LOCUS       NM_012245               2129 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens SNW domain containing 1 (SNW1), transcript variant 2,
            mRNA.
ACCESSION   NM_012245
VERSION     NM_012245.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2129)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2129)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2129)
  AUTHORS   Chai,G., Webb,A., Li,C., Antaki,D., Lee,S., Breuss,M.W., Lang,N.,
            Stanley,V., Anzenberg,P., Yang,X., Marshall,T., Gaffney,P.,
            Wierenga,K.J., Chung,B.H., Tsang,M.H., Pais,L.S., Lovgren,A.K.,
            VanNoy,G.E., Rehm,H.L., Mirzaa,G., Leon,E., Diaz,J., Neumann,A.,
            Kalverda,A.P., Manfield,I.W., Parry,D.A., Logan,C.V., Johnson,C.A.,
            Bonthron,D.T., Valleley,E.M.A., Issa,M.Y., Abdel-Ghafar,S.F.,
            Abdel-Hamid,M.S., Jennings,P., Zaki,M.S., Sheridan,E. and
            Gleeson,J.G.
  TITLE     Mutations in Spliceosomal Genes PPIL1 and PRP17 Cause
            Neurodegenerative Pontocerebellar Hypoplasia with Microcephaly
  JOURNAL   Neuron 109 (2), 241-256 (2021)
   PUBMED   33220177
REFERENCE   4  (bases 1 to 2129)
  AUTHORS   Zhang,Q., Liang,T., Gu,S., Ye,Y. and Liu,S.
  TITLE     SNW1 interacts with IKKgamma to positively regulate antiviral
            innate immune responses against influenza A virus infection
  JOURNAL   Microbes Infect 22 (10), 576-584 (2020)
   PUBMED   32805409
  REMARK    GeneRIF: SNW1 interacts with IKKgamma to positively regulate
            antiviral innate immune responses against influenza A virus
            infection.
REFERENCE   5  (bases 1 to 2129)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 2129)
  AUTHORS   Leong,G.M., Subramaniam,N., Figueroa,J., Flanagan,J.L.,
            Hayman,M.J., Eisman,J.A. and Kouzmenko,A.P.
  TITLE     Ski-interacting protein interacts with Smad proteins to augment
            transforming growth factor-beta-dependent transcription
  JOURNAL   J Biol Chem 276 (21), 18243-18248 (2001)
   PUBMED   11278756
REFERENCE   7  (bases 1 to 2129)
  AUTHORS   Zhou,S., Fujimuro,M., Hsieh,J.J., Chen,L., Miyamoto,A.,
            Weinmaster,G. and Hayward,S.D.
  TITLE     SKIP, a CBF1-associated protein, interacts with the ankyrin repeat
            domain of NotchIC To facilitate NotchIC function
  JOURNAL   Mol Cell Biol 20 (7), 2400-2410 (2000)
   PUBMED   10713164
REFERENCE   8  (bases 1 to 2129)
  AUTHORS   Zhou,S., Fujimuro,M., Hsieh,J.J., Chen,L. and Hayward,S.D.
  TITLE     A role for SKIP in EBNA2 activation of CBF1-repressed promoters
  JOURNAL   J Virol 74 (4), 1939-1947 (2000)
   PUBMED   10644367
REFERENCE   9  (bases 1 to 2129)
  AUTHORS   Baudino,T.A., Kraichely,D.M., Jefcoat,S.C. Jr., Winchester,S.K.,
            Partridge,N.C. and MacDonald,P.N.
  TITLE     Isolation and characterization of a novel coactivator protein,
            NCoA-62, involved in vitamin D-mediated transcription
  JOURNAL   J Biol Chem 273 (26), 16434-16441 (1998)
   PUBMED   9632709
REFERENCE   10 (bases 1 to 2129)
  AUTHORS   Dahl,R., Wani,B. and Hayman,M.J.
