LOCUS       NM_003099               8214 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens sorting nexin 1 (SNX1), transcript variant 1, mRNA.
ACCESSION   NM_003099
VERSION     NM_003099.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8214)
  AUTHORS   Garcia Delgado,L., Derome,A., Longpre,S., Giroux-Dansereau,M.,
            Basbous,G., Lavoie,C., Saucier,C. and Denault,J.B.
  TITLE     Spatiotemporal regulation of the hepatocyte growth factor receptor
            MET activity by sorting nexins 1/2 in HCT116 colorectal cancer
            cells
  JOURNAL   Biosci Rep 44 (6) (2024)
   PUBMED   38836326
  REMARK    GeneRIF: Spatiotemporal regulation of the hepatocyte growth factor
            receptor MET activity by sorting nexins 1/2 in HCT116 colorectal
            cancer cells.
REFERENCE   2  (bases 1 to 8214)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 8214)
  AUTHORS   Chandra,M., Collins,B.M. and Jackson,L.P.
  TITLE     Biochemical basis for an interaction between SNX27 and the flexible
            SNX1 N-terminus
  JOURNAL   Adv Biol Regul 83, 100842 (2022)
   PUBMED   34866035
  REMARK    GeneRIF: Biochemical basis for an interaction between SNX27 and the
            flexible SNX1 N-terminus.
REFERENCE   4  (bases 1 to 8214)
  AUTHORS   Carlton,J., Bujny,M., Peter,B.J., Oorschot,V.M., Rutherford,A.,
            Mellor,H., Klumperman,J., McMahon,H.T. and Cullen,P.J.
  TITLE     Sorting nexin-1 mediates tubular endosome-to-TGN transport through
            coincidence sensing of high- curvature membranes and
            3-phosphoinositides
  JOURNAL   Curr Biol 14 (20), 1791-1800 (2004)
   PUBMED   15498486
  REMARK    GeneRIF: SNX1 associates with a microdomain of the early endosome
            where it regulates tubular-based endosome-to-trans Golgi network
            retrieval of the cation-independent mannose-6-phosphate receptor.
REFERENCE   5  (bases 1 to 8214)
  AUTHORS   Shank,B.B., Wiley,H.S. and Kurten,R.C.
  TITLE     Structural and functional characterization of the human gene for
            sorting nexin 1 (SNX1)
  JOURNAL   DNA Cell Biol 20 (5), 287-296 (2001)
   PUBMED   11410165
REFERENCE   6  (bases 1 to 8214)
  AUTHORS   Kurten,R.C., Eddington,A.D., Chowdhury,P., Smith,R.D.,
            Davidson,A.D. and Shank,B.B.
  TITLE     Self-assembly and binding of a sorting nexin to sorting endosomes
  JOURNAL   J Cell Sci 114 (Pt 9), 1743-1756 (2001)
   PUBMED   11309204
REFERENCE   7  (bases 1 to 8214)
  AUTHORS   Chin,L.S., Raynor,M.C., Wei,X., Chen,H.Q. and Li,L.
  TITLE     Hrs interacts with sorting nexin 1 and regulates degradation of
            epidermal growth factor receptor
  JOURNAL   J Biol Chem 276 (10), 7069-7078 (2001)
   PUBMED   11110793
REFERENCE   8  (bases 1 to 8214)
  AUTHORS   Haft,C.R., de la Luz Sierra,M., Bafford,R., Lesniak,M.A., Barr,V.A.
            and Taylor,S.I.
  TITLE     Human orthologs of yeast vacuolar protein sorting proteins Vps26,
            29, and 35: assembly into multimeric complexes
  JOURNAL   Mol Biol Cell 11 (12), 4105-4116 (2000)
   PUBMED   11102511
REFERENCE   9  (bases 1 to 8214)
  AUTHORS   Haft,C.R., de la Luz Sierra,M., Barr,V.A., Haft,D.H. and
            Taylor,S.I.
  TITLE     Identification of a family of sorting nexin molecules and
            characterization of their association with receptors
  JOURNAL   Mol Cell Biol 18 (12), 7278-7287 (1998)
   PUBMED   9819414
REFERENCE   10 (bases 1 to 8214)
  AUTHORS   Kurten,R.C., Cadena,D.L. and Gill,G.N.
