LOCUS       NM_013323               2992 bp    mRNA    linear   PRI 04-AUG-2024
DEFINITION  Homo sapiens sorting nexin 11 (SNX11), transcript variant 2, mRNA.
ACCESSION   NM_013323
VERSION     NM_013323.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2992)
  AUTHORS   Xu,T., Gan,Q., Wu,B., Yin,M., Xu,J., Shu,X. and Liu,J.
  TITLE     Molecular Basis for PI(3,5)P2 Recognition by SNX11, a Protein
            Involved in Lysosomal Degradation and Endosome Homeostasis
            Regulation
  JOURNAL   J Mol Biol 432 (16), 4750-4761 (2020)
   PUBMED   32561432
  REMARK    GeneRIF: Molecular Basis for PI(3,5)P2 Recognition by SNX11, a
            Protein Involved in Lysosomal Degradation and Endosome Homeostasis
            Regulation.
REFERENCE   2  (bases 1 to 2992)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2992)
  AUTHORS   Liu,T., Li,J., Liu,Y., Qu,Y., Li,A., Li,C., Zhang,Q., Wu,W., Li,J.,
            Liu,Y., Li,D., Wang,S. and Liang,M.
  TITLE     SNX11 Identified as an Essential Host Factor for SFTS Virus
            Infection by CRISPR Knockout Screening
  JOURNAL   Virol Sin 34 (5), 508-520 (2019)
   PUBMED   31215001
  REMARK    GeneRIF: penetration of Severe fever with thrombocytopenia syndrome
            virus from the endolysosomes into the cytoplasm of host cells was
            blocked in the cells lacking SNX11
REFERENCE   4  (bases 1 to 2992)
  AUTHORS   Li,C., Ma,W., Yin,S., Liang,X., Shu,X., Pei,D., Egan,T.M.,
            Huang,J., Pan,A. and Li,Z.
  TITLE     Sorting Nexin 11 Regulates Lysosomal Degradation of Plasma Membrane
            TRPV3
  JOURNAL   Traffic 17 (5), 500-514 (2016)
   PUBMED   26818531
REFERENCE   5  (bases 1 to 2992)
  AUTHORS   Xu,J., Xu,T., Wu,B., Ye,Y., You,X., Shu,X., Pei,D. and Liu,J.
  TITLE     Structure of sorting nexin 11 (SNX11) reveals a novel extended phox
            homology (PX) domain critical for inhibition of SNX10-induced
            vacuolation
  JOURNAL   J Biol Chem 288 (23), 16598-16605 (2013)
   PUBMED   23615901
  REMARK    GeneRIF: Structure of sorting nexin 11 (SNX11) reveals a novel
            extended phox homology (PX) domain critical for inhibition of
            SNX10-induced vacuolation.
REFERENCE   6  (bases 1 to 2992)
  AUTHORS   Steffens,M., Leu,C., Ruppert,A.K., Zara,F., Striano,P.,
            Robbiano,A., Capovilla,G., Tinuper,P., Gambardella,A., Bianchi,A.,
            La Neve,A., Crichiutti,G., de Kovel,C.G., Kasteleijn-Nolst
            Trenite,D., de Haan,G.J., Lindhout,D., Gaus,V., Schmitz,B.,
            Janz,D., Weber,Y.G., Becker,F., Lerche,H., Steinhoff,B.J.,
            Kleefuss-Lie,A.A., Kunz,W.S., Surges,R., Elger,C.E., Muhle,H., von
            Spiczak,S., Ostertag,P., Helbig,I., Stephani,U., Moller,R.S.,
            Hjalgrim,H., Dibbens,L.M., Bellows,S., Oliver,K., Mullen,S.,
            Scheffer,I.E., Berkovic,S.F., Everett,K.V., Gardiner,M.R.,
            Marini,C., Guerrini,R., Lehesjoki,A.E., Siren,A., Guipponi,M.,
            Malafosse,A., Thomas,P., Nabbout,R., Baulac,S., Leguern,E.,
            Guerrero,R., Serratosa,J.M., Reif,P.S., Rosenow,F., Morzinger,M.,
            Feucht,M., Zimprich,F., Kapser,C., Schankin,C.J., Suls,A.,
            Smets,K., De Jonghe,P., Jordanova,A., Caglayan,H., Yapici,Z.,
            Yalcin,D.A., Baykan,B., Bebek,N., Ozbek,U., Gieger,C.,
            Wichmann,H.E., Balschun,T., Ellinghaus,D., Franke,A., Meesters,C.,
            Becker,T., Wienker,T.F., Hempelmann,A., Schulz,H., Ruschendorf,F.,
            Leber,M., Pauck,S.M., Trucks,H., Toliat,M.R., Nurnberg,P.,
            Avanzini,G., Koeleman,B.P. and Sander,T.
