcac tctgccataa cttggcccct ctgcttcctt
     9241 tccactggga gtgccagaaa tcacagggca gcagtcgctc accctgcctt tgtagacaag
     9301 aaaatgaaac catcgaaggg tgaatttcag ctagcatatt gccatcactc ttttatggta
     9361 taaaggatga gagaggcggt gagggagaca ttgccccaaa catgatgtcc acatcctaag
     9421 acttacctga tatttcttat tacacaaaga caacattgac tggtttaaga gagaaaaaaa
     9481 aaaaggaaat ccagaagaat gttttaattg tcaagcgtga aacaagtgaa aatcatcaga
     9541 atctttttcc ttctgtgact tggtagcaac agtgtgtaaa gccaaggcca ccgtgaagcg
     9601 gtgggggaaa tttgggcacc cgcagacctt ggcagacaca ctatgctatt ttcagacttg
     9661 cggagccttt gcactgcctc cctgtcatcc tcacctgtct ctggtctgaa agtccatttt
     9721 aactctgctt tcttggaggc agaaacaagc atgtgacagg atgcagagaa ttactcctgg
     9781 ctttgatgtc tcttcaacag cttgatgaaa cctggttttt ccacctgtct tcacttctcc
     9841 aagccttacc tgcaagcgct tccgtgaaag cccccagcac accatctctg ggatgtggaa
     9901 gcttaggagg ggagaattaa aaaaacaaaa cgaaggtaac agtaatcaag atccaaactt
     9961 agaaaacatt tcttgaagtg acattatctg ctccttttaa cccaatccct ttgtcaccag
    10021 tcagtgtttg tttaggaagt gtaagctaat tttaatatta aagtgttgta gtgattaaga
    10081 aggtaagttt gtgaataatg tatgaatcat ccacactttt gtcttttttc ccaccttatg
    10141 ttccatgtta ctgctgcacc ctgttataag caaagaagag ttggctgtga ttacttccag
    10201 aaactttgat taacccatga gagtaaagat gtagctagat aaacacagaa ctccctgatt
    10261 gcagacaaaa ggactcaaat gtcgacagaa gcaatggctt gtttatactg tgttgaactg
    10321 gatttggtga cttgtgagca taggtaatca gcccttttgc ccgtgcccct gggtgaagaa
    10381 tcatcctgct cctgtaacta tcaaaaagat taaccatgaa cgttgatatg aaatactgct
    10441 tttcatacct tgacaccaag aagaatagac cttattaagg gaggaaaaac acttttggag
    10501 tttacctcct ttacacatcc tgcttgcatg gaatccaaat tcagtgagct gacggcaggc
    10561 cagttccttg ccactttatg cagttgtgtt taaagtttac cctctgttat ctataaatgc
    10621 aagtggcttt ttcaagaata gtgagggcag ctttcattaa ggactcatgc atctctagga
    10681 gaatcacatg ggcttagttg gcagtagagc attttcttgg ggacagaatg tattatagat
    10741 ggtttaggca ggaggttaga cgagaaactt ccaaaaaaat ctagggattt tttattctgc
    10801 ccaaaccagc atgttccttc ctgctttcat ttttttgttc atgtccttcc ttccacgtgg
    10861 tagattacct tctcttctcc agctgggcaa gtaggctacc tctgcccata aggaccaatt
    10921 caagttccat tttcaagaag cactgtctga ttgcaccagc caaaactctt cccactttct
    10981 tttcagttat ttacactgcc tctctagtca atgtgcatgt atatgaagtc ctcagtaaga
    11041 gactataatt cttcaagggc aacgaacata tcttttatct tttttagtcc tattatgtcc
    11101 ttatgccccc cccccaacta tatgtatata cctagtgcat gataggtaca aaataaatat
    11161 taaagtttac ttaattaaag attatgttta tttaagaggc aaaatttgtg aataagtctg
    11221 gatcttgata ctgttacttt cattttgttg attcctttct cccaaccttc cacatcccag
    11281 agacagggtg ctggtgactt ttatggaaag gcttgaaggg tgaagatatg tggagaaacc
    11341 accgtaaacc tctttgagat taaccactta ttccagtgga gggcactggc tagtctgtac