  TITLE     Enhanced degradation of EGF receptors by a sorting nexin, SNX1
  JOURNAL   Science 272 (5264), 1008-1010 (1996)
   PUBMED   8638121
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB455188.1, AK291752.1,
            AC100840.2 and BX108623.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_003099.4.
            
            Summary: This gene encodes a member of the sorting nexin family.
            Members of this family contain a phox (PX) domain, which is a
            phosphoinositide binding domain, and are involved in intracellular
            trafficking. This endosomal protein regulates the cell-surface
            expression of epidermal growth factor receptor. This protein also
            has a role in sorting protease-activated receptor-1 from early
            endosomes to lysosomes. This protein may form oligomeric complexes
            with family members. This gene results in three transcript variants
            encoding distinct isoforms. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.160542.1,
                                           SRR1803614.174871.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000559844.6/ ENSP00000453785.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                DB455188.1         99-116
            19-1618             AK291752.1         1-1600
            1619-8170           AC100840.2         32906-39457         c
            8171-8214           BX108623.1         739-782
FEATURES             Location/Qualifiers
     source          1..8214
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q22.31"
     gene            1..8214
                     /gene="SNX1"
                     /gene_synonym="HsT17379; VPS5"
                     /note="sorting nexin 1"
                     /db_xref="GeneID:6642"
                     /db_xref="HGNC:HGNC:11172"
                     /db_xref="MIM:601272"
     exon            1..191
                     /gene="SNX1"
                     /gene_synonym="HsT17379; VPS5"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..1601
                     /gene="SNX1"
                     /gene_synonym="HsT17379; VPS5"
                     /note="isoform a is encoded by transcript variant 1;
                     sorting nexin 1A"
                     /codon_start=1
                     /product="sorting nexin-1 isoform a"
                     /protein_id="NP_003090.2"
                     /db_xref="CCDS:CCDS32266.1"
                     /db_xref="GeneID:6642"
                     /db_xref="HGNC:HGNC:11172"
                     /db_xref="MIM:601272"
                     /translation="MASGGGGCSASERLPPPFPGLEPESEGAAGGSEPEAGDSDTEGE
                     DIFTGAAVVSKHQSPKITTSLLPINNGSKENGIHEEQDQEPQDLFADATVELSLDSTQ
                     NNQKKVLAKTLISLPPQEATNSSKPQPTYEELEEEEQEDQFDLTVGITDPEKIGDGMN
                     AYVAYKVTTQTSLPLFRSKQFAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIG
                     MTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHPTMLQDPDVREFLEKEELPRAVGT
                     QTLSGAGLLKMFNKATDAVSKMTIKMNESDIWFEEKLQEVECEEQRLRKLHAVVETLV
                     NHRKELALNTAQFAKSLAMLGSSEDNTALSRALSQLAEVEEKIEQLHQEQANNDFFLL
                     AELLSDYIRLLAIVRAAFDQRMKTWQRWQDAQATLQKKREAEARLLWANKPDKLQQAK
                     DEILEWESRVTQYERDFERISTVVRKEVIRFEKEKSKDFKNHVIKYLETLLYSQQQLA
