LOCUS       NM_014748               2357 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens sorting nexin 17 (SNX17), transcript variant 1, mRNA.
ACCESSION   NM_014748
VERSION     NM_014748.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2357)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2357)
  AUTHORS   Pan,B., Liu,L., Hu,X., Sun,X., Zhu,Y., Zhang,T., Wei,D., Guo,Y. and
            Shan,J.
  TITLE     Promotion of esophageal adenocarcinoma metastasis via
            Wnt/ss-catenin signal pathway by sorting nexins 3
  JOURNAL   J Gastroenterol Hepatol 35 (12), 2131-2139 (2020)
   PUBMED   32187731
  REMARK    GeneRIF: Promotion of esophageal adenocarcinoma metastasis via
            Wnt/ss-catenin signal pathway by sorting nexins 3.
REFERENCE   3  (bases 1 to 2357)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 2357)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2357)
  AUTHORS   Wang,P., Xia,J., Zhang,L., Zhao,S., Li,S., Wang,H., Cheng,S.,
            Li,H., Yin,W., Pei,D. and Shu,X.
  TITLE     SNX17 Recruits USP9X to Antagonize MIB1-Mediated Ubiquitination and
            Degradation of PCM1 during Serum-Starvation-Induced Ciliogenesis
  JOURNAL   Cells 8 (11), 1335 (2019)
   PUBMED   31671755
  REMARK    GeneRIF: SNX17 Recruits USP9X to Antagonize MIB1-Mediated
            Ubiquitination and Degradation of PCM1 during
            Serum-Starvation-Induced Ciliogenesis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2357)
  AUTHORS   Gevaert,K., Goethals,M., Martens,L., Van Damme,J., Staes,A.,
            Thomas,G.R. and Vandekerckhove,J.
  TITLE     Exploring proteomes and analyzing protein processing by mass
            spectrometric identification of sorted N-terminal peptides
  JOURNAL   Nat Biotechnol 21 (5), 566-569 (2003)
   PUBMED   12665801
REFERENCE   7  (bases 1 to 2357)
  AUTHORS   Stockinger,W., Sailler,B., Strasser,V., Recheis,B., Fasching,D.,
            Kahr,L., Schneider,W.J. and Nimpf,J.
  TITLE     The PX-domain protein SNX17 interacts with members of the LDL
            receptor family and modulates endocytosis of the LDL receptor
  JOURNAL   EMBO J 21 (16), 4259-4267 (2002)
   PUBMED   12169628
REFERENCE   8  (bases 1 to 2357)
  AUTHORS   Teasdale,R.D., Loci,D., Houghton,F., Karlsson,L. and Gleeson,P.A.
  TITLE     A large family of endosome-localized proteins related to sorting
            nexin 1
  JOURNAL   Biochem J 358 (Pt 1), 7-16 (2001)
   PUBMED   11485546
REFERENCE   9  (bases 1 to 2357)
  AUTHORS   Florian,V., Schluter,T. and Bohnensack,R.
  TITLE     A new member of the sorting nexin family interacts with the
            C-terminus of P-selectin
  JOURNAL   Biochem Biophys Res Commun 281 (4), 1045-1050 (2001)
   PUBMED   11237770
REFERENCE   10 (bases 1 to 2357)
  AUTHORS   Hoja,M.R., Wahlestedt,C. and Hoog,C.
  TITLE     A visual intracellular classification strategy for uncharacterized
            human proteins
  JOURNAL   Exp Cell Res 259 (1), 239-246 (2000)
   PUBMED   10942595
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from D31764.1 and AC074117.7.
            
            On Nov 23, 2018 this sequence version replaced NM_014748.3.
            
            Summary: This gene encodes a member of the sorting nexin family.
            Members of this family contain a phox (PX) domain, which is a
            phosphoinositide binding domain, and are involved in intracellular
            trafficking. This protein does not contain a coiled coil region,
            like some family members, but contains a B41 domain. This protein
            interacts with the cytoplasmic domain of P-selectin, and may
            function in the intracellular trafficking of P-selectin.
            Alternative splicing results in multiple transcript variants
            encoding different isoforms. [provided by RefSeq, May 2012].
