LOCUS       NM_152836               3109 bp    mRNA    linear   PRI 24-JUN-2024
DEFINITION  Homo sapiens sorting nexin 16 (SNX16), transcript variant 2, mRNA.
ACCESSION   NM_152836
VERSION     NM_152836.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3109)
  AUTHORS   Yuan,L., Meng,Y. and Xiang,J.
  TITLE     SNX16 is required for hepatocellular carcinoma survival via
            modulating the EGFR-AKT signaling pathway
  JOURNAL   Sci Rep 14 (1), 13093 (2024)
   PUBMED   38849490
  REMARK    GeneRIF: SNX16 is required for hepatocellular carcinoma survival
            via modulating the EGFR-AKT signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3109)
  AUTHORS   Zeng,F.Y. and Lou,Y.F.
  TITLE     [Sorting Nexin 16:Structure,Function,and Role in Diseases]
  JOURNAL   Zhongguo Yi Xue Ke Xue Yuan Xue Bao 44 (6), 1107-1111 (2022)
   PUBMED   36373636
  REMARK    GeneRIF: [Sorting Nexin 16:Structure,Function,and Role in
            Diseases].
            Review article
REFERENCE   3  (bases 1 to 3109)
  AUTHORS   Mi,C., Ye,B., Gao,Z., Du,J., Li,R. and Huang,D.
  TITLE     BHLHE40 plays a pathological role in pre-eclampsia through
            upregulating SNX16 by transcriptional inhibition of miR-196a-5p
  JOURNAL   Mol Hum Reprod 26 (7), 532-548 (2020)
   PUBMED   32579212
  REMARK    GeneRIF: BHLHE40 plays a pathological role in pre-eclampsia through
            upregulating SNX16 by transcriptional inhibition of miR-196a-5p.
REFERENCE   4  (bases 1 to 3109)
  AUTHORS   Shen,Z., Li,Y., Fang,Y., Lin,M., Feng,X., Li,Z., Zhan,Y., Liu,Y.,
            Mou,T., Lan,X., Wang,Y., Li,G., Wang,J. and Deng,H.
  TITLE     SNX16 activates c-Myc signaling by inhibiting ubiquitin-mediated
            proteasomal degradation of eEF1A2 in colorectal cancer development
  JOURNAL   Mol Oncol 14 (2), 387-406 (2020)
   PUBMED   31876369
  REMARK    GeneRIF: SNX16 activates c-Myc signaling by inhibiting
            ubiquitin-mediated proteasomal degradation of eEF1A2 in colorectal
            cancer development.
REFERENCE   5  (bases 1 to 3109)
  AUTHORS   Xu,J., Zhang,L., Ye,Y., Shan,Y., Wan,C., Wang,J., Pei,D., Shu,X.
            and Liu,J.
  TITLE     SNX16 Regulates the Recycling of E-Cadherin through a Unique
            Mechanism of Coordinated Membrane and Cargo Binding
  JOURNAL   Structure 25 (8), 1251-1263 (2017)
   PUBMED   28712807
  REMARK    GeneRIF: SNX16 regulates the recycling trafficking of E-cadherin .
            SNX16 associates with the cytoplasmic domain of E-cadherin via
            PPII/alpha2 loop.
REFERENCE   6  (bases 1 to 3109)
  AUTHORS   Wolf,C., Gramer,E., Muller-Myhsok,B., Pasutto,F., Reinthal,E.,
            Wissinger,B. and Weisschuh,N.
  TITLE     Evaluation of nine candidate genes in patients with normal tension
            glaucoma: a case control study
  JOURNAL   BMC Med Genet 10, 91 (2009)
   PUBMED   19754948
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3109)
  AUTHORS   Hanson,B.J. and Hong,W.
  TITLE     Evidence for a role of SNX16 in regulating traffic between the
            early and later endosomal compartments
  JOURNAL   J Biol Chem 278 (36), 34617-34630 (2003)
   PUBMED   12813048
  REMARK    GeneRIF: SNX16 is a sorting nexin that may function in the
            trafficking of proteins between the early and late endosomal
            compartments
REFERENCE   8  (bases 1 to 3109)
  AUTHORS   Worby,C.A. and Dixon,J.E.
  TITLE     Sorting out the cellular functions of sorting nexins
  JOURNAL   Nat Rev Mol Cell Biol 3 (12), 919-931 (2002)
   PUBMED   12461558
  REMARK    Review article
            Erratum:[Nat Rev Mol Cell Biol. 2003 Feb;4(2):156.]
REFERENCE   9  (bases 1 to 3109)
  AUTHORS   Xu,Y., Seet,L.F., Hanson,B. and Hong,W.
  TITLE     The Phox homology (PX) domain, a new player in phosphoinositide
            signalling
  JOURNAL   Biochem J 360 (Pt 3), 513-530 (2001)
   PUBMED   11736640
  REMARK    Review article
REFERENCE   10 (bases 1 to 3109)
  AUTHORS   Teasdale,R.D., Loci,D., Houghton,F., Karlsson,L. and Gleeson,P.A.
