LOCUS       NM_013306               1908 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens sorting nexin 15 (SNX15), transcript variant A, mRNA.
ACCESSION   NM_013306
VERSION     NM_013306.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1908)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1908)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1908)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1908)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 1908)
  AUTHORS   Wang,W., Shen,P., Thiyagarajan,S., Lin,S., Palm,C., Horvath,R.,
            Klopstock,T., Cutler,D., Pique,L., Schrijver,I., Davis,R.W.,
            Mindrinos,M., Speed,T.P. and Scharfe,C.
  TITLE     Identification of rare DNA variants in mitochondrial disorders with
            improved array-based sequencing
  JOURNAL   Nucleic Acids Res 39 (1), 44-58 (2011)
   PUBMED   20843780
REFERENCE   6  (bases 1 to 1908)
  AUTHORS   Warner,T.T., Patel,H., Proukakis,C., Reed,J.A., McKie,L., Wills,A.,
            Patton,M.A. and Crosby,A.H.
  TITLE     A clinical, genetic and candidate gene study of Silver syndrome, a
            complicated form of hereditary spastic paraplegia
  JOURNAL   J Neurol 251 (9), 1068-1074 (2004)
   PUBMED   15372247
REFERENCE   7  (bases 1 to 1908)
  AUTHORS   Ciccarelli,F.D., Proukakis,C., Patel,H., Cross,H., Azam,S.,
            Patton,M.A., Bork,P. and Crosby,A.H.
  TITLE     The identification of a conserved domain in both spartin and
            spastin, mutated in hereditary spastic paraplegia
  JOURNAL   Genomics 81 (4), 437-441 (2003)
   PUBMED   12676568
REFERENCE   8  (bases 1 to 1908)
  AUTHORS   Phillips,S.A., Barr,V.A., Haft,D.H., Taylor,S.I. and Haft,C.R.
  TITLE     Identification and characterization of SNX15, a novel sorting nexin
            involved in protein trafficking
  JOURNAL   J Biol Chem 276 (7), 5074-5084 (2001)
   PUBMED   11085978
REFERENCE   9  (bases 1 to 1908)
  AUTHORS   Barr,V.A., Phillips,S.A., Taylor,S.I. and Haft,C.R.
  TITLE     Overexpression of a novel sorting nexin, SNX15, affects endosome
            morphology and protein trafficking
  JOURNAL   Traffic 1 (11), 904-916 (2000)
   PUBMED   11208079
REFERENCE   10 (bases 1 to 1908)
  AUTHORS   Guru,S.C., Agarwal,S.K., Manickam,P., Olufemi,S.E., Crabtree,J.S.,
            Weisemann,J.M., Kester,M.B., Kim,Y.S., Wang,Y., Emmert-Buck,M.R.,
            Liotta,L.A., Spiegel,A.M., Boguski,M.S., Roe,B.A., Collins,F.S.,
            Marx,S.J., Burns,L. and Chandrasekharappa,S.C.
  TITLE     A transcript map for the 2.8-Mb region containing the multiple
            endocrine neoplasia type 1 locus
  JOURNAL   Genome Res 7 (7), 725-735 (1997)
   PUBMED   9253601
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP000436.5 and AP003068.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_013306.4.
            
            Summary: This gene encodes a member of the sorting nexin family.
            Members of this family contain a phox (PX) domain, which is a
            phosphoinositide binding domain, and are involved in intracellular
            trafficking. Overexpression of this gene results in a decrease in
            the processing of insulin and hepatocyte growth factor receptors to
            their mature subunits. This decrease is caused by the
            mislocalization of furin, the endoprotease responsible for cleavage
            of insulin and hepatocyte growth factor receptors. This protein is
            involved in endosomal trafficking from the plasma membrane to
            recycling endosomes or the trans-Golgi network. Alternative
            splicing results in multiple transcript variants. Read-through
            transcription also exists between this gene and the upstream
            ADP-ribosylation factor-like 2 (ARL2) gene. [provided by RefSeq,
            Dec 2010].
