LOCUS       NM_001347924           13418 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens sorting nexin 19 (SNX19), transcript variant 9, mRNA.
ACCESSION   NM_001347924
VERSION     NM_001347924.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 13418)
  AUTHORS   Saric,A., Freeman,S.A., Williamson,C.D., Jarnik,M., Guardia,C.M.,
            Fernandopulle,M.S., Gershlick,D.C. and Bonifacino,J.S.
  TITLE     SNX19 restricts endolysosome motility through contacts with the
            endoplasmic reticulum
  JOURNAL   Nat Commun 12 (1), 4552 (2021)
   PUBMED   34315878
  REMARK    GeneRIF: SNX19 restricts endolysosome motility through contacts
            with the endoplasmic reticulum.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 13418)
  AUTHORS   Takahashi,Y., Maynard,K.R., Tippani,M., Jaffe,A.E., Martinowich,K.,
            Kleinman,J.E., Weinberger,D.R. and Hyde,T.M.
  TITLE     Single molecule in situ hybridization reveals distinct
            localizations of schizophrenia risk-related transcripts SNX19 and
            AS3MT in human brain
  JOURNAL   Mol Psychiatry 26 (7), 3536-3547 (2021)
   PUBMED   33649454
  REMARK    GeneRIF: Single molecule in situ hybridization reveals distinct
            localizations of schizophrenia risk-related transcripts SNX19 and
            AS3MT in human brain.
REFERENCE   3  (bases 1 to 13418)
  AUTHORS   Ma,L., Semick,S.A., Chen,Q., Li,C., Tao,R., Price,A.J., Shin,J.H.,
            Jia,Y., Brandon,N.J., Cross,A.J., Hyde,T.M., Kleinman,J.E.,
            Jaffe,A.E., Weinberger,D.R. and Straub,R.E.
  CONSRTM   BrainSeq Consortium
  TITLE     Schizophrenia risk variants influence multiple classes of
            transcripts of sorting nexin 19 (SNX19)
  JOURNAL   Mol Psychiatry 25 (4), 831-843 (2020)
   PUBMED   30635639
  REMARK    GeneRIF: Schizophrenia risk variants influence multiple classes of
            transcripts of sorting nexin 19 (SNX19).
REFERENCE   4  (bases 1 to 13418)
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Biological insights from 108 schizophrenia-associated genetic loci
  JOURNAL   Nature 511 (7510), 421-427 (2014)
   PUBMED   25056061
REFERENCE   5  (bases 1 to 13418)
  AUTHORS   Harashima,S., Horiuchi,T., Wang,Y., Notkins,A.L., Seino,Y. and
            Inagaki,N.
  TITLE     Sorting nexin 19 regulates the number of dense core vesicles in
            pancreatic beta-cells
  JOURNAL   J Diabetes Investig 3 (1), 52-61 (2012)
   PUBMED   24843546
REFERENCE   6  (bases 1 to 13418)
  AUTHORS   Shiffman,D., O'Meara,E.S., Bare,L.A., Rowland,C.M., Louie,J.Z.,
            Arellano,A.R., Lumley,T., Rice,K., Iakoubova,O., Luke,M.M.,
            Young,B.A., Malloy,M.J., Kane,J.P., Ellis,S.G., Tracy,R.P.,
            Devlin,J.J. and Psaty,B.M.
  TITLE     Association of gene variants with incident myocardial infarction in
            the Cardiovascular Health Study
  JOURNAL   Arterioscler Thromb Vasc Biol 28 (1), 173-179 (2008)
   PUBMED   17975119
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 13418)
  AUTHORS   Bare,L.A., Morrison,A.C., Rowland,C.M., Shiffman,D., Luke,M.M.,
            Iakoubova,O.A., Kane,J.P., Malloy,M.J., Ellis,S.G., Pankow,J.S.,
            Willerson,J.T., Devlin,J.J. and Boerwinkle,E.
  TITLE     Five common gene variants identify elevated genetic risk for
            coronary heart disease
  JOURNAL   Genet Med 9 (10), 682-689 (2007)
   PUBMED   18073581
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-gene interaction. (HuGE Navigator)
REFERENCE   8  (bases 1 to 13418)
  AUTHORS   Hu,Y.F., Zhang,H.L., Cai,T., Harashima,S. and Notkins,A.L.
