LOCUS       NM_052870               3288 bp    mRNA    linear   PRI 30-OCT-2024
DEFINITION  Homo sapiens sorting nexin 18 (SNX18), transcript variant 2, mRNA.
ACCESSION   NM_052870
VERSION     NM_052870.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3288)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3288)
  AUTHORS   Soreng,K., Munson,M.J., Lamb,C.A., Bjorndal,G.T., Pankiv,S.,
            Carlsson,S.R., Tooze,S.A. and Simonsen,A.
  TITLE     SNX18 regulates ATG9A trafficking from recycling endosomes by
            recruiting Dynamin-2
  JOURNAL   EMBO Rep 19 (4) (2018)
   PUBMED   29437695
  REMARK    GeneRIF: We propose a model where upon autophagy induction, SNX18
            recruits Dynamin-2 to induce budding of ATG9A and ATG16L1
            containing membranes from recycling endosomes that traffic to sites
            of autophagosome formation.
REFERENCE   3  (bases 1 to 3288)
  AUTHORS   Kleino,I., Jarviluoma,A., Hepojoki,J., Huovila,A.P. and Saksela,K.
  TITLE     Preferred SH3 domain partners of ADAM metalloproteases include
            shared and ADAM-specific SH3 interactions
  JOURNAL   PLoS One 10 (3), e0121301 (2015)
   PUBMED   25825872
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3288)
  AUTHORS   Ebsen,H., Lettau,M., Kabelitz,D. and Janssen,O.
  TITLE     Identification of SH3 domain proteins interacting with the
            cytoplasmic tail of the a disintegrin and metalloprotease 10
            (ADAM10)
  JOURNAL   PLoS One 9 (7), e102899 (2014)
   PUBMED   25036101
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3288)
  AUTHORS   Li,D., Mangan,A., Cicchini,L., Margolis,B. and Prekeris,R.
  TITLE     FIP5 phosphorylation during mitosis regulates apical trafficking
            and lumenogenesis
  JOURNAL   EMBO Rep 15 (4), 428-437 (2014)
   PUBMED   24591568
REFERENCE   6  (bases 1 to 3288)
  AUTHORS   Pisitkun,T., Shen,R.F. and Knepper,M.A.
  TITLE     Identification and proteomic profiling of exosomes in human urine
  JOURNAL   Proc Natl Acad Sci U S A 101 (36), 13368-13373 (2004)
   PUBMED   15326289
REFERENCE   7  (bases 1 to 3288)
  AUTHORS   Schulze,W.X. and Mann,M.
  TITLE     A novel proteomic screen for peptide-protein interactions
  JOURNAL   J Biol Chem 279 (11), 10756-10764 (2004)
   PUBMED   14679214
REFERENCE   8  (bases 1 to 3288)
  AUTHORS   Worby,C.A. and Dixon,J.E.
  TITLE     Sorting out the cellular functions of sorting nexins
  JOURNAL   Nat Rev Mol Cell Biol 3 (12), 919-931 (2002)
   PUBMED   12461558
  REMARK    Review article
            Erratum:[Nat Rev Mol Cell Biol. 2003 Feb;4(2):156.]
REFERENCE   9  (bases 1 to 3288)
  AUTHORS   Xu,Y., Seet,L.F., Hanson,B. and Hong,W.
  TITLE     The Phox homology (PX) domain, a new player in phosphoinositide
            signalling
  JOURNAL   Biochem J 360 (Pt 3), 513-530 (2001)
   PUBMED   11736640
  REMARK    Review article
REFERENCE   10 (bases 1 to 3288)
  AUTHORS   Teasdale,R.D., Loci,D., Houghton,F., Karlsson,L. and Gleeson,P.A.
  TITLE     A large family of endosome-localized proteins related to sorting
            nexin 1
  JOURNAL   Biochem J 358 (Pt 1), 7-16 (2001)
   PUBMED   11485546
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC091888.3, BC060791.1,
            BC117220.1, AF395536.1 and CN479485.1.
            
            On Aug 13, 2020 this sequence version replaced NM_052870.3.
            
            Summary: This gene encodes a member of the sorting nexin family.
