LOCUS       NM_013322               2665 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens sorting nexin 10 (SNX10), transcript variant 2, mRNA.
ACCESSION   NM_013322 XR_017855
VERSION     NM_013322.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2665)
  AUTHORS   Wu,D., Wang,Y., Xu,J., Wang,D., Zhang,J., Meng,L., Hu,Y., Wang,P.,
            Lin,J. and Zhou,S.
  TITLE     SNX10 promoted liver IR injury by facilitating macrophage M1
            polarization via NLRP3 inflammasome activation
  JOURNAL   Mol Immunol 166, 79-86 (2024)
   PUBMED   38271879
  REMARK    GeneRIF: SNX10 promoted liver IR injury by facilitating macrophage
            M1 polarization via NLRP3 inflammasome activation.
REFERENCE   2  (bases 1 to 2665)
  AUTHORS   Bao,W., You,Y., Ni,J., Hou,H., Lyu,J., Feng,G., Wang,Y., You,K.,
            Zhang,S., Zhang,L., Cao,X., Wang,X., Li,H., Li,H., Xu,J., Liu,C.,
            Luo,X., Du,P., Chen,D. and Shen,X.
  TITLE     Inhibiting sorting nexin 10 promotes mucosal healing through
            SREBP2-mediated stemness restoration of intestinal stem cells
  JOURNAL   Sci Adv 9 (35), eadh5016 (2023)
   PUBMED   37647408
  REMARK    GeneRIF: Inhibiting sorting nexin 10 promotes mucosal healing
            through SREBP2-mediated stemness restoration of intestinal stem
            cells.
            Erratum:[Sci Adv. 2024 Apr 12;10(15):eadp3968. doi:
            10.1126/sciadv.adp3968.. PMID: 38608031]
REFERENCE   3  (bases 1 to 2665)
  AUTHORS   Wang,Y., Sun,N., Zhang,Z., Zhou,Y., Liu,H., Zhou,X., Zhang,Y. and
            Zhao,Y.
  TITLE     Overexpression Pattern of miR-301b in Osteosarcoma and Its
            Relevance with Osteosarcoma Cellular Behaviors via Modulating SNX10
  JOURNAL   Biochem Genet 61 (1), 87-100 (2023)
   PUBMED   35732962
  REMARK    GeneRIF: Overexpression Pattern of miR-301b in Osteosarcoma and Its
            Relevance with Osteosarcoma Cellular Behaviors via Modulating
            SNX10.
REFERENCE   4  (bases 1 to 2665)
  AUTHORS   Huybrechts,Y. and Van Hul,W.
  TITLE     Osteopetrosis associated with PLEKHM1 and SNX10 genes, both
            involved in osteoclast vesicular trafficking
  JOURNAL   Bone 164, 116520 (2022)
   PUBMED   35981699
  REMARK    GeneRIF: Osteopetrosis associated with PLEKHM1 and SNX10 genes,
            both involved in osteoclast vesicular trafficking.
REFERENCE   5  (bases 1 to 2665)
  AUTHORS   Xiao,B., Liu,N., Hou,L., Jiang,M. and Yao,D.
  TITLE     Identification of Key Amino Acid Residues Involved in the
            Localization of Sorting Nexin 10 and Induction of Vacuole Formation
  JOURNAL   Biochemistry (Mosc) 86 (11), 1377-1387 (2021)
   PUBMED   34906048
  REMARK    GeneRIF: Identification of Key Amino Acid Residues Involved in the
            Localization of Sorting Nexin 10 and Induction of Vacuole
            Formation.
REFERENCE   6  (bases 1 to 2665)
  AUTHORS   Zhu,C.H., Morse,L.R. and Battaglino,R.A.
  TITLE     SNX10 is required for osteoclast formation and resorption activity
  JOURNAL   J Cell Biochem 113 (5), 1608-1615 (2012)
   PUBMED   22174188
  REMARK    GeneRIF: Since inhibition of vesicular trafficking is essential for
            osteoclast formation and activity and SNX10 is involved in
            vesicular trafficking, these studies may identify a new gene
            involved in the development of bone diseases including
            osteoporosis.
REFERENCE   7  (bases 1 to 2665)
  AUTHORS   Chen,Y., Wu,B., Xu,L., Li,H., Xia,J., Yin,W., Li,Z., Shi,D., Li,S.,
            Lin,S., Shu,X. and Pei,D.
  TITLE     A SNX10/V-ATPase pathway regulates ciliogenesis in vitro and in
            vivo
  JOURNAL   Cell Res 22 (2), 333-345 (2012)
   PUBMED   21844891
  REMARK    GeneRIF: SNX10 regulates the ciliary trafficking of Rab8a, which is
            a critical regulator of ciliary membrane extension.
REFERENCE   8  (bases 1 to 2665)
  AUTHORS   Qin,B., He,M., Chen,X. and Pei,D.