  TITLE     The IA-2 interactome
  JOURNAL   Diabetologia 48 (12), 2576-2581 (2005)
   PUBMED   16273344
REFERENCE   9  (bases 1 to 13418)
  AUTHORS   Worby,C.A. and Dixon,J.E.
  TITLE     Sorting out the cellular functions of sorting nexins
  JOURNAL   Nat Rev Mol Cell Biol 3 (12), 919-931 (2002)
   PUBMED   12461558
  REMARK    Review article
            Erratum:[Nat Rev Mol Cell Biol. 2003 Feb;4(2):156.]
REFERENCE   10 (bases 1 to 13418)
  AUTHORS   Weinmann,A.S., Bartley,S.M., Zhang,T., Zhang,M.Q. and Farnham,P.J.
  TITLE     Use of chromatin immunoprecipitation to clone novel E2F target
            promoters
  JOURNAL   Mol Cell Biol 21 (20), 6820-6832 (2001)
   PUBMED   11564866
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP001093.5, AP000824.5 and
            AP003486.3.
            
            On May 21, 2020 this sequence version replaced NM_001347924.1.
            
            Summary: Islet antigen-2 (IA-2) is an autoantigen in type 1
            diabetes and plays a role in insulin secretion. IA-2 is found in
            dense-core secretory vesicles and interacts with the product of
            this gene, a sorting nexin. In mouse pancreatic beta-cells, the
            encoded protein influenced insulin secretion by stabilizing the
            number of dense-core secretory vesicles. [provided by RefSeq, Dec
            2016].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.94067.1,
                                           SRR1803612.75914.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148093 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-200               AP001093.5         4664-4863           c
            201-301             AP000824.5         182568-182668       c
            302-432             AP000824.5         180251-180381       c
            433-529             AP000824.5         178923-179019       c
            530-710             AP000824.5         178251-178431       c
            711-840             AP000824.5         175553-175682       c
            841-1025            AP000824.5         152920-153104       c
            1026-1113           AP000824.5         151922-152009       c
            1114-5150           AP000824.5         146816-150852       c
            5151-13418          AP003486.3         209212-217479       c
FEATURES             Location/Qualifiers
     source          1..13418
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.3-q25"
     gene            1..13418
                     /gene="SNX19"
                     /gene_synonym="CHET8"
                     /note="sorting nexin 19"
                     /db_xref="GeneID:399979"
                     /db_xref="HGNC:HGNC:21532"
     exon            1..200
                     /gene="SNX19"
                     /gene_synonym="CHET8"
                     /inference="alignment:Splign:2.1.0"
     exon            201..301
                     /gene="SNX19"
                     /gene_synonym="CHET8"
                     /inference="alignment:Splign:2.1.0"
     CDS             248..1246
                     /gene="SNX19"
                     /gene_synonym="CHET8"
                     /note="isoform 9 is encoded by transcript variant 9"
                     /codon_start=1
                     /product="sorting nexin-19 isoform 9"