            Members of this family contain a phox (PX) domain, which is a
            phosphoinositide binding domain, and are involved in intracellular
            trafficking. This protein does not contain a coiled coil region,
            like some family members, but contains a SH3 domain. Multiple
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) uses an alternate splice
            pattern in the 3' coding region compared to variant 1. The
            resulting protein (isoform b) has a longer and distinct C-terminus
            compared to isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC117218.1, AF395536.1 [ECO:0000345]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AC091888.3         59276-59279
            5-106               BC060791.1         1-102
            107-463             BC117220.1         1-357
            464-464             AC091888.3         59739-59739
            465-805             BC117220.1         359-699
            806-806             AC091888.3         60081-60081
            807-1971            BC117220.1         701-1865
            1972-2081           AF395536.1         1778-1887
            2082-2152           BC117220.1         1976-2046
            2153-2712           AC091888.3         61428-61987
            2713-3246           CN479485.1         18-551              c
            3247-3288           AC091888.3         62522-62563
FEATURES             Location/Qualifiers
     source          1..3288
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q11.2"
     gene            1..3288
                     /gene="SNX18"
                     /gene_synonym="SH3PX2; SH3PXD3B; SNAG1"
                     /note="sorting nexin 18"
                     /db_xref="GeneID:112574"
                     /db_xref="HGNC:HGNC:19245"
                     /db_xref="MIM:621000"
     exon            1..3288
                     /gene="SNX18"
                     /gene_synonym="SH3PX2; SH3PXD3B; SNAG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..2081
                     /gene="SNX18"
                     /gene_synonym="SH3PX2; SH3PXD3B; SNAG1"
                     /note="isoform b is encoded by transcript variant 2;
                     sorting nexin associated golgi protein 1; SH3 and PX
                     domain-containing protein 3B; sorting nexin-associated
                     Golgi protein 1"
                     /codon_start=1
                     /product="sorting nexin-18 isoform b"
                     /protein_id="NP_443102.2"
                     /db_xref="CCDS:CCDS3962.1"
                     /db_xref="GeneID:112574"
                     /db_xref="HGNC:HGNC:19245"
                     /db_xref="MIM:621000"
                     /translation="MALRARALYDFRSENPGEISLREHEVLSLCSEQDIEGWLEGVNS
                     RGDRGLFPASYVQVIRAPEPGPAGDGGPGAPARYANVPPGGFEPLPVAPPASFKPPPD
                     AFQALLQPQQAPPPSTFQPPGAGFPYGGGALQPSPQQLYGGYQASQGSDDDWDDEWDD
                     SSTVADEPGALGSGAYPDLDGSSSAGVGAAGRYRLSTRSDLSLGSRGGSVPPQHHPSG
                     PKSSATVSRNLNRFSTFVKSGGEAFVLGEASGFVKDGDKLCVVLGPYGPEWQENPYPF
                     QCTIDDPTKQTKFKGMKSYISYKLVPTHTQVPVHRRYKHFDWLYARLAEKFPVISVPH
                     LPEKQATGRFEEDFISKRRKGLIWWMNHMASHPVLAQCDVFQHFLTCPSSTDEKAWKQ
                     GKRKAEKDEMVGANFFLTLSTPPAAALDLQEVESKIDGFKCFTKKMDDSALQLNHTAN
                     EFARKQVTGFKKEYQKVGQSFRGLSQAFELDQQAFSVGLNQAIAFTGDAYDAIGELFA
                     EQPRQDLDPVMDLLALYQGHLANFPDIIHVQKGKAWPLEQVIWSVLCRLKGATLTAVP
                     LWVSESYSTGEEASRDVDAWVFSLECKLDCSTGSFLLEYLALGNEYSFSKVQRVPLMT
                     VLSF"
     regulatory      3226..3231
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNX18"
                     /gene_synonym="SH3PX2; SH3PXD3B; SNAG1"
                     /note="hexamer: ATTAAA"
     polyA_site      3246
                     /gene="SNX18"
                     /gene_synonym="SH3PX2; SH3PXD3B; SNAG1"
                     /note="major polyA site"
     regulatory      3266..3271
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNX18"
                     /gene_synonym="SH3PX2; SH3PXD3B; SNAG1"
                     /note="hexamer: CATAAA"
     polyA_site      3288
                     /gene="SNX18"