  TITLE     A large family of endosome-localized proteins related to sorting
            nexin 1
  JOURNAL   Biochem J 358 (Pt 1), 7-16 (2001)
   PUBMED   11485546
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC033630.1, CB962009.1 and
            AL833763.1.
            
            On Nov 23, 2018 this sequence version replaced NM_152836.2.
            
            Summary: This gene encodes a member of the sorting nexin family.
            Members of this family contain a phox (PX) domain, which is a
            phosphoinositide binding domain, and are involved in intracellular
            trafficking. The protein encoded by this gene associates with late
            endosome membranes as is involved in tubule formation, cholesterol
            transport, and transport of tetraspanin CD81. The encoded protein
            also inhibits cell migration and tumorigenesis. [provided by
            RefSeq, Jan 2017].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.67396.1,
                                           SRR1660805.253040.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000345957.9/ ENSP00000322652.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                BC033630.1         10-64
            56-673              CB962009.1         135-752
            674-1734            BC033630.1         683-1743
            1735-3109           AL833763.1         1656-3030
FEATURES             Location/Qualifiers
     source          1..3109
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q21.13"
     gene            1..3109
                     /gene="SNX16"
                     /note="sorting nexin 16"
                     /db_xref="GeneID:64089"
                     /db_xref="HGNC:HGNC:14980"
                     /db_xref="MIM:614903"
     exon            1..64
                     /gene="SNX16"
                     /inference="alignment:Splign:2.1.0"
     exon            65..535
                     /gene="SNX16"
                     /inference="alignment:Splign:2.1.0"
     CDS             161..1195
                     /gene="SNX16"
                     /note="isoform a is encoded by transcript variant 2"
                     /codon_start=1
                     /product="sorting nexin-16 isoform a"
                     /protein_id="NP_690049.1"
                     /db_xref="CCDS:CCDS6234.1"
                     /db_xref="GeneID:64089"
                     /db_xref="HGNC:HGNC:14980"
                     /db_xref="MIM:614903"
                     /translation="MATPYVPVPMPIGNSASSFTTNRNQRSSSFGSVSTSSNSSKGQL
                     EDSNMGNFKQTSVPDQMDNTSSVCSSPLIRTKFTGTASSIEYSTRPRDTEEQNPETVN
                     WEDRPSTPTILGYEVMEERAKFTVYKILVKKTPEESWVVFRRYTDFSRLNDKLKEMFP
                     GFRLALPPKRWFKDNYNADFLEDRQLGLQAFLQNLVAHKDIANCLAVREFLCLDDPPG
                     PFDSLEESRAFCETLEETNYRLQKELLEKQKEMESLKKLLSEKQLHIDTLENRIRTLS
                     LEPEESLDVSETEGEQILKVESSALEVDQDVLDEESRADNKPCLSFSEPENAVSEIEV
                     AEVAYDAEED"
     exon            536..622
                     /gene="SNX16"
                     /inference="alignment:Splign:2.1.0"
     exon            623..771
                     /gene="SNX16"
                     /inference="alignment:Splign:2.1.0"
     exon            772..841
                     /gene="SNX16"
                     /inference="alignment:Splign:2.1.0"
     exon            842..978
                     /gene="SNX16"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1098
                     /gene="SNX16"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..3109
                     /gene="SNX16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1707..1712
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNX16"
                     /note="hexamer: AATAAA"
     polyA_site      1734
                     /gene="SNX16"
                     /note="major polyA site"
     regulatory      2176..2181
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNX16"
                     /note="hexamer: ATTAAA"
     polyA_site      2201
                     /gene="SNX16"
     regulatory      2343..2348
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNX16"
                     /note="hexamer: ATTAAA"
     polyA_site      2368
