LOCUS       NM_001102575            5223 bp    mRNA    linear   PRI 30-OCT-2024
DEFINITION  Homo sapiens sorting nexin 18 (SNX18), transcript variant 1, mRNA.
ACCESSION   NM_001102575
VERSION     NM_001102575.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5223)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 5223)
  AUTHORS   Soreng,K., Munson,M.J., Lamb,C.A., Bjorndal,G.T., Pankiv,S.,
            Carlsson,S.R., Tooze,S.A. and Simonsen,A.
  TITLE     SNX18 regulates ATG9A trafficking from recycling endosomes by
            recruiting Dynamin-2
  JOURNAL   EMBO Rep 19 (4) (2018)
   PUBMED   29437695
  REMARK    GeneRIF: We propose a model where upon autophagy induction, SNX18
            recruits Dynamin-2 to induce budding of ATG9A and ATG16L1
            containing membranes from recycling endosomes that traffic to sites
            of autophagosome formation.
REFERENCE   3  (bases 1 to 5223)
  AUTHORS   Kleino,I., Jarviluoma,A., Hepojoki,J., Huovila,A.P. and Saksela,K.
  TITLE     Preferred SH3 domain partners of ADAM metalloproteases include
            shared and ADAM-specific SH3 interactions
  JOURNAL   PLoS One 10 (3), e0121301 (2015)
   PUBMED   25825872
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5223)
  AUTHORS   Ebsen,H., Lettau,M., Kabelitz,D. and Janssen,O.
  TITLE     Identification of SH3 domain proteins interacting with the
            cytoplasmic tail of the a disintegrin and metalloprotease 10
            (ADAM10)
  JOURNAL   PLoS One 9 (7), e102899 (2014)
   PUBMED   25036101
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5223)
  AUTHORS   Li,D., Mangan,A., Cicchini,L., Margolis,B. and Prekeris,R.
  TITLE     FIP5 phosphorylation during mitosis regulates apical trafficking
            and lumenogenesis
  JOURNAL   EMBO Rep 15 (4), 428-437 (2014)
   PUBMED   24591568
REFERENCE   6  (bases 1 to 5223)
  AUTHORS   Pisitkun,T., Shen,R.F. and Knepper,M.A.
  TITLE     Identification and proteomic profiling of exosomes in human urine
  JOURNAL   Proc Natl Acad Sci U S A 101 (36), 13368-13373 (2004)
   PUBMED   15326289
REFERENCE   7  (bases 1 to 5223)
  AUTHORS   Schulze,W.X. and Mann,M.
  TITLE     A novel proteomic screen for peptide-protein interactions
  JOURNAL   J Biol Chem 279 (11), 10756-10764 (2004)
   PUBMED   14679214
REFERENCE   8  (bases 1 to 5223)
  AUTHORS   Worby,C.A. and Dixon,J.E.
  TITLE     Sorting out the cellular functions of sorting nexins
  JOURNAL   Nat Rev Mol Cell Biol 3 (12), 919-931 (2002)
   PUBMED   12461558
  REMARK    Review article
            Erratum:[Nat Rev Mol Cell Biol. 2003 Feb;4(2):156.]
REFERENCE   9  (bases 1 to 5223)
  AUTHORS   Xu,Y., Seet,L.F., Hanson,B. and Hong,W.
  TITLE     The Phox homology (PX) domain, a new player in phosphoinositide
            signalling
  JOURNAL   Biochem J 360 (Pt 3), 513-530 (2001)
   PUBMED   11736640
  REMARK    Review article
REFERENCE   10 (bases 1 to 5223)
  AUTHORS   Teasdale,R.D., Loci,D., Houghton,F., Karlsson,L. and Gleeson,P.A.
  TITLE     A large family of endosome-localized proteins related to sorting
            nexin 1
  JOURNAL   Biochem J 358 (Pt 1), 7-16 (2001)
   PUBMED   11485546
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC091888.3, BC060791.1,
            AK022059.1, BJ990551.1, AI669182.1, AI335241.1 and CD722181.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001102575.1.
            
            Summary: This gene encodes a member of the sorting nexin family.
