LOCUS       NM_001350870            4153 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens sorting nexin 13 (SNX13), transcript variant 9, mRNA.
ACCESSION   NM_001350870
VERSION     NM_001350870.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4153)
  AUTHORS   Lu,A., Hsieh,F., Sharma,B.R., Vaughn,S.R., Enrich,C. and
            Pfeffer,S.R.
  TITLE     CRISPR screens for lipid regulators reveal a role for ER-bound
            SNX13 in lysosomal cholesterol export
  JOURNAL   J Cell Biol 221 (2) (2022)
   PUBMED   34936700
  REMARK    GeneRIF: CRISPR screens for lipid regulators reveal a role for
            ER-bound SNX13 in lysosomal cholesterol export.
REFERENCE   2  (bases 1 to 4153)
  AUTHORS   Mas,C., Norwood,S.J., Bugarcic,A., Kinna,G., Leneva,N., Kovtun,O.,
            Ghai,R., Ona Yanez,L.E., Davis,J.L., Teasdale,R.D. and Collins,B.M.
  TITLE     Structural basis for different phosphoinositide specificities of
            the PX domains of sorting nexins regulating G-protein signaling
  JOURNAL   J Biol Chem 289 (41), 28554-28568 (2014)
   PUBMED   25148684
REFERENCE   3  (bases 1 to 4153)
  AUTHORS   Willer,C.J., Schmidt,E.M., Sengupta,S., Peloso,G.M., Gustafsson,S.,
            Kanoni,S., Ganna,A., Chen,J., Buchkovich,M.L., Mora,S.,
            Beckmann,J.S., Bragg-Gresham,J.L., Chang,H.Y., Demirkan,A., Den
            Hertog,H.M., Do,R., Donnelly,L.A., Ehret,G.B., Esko,T.,
            Feitosa,M.F., Ferreira,T., Fischer,K., Fontanillas,P., Fraser,R.M.,
            Freitag,D.F., Gurdasani,D., Heikkila,K., Hypponen,E., Isaacs,A.,
            Jackson,A.U., Johansson,A., Johnson,T., Kaakinen,M., Kettunen,J.,
            Kleber,M.E., Li,X., Luan,J., Lyytikainen,L.P., Magnusson,P.K.E.,
            Mangino,M., Mihailov,E., Montasser,M.E., Muller-Nurasyid,M.,
            Nolte,I.M., O'Connell,J.R., Palmer,C.D., Perola,M., Petersen,A.K.,
            Sanna,S., Saxena,R., Service,S.K., Shah,S., Shungin,D., Sidore,C.,
            Song,C., Strawbridge,R.J., Surakka,I., Tanaka,T., Teslovich,T.M.,
            Thorleifsson,G., Van den Herik,E.G., Voight,B.F., Volcik,K.A.,
            Waite,L.L., Wong,A., Wu,Y., Zhang,W., Absher,D., Asiki,G.,
            Barroso,I., Been,L.F., Bolton,J.L., Bonnycastle,L.L., Brambilla,P.,
            Burnett,M.S., Cesana,G., Dimitriou,M., Doney,A.S.F., Doring,A.,
            Elliott,P., Epstein,S.E., Ingi Eyjolfsson,G., Gigante,B.,
            Goodarzi,M.O., Grallert,H., Gravito,M.L., Groves,C.J., Hallmans,G.,
            Hartikainen,A.L., Hayward,C., Hernandez,D., Hicks,A.A., Holm,H.,
            Hung,Y.J., Illig,T., Jones,M.R., Kaleebu,P., Kastelein,J.J.P.,
            Khaw,K.T., Kim,E., Klopp,N., Komulainen,P., Kumari,M.,
            Langenberg,C., Lehtimaki,T., Lin,S.Y., Lindstrom,J., Loos,R.J.F.,
            Mach,F., McArdle,W.L., Meisinger,C., Mitchell,B.D., Muller,G.,
            Nagaraja,R., Narisu,N., Nieminen,T.V.M., Nsubuga,R.N., Olafsson,I.,