                     /gene_synonym="SH3PX2; SH3PXD3B; SNAG1"
                     /note="major polyA site"
ORIGIN      
        1 agtcggcgct gcgaagtgga ggcgctgcga gcggagccgc gcggagggcg cgaccggctg
       61 gtccgggcag cgtgggtttg ccgccttcgg ggctccagtc cgcgcgccag ggctcgagca
      121 gtaccgcggg cccctcaggt gggcctcggc tcgggacgcc gggagtcggg accgccagtc
      181 ggggcgccgg gaccatggcg ctgcgcgccc gggcgctgta cgacttcagg tcggagaacc
      241 caggagagat ctcgctgcga gagcacgagg tgctgagcct gtgcagcgag caggacatcg
      301 agggctggct cgagggggtc aacagccgcg gcgaccgcgg cctcttcccg gcctcctatg
      361 tgcaggtgat ccgcgccccc gagcctggcc cggcgggaga cggcggcccg ggcgccccgg
      421 cccgctacgc caatgtgccc cccgggggct tcgagcccct gcctgtcgcg ccccccgcct
      481 ccttcaagcc gccgcctgac gccttccagg cgctgctgca gccacagcag gcgccgcctc
      541 cgagcacctt ccagccgccc ggcgcgggct tcccgtacgg cgggggcgcc ctgcagccgt
      601 cgcctcagca gctctacggc ggctaccagg ccagccaagg cagcgatgat gactgggacg
      661 acgagtggga cgacagctcc acggtggcgg acgagccggg cgctctgggc agcggagcat
      721 acccggacct cgacggctcg tcttcggcgg gtgtgggcgc agccggccgc taccgcctgt
      781 ccacgcgctc cgacctgtcc ctgggttccc gcggcggctc ggtccccccg cagcaccacc
      841 cgtcggggcc caagagctcg gccaccgtga gccgcaacct caatcgcttc tccaccttcg
      901 tcaagtccgg cggggaggcc ttcgtgctgg gggaggcgtc aggcttcgtg aaggacgggg
      961 acaagctgtg cgtggtgctg gggccctatg gccccgagtg gcaggagaac ccctacccgt
     1021 tccagtgcac catcgacgac cccaccaagc agaccaagtt caagggcatg aagagctaca
     1081 tctcctacaa gctggtgccc acgcacacgc aggtgccggt gcatcggcgc tacaagcact
     1141 tcgactggct gtacgcgcgc ctggcggaga agttcccggt catctccgtg ccccacctgc
     1201 ccgagaagca ggccaccggc cgcttcgagg aggacttcat ctctaagcgc aggaagggcc
     1261 tgatctggtg gatgaaccac atggccagcc acccagtgct ggcgcagtgc gacgtcttcc
     1321 agcacttcct gacgtgcccc agcagcaccg acgagaaagc ctggaagcag ggcaagagga
     1381 aggccgagaa ggacgagatg gtgggcgcca acttcttcct gacccttagc acgccccccg
     1441 ccgctgccct tgacctgcag gaggtggaga gcaagatcga cggcttcaag tgcttcacca
     1501 agaagatgga cgacagcgcg ctgcagctca accacacggc caacgagttc gcgcgcaagc
     1561 aggtgaccgg cttcaaaaag gagtatcaga aggtgggcca gtccttccgc ggcctcagcc
     1621 aggcctttga gctggaccag caggccttct cggtgggcct gaaccaggct atcgccttca
     1681 ccggagatgc ctatgacgcc attggcgagc tcttcgcgga gcagcccagg caggacctgg
     1741 atcccgtcat ggacctatta gcgctgtatc aggggcatct ggctaacttc ccggacatca
     1801 tccacgttca gaaaggtaaa gcctggccct tagagcaggt gatatggagt gtattgtgca
     1861 ggctgaaagg ggcgactttg acagcagtac cactgtgggt ttcagaatca tattctacag
     1921 gtgaggaagc gagcagagac gtggacgcct gggtcttttc cctagagtgt aagttggatt
     1981 gctcgacagg cagcttcctc ctcgagtatc ttgcattagg gaatgagtac tctttctcga
     2041 aggttcaaag agtacctttg atgacagtgc tatcatttta gagtttgaat agttgagtaa
     2101 tgagctgctc aaatctgtaa tcttgagacg agggtagaat tagaagggga cctaaaccat
     2161 gttaggtatc tgtttgaaca ctgcactgtc acttagtggt gagtttcaaa aagtgaggaa
     2221 ataatggaga agaacggatg tctgtaaata gaaatctgct ttcacccttc cacacctctc
     2281 aatctctgct ttggtagagg aattaagatc aattctctga gtttaagaaa ttcctgcaaa
     2341 gaattcttgc ctgcaacctt tacgaagtga agtaatttca ggaaaagcgt actcattttg
     2401 agtttgaaat ctattaatgt actgaaattg agaacgttgt ttaggaaaat tgtttaggga
     2461 aactacatag aatgaatata atctgagtat tggatctgag agcagcgttg ctggtatccc
     2521 agtgagttag ctgtccaact atcagagttc atgagttatt aatagttgtt agtgtctctg
     2581 acctttgcta aagcaccaga atttgcaaat taaaaaaata tatagcagta gtgcttgtct
     2641 taacatttct tactaatgtg cattctcata taatgccttg attgagagaa tggggaggtg
     2701 tgggagttag ggaggcagtc ttgcctgtga aagtccagtg taggggcggc tgggcaggga
     2761 aacctactcc tgagcaggga aacctactgt ccctgtttcc tcagcgggtc tggcctttac
     2821 tggtgaagtg ctcactgcct ttctggtggg ccagtccgtt tatgagcaac cctgatctct
     2881 ggcatgtctt ttcttgtatt gaactgaagt ttgcctccct tgattgtctt tctgttccct
     2941 gggaccgcct tcagacattt ggagacagca gtctcgcttc cttcctctct gcttctctcc
     3001 ttccccttcc aaatgcgtga ctggtcttct gactcctatg ggggaagggg cttgctggga
     3061 gaatgatcaa acgttttcag tcttgttgct gccgctgaaa gggagtaccc tggacatcag
     3121 tactaatttt agtagacagt agtaactttc ttggcaattt gcgatttgta aatgcagtct
     3181 aatattgaat tcgttttttg tgcaatcata ttgctgttgg cctgtattaa acctgtattt
     3241 acattaccta tgcctttttt taaaacataa attgttatga atctttga
//