            Members of this family contain a phox (PX) domain, which is a
            phosphoinositide binding domain, and are involved in intracellular
            trafficking. This protein does not contain a coiled coil region,
            like some family members, but contains a SH3 domain. Multiple
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript but encodes the shorter isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060791.1, SRR1660803.46165.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381410.5/ ENSP00000370817.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AC091888.3         59276-59279
            5-463               BC060791.1         1-459
            464-464             AC091888.3         59739-59739
            465-805             BC060791.1         461-801
            806-806             AC091888.3         60081-60081
            807-2528            BC060791.1         803-2524
            2529-3251           AK022059.1         416-1138
            3252-3284           BJ990551.1         220-252
            3285-4507           AK022059.1         1171-2393
            4508-4831           AI669182.1         28-351              c
            4832-5222           AI335241.1         8-398               c
            5223-5223           CD722181.1         49-49               c
FEATURES             Location/Qualifiers
     source          1..5223
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q11.2"
     gene            1..5223
                     /gene="SNX18"
                     /gene_synonym="SH3PX2; SH3PXD3B; SNAG1"
                     /note="sorting nexin 18"
                     /db_xref="GeneID:112574"
                     /db_xref="HGNC:HGNC:19245"
                     /db_xref="MIM:621000"
     exon            1..1815
                     /gene="SNX18"
                     /gene_synonym="SH3PX2; SH3PXD3B; SNAG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..2069
                     /gene="SNX18"
                     /gene_synonym="SH3PX2; SH3PXD3B; SNAG1"
                     /note="isoform a is encoded by transcript variant 1;
                     sorting nexin associated golgi protein 1; SH3 and PX
                     domain-containing protein 3B; sorting nexin-associated
                     Golgi protein 1"
                     /codon_start=1
                     /product="sorting nexin-18 isoform a"
                     /protein_id="NP_001096045.1"
                     /db_xref="CCDS:CCDS43317.1"
                     /db_xref="GeneID:112574"
                     /db_xref="HGNC:HGNC:19245"
                     /db_xref="MIM:621000"
                     /translation="MALRARALYDFRSENPGEISLREHEVLSLCSEQDIEGWLEGVNS
                     RGDRGLFPASYVQVIRAPEPGPAGDGGPGAPARYANVPPGGFEPLPVAPPASFKPPPD
                     AFQALLQPQQAPPPSTFQPPGAGFPYGGGALQPSPQQLYGGYQASQGSDDDWDDEWDD
                     SSTVADEPGALGSGAYPDLDGSSSAGVGAAGRYRLSTRSDLSLGSRGGSVPPQHHPSG
                     PKSSATVSRNLNRFSTFVKSGGEAFVLGEASGFVKDGDKLCVVLGPYGPEWQENPYPF
                     QCTIDDPTKQTKFKGMKSYISYKLVPTHTQVPVHRRYKHFDWLYARLAEKFPVISVPH
                     LPEKQATGRFEEDFISKRRKGLIWWMNHMASHPVLAQCDVFQHFLTCPSSTDEKAWKQ
                     GKRKAEKDEMVGANFFLTLSTPPAAALDLQEVESKIDGFKCFTKKMDDSALQLNHTAN
                     EFARKQVTGFKKEYQKVGQSFRGLSQAFELDQQAFSVGLNQAIAFTGDAYDAIGELFA
                     EQPRQDLDPVMDLLALYQGHLANFPDIIHVQKGALTKVKESRRHVEEGKMEVQKADGI
                     QDRCNTISFATLAEIHHFHQIRVRDFKSQMQHFLQQQIIFFQKVTQKLEEALHKYDSV
                     "
     exon            1816..5223
                     /gene="SNX18"
                     /gene_synonym="SH3PX2; SH3PXD3B; SNAG1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4483..4488