                     /protein_id="NP_001334853.1"
                     /db_xref="GeneID:399979"
                     /db_xref="HGNC:HGNC:21532"
                     /translation="MDSDRVEARKSLLESFLKMVVSAIVDTLKTAFPRSEPQSPTEEL
                     SEAETESKPQTEGKKASKSRLRFSSSKISPALSVTEAQDKILYCLQEGNVESETLSMS
                     AMESFIEKQTKLLEMQPTKAPEKDPEQPPKGRVDSCVSDAAVPAQDPSNSDPGTETEL
                     ADTALDLLLLLLTEQWKWLCTENMQKFLRLIFGTLVQRWLEVQVANLTSPQRWVQYLL
                     LLQESIWPGGVLPKFPRPVRTQEQKLAAEKQALQSLMGVLPDLVVEILGVNKCRLSWG
                     LVLESLQQPLINRHLIYCLGDIILEFLDLSASVEESAATTSASDTPGNSKRMGVSS"
     exon            302..432
                     /gene="SNX19"
                     /gene_synonym="CHET8"
                     /inference="alignment:Splign:2.1.0"
     exon            433..529
                     /gene="SNX19"
                     /gene_synonym="CHET8"
                     /inference="alignment:Splign:2.1.0"
     exon            530..710
                     /gene="SNX19"
                     /gene_synonym="CHET8"
                     /inference="alignment:Splign:2.1.0"
     exon            711..840
                     /gene="SNX19"
                     /gene_synonym="CHET8"
                     /inference="alignment:Splign:2.1.0"
     exon            841..1025
                     /gene="SNX19"
                     /gene_synonym="CHET8"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1113
                     /gene="SNX19"
                     /gene_synonym="CHET8"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..13418
                     /gene="SNX19"
                     /gene_synonym="CHET8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2666..2671
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNX19"
                     /gene_synonym="CHET8"
                     /note="hexamer: ATTAAA"
     polyA_site      2688
                     /gene="SNX19"
                     /gene_synonym="CHET8"
                     /note="major polyA site"
     regulatory      3771..3776
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNX19"
                     /gene_synonym="CHET8"
                     /note="hexamer: AATAAA"
     polyA_site      3789
                     /gene="SNX19"
                     /gene_synonym="CHET8"
                     /note="major polyA site"
     regulatory      13383..13388
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNX19"
                     /gene_synonym="CHET8"
                     /note="hexamer: CATAAA"
     regulatory      13397..13402
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNX19"
                     /gene_synonym="CHET8"
                     /note="hexamer: AGTAAA"
     polyA_site      13408
                     /gene="SNX19"
                     /gene_synonym="CHET8"
     polyA_site      13418
                     /gene="SNX19"
                     /gene_synonym="CHET8"
ORIGIN      
        1 agctgtcgcc ggcggccggc cggcggtcag ccttcacaca ggcccggctg cggagcgcag
       61 tcgcccaggt ttacggcggc agagggccga ggctcccgga gaggaccgcg atgagtccac
      121 ttcaggtcgg ggctgagtgt gggcgcgcgg ttcccggcgg cgtgtgaccc agtcttcgcc
      181 ggccgctgcc cgctgcgtgt atgtgaaggg tcctaaaaag ctctttccag atcttccatt
      241 gggaaacatg gacagtgaca gagtagaagc ccgtaagagc ctcctagaat cattcctaaa