  CONSRTM   EPICURE Consortium; EMINet Consortium
  TITLE     Genome-wide association analysis of genetic generalized epilepsies
            implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32
  JOURNAL   Hum Mol Genet 21 (24), 5359-5372 (2012)
   PUBMED   22949513
REFERENCE   7  (bases 1 to 2992)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   8  (bases 1 to 2992)
  AUTHORS   Worby,C.A. and Dixon,J.E.
  TITLE     Sorting out the cellular functions of sorting nexins
  JOURNAL   Nat Rev Mol Cell Biol 3 (12), 919-931 (2002)
   PUBMED   12461558
  REMARK    Review article
            Erratum:[Nat Rev Mol Cell Biol. 2003 Feb;4(2):156.]
REFERENCE   9  (bases 1 to 2992)
  AUTHORS   Teasdale,R.D., Loci,D., Houghton,F., Karlsson,L. and Gleeson,P.A.
  TITLE     A large family of endosome-localized proteins related to sorting
            nexin 1
  JOURNAL   Biochem J 358 (Pt 1), 7-16 (2001)
   PUBMED   11485546
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC006468.10.
            
            On Feb 27, 2020 this sequence version replaced NM_013323.2.
            
            Summary: This gene encodes a member of the sorting nexin family.
            Members of this family contain a phox (PX) domain, which is a
            phosphoinositide binding domain, and are involved in intracellular
            trafficking. This protein does not contain a coiled coil region,
            like some family members. This gene encodes a protein of unknown
            function. This gene results in two transcript variants differing in
            the 5' UTR, but encoding the same protein. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC103721.1, AF121861.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359238.7/ ENSP00000352175.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                AC006468.10        73376-73448         c
            74-128              AC006468.10        69129-69183         c
            129-215             AC006468.10        68554-68640         c
            216-316             AC006468.10        67813-67913         c
            317-412             AC006468.10        62415-62510         c
            413-625             AC006468.10        62028-62240         c
            626-2992            AC006468.10        57613-59979         c
FEATURES             Location/Qualifiers
     source          1..2992
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.32"
     gene            1..2992
                     /gene="SNX11"
                     /note="sorting nexin 11"
                     /db_xref="GeneID:29916"
                     /db_xref="HGNC:HGNC:14975"
                     /db_xref="MIM:614906"
     exon            1..73
                     /gene="SNX11"
                     /inference="alignment:Splign:2.1.0"
     exon            74..128
                     /gene="SNX11"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..899
                     /gene="SNX11"
                     /note="isoform 1 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="sorting nexin-11 isoform 1"
                     /protein_id="NP_037455.2"
                     /db_xref="CCDS:CCDS11526.1"
                     /db_xref="GeneID:29916"
                     /db_xref="HGNC:HGNC:14975"
                     /db_xref="MIM:614906"
                     /translation="MGFWCRMSENQEQEEVITVRVQDPRVQNEGSWNSYVDYKIFLHT
                     NSKAFTAKTSCVRRRYREFVWLRKQLQRNAGLVPVPELPGKSTFFGTSDEFIEKRRQG
                     LQHFLEKVLQSVVLLSDSQLHLFLQSQLSVPEIEACVQGRSTMTVSDAILRYAMSNCG
                     WAQEERQSSSHLAKGDQPKSCCFLPRSGRRSSPSPPPSEEKDHLEVWAPVVDSEVPSL
                     ESPTLPPLSSPLCCDFGRPKEGTSTLQSVRRAVGGDHAVPLDPGQLETVLEK"
     exon            129..215
                     /gene="SNX11"
                     /inference="alignment:Splign:2.1.0"
     exon            216..316
                     /gene="SNX11"
                     /inference="alignment:Splign:2.1.0"
     exon            317..412
                     /gene="SNX11"
                     /inference="alignment:Splign:2.1.0"
     exon            413..625
                     /gene="SNX11"
                     /inference="alignment:Splign:2.1.0"
     exon            626..2992