    11401 cagacctgcc ccagacagct ttgtacatct tgcgtgtggg tgggaaccca aaaagtttcc
    11461 ttttcagtgg atctgtttag gtgaggtaaa gaaatccatt actcaaatgt ttcatcagag
    11521 gctaccccct gttcaggtgt gcaccctgca cccatgtggg tttgcggatg gcatataaca
    11581 cttgcagcag cagagctcgt tgccacacat ccaagggaag taagtgtgca tatgtggatg
    11641 cggcgggaat acctgcggtc tttctgctga agagcagggt tatacacctc cttttagcaa
    11701 tctggagagg actgaggcaa gagcttgtat tgaaacacaa gcaagctcca cgtatggttt
    11761 tggacatgga agaaagagta ctgttggggt ggaatgacct aagtttttaa taggattagg
    11821 atttctgtgg atttttccca agtgatagaa gttttcttca tctagcaggg agcctcaccc
    11881 aattgcttct ctatgttcat ttctgaaact cctttgttaa aactaaatag caacagagaa
    11941 gaaactttct tcaaaaaact cttcatatct gtcatttctc ctattcttat ggaacttcac
    12001 aattgctttt tctttattcc tttttttttt tctatatcag ctcatcagtc tttgtgggtg
    12061 acttggctac cccactaatc taattgcctt tttgatagtt aaatcaatat ggacatcaac
    12121 ttaaggctat atgtgaacct taaatgcatg atattcccta tacttgattc cacaattgat
    12181 attctgtgag gaaagttggc cagatattcc cttctgtgaa gtcagaataa ctaccgaccc
    12241 taagaataaa cattttgacc aattctttat atgttgcaaa ctattcacac aactagaaag
    12301 tttagccatt cacatctctt cccctgattt taagtcccag attctgagac tcagaaagtt
    12361 tagtgacttg ttgagctttc tgtggaaaat ctgttgtaaa aacagttcag acattggaaa
    12421 atataaaata gcccctagag atcccaataa agcttcctct ccccaaatcc ctctacaagt
    12481 ttatcctcga aaaactttct gaaaactgat gagaaaatac tgagtaatta atgctcaaat
    12541 gggaaagatg acatgtaaaa gcaaaaacct gttaatggca tctgttcata tagttccatg
    12601 tgccttttta cttaactgca ctgataggca atgtaatgaa gaagtttcct tttaaaacgt
    12661 aaaatgtaat taaacagagt ttatcttaaa ttggctggac ccgcacagct tgactgagac
    12721 atacacagct gtcttcattt tgaagcacct acactagtca agcttctttc taacccgccc
    12781 ttagggtttg cctgttggtc tgtcttccct actgggctgt taatcccttg gaggcagatt
    12841 gtcttgtttc ccagagtttt tccagcatat accatggcag acaattttca ccttatctat
    12901 tctaactcgt aagcctcagc tagtgcctcc atcctcgggt gcatagccca gtgacaggca
    12961 tgtaacagac tttgcctaca agcagttgct gatccataaa tgacgttggc aaccttcttg
    13021 tggcagtgag taacatattt ctttcctcct gataggcttg gaatcctcat ccccatctgg
    13081 caattttctt tccatctttc ctacactcac aatggagccc acacgcctca caaccccctt
    13141 gactaaacca gatgacagca agaatgccta gttccaagtg agcaagggtg aagccttagg
    13201 cccttgtctc ctccagacct cctctctgct ctaagagtat actgggcatg gggtgtggtc
    13261 ggggggttgg gggcggagga gtacttaacc tcaaactgag aaaaagggtg tcctgagcaa
    13321 gtttcatagc gtagcagctt ccatttgaaa tgtgaagctt tgaaggcctg ttgctacagt
    13381 aaccagctag ctcctgactc caatgcctgt ctaatctaag gtggaaatgt cccagaaaca
    13441 gaccccaggc tggcagctct taactatgac ccatctcata agcacatatc cagctgtagc
    13501 ctcttggttg ctggggtgaa ggggcctctg tatcgccaca ggaaaaaaaa tctgataaat