            Ong,K.K., Palotie,A., Papamarkou,T., Pomilla,C., Pouta,A.,
            Rader,D.J., Reilly,M.P., Ridker,P.M., Rivadeneira,F., Rudan,I.,
            Ruokonen,A., Samani,N., Scharnagl,H., Seeley,J., Silander,K.,
            Stancakova,A., Stirrups,K., Swift,A.J., Tiret,L.,
            Uitterlinden,A.G., van Pelt,L.J., Vedantam,S., Wainwright,N.,
            Wijmenga,C., Wild,S.H., Willemsen,G., Wilsgaard,T., Wilson,J.F.,
            Young,E.H., Zhao,J.H., Adair,L.S., Arveiler,D., Assimes,T.L.,
            Bandinelli,S., Bennett,F., Bochud,M., Boehm,B.O., Boomsma,D.I.,
            Borecki,I.B., Bornstein,S.R., Bovet,P., Burnier,M., Campbell,H.,
            Chakravarti,A., Chambers,J.C., Chen,Y.I., Collins,F.S.,
            Cooper,R.S., Danesh,J., Dedoussis,G., de Faire,U., Feranil,A.B.,
            Ferrieres,J., Ferrucci,L., Freimer,N.B., Gieger,C., Groop,L.C.,
            Gudnason,V., Gyllensten,U., Hamsten,A., Harris,T.B., Hingorani,A.,
            Hirschhorn,J.N., Hofman,A., Hovingh,G.K., Hsiung,C.A.,
            Humphries,S.E., Hunt,S.C., Hveem,K., Iribarren,C., Jarvelin,M.R.,
            Jula,A., Kahonen,M., Kaprio,J., Kesaniemi,A., Kivimaki,M.,
            Kooner,J.S., Koudstaal,P.J., Krauss,R.M., Kuh,D., Kuusisto,J.,
            Kyvik,K.O., Laakso,M., Lakka,T.A., Lind,L., Lindgren,C.M.,
            Martin,N.G., Marz,W., McCarthy,M.I., McKenzie,C.A., Meneton,P.,
            Metspalu,A., Moilanen,L., Morris,A.D., Munroe,P.B., Njolstad,I.,
            Pedersen,N.L., Power,C., Pramstaller,P.P., Price,J.F., Psaty,B.M.,
            Quertermous,T., Rauramaa,R., Saleheen,D., Salomaa,V.,
            Sanghera,D.K., Saramies,J., Schwarz,P.E.H., Sheu,W.H.,
            Shuldiner,A.R., Siegbahn,A., Spector,T.D., Stefansson,K.,
            Strachan,D.P., Tayo,B.O., Tremoli,E., Tuomilehto,J., Uusitupa,M.,
            van Duijn,C.M., Vollenweider,P., Wallentin,L., Wareham,N.J.,
            Whitfield,J.B., Wolffenbuttel,B.H.R., Ordovas,J.M., Boerwinkle,E.,
            Palmer,C.N.A., Thorsteinsdottir,U., Chasman,D.I., Rotter,J.I.,
            Franks,P.W., Ripatti,S., Cupples,L.A., Sandhu,M.S., Rich,S.S.,
            Boehnke,M., Deloukas,P., Kathiresan,S., Mohlke,K.L., Ingelsson,E.
            and Abecasis,G.R.
  CONSRTM   Global Lipids Genetics Consortium
  TITLE     Discovery and refinement of loci associated with lipid levels
  JOURNAL   Nat Genet 45 (11), 1274-1283 (2013)
   PUBMED   24097068
REFERENCE   4  (bases 1 to 4153)
  AUTHORS   Hillman,R.T., Green,R.E. and Brenner,S.E.
  TITLE     An unappreciated role for RNA surveillance
  JOURNAL   Genome Biol 5 (2), R8 (2004)
   PUBMED   14759258
REFERENCE   5  (bases 1 to 4153)
  AUTHORS   Worby,C.A. and Dixon,J.E.
  TITLE     Sorting out the cellular functions of sorting nexins
  JOURNAL   Nat Rev Mol Cell Biol 3 (12), 919-931 (2002)
   PUBMED   12461558
  REMARK    Review article
            Erratum:[Nat Rev Mol Cell Biol. 2003 Feb;4(2):156.]
REFERENCE   6  (bases 1 to 4153)
  AUTHORS   Kosan,C. and Kunz,J.