  TITLE     The Ski oncoprotein interacts with Skip, the human homolog of
            Drosophila Bx42
  JOURNAL   Oncogene 16 (12), 1579-1586 (1998)
   PUBMED   9569025
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC008372.6.
            
            On Jun 2, 2019 this sequence version replaced NM_012245.2.
            
            Summary: This gene, a member of the SNW gene family, encodes a
            coactivator that enhances transcription from some Pol II promoters.
            This coactivator can bind to the ligand-binding domain of the
            vitamin D receptor and to retinoid receptors to enhance vitamin D-,
            retinoic acid-, estrogen-, and glucocorticoid-mediated gene
            expression. It can also function as a splicing factor by
            interacting with poly(A)-binding protein 2 to directly control the
            expression of muscle-specific genes at the transcriptional level.
            Finally, the protein may be involved in oncogenesis since it
            interacts with a region of SKI oncoproteins that is required for
            transforming activity. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Jan 2016].
            
            Transcript Variant: This variant (2) differs in the 3' UTR and has
            multiple coding region differences, compared to variant 1, one of
            which results in a frameshift. The resulting protein (isoform 2)
            has a distinct C-terminus and is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF045184.1, U51432.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261531.12/ ENSP00000261531.8
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AC008372.6         52225-52267         c
            44-197              AC008372.6         46078-46231         c
            198-359             AC008372.6         42430-42591         c
            360-455             AC008372.6         30077-30172         c
            456-562             AC008372.6         29889-29995         c
            563-667             AC008372.6         28082-28186         c
            668-737             AC008372.6         27048-27117         c
            738-803             AC008372.6         26058-26123         c
            804-920             AC008372.6         23596-23712         c
            921-1062            AC008372.6         22099-22240         c
            1063-1159           AC008372.6         14292-14388         c
            1160-1277           AC008372.6         11822-11939         c
            1278-1441           AC008372.6         9478-9641           c
            1442-2129           AC008372.6         8710-9397           c
FEATURES             Location/Qualifiers
     source          1..2129
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.3"
     gene            1..2129
                     /gene="SNW1"
                     /gene_synonym="Bx42; FUN20; NCOA-62; Prp45; PRPF45; SKIIP;
                     SKIP; SKIP1"
                     /note="SNW domain containing 1"
                     /db_xref="GeneID:22938"
                     /db_xref="HGNC:HGNC:16696"
                     /db_xref="MIM:603055"
     exon            1..43
                     /gene="SNW1"
                     /gene_synonym="Bx42; FUN20; NCOA-62; Prp45; PRPF45; SKIIP;
                     SKIP; SKIP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..1640
                     /gene="SNW1"
                     /gene_synonym="Bx42; FUN20; NCOA-62; Prp45; PRPF45; SKIIP;
                     SKIP; SKIP1"
                     /note="isoform 2 is encoded by transcript variant 2; SKI