      301 gatggtggtg agtgccattg tggacacctt gaagacagcg tttcctcgct ctgaacccca
      361 gagccccaca gaggagctga gtgaggccga gaccgaaagc aagccccaga cagaaggcaa
      421 gaaggctagc aagtctaggc tgaggttctc atccagtaaa atttctccag cactaagtgt
      481 gactgaagca caagacaaga ttctttattg tctccaggaa ggcaatgtgg agtctgagac
      541 tctatccatg tctgcgatgg aatcttttat tgaaaaacag acaaagttac tggaaatgca
      601 gccaacaaaa gccccagaaa aagatcctga acaacctccc aaaggacgtg tggacagttg
      661 cgtgtcagat gcagccgtgc cagcccaaga ccccagcaac agcgatccag gaacagagac
      721 agagttagct gacacagccc tggatctgct cctcttgcta ctaacagaac agtggaaatg
      781 gctatgtacc gaaaacatgc aaaagtttct tcgtcttatc tttgggaccc tagttcaaag
      841 gtggctagag gtgcaggtag ctaatttaac aagtccacag cgctgggtgc agtacctcct
      901 gcttcttcag gagtccatct ggcctggtgg agttttgcct aagtttccac ggcccgtaag
      961 gacccaagag cagaaactgg ctgctgagaa acaggctttg cagagcctga tgggagtcct
     1021 cccagatctc gtagtagaaa ttcttggggt gaacaaatgc cggctgagct ggggtctagt
     1081 cctggagtca ctacaacaac ccctcatcaa caggcatttg atttactgcc ttggggacat
     1141 catcctggaa ttcttggatc tcagtgcctc tgttgaggag tctgctgcta ccacctctgc
     1201 ctcagatacc ccaggcaact ctaagaggat gggtgtctcc tcttagctgg ttattcacgc
     1261 cttcttccca ggtcagggaa gtagagttac tcggccacca gagaccagtc aggaagcccg
     1321 tgccctcttc aagtaggcta cagctaagaa ggcctaggtt ctcggtggct cacttctctc
     1381 ccacttctgc tccatttgta gcaggtgaca ggggtctgtg tgtcccagtt gtatgcacgt
     1441 ttatttccct gttccttttg tgatgttggg attgttgctg gtgagtagat cctgtttcct
     1501 ttgggaaaag aagctgtgag gtagaggaat gaaccccttt tgcttctcct tttgccatcc
     1561 tccctgagat tgtttgccag aatcctggcc ctgtgcacac atgtgcttaa tccaccagca
     1621 cacaagctct agatagaaca ggaaaaaaac tgtggccaga tttccttgga ggagaaaaca
     1681 accttctcag ctctctgttc ctacccggaa actaaaaatt cattcagggc cattctcaaa
     1741 aaccagactc ctgggtctaa tctagtttcc caacagttcc agaagaagaa ggagggaaga
     1801 aaatttttca aggaacttct tgctcatgtg ttgctgtttc ccaacacatc agccttatgg
     1861 aagatgtcat gaggctgctt gcctgggagg ctacactttc ctttccagaa gacttcaaag
     1921 ctgactgcca aagcttctgg taaatccacc ccacccttca caccctttcc tgaaaggcat
     1981 ttataccacc cattttattt attggctttg ctcccaaccc cctgccctag agcaattgag
     2041 tttttgaatt tttgaccctc tctctgtctt cagcaaaact gcatgacaag ctgcatattc
     2101 agcctcagtt tttccaagga gaatggaaag cacttgcctc ctgtcttaag aatgcacaaa
     2161 gagtaggact agcaaggctg ggggatgaaa tctcccttcc taagtctttg acagagaact
     2221 tttattattc tgaacagata agattagcaa acttacaagg aatagcttct tatttcccat
     2281 tccttacggt tataatcagt cctttaacaa caccagcatg aaggcaaagg tgttttgtca
     2341 gactgcaaca tctattagaa aggcaaggca actgggaatt gctggagaag gataaatcag
     2401 gaggaattgc tggtagaaaa ggctgcagac agtcacaggg aagtgctgta tattaaatgc
     2461 atgtgaatag ctggcaaaaa gatgtcaagg atgtcactgg gagccctttg gcttcacact
     2521 cgcctgttag cgccttgctt tcgctgaatt accagagcct accactcgga ggaaggtctt
     2581 ggagttagac tgatgagaag gcaatggggt gtcaaaaaca agtgtcaaag ttctcttaga
     2641 ttctgaagtc ggtgatgagc acacaattaa agtggtttgt ggaagaaagt tgtaaaatct
     2701 ttttactttt ttgcccctct ggaggctttt aaccctaaat tgtgtctgat gtattcggga
     2761 ggcttaggtg tgcaattctt gcccaaaggc aaggagatga atgagatgtc tcatggcctc
     2821 ttctagcctt aaaagttgac cattacagtg actttatggc tccaaagttc ttgaagcatc
     2881 tccagcccta gactttgaca agaaaaggta gctcagcatc tctactttcc gtgagtacct