                     /gene="SNX11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2117..2122
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNX11"
                     /note="hexamer: AATAAA"
     polyA_site      2136
                     /gene="SNX11"
                     /note="major polyA site"
     regulatory      2437..2442
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNX11"
                     /note="hexamer: AATAAA"
     polyA_site      2465
                     /gene="SNX11"
ORIGIN      
        1 aaggagaagc cgtgatctgg ctatatggtg gggcgcgggc ggtgtcgctg tggggagctg
       61 gtgctgttct cagatgtttc cttccaatgg gcttttggtg taggatgtcg gagaaccaag
      121 aacaggagga ggtgattaca gtgcgtgttc aggacccccg agtgcagaat gagggctcct
      181 ggaactctta tgtggattat aagatattcc tccataccaa cagcaaagcc tttactgcca
      241 agacttcctg tgtgcggcgc cgctaccgtg agttcgtgtg gctgagaaag cagctacaga
      301 gaaatgctgg tttggtgcct gttcctgaac ttcctgggaa gtcaaccttc ttcggcacct
      361 cagatgagtt cattgagaag cgacgacaag gtctgcagca cttccttgaa aaggtcctgc
      421 agagtgtggt tctcctgtca gacagccagt tgcacctatt cctgcaaagc cagctctcgg
      481 tgcctgagat agaagcctgt gtccagggcc gaagtaccat gactgtgtct gatgccattc
      541 ttcgatatgc tatgtcaaac tgtggctggg cccaggaaga gaggcagagc tcttctcacc
      601 tggctaaagg agaccagcct aagagttgct gctttcttcc aagatcgggt aggaggagct
      661 ctccctcacc gcctcccagt gaagaaaagg accatttaga agtgtgggct ccagttgttg
      721 actctgaggt tccttccttg gaaagtccca ctctcccacc cctctcctca ccattatgct
      781 gtgattttgg aagacccaaa gagggaacct ccactcttca gtctgtgagg agggctgtgg
      841 gaggagatca tgctgtgcct ttggaccctg gtcagttaga aacagttttg gaaaagtgag
      901 ctctgggttc tgctctgaga tggtcagaga agatgcgggc caggagactt actcaggtgg
      961 gactgggcac agggcaggta tgtgggaggc tgggctgctt agtgtcttct agtcacctct
     1021 gcttgggctg attgacagag gtcagtcatt acagcccctt atgcctcttc catgggaaca
     1081 aatactgtgc agatgtttgt aagttaaaca taagacacag gggctgttgc ttttgaacag
     1141 aaccctatat tactctcctg ggatctgagt ttctgcaggt catttgtatg taggaccagg
     1201 agtatctcct caggtgacca gttttgggga cccgtatgtg gcaaattcta agctgccata
     1261 ttgaacatca tcccactggg agtggttatg ttgtatcccc atcttggctg gcttcagttt
     1321 ttgctgtagc cctagagcac tttgtttgtg ggaggctggc ctcttgccta cctccttgca
     1381 tggacagggg gatgaatatt tactttccca cctccttgct ttttctttca ctgataccac
     1441 tgaatggaac tggtgctgtg actcctgctg ctggggattt atgtcccgag accttagcct
     1501 ggctgagtgg agcctgagac ctgcacaaca gctcatggtc atgcatgaga gagaagtggc
     1561 tggccacagc cagagggaac agtaacagcc caggggcctt tattttggga aaggctgtcc
     1621 cgggctgtta ctgtctcttc tggttataaa gcagacatgt ggccatcttt tccgcagggt
     1681 tagagtgggc tcctttcttt ttggaatcct tttcttctcc tttggtagca gctccctgcc
     1741 tccagggctt ccgccaccag cgtctctgct gtgttgcgca gtgcagtggg gtgcaagggc
     1801 tttgtttctg cctgcctgaa agagagggct ctggggatgg agatgagaaa caacacgctc
     1861 tccttcagac aatgaggcat tctgtcctcc tgctgccatt cttcatctcc actgagagcc
     1921 agagctggta ggagccgagt gccacaggca ttctgcattg ctctactctt aggtttgtgt
     1981 gtgtgatcct tcccctccct gtcgcccact cctccctcct ctggctatcc taccctgtct
     2041 gtgggctctt ttactaccag cctatgctgt gggactgtca tggcatttag ttcagagtgg
     2101 aggggctttg gcctgaaata aaatgcaagt atttaagatt gttgttgcaa tttgtgtcta
     2161 acaagctgta gcagagaagg agggagtgag cgctggcagt atttcctttc ataaatcatg
     2221 aatttatcag tgtggaaata atgcttcaga actgtgctct gtagccctcc tgcattgtgt
     2281 gtgcagctca agttcaccac tggaggaagg attgtcttcc aaagagctgg gatccaactc
     2341 ttctcacagt tctgggcgtg aaccttgtta ggtataattt acctgatgct gcttccatcc
     2401 tcgcagtctg tctgaggtgc caggtgctga aagagaaata aagtttgtca acaggcagat
     2461 gcaaagccct ggctggtatt catccctctt tcctgcccgc ctcccctggg tctctccttt
     2521 atatgatgca gcagagcaag gcgaggatag aaaacctaca gaggcaaatc caaaatgtca
     2581 gaagaagttc atttaaaagg ggaaaaaaac tccatgtgca accctcacaa aaacccgaca
     2641 gatgctaagc taatggcatc cgctctgccg attggtgggg atggctcatg aatattaatg
     2701 agcccaatgc tccaaatggt gcagctgtga acccagctgt gcctgaagct ctctgatctc
     2761 gaaacttcca gacaggagct ggaggtggtc tgtgtcaatt ccctactcag ccaaaaaaac
     2821 agcaagctgg gttggccttc ttctgtttgc tccttttctt cctggagttg gtgctcagca
     2881 gctagttctg ccagccggct aggctgctgg gacagcagga gccattcaaa gacatggatg
     2941 tgatttttct gactcccagc ttttttaatg atccattagc agcatgcata ca
//