  TITLE     Identification and characterisation of the gene TWIST NEIGHBOR
            (TWISTNB) located in the microdeletion syndrome 7p21 region
  JOURNAL   Cytogenet Genome Res 97 (3-4), 167-170 (2002)
   PUBMED   12438708
REFERENCE   7  (bases 1 to 4153)
  AUTHORS   Zheng,B., Ma,Y.C., Ostrom,R.S., Lavoie,C., Gill,G.N., Insel,P.A.,
            Huang,X.Y. and Farquhar,M.G.
  TITLE     RGS-PX1, a GAP for GalphaS and sorting nexin in vesicular
            trafficking
  JOURNAL   Science 294 (5548), 1939-1942 (2001)
   PUBMED   11729322
REFERENCE   8  (bases 1 to 4153)
  AUTHORS   Teasdale,R.D., Loci,D., Houghton,F., Karlsson,L. and Gleeson,P.A.
  TITLE     A large family of endosome-localized proteins related to sorting
            nexin 1
  JOURNAL   Biochem J 358 (Pt 1), 7-16 (2001)
   PUBMED   11485546
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC080080.5 and AC073205.6.
            
            On May 31, 2019 this sequence version replaced NM_001350870.1.
            
            Summary: This gene encodes a PHOX domain- and RGS domain-containing
            protein that belongs to the sorting nexin (SNX) family and the
            regulator of G protein signaling (RGS) family. The PHOX domain is a
            phosphoinositide binding domain, and the SNX family members are
            involved in intracellular trafficking. The RGS family members are
            regulatory molecules that act as GTPase activating proteins for G
            alpha subunits of heterotrimeric G proteins. The RGS domain of this
            protein interacts with G alpha(s), accelerates its GTP hydrolysis,
            and attenuates G alpha(s)-mediated signaling. Overexpression of
            this protein delayes lysosomal degradation of the epidermal growth
            factor receptor. Because of its bifunctional role, this protein may
            link heterotrimeric G protein signaling and vesicular trafficking.
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.123425.1,
                                           SRR1803616.251225.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMN03267753
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-211               AC080080.5         17192-17402         c
            212-324             AC073205.6         122156-122268       c
            325-427             AC073205.6         118154-118256       c
            428-517             AC073205.6         116368-116457       c
            518-639             AC073205.6         115185-115306       c
            640-4153            AC073205.6         104252-107765       c
FEATURES             Location/Qualifiers
     source          1..4153
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p21.1"
     gene            1..4153
                     /gene="SNX13"
                     /gene_synonym="RGS-PX1"
                     /note="sorting nexin 13"
                     /db_xref="GeneID:23161"
                     /db_xref="HGNC:HGNC:21335"
                     /db_xref="MIM:606589"
     exon            1..211
                     /gene="SNX13"
                     /gene_synonym="RGS-PX1"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..769
                     /gene="SNX13"
                     /gene_synonym="RGS-PX1"
                     /note="isoform g is encoded by transcript variant 9; rgs
                     domain- and phox domain-containing protein"
                     /codon_start=1
                     /product="sorting nexin-13 isoform g"
                     /protein_id="NP_001337799.1"