    13561 tacgggctca agaagggtgt tgcttttttt tccactaaca gactttgcaa cccagttcct
    13621 ggtgaaaggg ctccgcaccc acccgttttg tgtgtataat gctgagctaa agtgggaagg
    13681 agcagtaaca ccaaaggagg ctaattctct tcctgtcagt aggagagagt gtctgccccc
    13741 agtgtgtgaa aagggaaggc atgagaagtg aaaaatcagc cttctggaag caccttctta
    13801 ccacgagaaa acaggtgatt cttactatct ttgagactca tccagattgt gtctgtttaa
    13861 ctcttcaggc aatatgaagg cagagaagcc atttcagaga agagattttt taaaaaatca
    13921 tttcgttctt tggcattgtc acaggattat gatgtgggtt ctcataaaaa tttcactccc
    13981 cccaaagcca cccaaaggaa aggcagtgaa atggggagga acacacattt gcctggcatc
    14041 gcaagagctg ccttgtagtc atgggttcca gtgatcttgg accgatctct tcacttccct
    14101 ggacctcagt ttcttccata caaagaagtt gaactggatc atagaaaaga tgctgtccag
    14161 cttggtaata tcagataggg agcagaagct gtctcttagc acatggccag attccggaac
    14221 aacgatgatg gtctccatgt ttgtcctaaa aatgcatctc atctcagtag agattttctt
    14281 ccacctcatt tgggtctcaa tttaaggaag gaagaaagga aagaaacccg gggattctct
    14341 tcttgaaagg aatatacttc actttctcta ggcttctagg ataaaaactt cctatccttc
    14401 atttttcctc tttaaacctg ccaaaatcaa gttgagtaaa gataccatac agatatgaaa
    14461 aagaagccac atccttaaat tttcatggag tccaagagcc tgctcaccgc cagttagctt
    14521 ttcccaggat ggtggtggca ctgatcatct aggttgcact tttatgttca tgtcccagag
    14581 cgtttcccat cagccatctc atttcatctt ttcatcattc ctctgaggaa aagacttcac
    14641 acatgtatag gactttctat atcacaaagt atttcatatc caatgtctta tttagatctt
    14701 gacaatcact gtttaaggta atttggcaag ttattaatac tcatgtcctc attttactga
    14761 agaggaaact gaaatgcaga gagcttgtct tttgcccagg atcactcacc cagtttattg
    14821 ggaggcagca gcacggggat taagaacatg ggttatgccg acaaccaacc aggcagaatt
    14881 ccagctctgt cagtagttag ctgtctggcc ttaggaaagg gatttcacac ctctgtggct
    14941 tagtttcctt gtccattaaa tgctcataag aatagagctt tcctcacaga gattgggtgg
    15001 gcacgggagc taaatgagct catacgttta agaacaacct ctagcacaca gtgcataata
    15061 aatgtcatta ttattagcaa agccaggacc tgggtcttcc agcttctagc tcagtggcat
    15121 ttctgctgcc ccacaccagg actatccttc gtatacaggt atgaacctaa agccttcagt
    15181 gtttcaatga aaagttcacc caaggtcttt ctgttcagta agtctagagc taagggctcc
    15241 tggcactctg ttcagtcctt tcgctggtaa accacgctgc cctccgttgc tctgggcaga
    15301 atgtcaaacc ttcttatgtt tttaaaattt ataaatcaag cactcttatt taatattact
    15361 gacagcccga aggcagacgc tcccactctc ctggggaaga gggtcttcta atctgccatc
    15421 ttaaggaggt aaaagggctt gattgggtaa ctcattgcaa tgggcacgta tttattactg
    15481 tctcccggcc ttttctcatg ctgtttgtct gctggaatta ccactagtgc caggccattt
    15541 gaatatttga ccatttgtct tagaattctc tgaatacaaa tgtttttcat acctttacta
    15601 tgtacttttt aagaatgaag actatgttgc atgttggttt gtactctctc ctgcacataa
    15661 aaaatgctta gtaaatagat acacaaatgt t
//