  TITLE     Sorting nexin 10 induces giant vacuoles in mammalian cells
  JOURNAL   J Biol Chem 281 (48), 36891-36896 (2006)
   PUBMED   17012226
  REMARK    GeneRIF: SNX10 activity may be involved in the regulation of
            endosome homeostasis
REFERENCE   9  (bases 1 to 2665)
  AUTHORS   Worby,C.A. and Dixon,J.E.
  TITLE     Sorting out the cellular functions of sorting nexins
  JOURNAL   Nat Rev Mol Cell Biol 3 (12), 919-931 (2002)
   PUBMED   12461558
  REMARK    Review article
            Erratum:[Nat Rev Mol Cell Biol. 2003 Feb;4(2):156.]
REFERENCE   10 (bases 1 to 2665)
  AUTHORS   Teasdale,R.D., Loci,D., Houghton,F., Karlsson,L. and Gleeson,P.A.
  TITLE     A large family of endosome-localized proteins related to sorting
            nexin 1
  JOURNAL   Biochem J 358 (Pt 1), 7-16 (2001)
   PUBMED   11485546
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010677.4, AC074295.7 and
            AC004540.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Oct 25, 2019 this sequence version replaced NM_013322.2.
            
            Summary: This gene encodes a member of the sorting nexin family.
            Members of this family contain a phox (PX) domain, which is a
            phosphoinositide binding domain, and are involved in intracellular
            trafficking. This protein does not contain a coiled coil region,
            like some family members. This gene may play a role in regulating
            endosome homeostasis. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Dec 2010].
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1, and encodes isoform (1). Variants 1, 2, and
            6 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034992.1, SRR14038191.2061435.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000338523.9/ ENSP00000343709.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-225               AC010677.4         99628-99852
            226-272             AC074295.7         41727-41773
            273-359             AC074295.7         56282-56368
            360-460             AC074295.7         59842-59942
            461-559             AC074295.7         60354-60452
            560-772             AC004540.1         925-1137
            773-2665            AC004540.1         1595-3487
FEATURES             Location/Qualifiers
     source          1..2665
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p15.2"
     gene            1..2665
                     /gene="SNX10"
                     /gene_synonym="OPTB8"
                     /note="sorting nexin 10"
                     /db_xref="GeneID:29887"
                     /db_xref="HGNC:HGNC:14974"
                     /db_xref="MIM:614780"
     exon            1..225
                     /gene="SNX10"
                     /gene_synonym="OPTB8"
                     /inference="alignment:Splign:2.1.0"
     exon            226..272
                     /gene="SNX10"
                     /gene_synonym="OPTB8"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..854
                     /gene="SNX10"
                     /gene_synonym="OPTB8"
                     /note="isoform 1 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="sorting nexin-10 isoform 1"
                     /protein_id="NP_037454.2"
                     /db_xref="CCDS:CCDS5399.1"
                     /db_xref="GeneID:29887"
                     /db_xref="HGNC:HGNC:14974"
                     /db_xref="MIM:614780"
                     /translation="MFPEQQKEEFVSVWVRDPRIQKEDFWHSYIDYEICIHTNSMCFT
                     MKTSCVRRRYREFVWLRQRLQSNALLVQLPELPSKNLFFNMNNRQHVDQRRQGLEDFL
                     RKVLQNALLLSDSSLHLFLQSHLNSEDIEACVSGQTKYSVEEAIHKFALMNRRFPEED
                     EEGKKENDIDYDSESSSSGLGHSSDDSSSHGCKVNTAPQES"
     exon            273..359
                     /gene="SNX10"
                     /gene_synonym="OPTB8"
                     /inference="alignment:Splign:2.1.0"
     exon            360..460
                     /gene="SNX10"
                     /gene_synonym="OPTB8"
                     /inference="alignment:Splign:2.1.0"
     exon            461..559
                     /gene="SNX10"
                     /gene_synonym="OPTB8"
                     /inference="alignment:Splign:2.1.0"
     exon            560..772
                     /gene="SNX10"
                     /gene_synonym="OPTB8"
                     /inference="alignment:Splign:2.1.0"
     exon            773..2665
                     /gene="SNX10"
                     /gene_synonym="OPTB8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2205..2210