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNX18"
                     /gene_synonym="SH3PX2; SH3PXD3B; SNAG1"
                     /note="hexamer: AATAAA"
     polyA_site      4508
                     /gene="SNX18"
                     /gene_synonym="SH3PX2; SH3PXD3B; SNAG1"
                     /note="major polyA site"
     regulatory      5199..5204
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNX18"
                     /gene_synonym="SH3PX2; SH3PXD3B; SNAG1"
                     /note="hexamer: AATAAA"
     polyA_site      5223
                     /gene="SNX18"
                     /gene_synonym="SH3PX2; SH3PXD3B; SNAG1"
ORIGIN      
        1 agtcggcgct gcgaagtgga ggcgctgcga gcggagccgc gcggagggcg cgaccggctg
       61 gtccgggcag cgtgggtttg ccgccttcgg ggctccagtc cgcgcgccag ggctcgagca
      121 gtaccgcggg cccctcaggt gggcctcggc tcgggacgcc gggagtcggg accgccagtc
      181 ggggcgccgg gaccatggcg ctgcgcgccc gggcgctgta cgacttcagg tcggagaacc
      241 caggagagat ctcgctgcga gagcacgagg tgctgagcct gtgcagcgag caggacatcg
      301 agggctggct cgagggggtc aacagccgcg gcgaccgcgg cctcttcccg gcctcctatg
      361 tgcaggtgat ccgcgccccc gagcctggcc cggcgggaga cggcggcccg ggcgccccgg
      421 cccgctacgc caatgtgccc cccgggggct tcgagcccct gcctgtcgcg ccccccgcct
      481 ccttcaagcc gccgcctgac gccttccagg cgctgctgca gccacagcag gcgccgcctc
      541 cgagcacctt ccagccgccc ggcgcgggct tcccgtacgg cgggggcgcc ctgcagccgt
      601 cgcctcagca gctctacggc ggctaccagg ccagccaagg cagcgatgat gactgggacg
      661 acgagtggga cgacagctcc acggtggcgg acgagccggg cgctctgggc agcggagcat
      721 acccggacct cgacggctcg tcttcggcgg gtgtgggcgc agccggccgc taccgcctgt
      781 ccacgcgctc cgacctgtcc ctgggttccc gcggcggctc ggtccccccg cagcaccacc
      841 cgtcggggcc caagagctcg gccaccgtga gccgcaacct caatcgcttc tccaccttcg
      901 tcaagtccgg cggggaggcc ttcgtgctgg gggaggcgtc aggcttcgtg aaggacgggg
      961 acaagctgtg cgtggtgctg gggccctatg gccccgagtg gcaggagaac ccctacccgt
     1021 tccagtgcac catcgacgac cccaccaagc agaccaagtt caagggcatg aagagctaca
     1081 tctcctacaa gctggtgccc acgcacacgc aggtgccggt gcatcggcgc tacaagcact
     1141 tcgactggct gtacgcgcgc ctggcggaga agttcccggt catctccgtg ccccacctgc
     1201 ccgagaagca ggccaccggc cgcttcgagg aggacttcat ctctaagcgc aggaagggcc
     1261 tgatctggtg gatgaaccac atggccagcc acccagtgct ggcgcagtgc gacgtcttcc
     1321 agcacttcct gacgtgcccc agcagcaccg acgagaaagc ctggaagcag ggcaagagga
     1381 aggccgagaa ggacgagatg gtgggcgcca acttcttcct gacccttagc acgccccccg
     1441 ccgctgccct tgacctgcag gaggtggaga gcaagatcga cggcttcaag tgcttcacca
     1501 agaagatgga cgacagcgcg ctgcagctca accacacggc caacgagttc gcgcgcaagc
     1561 aggtgaccgg cttcaaaaag gagtatcaga aggtgggcca gtccttccgc ggcctcagcc
     1621 aggcctttga gctggaccag caggccttct cggtgggcct gaaccaggct atcgccttca
     1681 ccggagatgc ctatgacgcc attggcgagc tcttcgcgga gcagcccagg caggacctgg
     1741 atcccgtcat ggacctatta gcgctgtatc aggggcatct ggctaacttc ccggacatca
     1801 tccacgttca gaaaggagct cttaccaaag tcaaggagag taggcgacac gtggaggaag
     1861 ggaagatgga ggtgcagaag gctgacggca ttcaggatcg ctgtaacact atttcttttg
     1921 ccactttggc tgaaattcac cacttccatc aaattcgagt gagagacttt aaatcacaga
     1981 tgcagcattt cttacaacaa caaataatat ttttccaaaa agttacccag aagttggaag
     2041 aagctcttca caaatatgat agtgtttaat gactggacgt tggattatgg actttttcag
     2101 ttcaaggata atttctacag cagaataaaa actgctgtca aagagctatt gccagctatc
     2161 agtggtggta caaggacggt tttgtgttca tctgaaaccc agctgaattt ataattatgt
     2221 aggaaataaa cagttaatat ggttatataa tagaaacagt accacacatt gtaactaaat
     2281 tatactatgt atgcctacac taccattgta acttttggaa taatgattat actatttgcc