                     KYWEAFLPEAKAIS"
     exon            192..303
                     /gene="SNX1"
                     /gene_synonym="HsT17379; VPS5"
                     /inference="alignment:Splign:2.1.0"
     exon            304..431
                     /gene="SNX1"
                     /gene_synonym="HsT17379; VPS5"
                     /inference="alignment:Splign:2.1.0"
     exon            432..498
                     /gene="SNX1"
                     /gene_synonym="HsT17379; VPS5"
                     /inference="alignment:Splign:2.1.0"
     exon            499..542
                     /gene="SNX1"
                     /gene_synonym="HsT17379; VPS5"
                     /inference="alignment:Splign:2.1.0"
     exon            543..684
                     /gene="SNX1"
                     /gene_synonym="HsT17379; VPS5"
                     /inference="alignment:Splign:2.1.0"
     exon            685..763
                     /gene="SNX1"
                     /gene_synonym="HsT17379; VPS5"
                     /inference="alignment:Splign:2.1.0"
     exon            764..839
                     /gene="SNX1"
                     /gene_synonym="HsT17379; VPS5"
                     /inference="alignment:Splign:2.1.0"
     exon            840..953
                     /gene="SNX1"
                     /gene_synonym="HsT17379; VPS5"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1047
                     /gene="SNX1"
                     /gene_synonym="HsT17379; VPS5"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1253
                     /gene="SNX1"
                     /gene_synonym="HsT17379; VPS5"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1397
                     /gene="SNX1"
                     /gene_synonym="HsT17379; VPS5"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1478
                     /gene="SNX1"
                     /gene_synonym="HsT17379; VPS5"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1550
                     /gene="SNX1"
                     /gene_synonym="HsT17379; VPS5"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..8214
                     /gene="SNX1"
                     /gene_synonym="HsT17379; VPS5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1968..1973
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNX1"
                     /gene_synonym="HsT17379; VPS5"
                     /note="hexamer: AATAAA"
     polyA_site      1989
                     /gene="SNX1"
                     /gene_synonym="HsT17379; VPS5"
                     /note="major polyA site"
     regulatory      8188..8193
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNX1"
                     /gene_synonym="HsT17379; VPS5"
                     /note="hexamer: AATAAA"
     polyA_site      8214
                     /gene="SNX1"
                     /gene_synonym="HsT17379; VPS5"
                     /note="major polyA site"
ORIGIN      
        1 gttgttgcgg cttccgccgc gggtggaaga agatggcgtc gggtggtggt ggctgtagcg
       61 cttcggagag actgcctccg cccttccccg gcctggagcc ggagtccgag ggggcggccg
      121 ggggatcaga acccgaggct ggggacagcg acaccgaggg ggaggacatt ttcaccggcg
      181 ccgcggtggt cagtaaacat cagtctccaa agataactac atcccttctt cccatcaaca
      241 atggctccaa agaaaatggg atccatgaag aacaagacca agagccacag gatctctttg