            
            Transcript Variant: This variant (1) encodes the longest protein
            (isoform 1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.176180.1,
                                           SRR1803615.195274.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000233575.7/ ENSP00000233575.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1829              D31764.1           95-1923
            1830-2357           AC074117.7         168533-169060       c
FEATURES             Location/Qualifiers
     source          1..2357
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.3"
     gene            1..2357
                     /gene="SNX17"
                     /note="sorting nexin 17"
                     /db_xref="GeneID:9784"
                     /db_xref="HGNC:HGNC:14979"
                     /db_xref="MIM:605963"
     exon            1..191
                     /gene="SNX17"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..1541
                     /gene="SNX17"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="sorting nexin-17 isoform 1"
                     /protein_id="NP_055563.1"
                     /db_xref="CCDS:CCDS1750.1"
                     /db_xref="GeneID:9784"
                     /db_xref="HGNC:HGNC:14979"
                     /db_xref="MIM:605963"
                     /translation="MHFSIPETESRSGDSGGSAYVAYNIHVNGVLHCRVRYSQLLGLH
                     EQLRKEYGANVLPAFPPKKLFSLTPAEVEQRREQLEKYMQAVRQDPLLGSSETFNSFL
                     RRAQQETQQVPTEEVSLEVLLSNGQKVLVNVLTSDQTEDVLEAVAAKLDLPDDLIGYF
                     SLFLVREKEDGAFSFVRKLQEFELPYVSVTSLRSQEYKIVLRKSYWDSAYDDDVMENR
                     VGLNLLYAQTVSDIERGWILVTKEQHRQLKSLQEKVSKKEFLRLAQTLRHYGYLRFDA
                     CVADFPEKDCPVVVSAGNSELSLQLRLPGQQLREGSFRVTRMRCWRVTSSVPLPSGST
                     SSPGRGRGEVRLELAFEYLMSKDRLQWVTITSPQAIMMSICLQSMVDELMVKKSGGSI
                     RKMLRRRVGGTLRRSDSQQAVKSPPLLESPDATRESMVKLSSKLSAVSLRGIGSPSTD
                     ASASDVHGNFAFEGIGDEDL"
     exon            192..266
                     /gene="SNX17"
                     /inference="alignment:Splign:2.1.0"
     exon            267..384
                     /gene="SNX17"
                     /inference="alignment:Splign:2.1.0"
     exon            385..449
                     /gene="SNX17"
                     /inference="alignment:Splign:2.1.0"
     exon            450..560
                     /gene="SNX17"
                     /inference="alignment:Splign:2.1.0"
     exon            561..651
                     /gene="SNX17"
                     /inference="alignment:Splign:2.1.0"
     exon            652..739
                     /gene="SNX17"
                     /inference="alignment:Splign:2.1.0"
     exon            740..809
                     /gene="SNX17"
                     /inference="alignment:Splign:2.1.0"
     exon            810..902
                     /gene="SNX17"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1106
                     /gene="SNX17"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1232
                     /gene="SNX17"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1310
                     /gene="SNX17"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1385
                     /gene="SNX17"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1427
                     /gene="SNX17"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..2357
                     /gene="SNX17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1925..1930
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNX17"
                     /note="hexamer: ATTAAA"
     polyA_site      1950