     2341 ttattgcttt ttgaagtatg ggtattttag tgcatacttt gtagacctca aaacccatga
     2401 agggtctcaa agaagctggc tggatacaag cctgctgtgg atgccttttt actctcatag
     2461 attgggatta cctaaattca acctattctc tgtttacaaa ctccaactag agcagctatg
     2521 cgaccttgtg cctttagact cttggttttt catttctccc cgtcccttcc ccaccttttt
     2581 aaagtaagcc acagcttttc tgattgaaag agtgaaaggc cagtgcatat aatgacaaac
     2641 tgatgataac cttatattgg cagtaggggg tggggggggc ggtggggtgg gacgatcagc
     2701 tgtcatcaat ttgcacagca agtattatct cctgataaga tgctggtgaa tgcaggggag
     2761 tgagattcat tgctcatctt tggatatgaa gtctgttagg gaagaaacag tgccactatt
     2821 cccttagatg caacagtagc atagcctctt cacccaggcg tcccaaaagc ttggcgtgaa
     2881 gatttcagca aacatgtctt acaacatgag gaggaggagt ctaaatcagt caggggataa
     2941 aagtatcgaa tcattgacaa cacacacttg gctttagttc ttaggagggt tttgtttttg
     3001 tttttgtttt taggttgaag attttctttt aatattcagt tttttgaaaa aaaatggatc
     3061 tacactgtta actgattgag actccactgt gattcacttg tttacttaaa aacttttcag
     3121 ggatgtctgt aaatttcagt gttaatatgt catgaaaagt ggtgtggatt gatctaagga
     3181 gggaccagaa ataatttttg ctattccaaa tactgaagga aaaagataat tgatttatac
     3241 tatgttttaa aaaaaaaaaa ggtattgatg agcccccccc ccccaggaca tttaacctta
     3301 aaatttattt taaatgtatt cttttattat tataagggaa atacagatgg ctgataaata
     3361 ccaaaaagat tcaaaagcag cttaatttaa aaagcacaaa gagattctgg cttacagtgc
     3421 cccaatctca atgtttttat agttgctgag ctaactaatg tgattattga gtttacagat
     3481 ttaaaaattg tcactgttag agtatctact gtttttatga agtcaaactt atgctgcctc
     3541 agaaatccct gggtactgaa atggtaacat ggaagtgaag aggtcacttt gaaatattgg
     3601 tgagtcacaa agattaaaga aaaggatcag tttgcagata ctcagaaaag gttattgaaa
     3661 taattactga acagcacatt ttctctctaa aaagtagttt catatgggtt gtatttttaa
     3721 gatcagatta tcattttgat atttggtcaa aattttgtac cttaggttac ttagagccag
     3781 atttaacatc atgaacatta tgtggctttg tctttactac agatatgtgg aactgtaacc
     3841 aaatatgttg tctctaaaac ttgttgattg caaaatacag ttctataaac aaaacccata
     3901 tgtatatata aatgttaatt ttgcggaagt ctggaaatta taactatagc atttaagttt
     3961 gagtctgtat tggacaaata agcaccatgc ttttcaaatg atttaaaaat tacttttatt
     4021 tgcctcttta ttttgatggt ggttggattt tttttttttt aatagtaaaa tcactaaact
     4081 tgtgcaatgg tagcatggaa attatctgag gtatattgta tgattgtact ttagccaggg
     4141 tggacatagc ttaaattata aaaactaaag atgaaagtac aaggaagtat aagttatact
     4201 tatgtaagta taaattcatg ctgcctactt ctaagagaaa tttcattctt cataaccaca
     4261 taacattata atgccactga ttcatacggg atttacatta attctatggg ggaggacact
     4321 agaattatta gtgttcattt tcatctaaga tctttattct ctaacgttct tggtcctatt
     4381 gaaacattgc agtatgcaaa actactgcaa tgttaaaccc aagagaaaag ccattatcat
     4441 gtgtatgctg gtcatcatga tcagtgtggt acaattttta aaaataaact atcatgccct
     4501 tcatgccatt atttgtcttt atttctatga tttataatcc tgatatgtga tgtgtttgta
     4561 acacagggtg tgcacttgag cctggtttta ctgtttttat tagacagagt tgtttatatg
     4621 ctgtaactgt aacgcagcga gactggttct acagccatgt gtcgtaatct tgttccccgt
     4681 ccaagctgtt gtatctgaag gtacccagtt tgcacccagg atgagggaac gcattcaaaa
     4741 gtgaaatgta aagccagtgc acgaatatta tagtaattga gattttccca ggcttcactg
     4801 atacagttgt tttgcattta ttcacaataa tacagcagat tcttaaatgc cgatttttaa
     4861 ttgtcttaaa ttttgctgct gttctcataa ttaaggactt gaaaaatgtt ttagtctgtc
     4921 aagtatgtaa agtttgtgta aaaactttta aatgtcattc ttaagttcat tgccatagcc
     4981 attttccatt tatgtcttca ttttccaaaa atcaaatgcc atgtctgata cctttaagtc
     5041 cataagcatt caattttctc atttccacct tcatctttgg ttaacagaat aagtaaaaca
     5101 gggtattatt tatttgtagt ctagaaatgt tgaatattgt tttatttcct tcaaaatgtt
     5161 atgattagtg cagatcagcc atgtttatct ttttaaaaaa taaacaggtt gctttatttc
     5221 tta
//