      301 cagatgccac agtggagcta tccttggaca gcacacaaaa taatcagaag aaggtgctag
      361 ccaaaacact catttctctt cctcctcagg aagccacaaa ttcttcgaag ccccagccaa
      421 cctatgagga gctagaggaa gaagaacagg aggatcaatt tgatttgaca gtcggtataa
      481 ctgatcctga gaagataggg gatggtatga atgcatatgt agcctacaaa gttacaacac
      541 agacaagctt accattgttc agaagcaaac agtttgcagt aaaaagaaga tttagtgact
      601 ttctgggtct ttatgagaag ctttccgaga agcactctca gaatggcttc attgtccctc
      661 cgcccccgga gaagagcctc atagggatga caaaagtgaa agttgggaag gaagattctt
      721 cttctgcaga atttcttgaa aaacggaggg ccgctttaga aaggtacctt cagaggattg
      781 taaatcatcc taccatgtta caggaccctg acgtcagaga gttcttggaa aaagaagagc
      841 tgccacgtgc cgtgggtacc cagacattga gtggtgctgg tctcctcaag atgttcaaca
      901 aagccacaga tgccgtcagc aaaatgacca tcaagatgaa tgaatcagac atttggtttg
      961 aggagaagct ccaggaggta gagtgtgagg agcagcgctt acggaaactg catgctgttg
     1021 tagaaactct agtcaaccat aggaaagagc tagcgctgaa cacagcccag tttgcaaaga
     1081 gtctagccat gcttgggagc tctgaggaca acacggcatt gtcacgggca ctctcccagc
     1141 tggctgaggt ggaagaaaaa attgagcagc tccaccagga acaggccaac aatgacttct
     1201 tcctccttgc tgagctcctg agtgactaca ttcgcctcct ggccatagtc cgcgctgcct
     1261 tcgaccagcg catgaagaca tggcagcgct ggcaggatgc ccaagccaca ctgcagaaga
     1321 agcgggaggc cgaggctcgg ctgctgtggg ccaacaagcc tgataagctg cagcaggcca
     1381 aggacgagat cctcgagtgg gagtctcggg tgactcaata tgaaagggac ttcgagagga
     1441 tttcaacagt ggtccgaaaa gaagtgatac ggtttgagaa agagaaatcc aaggacttca
     1501 agaaccacgt gatcaagtac cttgagacac tcctttactc acagcagcag ctggcaaagt
     1561 actgggaagc cttccttcct gaggcaaagg ccatctccta atggaccaag gaccccagag
     1621 cccacctgtg tgacgctgcc tttttataca ctgtcctcct ccaccttgat ggacccctag
     1681 tgatgcatcc tgcctaggct ggacttaacc ccttcctccc tgtccccacg accaactgtc
     1741 cccagttact ctaaccgtta tttcatttag cttccatata tattttctta cctaagagaa
     1801 tagtttcctg ctttaagcaa aagacctaca ataggtggtg gaattatggg atggggtgga
     1861 gtattgatat aaatatataa atacaaatgt atatttttca ggatgtggtt taggaactgg
     1921 gaataacgtt ttctgttact cctgatggtg ccatgaaaag gttatgtaat aaaatatttt
     1981 aaaatcaggt cacatgactc agaatgttgg tggtttttgc ttaggctggg gagcagttgg
     2041 gaatcaggtc tggaatactc ctaaccaaga agttgcccag gtatagtaag tttttctcta
     2101 ccgttcacaa gttttgtgct gctgcttccc tctggaaatg gggtttcttt ctctccgcct
     2161 acctcagcta cctgttctga gggtctcaat ctgtttcgta ttcccacttc tttagggaag
     2221 gagttttaaa aacatctctt aaaataagag gagcaaaatc tattaaaacc tattctcctg
     2281 caaaggaggc agagactttc tctctctctt tttttttttt ttttggtgtc cctatcatta
     2341 agcaagagcc tttctctttt attcttcctg cttccctaag ctgctcaggg ttctctgagt
     2401 cttgccctct gatggcaagt cttatatata actaaaccta tttttgtcac ccatcaaaac
     2461 acatcctcag tagactgtgt gaaggtgtga aggtctgata atgacttgat gctttgtctc
     2521 catagacatg aaagccatgc cctctgcctc tagatagggt gatccaagag ctcctgaacc
     2581 ttaggaggtt caaagaagct ctactgtctg tgcccaggag gtagcctgcc agcaagagcc
     2641 ctcaggagtt gcacacacag ccaaagggtg ttcacacaga tctctgccgg tctagccagg
     2701 ggaggccaga gtctcgtcag tcaaggatgg gcttccccct tagctgtgtc cacagctgct
     2761 caagctatac tggtcagagt gggctttgaa gctcctttgt gagctcgagc tgctgactgc
     2821 cactatggga gccttgccac ctccagcccc tccatcccaa agacgctcct gccactgggg
     2881 ccccaggtcc tgctgtatca gttctctttg gtggggggct aaggtttggg gcgaggcaac