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNX10"
                     /gene_synonym="OPTB8"
                     /note="hexamer: ATTAAA"
     regulatory      2214..2219
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNX10"
                     /gene_synonym="OPTB8"
                     /note="hexamer: ATTAAA"
     polyA_site      2229
                     /gene="SNX10"
                     /gene_synonym="OPTB8"
                     /note="major polyA site"
     polyA_site      2235
                     /gene="SNX10"
                     /gene_synonym="OPTB8"
     regulatory      2276..2281
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNX10"
                     /gene_synonym="OPTB8"
                     /note="hexamer: ATTAAA"
     polyA_site      2299
                     /gene="SNX10"
                     /gene_synonym="OPTB8"
                     /note="major polyA site"
     regulatory      2642..2647
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNX10"
                     /gene_synonym="OPTB8"
                     /note="hexamer: AATATA"
     polyA_site      2665
                     /gene="SNX10"
                     /gene_synonym="OPTB8"
                     /note="major polyA site"
ORIGIN      
        1 actaggcgcg gcgcccacag gcggacggct ggcgctgagc gcgggcgcgg ggccgctacg
       61 tgcgcgggga gcgcggggag cgcggggagc gcggggctgc gctcgtgtgc gctcctgggc
      121 gctcgccgcc gccgctgccg ccgcgcgcct ttgagtcagc aaactccgcg gcccgcaagc
      181 ccggctcggc ccggccctgc tctgttctgc ccggaggagc cgcccattga tcgtgtcctg
      241 tgctgaagat gtttccggaa caacagaaag aggaatttgt aagtgtctgg gttcgagatc
      301 ctaggattca gaaggaggac ttctggcatt cttacattga ctatgagata tgtattcata
      361 ctaatagcat gtgttttaca atgaaaacat cctgtgtacg aagaagatat agagaattcg
      421 tgtggctgag gcagagactc caaagtaatg cgttgctggt acaactgcca gaacttccat
      481 ctaaaaacct gtttttcaac atgaacaatc gccagcacgt ggatcagcgt cgccagggtc
      541 tggaagattt cctcagaaaa gtcctacaga atgcactttt gctttcagat agcagccttc
      601 acctcttctt acagagccat ctgaattcag aagacattga ggcgtgtgtt tctgggcaga
      661 ctaagtactc tgtggaagaa gcaattcaca agtttgcctt aatgaataga cgtttccctg
      721 aagaagatga agaaggaaaa aaagaaaatg atatagatta tgattcagaa agttcatcct
      781 ctgggcttgg acacagtagt gatgacagca gttcacatgg atgtaaagta aatacagctc
      841 cgcaggaatc ctgaaaaata attctaatgt tactatctta ggaatagcaa attatgtcca
      901 gtcatagaga agaaagcttc ataataatac attcttacct aaagctcact gtcatgatgt
      961 taggtattta aattcttaaa gatgttgggt tgtttattag tggtattttt atgttgtctt
     1021 attttaggta agcttctgtg taaagctaaa aatcctgtga atacaatact atcctttaca
     1081 ggcagacatt attggtaaac aagatcttgc cctccaatga aatgacttac atgttttaaa
     1141 aaaccgagtt ggttttattg aatttaaaaa gataggtaac taagtagcat ttaaaatcaa
     1201 gatagagcat tccttcttgt atcagtgggg cagtgttacc ataaacacgg tgtatatgtt
     1261 gttaaaccct atgaagagta acagtgtaga ccagactgcc tctctcagat atgtgcctga
     1321 tattttgtgg atacctcccc tgcactggca aaacactatg cttttgggtg ttagactgaa
     1381 atattttaag agtatttaac ctttccagta ttctgtttca cgcttagatg gaaatgtatc
     1441 ttatgaatag agacatatta aaataatgtt tacatcttag aaaaaacata gatagtgcta
     1501 gtaatattac ttataactgt aatatataga ttcagaaata cattttcatt atccaaaatc
     1561 agcttcaaca aatggtttct ggagacaaat aatttgtttt cattatcatt gtataatcag
     1621 gttaatgatt tattttttga ctaaatgtgc aatttcttat cactagataa ctttcagtat
     1681 cagtggtggt tacttattac ttaaatcaga ggaaggattt tataaagatt aataaattta
     1741 attttaccaa taaatattcc cataatttag aaaaggatgt cgacttgcta atttcagaaa
     1801 taattattca tttttaaaaa gcccctttta aagcatctac ttgaagattg gtataatttt
     1861 cataaaatgt cttttttttt agtgtcccaa agatatctta gataaactat tttgaagttc
     1921 agatttcaga tgaggcaaca ttttcttgag ataattaccc aagtttcatc catgttgaat
     1981 ggtacaaaat atttctgtga aactaacagg aagatatttt cagataacta ggataacttg
     2041 ttgctttgtt acccagccta attgaagagt ggcagaggct actacaaaaa gcaacctttt
     2101 cattttcact aagagtttaa aagctattgt attattaaaa agtctttaca atgcttgttt
     2161 caaagaacca acagaaaaaa aagctaagaa aactgagaac taacattaaa aaaattaaat
     2221 ttagaataag aatgatttct ttaatttgtc ctttttttct ttggtctaaa acattattaa
     2281 atttttgtaa atattttgat ttaatgtgtc ttagatcctc attattttaa tacaggaaaa
     2341 gaaaagattt agtaatttct taccatgcta atatgtaaag ttcatgccat ccaggcattt
     2401 aagagcgatc ctcatccctt cagcaatatg tatttgagtt cacactattt ctgttttaca
     2461 gcagttttga aaaacacata ctatgccacc aattgtcata ttatttttag atgatgtaac
     2521 atagccatca aaattaatat tatgtaatgc ctaatactta gtatgtaaat gtcacgagat
     2581 catttttaca ttaaacgtga aaaaaaatca actttgccgg atcacttatt ttatacaaga
     2641 gaatatattc tgccttagac ccaaa
//