     2941 gcaggagtcc agccaatgta ttagagctga tcattaagct ccttcagtga gggctaagat
     3001 cctattctcg atgagcatag ggggacagcc ttgttttatg ccacttttct ctccccatac
     3061 ctaccttccc ctcatgtgta cttagccacc tgtgttgctt tgaatctgct gccagttctg
     3121 gctcaaatgt ggcacaaaat cagtacatca gacacaccat gaaatccctg tggctataaa
     3181 ttctaaggaa tcttttgaca cttccagccc aaagaactta tttttatttc gtattatata
     3241 agagtcccca cctctactcc acgtacccca aaaagataag ctgtcctcag atcctccttc
     3301 tacccaggag ggaaataatg gatattgcca agggaacaat cagaactcat ctggctttga
     3361 aaacgacctg ccaagtttgg ctagcaggtt cagacaacaa gagagtaaca attggtagag
     3421 agccacaggt agaaaagata ctcccagctg acagggtgat aaaaggcagg gaagaattgg
     3481 gcctgtgctg atccaggaag gttttattgt ttgcttgttt tttgtattta ctcgtgacta
     3541 aattttattc atttaagtca gaattttgat atttgaaata agactacttt cccttttctt
     3601 actatctata aaaaagacga ggcagggatg ctgtgttctt tctgtcaaat tctaaatgtg
     3661 atctttgcca ttgcttattt gaattcaaga aagctatact ttttcatcac atataactca
     3721 cagtttcatt tttgcattgt tggattagac ttaataaaac ctaaatggaa aataaattcc
     3781 taaatctgag cctaggagca tgtataaatt ttatttttat tattattata cattaagttc
     3841 tagggaacat gtgcacaaca tgcaggtttg ttgcatatgt atacatgtgc cgtgttggtg
     3901 tgctgcaccc gttaactcgt catttacatt aggtatatct cctgatgcta tcccttcccc
     3961 ctcccccgac ctcacaacag gccccagtgt gtgatgttca ccttcctgtg tccaagtgtt
     4021 ctcattgttc aattcccacc tatgagtgag agcatgtata aattttaaaa tcaatacaag
     4081 ctactccaat ttccattttg gaaatttcca gtttacaagg tgattttctt attgttgtaa
     4141 agaaacacat aatgtgagat ctaccctctt aagtgtacag tacattattt atttattttg
     4201 agacggtaca ttattaacta gaagcagcac agtgctttgt agcagactgc tacaagtttt
     4261 tcatcttgca taaccaaaag tttataccca ttgaacagcc actcctcgtt tcccctccca
     4321 ccagcctctg gcaatcactg ttctactttc tgcttctgtg agtttgacta ctttgaacgc
     4381 ctcatataag tggaatcatg cagtgtttgt cctttgactg gcttatttca cttagcataa
     4441 tgtcctccag gttcatccac gttacagcat gtgacagaat tttcttttta aggctgaaaa
     4501 cattccattg tatggctatg ccacattttc tttgttcatt cattgaggga catttaggtt
     4561 ggctccgcgc cttgattgtt gaaaacaatg ctgcagtgaa catgggagtg tgactgtttc
     4621 ttcgaggccc tgcttttaat tattttagat aaatacccag aagtaggatt gctggatcat
     4681 atattgttct gtttttaatt ctttgaagac cttcatactg ttttccatag tgactagacc
     4741 attttacatt cccaccaaca atgtacaagg gttccagttt ctccacatcc tctccaacac
     4801 ttgtaatgtt ttgttttttc ataatggcat cttaaaaggt attaggtgat attactatct
     4861 catggttttg atttgcatag cctagaacat ttttgagtct tcctgtgtcc tacccaggtt
     4921 attcatttcc agctactgct cttcctttgc tcatagcaca caacaccagt tgttaggtcc
     4981 tggaggaagt aaaaatatgt gtaactatgg tccctggcta tatgaatcag gatgctctgg
     5041 acaagaatta aattatgagg aaaatttatt ttatttcata acattagtac gtgagtaggt
     5101 aagcccagga gtttggtgat tcagcaactc tgagacctct taaggggcct gaattctttc
     5161 catctttctt ccttgccatt ctaattaggt cagctgtgct ctcagactgc ctgccttcct
     5221 gctgctgcag tttcaggcat cacacccaga gataacattc ataaaagaac aggagcatct
     5281 cttctgtgtt ttcttctaag gaatgaagga accatttccc agaagtcctt caagaatcct
     5341 cttctaggcc gggcacagcg gctcacacct ataatctcaa cactttggga ggccaaggtt
     5401 gggggattgt ttgagtccag gagtttaaga ccagcctgga acatagcaag accctgtctc
     5461 tacaaaaaat ataaaaaatg agcggggcat ggtggctctc gcctgtggtt ccacctacta
     5521 gggaggctga ggcaggagga tcacttgagc ccaggaattt gaggctgcag tgagctacga