                     /gene="SNX16"
     regulatory      3087..3092
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNX16"
                     /note="hexamer: AATAAA"
     polyA_site      3109
                     /gene="SNX16"
                     /note="major polyA site"
ORIGIN      
        1 aaggagagtc cggtttaacc gtcaccggga agcgcgctcg ttcgggatcg ccgagggggc
       61 tgagatagtg aattcctaag aagaaaataa tggattgcat attagttgtt ctctaagtgg
      121 actcaacagt gtgcaagctt gttggaaaag ccaaaagaag atggcaactc cttatgtccc
      181 agttcctatg cccataggaa actctgcttc cagttttaca acaaacagaa atcaaagaag
      241 ttcttctttt ggcagtgtct caacaagctc aaattcttct aagggccagt tagaagactc
      301 aaatatgggt aattttaaac agacaagtgt tcctgatcaa atggataata cttcatctgt
      361 ctgtagcagt cccctcatta ggactaaatt tacaggtaca gcttcttcca ttgagtattc
      421 tactagacca agagacactg aagaacaaaa tccggaaaca gtgaattggg aagatagacc
      481 atctacacct actatactgg gttatgaagt gatggaagaa agagctaaat ttactgtata
      541 taaaatacta gtaaagaaaa ccccagaaga aagctgggta gttttcagaa gatacactga
      601 cttctctagg cttaatgaca aattaaaaga gatgtttcca ggttttcgac tagcacttcc
      661 tccaaaacgc tggtttaaag ataattacaa tgctgacttt ttagaagaca gacaattagg
      721 attacaagcg tttcttcaaa atttagtagc tcacaaggac attgctaact gccttgcagt
      781 gagagaattt ctttgtttgg atgatccacc gggtccattt gatagcctag aagaaagcag
      841 ggcattctgt gaaactttag aagagacaaa ctaccgctta cagaaagaac tacttgaaaa
      901 acaaaaggag atggaatcac taaagaaact gctcagtgag aagcaacttc atatagacac
      961 tttagagaac agaatcagaa cattgtcttt agaacctgaa gaatcactgg atgtgtcaga
     1021 aacagaaggt gaacagatcc taaaggtgga gtcctctgca cttgaggttg atcaagatgt
     1081 cctggatgaa gaatctagag ctgataataa accatgctta agttttagtg aacctgaaaa
     1141 tgctgtatca gagatagaag tagcagaagt ggcatatgat gctgaagaag actaatgtat
     1201 cacaagcagt tccctccatt tagactattc aaaaatttag aagagtggca aatactattt
     1261 taaaagaaga accaagaact gtaaaacata tagaaaagag caagaatgca catgtataaa
     1321 gtttacataa agaagttttt ttaagttatt gagataggaa atatattcac tgctgctttt
     1381 aattgtattt tatccaatta catttaatac actaaaaaaa atcttgttgg aattctgtta
     1441 tcaaggccca cattcttaaa tactgtgcat aaattattat ggtgttttgc ctatatattg
     1501 ctccaaacta ctgtgtatat atgtatgtgt gttaaatcac caattatatt aatcaaatgg
     1561 aaattaattg catgttacta tctgggtgat atattcttct ttatatctct gacatgacat
     1621 attttcatta atagtttaaa tcagtgacca tcataataaa gataaaattt agttgagttt
     1681 ttaatgttta catgtttaca tctctaaata aaatttgctt atttgaaatg ttaatgctct
     1741 ttagaaaaat gactttctag taccaaagga aaactacttg aaagagctgt aatcatatag
     1801 ctaaagtgat aagatagcct tgattttaaa agctgattca ttaatatcaa aatactttaa
     1861 taagtgtcac agttattaat atgttacatt tgtttagttt ccacgtaatc tttatctcta
     1921 cctagattta gtgagtttgc ctctttcaga atactacctc cttttgttaa ggcatattct
     1981 ttcgaaaata tagattctaa ataaataggg gcttatacaa aaaagaaaat aaaaagccat
     2041 atatactgca aagttcctaa ctggcttgac tcctgacatt gcatttttat ttctatttgt
     2101 gtgaagatgt tgttatactg tattatggct gattttcttt ttaatatatt tagccaagtg
     2161 atgcacttta tgataattaa actcttttgt gccaagttta attggtggat ttttttagta
     2221 agtagagtta ggagaaagaa ttatgtagtg cctttactat ttcactttct acaaaagtct
     2281 cctagggtct ttgagtcagc tttatgaaaa aatgtttgtt tatttcagct ttgtgtacag
     2341 tcattaaaag tgccttgttt catttttata ggatgaagtt atttattttc tattttcact
     2401 gttttgcata ttgctgttaa taagcattgt aatcatgctg gcattttgca atcccagtcg
     2461 gtatgctttc taaaaactga gggaaactta ctggggaaat agaataacaa tctccatttt
     2521 tttctttact atctaaaagt ttatcggtat cttgatgtat atatatatta aggtgtggct
     2581 gtttaaaatt ctaatgacat atatcaacac attcaatggc tgttgttaac ctttgaagta
     2641 aaaaggagat cactttttac caaataacca aaaattttta gtctgtcaaa gtgcacaggt
     2701 atgttctcag aacatttttc acaatgtgta tcagaaatat gtttgctatc cttagagaca
     2761 gaaatgaata taataaattg atctgcttat ttattaaaat tattattcta gacttacaaa
     2821 aggcttaaaa agaacaatca tttaatcagt accattctgt atcttatata acagatcttt
     2881 gccaaattct agatattata gtgttgcctg tctgttctaa agcgaaccag ccactttttc
     2941 aatctggctt tttggaagat tgtatttaaa gttcttcaag gatgaagaaa aaaatctgtt
     3001 aattaggtaa accactatta tttatattta taatttactt ttttttactt ttataatgca
     3061 ttttactccc agtattatgt tcatttaata aattattttt tcactacaa
//