                     /db_xref="CCDS:CCDS87483.1"
                     /db_xref="GeneID:23161"
                     /db_xref="HGNC:HGNC:21335"
                     /db_xref="MIM:606589"
                     /translation="MLTEASLSIWGWGSLGIVLFLITFGPFVIFYLTFYILCFVGGGL
                     VVTLLFGKTNSEKYLEQCEHSFLPPTSPGVPKCLEEMKREARTIKIDRRLTGANIIDE
                     PLQQVIQFSLRDYVQYWYYTLSDDESFLLEIRQTLQNALIQFATRVSPCRPGWSTMAQ
                     SRLTATSASWNPVLFNKTLVSLCLLEYVI"
     exon            212..324
                     /gene="SNX13"
                     /gene_synonym="RGS-PX1"
                     /inference="alignment:Splign:2.1.0"
     exon            325..427
                     /gene="SNX13"
                     /gene_synonym="RGS-PX1"
                     /inference="alignment:Splign:2.1.0"
     exon            428..517
                     /gene="SNX13"
                     /gene_synonym="RGS-PX1"
                     /inference="alignment:Splign:2.1.0"
     exon            518..639
                     /gene="SNX13"
                     /gene_synonym="RGS-PX1"
                     /inference="alignment:Splign:2.1.0"
     exon            640..4153
                     /gene="SNX13"
                     /gene_synonym="RGS-PX1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1174..1179
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNX13"
                     /gene_synonym="RGS-PX1"
                     /note="hexamer: AATAAA"
     polyA_site      1196
                     /gene="SNX13"
                     /gene_synonym="RGS-PX1"
                     /note="major polyA site"
     regulatory      4124..4129
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNX13"
                     /gene_synonym="RGS-PX1"
                     /note="hexamer: AATAAA"
     polyA_site      4153
                     /gene="SNX13"
                     /gene_synonym="RGS-PX1"
ORIGIN      
        1 gctcttccaa gatggcggcg cgtccgtcgc gagcgaccgg gccgagggga ggccagcgaa
       61 gccgagtaaa accgccgccc gggagaagac tgaaggagca gttgccgccg ttggcggcgg
      121 cccgagcagt tttcgctgct gctacggctg ttgccatgag gcgaggctag ggaggacctc
      181 acttccccgg ggtgtaataa tgttaactga ggccagtcta tccatatggg gatggggaag
      241 ccttggcatt gtcctttttc tgataacctt tggacccttt gtaatatttt atttgacatt
      301 ttatatcctc tgctttgtgg gtgggggttt agtggttact ctcctgtttg gaaaaacaaa
      361 ctcagagaag tacctagaac agtgtgaaca ctcatttctt cctccaacat cacctggggt
      421 tcctaagtgc ttagaagaaa tgaaacggga agccaggact attaagattg atagaagatt
      481 gacgggtgcc aatataattg atgaacctct ccagcaagtt atccagtttt ccttgaggga
      541 ttatgtccag tattggtatt atacactaag cgatgatgaa tcttttcttc ttgaaattag
      601 gcagactctt caaaacgcac tcattcagtt tgctactaga gtctcgccct gtcgcccagg
      661 ctggagtaca atggcgcaat ctcggctcac tgcaacctcc gcttcctgga accctgtttt
      721 gtttaacaaa accttggtct cactgtgtct cctagaatat gtaatttaaa ttctggctct
      781 gaaattacag ggaattgtgg tagtgatttg agaacccttt cagttctaaa atagtaagat
      841 tctctggtca ggttgttact aatcttgatt tcttttcaat catgtttcct cccaaaacac
      901 acactaacat actccatcac actccacatt ttgaatacca tttggggagt tatttttttt
      961 taagtatata ggattgctaa ttagagttaa tttactttgg gattaaagta ctcttcatat
     1021 ctattgtttt attagtaggg gtcttatagt aggataacaa aatttattta aaccttttaa
     1081 tatatttcta aatgatcaga aagaatgctt gattctaaac ataaaataca tttactaatc
     1141 tcttctcgat gattaaaacc cttgtatcaa tgaaataaaa agtttttgta caaccagact
     1201 attgctgttc tttatagaat gctgaaaaca ataaatctgt agtgttatga gtttgatttt
     1261 ttttaagttt tctgaagtgt aagttctccc accacgttca gttttaagct atcagcatga