     5581 tcacaccact gcattctagc cttaagtgac agagtgagac cccaaataaa aaaaaaaaaa
     5641 acaaaaaacc tcttatgact cattggctag aaccacccac ctcatgccaa tccactgaca
     5701 ctgagaatgg cattgtgatt ggctttcaat agtattttcc cccagagatg aggtcatctt
     5761 ccatgaaggt cagatatcta cagaaataat tgatgttagc aaggaagaag cagagaatgg
     5821 gtattgatag acaatgtctg ctctagggat gggtcattct gccaacattc agcagatccc
     5881 ctatctactc ccaaaatgcc tggtaccagc taatagttaa catcttctga gagcattact
     5941 taaagtcttt acatatcttc acttatttaa cccacaaatc aacccttaaa ggtaggttct
     6001 gatgtagtgg gttggtgcaa aagtaattgg agttttgcca ttttaatgca attacttttg
     6061 caccaatcta atatatcccc attttctagg tggggaacat gaggcacaga gtggttatgt
     6121 cttacccaca gtcatttgca agggagtggc agagcctaga tacaaaccat gtcaatctgc
     6181 ctctgagtct acgtagtata tccactatac taaactgccc ttctacctta caaagcagaa
     6241 caagatcagg ttctcacttt taaggagtct acagtctagt ataggagcca gcaaactttc
     6301 tctgtaaagg tctggagact aaatactagg ttttgcagca gtatggtctc tgttgtaact
     6361 actcagcttt tccactgtag cgtaaaaaca gttgtagaca attcataaac aagtgtggct
     6421 gtgttccaat aaaacttgat ttacaaaaat aggcagctgg ccgggtttgt cccatgagtc
     6481 agtttgtgga cctgcggtct agtgagttag aatactgctt accaaatttt aatgtgtgtg
     6541 tgattcacgt gggatcgggt taaaatgcaa attttgattc aataggtccg gagtgaggcc
     6601 tagtaaaagt gtaagtgcta tgctctaaaa atgttgacag catgattatc acactcctct
     6661 gctgtttgag gggcagggag catttggaga tgccttgttt caggaaccca ttcagccaag
     6721 ttgtcctggc aagccgtacc tcccacagcc ccctccacac cggctgtttg tccaatctaa
     6781 ctttgcactg gagcaagatg tgttttccca ggatgaggaa aggaaggtta gcccacactg
     6841 ctggatgtgg aaggggatgg gaaccaggga aagaatggta actggggagg aagggaaacc
     6901 atgatacttt tgtagtcgaa ggcctaactg ggcgcactct gccataactt ggcccctctg
     6961 cttcctttcc actgggagtg ccagaaatca cagggcagca gtcgctcacc ctgcctttgt
     7021 agacaagaaa atgaaaccat cgaagggtga atttcagcta gcatattgcc atcactcttt
     7081 tatggtataa aggatgagag aggcggtgag ggagacattg ccccaaacat gatgtccaca
     7141 tcctaagact tacctgatat ttcttattac acaaagacaa cattgactgg tttaagagag
     7201 aaaaaaaaaa aggaaatcca gaagaatgtt ttaattgtca agcgtgaaac aagtgaaaat
     7261 catcagaatc tttttccttc tgtgacttgg tagcaacagt gtgtaaagcc aaggccaccg
     7321 tgaagcggtg ggggaaattt gggcacccgc agaccttggc agacacacta tgctattttc
     7381 agacttgcgg agcctttgca ctgcctccct gtcatcctca cctgtctctg gtctgaaagt
     7441 ccattttaac tctgctttct tggaggcaga aacaagcatg tgacaggatg cagagaatta
     7501 ctcctggctt tgatgtctct tcaacagctt gatgaaacct ggtttttcca cctgtcttca
     7561 cttctccaag ccttacctgc aagcgcttcc gtgaaagccc ccagcacacc atctctggga
     7621 tgtggaagct taggagggga gaattaaaaa aacaaaacga aggtaacagt aatcaagatc
     7681 caaacttaga aaacatttct tgaagtgaca ttatctgctc cttttaaccc aatccctttg
     7741 tcaccagtca gtgtttgttt aggaagtgta agctaatttt aatattaaag tgttgtagtg
     7801 attaagaagg taagtttgtg aataatgtat gaatcatcca cacttttgtc ttttttccca
     7861 ccttatgttc catgttactg ctgcaccctg ttataagcaa agaagagttg gctgtgatta
     7921 cttccagaaa ctttgattaa cccatgagag taaagatgta gctagataaa cacagaactc
     7981 cctgattgca gacaaaagga ctcaaatgtc gacagaagca atggcttgtt tatactgtgt
     8041 tgaactggat ttggtgactt gtgagcatag gtaatcagcc cttttgcccg tgcccctggg
     8101 tgaagaatca tcctgctcct gtaactatca aaaagattaa ccatgaacgt tgatatgaaa