                     interacting protein; nuclear receptor coactivator, 62-kD;
                     homolog of Drosophila BX42; nuclear protein SkiP; SNW
                     domain-containing protein 1; nuclear receptor coactivator
                     NCoA-62; ski-interacting protein"
                     /codon_start=1
                     /product="SNW domain-containing protein 1 isoform 2"
                     /protein_id="NP_036377.1"
                     /db_xref="CCDS:CCDS9867.1"
                     /db_xref="GeneID:22938"
                     /db_xref="HGNC:HGNC:16696"
                     /db_xref="MIM:603055"
                     /translation="MALTSFLPAPTQLSQDQLEAEEKARSQRSRQTSLVSSRREPPPY
                     GYRKGWIPRLLEDFGDGGAFPEIHVAQYPLDMGRKKKMSNALAIQVDSEGKIKYDAIA
                     RQGQSKDKVIYSKYTDLVPKEVMNADDPDLQRPDEEAIKEITEKTRVALEKSVSQKVA
                     AAMPVRAADKLAPAQYIRYTPSQQGVAFNSGAKQRVIRMVEMQKDPMEPPRFKINKKI
                     PRGPPSPPAPVMHSPSRKMTVKEQQEWKIPPCISNWKNAKGYTIPLDKRLAADGRGLQ
                     TVHINENFAKLAEALYIADRKAREAVEMRAQVERKMAQKEKEKHEEKLREMAQKARER
                     RAGIKTHVEKEDGEARERDEIRHDRRKERQHDRNLSRAAPDKRSKLQRNENRDISEVI
                     ALGVPNPRTSNEVQYDQRLFNQSKGMDSGFAGGEDEIYNVYDQAWRGGKDMAQSIYRP
                     SKNLDKDMYGDDLEARIKTNRFVPDKEFSGSDRRQRGREGPVQFEEDPFGLDKFLEEA
                     KQHGGSKRPSDSSRPKEHEHEGKKRRKE"
     exon            44..197
                     /gene="SNW1"
                     /gene_synonym="Bx42; FUN20; NCOA-62; Prp45; PRPF45; SKIIP;
                     SKIP; SKIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            198..359
                     /gene="SNW1"
                     /gene_synonym="Bx42; FUN20; NCOA-62; Prp45; PRPF45; SKIIP;
                     SKIP; SKIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            360..455
                     /gene="SNW1"
                     /gene_synonym="Bx42; FUN20; NCOA-62; Prp45; PRPF45; SKIIP;
                     SKIP; SKIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            456..562
                     /gene="SNW1"
                     /gene_synonym="Bx42; FUN20; NCOA-62; Prp45; PRPF45; SKIIP;
                     SKIP; SKIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            563..667
                     /gene="SNW1"
                     /gene_synonym="Bx42; FUN20; NCOA-62; Prp45; PRPF45; SKIIP;
                     SKIP; SKIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            668..737
                     /gene="SNW1"
                     /gene_synonym="Bx42; FUN20; NCOA-62; Prp45; PRPF45; SKIIP;
                     SKIP; SKIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            738..803
                     /gene="SNW1"
                     /gene_synonym="Bx42; FUN20; NCOA-62; Prp45; PRPF45; SKIIP;
                     SKIP; SKIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            804..920
                     /gene="SNW1"
                     /gene_synonym="Bx42; FUN20; NCOA-62; Prp45; PRPF45; SKIIP;
                     SKIP; SKIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1062
                     /gene="SNW1"
                     /gene_synonym="Bx42; FUN20; NCOA-62; Prp45; PRPF45; SKIIP;
                     SKIP; SKIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1159
                     /gene="SNW1"
                     /gene_synonym="Bx42; FUN20; NCOA-62; Prp45; PRPF45; SKIIP;
                     SKIP; SKIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1277
                     /gene="SNW1"
                     /gene_synonym="Bx42; FUN20; NCOA-62; Prp45; PRPF45; SKIIP;