            
            Transcript Variant: This variant (A, also known as SNX15)
            represents the longer transcript and encodes the longer isoform
            (A).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012767.2, SRR3476690.828136.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377244.8/ ENSP00000366452.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-198               AP000436.5         85246-85443
            199-234             AP000436.5         89975-90010
            235-355             AP000436.5         90238-90358
            356-471             AP000436.5         92654-92769
            472-619             AP000436.5         92866-93013
            620-763             AP000436.5         93327-93470
            764-1021            AP000436.5         96379-96636
            1022-1270           AP000436.5         97493-97741
            1271-1908           AP003068.3         1-638
FEATURES             Location/Qualifiers
     source          1..1908
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..1908
                     /gene="SNX15"
                     /gene_synonym="HSAF001435"
                     /note="sorting nexin 15"
                     /db_xref="GeneID:29907"
                     /db_xref="HGNC:HGNC:14978"
                     /db_xref="MIM:605964"
     exon            1..198
                     /gene="SNX15"
                     /gene_synonym="HSAF001435"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..1128
                     /gene="SNX15"
                     /gene_synonym="HSAF001435"
                     /note="isoform A is encoded by transcript variant A; clone
                     iota unknown protein"
                     /codon_start=1
                     /product="sorting nexin-15 isoform A"
                     /protein_id="NP_037438.2"
                     /db_xref="CCDS:CCDS8089.1"
                     /db_xref="GeneID:29907"
                     /db_xref="HGNC:HGNC:14978"
                     /db_xref="MIM:605964"
                     /translation="MSRQAKDDFLRHYTVSDPRTHPKGYTEYKVTAQFISKKDPEDVK
                     EVVVWKRYSDFRKLHGDLAYTHRNLFRRLEEFPAFPRAQVFGRFEASVIEERRKGAED
                     LLRFTVHIPALNNSPQLKEFFRGGEVTRPLEVSRDLHILPPPLIPTPPPDDPRLSQLL
                     PAERRGLEELEVPVDPPPSSPAQEALDLLFNCESTEEASGSPARGPLTEAELALFDPF
                     SKEEGAAPSPTHVAELATMEVESARLDQEPWEPGGQEEEEDGEGGPTPAYLSQATELI
                     TQALRDEKAGAYAAALQGYRDGVHVLLQGVPSDPLPARQEGVKKKAAEYLKRAEEILR
                     LHLSQLPP"
     exon            199..234
                     /gene="SNX15"
                     /gene_synonym="HSAF001435"
                     /inference="alignment:Splign:2.1.0"
     exon            235..355
                     /gene="SNX15"
                     /gene_synonym="HSAF001435"
                     /inference="alignment:Splign:2.1.0"
     exon            356..471
                     /gene="SNX15"
                     /gene_synonym="HSAF001435"
                     /inference="alignment:Splign:2.1.0"
     exon            472..619
                     /gene="SNX15"
                     /gene_synonym="HSAF001435"
                     /inference="alignment:Splign:2.1.0"
     exon            620..763
                     /gene="SNX15"
                     /gene_synonym="HSAF001435"
                     /inference="alignment:Splign:2.1.0"
     exon            764..1021
                     /gene="SNX15"
                     /gene_synonym="HSAF001435"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1908
                     /gene="SNX15"
                     /gene_synonym="HSAF001435"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1887..1892
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNX15"
                     /gene_synonym="HSAF001435"
                     /note="hexamer: AATAAA"
     polyA_site      1908
                     /gene="SNX15"
                     /gene_synonym="HSAF001435"
                     /note="major polyA site"
ORIGIN      
        1 gcaggcctgg cgaggcggcg gcgggcggag gctgggccgg aggggtgggg acggcgagga
       61 ggtggaggcc ggcgctccgc tccgctccag ctcggtttca tgtcccgcca ggcgaaggat
      121 gacttcctgc ggcactacac agtgtcggac cccaggactc accccaaggg ctacaccgag
      181 tacaaagtaa ccgcgcagtt catctcaaag aaggacccag aggatgtcaa agaggtggtg
      241 gtctggaagc ggtacagcga cttccgcaag ctgcatggag acctggccta cacccaccgc
      301 aacctcttcc gccgcctcga ggagttccct gctttccccc gggcccaggt gtttggccgg
      361 tttgaagcct cagtgatcga ggagcggcga aagggggcag aggacctgct tcgcttcact
      421 gtgcacatac ctgcgctcaa caacagcccc cagctcaagg agttcttccg gggtggggag
      481 gtgacccgac ccttggaggt gtccagggac ctacacatcc tgccaccccc tctgatcccc
      541 accccgcccc ctgatgaccc ccggctatcc caactgctcc ctgcagaaag gaggggcctc
      601 gaggaattgg aggtgccagt ggacccccca ccatccagcc ctgcccagga ggccctggat
      661 ctcctcttta actgtgagag caccgaggag gcatctggtt cccctgcccg aggccccctc
      721 accgaggctg agcttgccct cttcgacccc ttctccaagg aagaaggcgc agcccccagc
      781 cccacccatg tggctgagct ggcaacgatg gaggtggagt ctgcaaggct ggaccaggaa
      841 ccctgggagc caggagggca ggaggaggaa gaggatgggg aaggagggcc cacccctgcc
      901 tacctaagcc aggccacaga gctcatcacc caggccctgc gggatgagaa ggcaggcgct
      961 tacgctgctg cactccaggg ctatcgagac ggcgtgcacg tcttgcttca gggagtcccc
     1021 agtgacccgt tgcctgcccg ccaggaaggt gtgaagaaga aggcagctga gtacctgaag
     1081 cgggcagagg agatcctgcg cctgcacctg tctcaactcc caccctaaca gggagtgggc
     1141 cattccctgg gactctcgct cctgcactgc cagccccttc tcctctcccc agggcctggc
     1201 cctacctcct ggtcttgtaa ttacaggagc catttctgta ggtaactgga ccaagaatga
     1261 gaaaaataat gaattcttag ctccctgatt acacctgcca ccttggaatc aaggactcac
     1321 acttctgacc ctgcctgtct ttttggggtt tttttgagtt ggagtctcgc tgtgtcgccc
     1381 agactggagt gcagtggtgg gatcgcggct cactgcaacc tccacctccc aggttcaagc
     1441 agttctcctg tctcagcctc cccagtagct gagattgcag gcacatgcca ccacgcccag
     1501 ctaatatttt gtattttcag tagggacggg gttacaccat gttggccagg ctggtctcga
     1561 actcctgacc tcaagtgatc cacccgcctc agtctcccaa agtgctgaga ttacaggcat
     1621 gagtcactac gcccggccca tgtctgtctg tcttgatgtg tgagcagcag ctgtggtcat
     1681 taaaccatta gtttacccct ctagaactgg ggtctgcaaa ctcccacctg cagccaaatc
     1741 tggcccacct cctttttaat gtaagggctg tgagagtggt ttttactttt tttaatgatt
     1801 aaaaaaatca aaataatatt ctgtgacaat gacaggtgaa atttatatgt gacaagtgaa
     1861 aattatatga aatttaagag tccataaata aaatttgttg gaacacaa
//