     8161 tactgctttt cataccttga caccaagaag aatagacctt attaagggag gaaaaacact
     8221 tttggagttt acctccttta cacatcctgc ttgcatggaa tccaaattca gtgagctgac
     8281 ggcaggccag ttccttgcca ctttatgcag ttgtgtttaa agtttaccct ctgttatcta
     8341 taaatgcaag tggctttttc aagaatagtg agggcagctt tcattaagga ctcatgcatc
     8401 tctaggagaa tcacatgggc ttagttggca gtagagcatt ttcttgggga cagaatgtat
     8461 tatagatggt ttaggcagga ggttagacga gaaacttcca aaaaaatcta gggatttttt
     8521 attctgccca aaccagcatg ttccttcctg ctttcatttt tttgttcatg tccttccttc
     8581 cacgtggtag attaccttct cttctccagc tgggcaagta ggctacctct gcccataagg
     8641 accaattcaa gttccatttt caagaagcac tgtctgattg caccagccaa aactcttccc
     8701 actttctttt cagttattta cactgcctct ctagtcaatg tgcatgtata tgaagtcctc
     8761 agtaagagac tataattctt caagggcaac gaacatatct tttatctttt ttagtcctat
     8821 tatgtcctta tgcccccccc ccaactatat gtatatacct agtgcatgat aggtacaaaa
     8881 taaatattaa agtttactta attaaagatt atgtttattt aagaggcaaa atttgtgaat
     8941 aagtctggat cttgatactg ttactttcat tttgttgatt cctttctccc aaccttccac
     9001 atcccagaga cagggtgctg gtgactttta tggaaaggct tgaagggtga agatatgtgg
     9061 agaaaccacc gtaaacctct ttgagattaa ccacttattc cagtggaggg cactggctag
     9121 tctgtaccag acctgcccca gacagctttg tacatcttgc gtgtgggtgg gaacccaaaa
     9181 agtttccttt tcagtggatc tgtttaggtg aggtaaagaa atccattact caaatgtttc
     9241 atcagaggct accccctgtt caggtgtgca ccctgcaccc atgtgggttt gcggatggca
     9301 tataacactt gcagcagcag agctcgttgc cacacatcca agggaagtaa gtgtgcatat
     9361 gtggatgcgg cgggaatacc tgcggtcttt ctgctgaaga gcagggttat acacctcctt
     9421 ttagcaatct ggagaggact gaggcaagag cttgtattga aacacaagca agctccacgt
     9481 atggttttgg acatggaaga aagagtactg ttggggtgga atgacctaag tttttaatag
     9541 gattaggatt tctgtggatt tttcccaagt gatagaagtt ttcttcatct agcagggagc
     9601 ctcacccaat tgcttctcta tgttcatttc tgaaactcct ttgttaaaac taaatagcaa
     9661 cagagaagaa actttcttca aaaaactctt catatctgtc atttctccta ttcttatgga
     9721 acttcacaat tgctttttct ttattccttt ttttttttct atatcagctc atcagtcttt
     9781 gtgggtgact tggctacccc actaatctaa ttgccttttt gatagttaaa tcaatatgga
     9841 catcaactta aggctatatg tgaaccttaa atgcatgata ttccctatac ttgattccac
     9901 aattgatatt ctgtgaggaa agttggccag atattccctt ctgtgaagtc agaataacta
     9961 ccgaccctaa gaataaacat tttgaccaat tctttatatg ttgcaaacta ttcacacaac
    10021 tagaaagttt agccattcac atctcttccc ctgattttaa gtcccagatt ctgagactca
    10081 gaaagtttag tgacttgttg agctttctgt ggaaaatctg ttgtaaaaac agttcagaca
    10141 ttggaaaata taaaatagcc cctagagatc ccaataaagc ttcctctccc caaatccctc
    10201 tacaagttta tcctcgaaaa actttctgaa aactgatgag aaaatactga gtaattaatg
    10261 ctcaaatggg aaagatgaca tgtaaaagca aaaacctgtt aatggcatct gttcatatag
    10321 ttccatgtgc ctttttactt aactgcactg ataggcaatg taatgaagaa gtttcctttt
    10381 aaaacgtaaa atgtaattaa acagagttta tcttaaattg gctggacccg cacagcttga
    10441 ctgagacata cacagctgtc ttcattttga agcacctaca ctagtcaagc ttctttctaa
    10501 cccgccctta gggtttgcct gttggtctgt cttccctact gggctgttaa tcccttggag
    10561 gcagattgtc ttgtttccca gagtttttcc agcatatacc atggcagaca attttcacct
    10621 tatctattct aactcgtaag cctcagctag tgcctccatc ctcgggtgca tagcccagtg
    10681 acaggcatgt aacagacttt gcctacaagc agttgctgat ccataaatga cgttggcaac
    10741 cttcttgtgg cagtgagtaa catatttctt tcctcctgat aggcttggaa tcctcatccc