                     SKIP; SKIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1441
                     /gene="SNW1"
                     /gene_synonym="Bx42; FUN20; NCOA-62; Prp45; PRPF45; SKIIP;
                     SKIP; SKIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..2129
                     /gene="SNW1"
                     /gene_synonym="Bx42; FUN20; NCOA-62; Prp45; PRPF45; SKIIP;
                     SKIP; SKIP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2109..2114
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNW1"
                     /gene_synonym="Bx42; FUN20; NCOA-62; Prp45; PRPF45; SKIIP;
                     SKIP; SKIP1"
                     /note="hexamer: AATAAA"
     polyA_site      2129
                     /gene="SNW1"
                     /gene_synonym="Bx42; FUN20; NCOA-62; Prp45; PRPF45; SKIIP;
                     SKIP; SKIP1"
                     /note="major polyA site"
ORIGIN      
        1 gtcgctcgcg ctggaagaag cggaagaaga tggcgctcac cagcttttta cctgcaccta
       61 ctcagctatc tcaggaccag cttgaggctg aagaaaaggc aagatcccag agatcacggc
      121 agacctcact ggtctcctcc cgaagagaac ctcccccgta cggataccgg aaaggctgga
      181 tacctcggtt attagaggat tttggagatg gaggtgcttt tccagagatc catgtggccc
      241 agtatccact ggatatggga cgaaagaaaa aaatgtcgaa tgcgctggcc attcaggtgg
      301 attctgaagg aaaaattaaa tatgatgcaa ttgctcgaca aggacagtca aaagacaagg
      361 tcatttatag caaatacact gacctggttc caaaggaggt tatgaatgca gatgatccag
      421 acctgcaaag gcccgatgaa gaagctatta aagagataac agaaaagaca agagtagcct
      481 tagaaaaatc tgtatcacag aaggtcgccg cagccatgcc agttcgagca gctgacaaat
      541 tggctcctgc tcagtatatc cgatacacac catctcagca aggagtggca ttcaactctg
      601 gagctaaaca gagggttatt cggatggtag aaatgcagaa agatccaatg gagcctccaa
      661 ggttcaagat taataagaaa attccccggg gaccaccttc tcctcctgcg cctgtcatgc
      721 attctcctag ccgaaagatg actgtaaagg aacaacaaga gtggaagatt cctccttgta
      781 tttctaactg gaaaaatgca aagggttata caattccatt agacaaacgt ctggctgctg
      841 atggaagagg actacagaca gtacacataa atgaaaattt cgccaaattg gcagaagccc
      901 tctacattgc tgatcggaag gctcgtgaag ctgtggaaat gcgtgcccaa gtagagagaa
      961 aaatggctca gaaagaaaag gaaaaacatg aagagaaact tagagaaatg gcccagaaag
     1021 ccagggagag aagagctggg atcaaaactc atgtggaaaa agaggatggg gaggcacgtg
     1081 agagggatga aatccggcat gacaggcgaa aagagagaca gcatgaccgg aatctttcca
     1141 gggcagctcc tgataagagg tcgaaacttc agagaaatga aaatcgggat atcagtgaag
     1201 ttattgctct cggtgttcct aatcctcgga cttccaatga agttcagtat gaccaaaggc
     1261 tcttcaacca atccaagggt atggacagtg gatttgcagg tggagaagat gaaatttata
     1321 atgtttatga tcaagcctgg agaggtggta aagatatggc ccagagtatt tataggccca
     1381 gtaaaaatct ggacaaggac atgtatggtg atgacctaga agccagaata aagaccaaca
     1441 gatttgttcc cgacaaggag ttttctggtt cagaccgtag acagagaggc cgagaaggac
     1501 cagtgcagtt tgaggaagat ccttttggtt tggacaagtt tttggaagaa gccaaacagc
     1561 atggtggctc taaaagaccc tcagatagca gccgccccaa ggaacacgag catgaaggca
     1621 agaagaggag gaaggaatag gcacaggtct ctccaaagtg aatgaactct tacccataac
     1681 cctaatgatg caagtcatat gggggaacac tttgtaaatg gtcaggataa aaaccaaatc
     1741 tgggtgccag atcccagcac tactttttat tactggagaa atggggggga tagaaaattc
     1801 tactttgaat tatttagttt tttttaaaga gtgggttgtg tttgtgcttc tcccaccttt
     1861 cagcatttat agaacatgct gccccacata caaagtcaag accacttact tttatgtgac
     1921 actagtagtt tggggttaat gttttgtgta agaacagctg catatgagta aagttacccc
     1981 aaccacagtg aggaggaaga tgttcacata ctggaactgt cctgccaaat aaattttgcc
     2041 cctattgtgc tctgttttaa tttggagtgg gcaaagtaac ctcttgcttg gtgcaactat
     2101 ttgtttcaaa taaaaacatt tagacaaaa
//