     2941 ctgagacaag aaaacgcagt aaacattctg attccctgta cacagatgca gcaccagggg
     3001 aagggccagt ggtgcaagta tttcttttta acaggtgaag tttttggaaa aagtcactct
     3061 ccctacccct cagtatcctt accatcaact ttggttttat ccttccagtc tttattatat
     3121 gcttgctttt acatagttgt aataatatac acataaagta ttttgtatcc tgcttttatc
     3181 attcaacatt gtacatgtta taagcatttt actatattgt tatatatctt cacaaagttg
     3241 atctgtaaag ctgtgtaatt tgaaggcatc catagggtga ctgtaccata attttgattc
     3301 atcccttgtt gttggattct tggtcagggg ttgtttgttt tgttttattg gtaactttaa
     3361 aattttgaat acaatttcag atttacagaa aagttgcagg aatatcacaa agaactccta
     3421 tatatctttt atccagattt actgagtgtt tacattttat cccatttgcc ttatctatat
     3481 ttcatgttgc attttcttaa tcatttgaga ataatttgca cagatacccc attatgccca
     3541 aaacagtatg catttcccta agaacaggac attctcttct aagagaagaa gagaattact
     3601 ttaagcatta ttcagtattt ttttaagtat tattatcaaa atcaggaagt ttaacagtga
     3661 tttaatactg ttatctaacc catgattcat atttaaattt tgccatttat cccaataatg
     3721 tcctttgtag ccattctttt accttgtgca ggatcatgtt acatttgtaa acgtgtgtct
     3781 ctcaatactg cagattcctc aactttcttt tgtctttcat taccatgaca tttttgaaga
     3841 atacaggcta ttttgtcgaa tgttcctcag tttggatttg tgtgatggtt ccgcatgact
     3901 aggtgagggt tttgcattct gggtgggaat atcacagaag cagtgtgtcg tcagtgcgtc
     3961 gtaatcagca tataatgtca gttggtccca ttaatgttgt taactctgtt caccgcttag
     4021 gttggtgtct gccagatttc attttaaatt tacgatttcc tctttgtaat ttacaagtaa
     4081 tttgtgggga gatactttga gactatataa gtattttgtt cctcattcac cagttatata
     4141 gtatcagttg attagtcttg tcccagttat tactgtcatg attgaccaac atgatttcct
     4201 aactccataa tgccttctac atttattggt tgacattcta catacaaaga aaaacatcct
     4261 ttctcaccat ttatttattc acttgtttat caatatggat gcagggattc ctgttttact
     4321 cagagttgca agccattgct ttgattttat cttgattctc aaattgtccc agatttatag
     4381 cggcctcttg tgtgtttgta gcttgctccc atcatgtttt gagtactttc ttaccttctg
     4441 gcataacaag atgttccagg ctcatcttga atgttcccta ccctagccct ggaatcagcc
     4501 atttctccag ggagtcttgg ttccttataa tggagaatgg tatttattta tttttatttg
     4561 atttgattat tattactatt tttgagacag agtctcgctc ttgtcgccca ggctggattg
     4621 caatggcaca atctcagctc actgcaacct ccacctacca ggttcaagca attctcctgc
     4681 ctcagccttc caagtagctg ggattacagg tgcctgcccc cacacccagc taatttttgc
     4741 atttttggta gaaatggggg ttttaccatg ttggggaggc tggtctcgaa ctcctgacct
     4801 caggtgatct gcccacctca acctcccaaa gtgctgggat tacaggtgtg agccaccata
     4861 cccagccaga gaatgttatt tagaaaccaa gatctgggtg ccaaatgtgc tgcttgttac
     4921 tggaatgtca ttgcctctag gctctcacca tacagtgcaa agagatgata gatagataga
     4981 tagatagata gatagataga tagatagatg atagatatag atagatagat agattgattg
     5041 atttgtagaa acaagatagg ttagagatac ctgacataaa tagatactaa aaatcatgaa
     5101 ttcacactga tgctttgaga ccagccctgt aggtttattc cagtctgccc ccttttccat
     5161 gttgttaact ctttcctcca gagagacaaa gatttcaggt tgctttgtta agttccatct
     5221 aatgatcatt ctgacgtaag tctgtttttc ttatttcctt ggaatgatgt ctcctctggt
     5281 ttcagaactt cctcctctgc ttcctgtatc ctgaggctgg cggggccagt tgtctttagg
     5341 gcttgtgcat ttttgtaaag agcttgcacg tgtggaaatc aagtaggcca gtagtgggtt
     5401 aggggtactg agccagaagc ctctacaagg aataacagga gcacaaagga agaaggtggt
     5461 attccagctg gggacccagg agggaggact ttgtggagaa cctgatgctt gaactgagtc
     5521 taaaaggtgt aaaagtgttt gttgcttctg cctccctgtc tgtctggcag ggtgaggtag