    10801 catctggcaa ttttctttcc atctttccta cactcacaat ggagcccaca cgcctcacaa
    10861 cccccttgac taaaccagat gacagcaaga atgcctagtt ccaagtgagc aagggtgaag
    10921 ccttaggccc ttgtctcctc cagacctcct ctctgctcta agagtatact gggcatgggg
    10981 tgtggtcggg gggttggggg cggaggagta cttaacctca aactgagaaa aagggtgtcc
    11041 tgagcaagtt tcatagcgta gcagcttcca tttgaaatgt gaagctttga aggcctgttg
    11101 ctacagtaac cagctagctc ctgactccaa tgcctgtcta atctaaggtg gaaatgtccc
    11161 agaaacagac cccaggctgg cagctcttaa ctatgaccca tctcataagc acatatccag
    11221 ctgtagcctc ttggttgctg gggtgaaggg gcctctgtat cgccacagga aaaaaaatct
    11281 gataaattac gggctcaaga agggtgttgc ttttttttcc actaacagac tttgcaaccc
    11341 agttcctggt gaaagggctc cgcacccacc cgttttgtgt gtataatgct gagctaaagt
    11401 gggaaggagc agtaacacca aaggaggcta attctcttcc tgtcagtagg agagagtgtc
    11461 tgcccccagt gtgtgaaaag ggaaggcatg agaagtgaaa aatcagcctt ctggaagcac
    11521 cttcttacca cgagaaaaca ggtgattctt actatctttg agactcatcc agattgtgtc
    11581 tgtttaactc ttcaggcaat atgaaggcag agaagccatt tcagagaaga gattttttaa
    11641 aaaatcattt cgttctttgg cattgtcaca ggattatgat gtgggttctc ataaaaattt
    11701 cactcccccc aaagccaccc aaaggaaagg cagtgaaatg gggaggaaca cacatttgcc
    11761 tggcatcgca agagctgcct tgtagtcatg ggttccagtg atcttggacc gatctcttca
    11821 cttccctgga cctcagtttc ttccatacaa agaagttgaa ctggatcata gaaaagatgc
    11881 tgtccagctt ggtaatatca gatagggagc agaagctgtc tcttagcaca tggccagatt
    11941 ccggaacaac gatgatggtc tccatgtttg tcctaaaaat gcatctcatc tcagtagaga
    12001 ttttcttcca cctcatttgg gtctcaattt aaggaaggaa gaaaggaaag aaacccgggg
    12061 attctcttct tgaaaggaat atacttcact ttctctaggc ttctaggata aaaacttcct
    12121 atccttcatt tttcctcttt aaacctgcca aaatcaagtt gagtaaagat accatacaga
    12181 tatgaaaaag aagccacatc cttaaatttt catggagtcc aagagcctgc tcaccgccag
    12241 ttagcttttc ccaggatggt ggtggcactg atcatctagg ttgcactttt atgttcatgt
    12301 cccagagcgt ttcccatcag ccatctcatt tcatcttttc atcattcctc tgaggaaaag
    12361 acttcacaca tgtataggac tttctatatc acaaagtatt tcatatccaa tgtcttattt
    12421 agatcttgac aatcactgtt taaggtaatt tggcaagtta ttaatactca tgtcctcatt
    12481 ttactgaaga ggaaactgaa atgcagagag cttgtctttt gcccaggatc actcacccag
    12541 tttattggga ggcagcagca cggggattaa gaacatgggt tatgccgaca accaaccagg
    12601 cagaattcca gctctgtcag tagttagctg tctggcctta ggaaagggat ttcacacctc
    12661 tgtggcttag tttccttgtc cattaaatgc tcataagaat agagctttcc tcacagagat
    12721 tgggtgggca cgggagctaa atgagctcat acgtttaaga acaacctcta gcacacagtg
    12781 cataataaat gtcattatta ttagcaaagc caggacctgg gtcttccagc ttctagctca
    12841 gtggcatttc tgctgcccca caccaggact atccttcgta tacaggtatg aacctaaagc
    12901 cttcagtgtt tcaatgaaaa gttcacccaa ggtctttctg ttcagtaagt ctagagctaa
    12961 gggctcctgg cactctgttc agtcctttcg ctggtaaacc acgctgccct ccgttgctct
    13021 gggcagaatg tcaaaccttc ttatgttttt aaaatttata aatcaagcac tcttatttaa
    13081 tattactgac agcccgaagg cagacgctcc cactctcctg gggaagaggg tcttctaatc
    13141 tgccatctta aggaggtaaa agggcttgat tgggtaactc attgcaatgg gcacgtattt
    13201 attactgtct cccggccttt tctcatgctg tttgtctgct ggaattacca ctagtgccag
    13261 gccatttgaa tatttgacca tttgtcttag aattctctga atacaaatgt ttttcatacc
    13321 tttactatgt actttttaag aatgaagact atgttgcatg ttggtttgta ctctctcctg
    13381 cacataaaaa atgcttagta aatagataca caaatgtt
//