     1321 agtcactgaa catggaaata ggaagagatg tacacaattg tttgcctact ccagctcaca
     1381 gttggagagg atacagctaa gtgaagaggg ggcagaggca gatttgtaaa cctgaagtaa
     1441 tgagttgtat ttccttgtgt ggttgctaat ttagctccta tgaaagaatt ccccgtatat
     1501 ttttgaggac tatggtaggg ggtactcata cattaacttt aagttcagga atgtttgtga
     1561 agaaggtcaa attagtttca ttattttaat caatactgac aactaaatcc ttaaagtgga
     1621 tgataaaagg agactctgga gagatggtta tggtaacatg tagtatttat gactgaattg
     1681 acgtaggggg gattgattta gtggattcaa aatgaagctt acaattctgt gcctttacaa
     1741 ttttacccaa attcaatttc agcctgagtt tttgacaccg ttaacaaagt agttcttcaa
     1801 ggactctgaa ggatggaaac aagtaaagga ttatgtattt agagtgaaga gtagtatatc
     1861 ctttctaata gtgaattaag agggggactt agtatctgat tcagagactc aggagaagga
     1921 atttttttct ttcacagata agccactcag ttgctttctc tcaacaaaaa aaagtctgag
     1981 tcagttgatc aaaaggcctt ctaatggagt aaaacttttc tcaaaatcta ctcaaagtta
     2041 cttgtcaaaa atctacccaa gaaaactagg aattctattt taatgatttt tcaaaaattt
     2101 ctattttttt tacatagaag ataaagacct tttgttgaag attaatacat attattataa
     2161 ttttatgtga ttggttatta tattgatctt attaacatac ctttaaaaag gccaactctt
     2221 aacgtgcgtg tgtgtgtgtg tgtttgtgta tgtgtatatg tatatacctt ttcccttgag
     2281 attcctttca gttctaaaat actaagattc tatggacctc tgtgtgtgtg tgtgtgtgtg
     2341 tgtgttgtac atatagtgtc tatgtatacc tacacattat gcagtatata gtatactcta
     2401 ccattcttac tgtttttaaa aaaggtcttc gtagtcattt ctctgaaaaa ctaatgtggc
     2461 atcaggagca taacatttat tataggattg ttttctgtgg aaaaagcagc ttttactttt
     2521 atcattttga cataaggcac cttttccagg aaaatattct gccatgaatg tgaagatcgc
     2581 ctttactgcc aagcgatcac cctctcctct agtcaggcaa gtctacaaga tgacccttgc
     2641 atatatattt atcatgctca tccccctctt ctgctcattc ctgtgtcctt tcttctccca
     2701 tataaatact gctctttcat caagatttaa gtgtagcctc tttaatgaag cctctttaaa
     2761 ttatgacata ttccttaatc tatagtcttt gtgtgtgtgg ttctcgtcaa caaaatttta
     2821 agctgatttt gaaatggttc ctattctgtg ctattgcagt gaaagttctc ttaactgatg
     2881 tttggttagc cagtgctctc cattcccttt gtatgctgta ctgactgata accttagcat
     2941 taagactagg ctctattaca tctatccact tctgtttcca cccttggagt tgtatgctta
     3001 tcaaaagtca gttgtgtgat acctggaccc cacctccaga aaatctgata caattagtct
     3061 gtagtgtgac ctgaatattg gtgatttaga ggagacagat aatcaaacac gttgaaataa
     3121 aagttgtatt tgtttttgag cctaaatatc ccagttacac tttttatgat aatcaggtcg
     3181 tttaattaac agtcaactta gattgaagaa atatgaatat gacaaggtag tttctatgaa
     3241 aaccaagtca cttgctttgg aattactcgc agctggttga agagtgtaat tgaattaagt
     3301 gagcgaaagg cagctatgaa atttgaaagt cttcaaggac tctgcatgca gatttgttca
     3361 caaatgtctt tattgccatg ccattttaaa gaaactggaa accataggtt ttgcagtgta
     3421 ggaacagttc atagtttttt caagacccag gtcatgttaa taccactcag cagagcctta
     3481 accaaagaaa aagtcttatt cctacacagg aagatttata taattgaact taaagtgaaa
     3541 tatattcatg gctccctctt ttgatcgaat gtttaaattt acctactgcc caattaccag
     3601 ttttttatac actccatccc tgtgtatgta tatgtgtggt tttatgtagc taatataatc
     3661 atagactcaa agatgtaatg agtgttgtta gagaaaacaa actttgggaa atgatgtgac
     3721 ttgctgaatt tcatagactg gcactgatgc ctttgatttg agtaaaagac ccatcatttg
     3781 ggggagtctt ttgttagaat caaaggcatc tgtgtcagtc cagtgcgttt tccagaaata
     3841 cttgattttg gtagtgtttt gtgctactga tgatgagctg tacactgctt agaatagatg
     3901 gaacaagtga ggcaatttac aatcctaaac tcaaccacat atttgggcct ttacttgcct
     3961 ttttaaggga ttggcattaa gtagccatgg gacaaaaaga gcttctcagt acatattcta
     4021 ctttaacact ttaaggagta aggaagcaat tgttgtttgt gcctcctgtt gccattgtcc
     4081 aaacacccat tgtaaacagt gctccgaccc tgaaaaagga atcaataaat caatatgcat
     4141 tgagtgcctc taa
//