     5581 gcgcatctag ggaaatgtca agtggcttgg tgtagggtaa agtcagtgag gcccatggag
     5641 aaaaacgagc aggagccaca tcacatgggt gtctgatagg acctgggagg cgctttccac
     5701 attaccattg tcgcttcgtg atctggacac accagaaggc gtgagactgg aggcaggaag
     5761 agcagccagg cttatcccta ccctcaggag agctgaaaag ggcaggtatg gtggggccag
     5821 agctcaggag agtttcggaa ccactgagat cggtccttga tttgatgaga ggcttgaggg
     5881 gagagggagg tagctaggat gccccgcaag cttctggccc agacactggg cagacaatga
     5941 aaccctttgt aacacatgag gcaataggtt tggggcagat gggaggggaa gcagtggtgg
     6001 gggcagtgag tgctgaaggt gttttaagaa gcggctctgg gccaggcaca gtggcttatg
     6061 cctgtattcc tagcattttg ggaggccgag gtgggagaat cacttgagcc caagaatttg
     6121 agaccagcct ggggaatata gtgagaccct gtccctacaa aaataaaaac aactagctgg
     6181 gtgtgtggtg gtgcatgcct gtaggcccag ctacgcggga acatcacctg agcccaggag
     6241 gttgaggttg cagtgagcta cagttgcgcc actgcactcc agcctaggtg acagagcaag
     6301 atcttgtctc aaaaaaaaaa gcagctctgg atgggaaggg aggccagttg ctttaagtag
     6361 gggagataga gttaaaggag gctttgtttt atttaaaggt gggacaaact taagcatgtt
     6421 aataaaattc agagaagaga aagagaatga ctatcagagc catgtttgga agaaaatggg
     6481 gtccagagca caggaagggg acctgtgttc agagggtgcc tcactgctga ggccacagga
     6541 aagaatctgt aggtggaggg gaggccgaag aggggaagtt tcatgcttga taattaaaat
     6601 tttctgagat aggaatgtca tatttaccta tttaagccaa gtttttttag ataaaaggta
     6661 tggaacctgc tttccccttg gctagttcag cgtttgggct ccggagtgct gaagatgagg
     6721 actggacttc gagctggtgt gatcccagta ttcagtgtca gtactcagtg acaaaataaa
     6781 tgagagaaac gggaataaga attgtcgcct acacaaaaat accagcaact gttaactctt
     6841 cccagaagat tttcattctg aatgctcctg tagctaggaa ccctaaaaag tctttgaagc
     6901 aactcaagtt ttaaaaaagg ggaggaactc ctggaaatct caggatgggg ccaagatgtg
     6961 gctggagagt gtgtggtgat ggagggcgtg tcttttgccg agcacactca gggcccacgg
     7021 gaagcccata gacttcaagg acatcaagcc ccaaggtggt gggattttcc ccaccagtac
     7081 ttggcagcct agggggaagg ggagggcggg agaagataat ggggatccct ggctccaaac
     7141 ataggaggac acatctgtgc tacagtgcgc acatgcctgg atgtacactc tgtctttgga
     7201 gacactggct aagattctct gctccatgtt tggacagggt cgtgcctgat ctgagataaa
     7261 tggacaagaa caactgaagc ctgtcttctg gtgcatgtgt cacctgccga taactgcatc
     7321 ttgtgataaa gttgggtgat ttacagtctc caccaaatgc taaactctgg ggtcttacgc
     7381 ctttataact ccatgggccc cagcaaaggt tcaggctcaa aacaggtgtc aaatagataa
     7441 ctgttgaatg attgttcccc agttgcaggc tctgccacct ggcgttcata ctgtctgtga
     7501 aaggacccag ctcacctttc cctctttatc tcccagtcct tcccaacagc gccgacacct
     7561 catggaaact gattgcaaat gtgctacttc tcacttctgt gtggcccgag gaggctgggt
     7621 taatgctggg cttggtacct taagcaccct ttctcccttc cccatcttca ttctcagaat
     7681 tacacctgtc tgaagcaggc attttccaat gccctagatg ggaatataag tgtaaggaga
     7741 tgtgaagcat ttgcctgtgt gtcagaacat tcactgagga tcctcatagg cacttctaga
     7801 aaccaaatcc ttgaagatga ctaaccagaa atgcccgtca tagcactgtt tacagttgca
     7861 aaaactgaag ccaattgaaa tgtccatcag gaggggatta aatgaattat ggtacagtta
     7921 caccgttgaa tattttacag ccattgaaga tgatatatag ctatattcat tgacaaggaa
     7981 aactcatatt ttttagtgaa aaaagcaggt tatagaattg catgatattc acatttatat
     8041 aaaactttat atatgggaag gatgttgatt gaattgttaa taactatggt cacctctaga
     8101 gatggaagtt tgcattacct ttaattttta ataccatttt gtattgctta aaatttgtat
     8161 gtattatcgt taaaataaga aaaatcaaat aaagctattt tcattatggg aaaa
//