                     /gene="SNX17"
                     /note="major polyA site"
     regulatory      2099..2104
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNX17"
                     /note="hexamer: AATAAA"
     polyA_site      2122
                     /gene="SNX17"
     regulatory      2168..2173
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNX17"
                     /note="hexamer: AATACA"
     polyA_site      2169
                     /gene="SNX17"
     regulatory      2339..2344
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNX17"
                     /note="hexamer: TATAAA"
     polyA_site      2357
                     /gene="SNX17"
ORIGIN      
        1 catcggatcg cagggctccc aaaatggcga gtgaggctgc ggggactcgc tgagcagcgg
       61 agggggagcg tgcagagccg ctgcggccct cacagtccgg agcccggccg tgccgtgccg
      121 tagggaacat gcacttttcc attcccgaaa ccgagtcccg cagcggggac agcggcggct
      181 ccgcctacgt ggcctataac attcacgtga atggagtcct gcactgtcgg gtgcgctaca
      241 gccagctcct ggggctgcac gagcagcttc ggaaggagta tggggccaat gtgcttcctg
      301 cattcccccc aaagaagctt ttctctctga ctcctgctga ggtagaacag aggagagagc
      361 agttagagaa gtacatgcaa gctgttcggc aagacccatt gcttgggagc agcgagactt
      421 tcaacagttt cctgcgtcgg gcacaacagg agacacagca ggtccccaca gaggaagtgt
      481 ccttggaagt gctgctcagc aacgggcaga aagttctggt caacgtgcta acttcagatc
      541 agactgagga tgtcctggag gctgtagctg caaagctgga tcttccagat gacttgattg
      601 gatactttag tctattctta gttcgagaaa aagaggatgg agccttttct tttgtacgga
      661 agttgcaaga gtttgagctg ccttatgtgt ctgtcaccag ccttcggagt caagagtata
      721 agattgtgct aaggaagagt tattgggact ctgcctatga tgacgatgtc atggagaacc
      781 gggttggcct gaacctgctt tatgctcaga cggtatcaga tattgagcgt gggtggatct
      841 tggtcaccaa ggaacagcac cggcaactca aatctctgca agagaaagtc tccaagaagg
      901 agttcctgag actggcccag acgctgcggc actatggcta cttgcgcttt gatgcctgtg
      961 tggctgactt cccagaaaag gactgtcctg tggtggtgag cgcgggcaac agtgagctca
     1021 gcctgcagct ccgcctgcct ggccagcaac tccgagaagg ctccttccgg gtcacccgca
     1081 tgcgatgctg gcgggtcacc tcctctgtac cattgcccag tggaagcacg agcagcccag
     1141 gccggggccg gggtgaggtg cgcctggaac tggcttttga atacctcatg agcaaggacc
     1201 ggctacagtg ggtcaccatc actagccccc aggctatcat gatgagcatc tgcttgcagt
     1261 ccatggttga tgaactgatg gtgaagaaat ctggcggcag tatcaggaag atgctgcgcc
     1321 ggcgggtggg gggtactctg agacgctcag acagccagca agcagtgaag tccccaccac
     1381 tgcttgagtc acctgatgcc acccgggagt ctatggtcaa actctcaagt aagctgagtg
     1441 ccgtgagctt gcggggaatt ggcagtccca gcacagatgc cagtgccagt gatgtccacg
     1501 gcaatttcgc cttcgagggc attggagatg aggatctgta atctccactg cttggatgtc
     1561 tgccctctac cccagaggaa tttacagaaa cttgccctgt gcctgtgtcc cccatgctag
     1621 gggcggaggg gtcttttcct tcttctttcc tacctacccc ttttctcttg gccaggggcc
     1681 tcgtatccta cctttccttg tcccctgggc tggctgcaca gaggattgcc ccttctcttt
     1741 tcagagctgg ccctcgatgc caaattagca tttagtattt tgcacaaagt ctaagggacc
     1801 atggctgcct gccttgggga ggaaccatat ctccctctgg gccgcttctg gcctcttgga
     1861 gccatgggcc aaaggccaag gggatgggca gaggtctgtg tttggtctgg cccagttccc
     1921 catcattaaa ctcagcctga ctgctgccta cctctggttc cctctcactg cccctgcttc
     1981 ccccatcaca gcatggacta ctatgctaag ggtaaggcca aattgcctgc cattgccaat
     2041 tcagcataga catggctttg ttagtgtttc ctttattata aagcactgaa ataagttaaa
     2101 taaacaggtg ggaggctggg cagtccccca gccggtttgt ccacagcccc tgggggcagt
     2161 ggaggtgaat acagggccct tctcactgag ctcgtgaagt gcctcagtca aggcaaggtc
     2221 ccctggtcca tatgggcccc cccgcccatg gggttgggct ggtccttata gtgcctacgt
     2281 tagtctgtgt ggagcccctg gccagcgggg gagaaaaagg tggcttctgg tccgtctgta
     2341 taaaacatgg ggaagaa
//
