LOCUS       NM_001003796            1458 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens small nuclear ribonucleoprotein 13 (SNU13), transcript
            variant 2, mRNA.
ACCESSION   NM_001003796
VERSION     NM_001003796.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1458)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 1458)
  AUTHORS   Singh,S., Vanden Broeck,A., Miller,L., Chaker-Margot,M. and
            Klinge,S.
  TITLE     Nucleolar maturation of the human small subunit processome
  JOURNAL   Science 373 (6560), eabj5338 (2021)
   PUBMED   34516797
REFERENCE   3  (bases 1 to 1458)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1458)
  AUTHORS   Charenton,C., Wilkinson,M.E. and Nagai,K.
  TITLE     Mechanism of 5' splice site transfer for human spliceosome
            activation
  JOURNAL   Science 364 (6438), 362-367 (2019)
   PUBMED   30975767
REFERENCE   5  (bases 1 to 1458)
  AUTHORS   Fasci,D., van Ingen,H., Scheltema,R.A. and Heck,A.J.R.
  TITLE     Histone Interaction Landscapes Visualized by Crosslinking Mass
            Spectrometry in Intact Cell Nuclei
  JOURNAL   Mol Cell Proteomics 17 (10), 2018-2033 (2018)
   PUBMED   30021884
REFERENCE   6  (bases 1 to 1458)
  AUTHORS   Chang,M.S., Sasaki,H., Campbell,M.S., Kraeft,S.K., Sutherland,R.,
            Yang,C.Y., Liu,Y., Auclair,D., Hao,L., Sonoda,H., Ferland,L.H. and
            Chen,L.B.
  TITLE     HRad17 colocalizes with NHP2L1 in the nucleolus and redistributes
            after UV irradiation
  JOURNAL   J Biol Chem 274 (51), 36544-36549 (1999)
   PUBMED   10593953
REFERENCE   7  (bases 1 to 1458)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
REFERENCE   8  (bases 1 to 1458)
  AUTHORS   Nottrott,S., Hartmuth,K., Fabrizio,P., Urlaub,H., Vidovic,I.,
            Ficner,R. and Luhrmann,R.
  TITLE     Functional interaction of a novel 15.5kD [U4/U6.U5] tri-snRNP
            protein with the 5' stem-loop of U4 snRNA
  JOURNAL   EMBO J 18 (21), 6119-6133 (1999)
   PUBMED   10545122
REFERENCE   9  (bases 1 to 1458)
  AUTHORS   Zhu,X. and Naz,R.K.
  TITLE     Fertilization antigen-1: cDNA cloning, testis-specific expression,
            and immunocontraceptive effects
  JOURNAL   Proc Natl Acad Sci U S A 94 (9), 4704-4709 (1997)
   PUBMED   9114055
REFERENCE   10 (bases 1 to 1458)
  AUTHORS   Saito,H., Fujiwara,T., Shin,S., Okui,K. and Nakamura,Y.
  TITLE     Cloning and mapping of a human novel cDNA (NHP2L1) that encodes a
            protein highly homologous to yeast nuclear protein NHP2
  JOURNAL   Cytogenet Cell Genet 72 (2-3), 191-193 (1996)
   PUBMED   8978773
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CF552526.1, D50420.1 and
            BI770951.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001003796.1.
            
            Summary: Originally named because of its sequence similarity to the
            Saccharomyces cerevisiae NHP2 (non-histone protein 2), this protein
            appears to be a highly conserved nuclear protein that is a
            component of the [U4/U6.U5] tri-snRNP. It binds to the 5' stem-loop
            of U4 snRNA. Two transcript variants encoding the same protein have
            been found for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 use different start codons but
            encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.67582.1,
                                           SRR5189661.62648.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000401959.6/ ENSP00000383949.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-601               CF552526.1         43-643
            602-1452            D50420.1           625-1475
            1453-1458           BI770951.1         436-441
FEATURES             Location/Qualifiers
     source          1..1458
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.2"
     gene            1..1458
                     /gene="SNU13"
                     /gene_synonym="15.5K; FA-1; FA1; NHP2L1; NHPX; OTK27;
                     SNRNP15-5; SPAG12; SSFA1"
                     /note="small nuclear ribonucleoprotein 13"
                     /db_xref="GeneID:4809"
                     /db_xref="HGNC:HGNC:7819"
                     /db_xref="MIM:601304"
     exon            1..74
                     /gene="SNU13"
                     /gene_synonym="15.5K; FA-1; FA1; NHP2L1; NHPX; OTK27;
                     SNRNP15-5; SPAG12; SSFA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..458
                     /gene="SNU13"
                     /gene_synonym="15.5K; FA-1; FA1; NHP2L1; NHPX; OTK27;
                     SNRNP15-5; SPAG12; SSFA1"
                     /note="non-histone chromosome protein 2-like 1; sperm
                     specific antigen 1; SNU13 homolog, small nuclear
                     ribonucleoprotein (U4/U6.U5); high mobility group-like
                     nuclear protein 2 homolog 1; NHP2 non-histone chromosome
                     protein 2-like 1; [U4/U6.U5] tri-snRNP 15.5 kD RNA binding
                     protein; U4/U6.U5 tri-snRNP 15.5 kDa protein"
                     /codon_start=1
                     /product="NHP2-like protein 1"
                     /protein_id="NP_001003796.1"
                     /db_xref="CCDS:CCDS33653.1"
                     /db_xref="GeneID:4809"
                     /db_xref="HGNC:HGNC:7819"
                     /db_xref="MIM:601304"
                     /translation="MTEADVNPKAYPLADAHLTKKLLDLVQQSCNYKQLRKGANEATK
                     TLNRGISEFIVMAADAEPLEIILHLPLLCEDKNVPYVFVRSKQALGRACGVSRPVIAC
                     SVTIKEGSQLKQQIQSIQQSIERLLV"
     exon            75..195
                     /gene="SNU13"
                     /gene_synonym="15.5K; FA-1; FA1; NHP2L1; NHPX; OTK27;
                     SNRNP15-5; SPAG12; SSFA1"
                     /inference="alignment:Splign:2.1.0"
     exon            196..1458
                     /gene="SNU13"
                     /gene_synonym="15.5K; FA-1; FA1; NHP2L1; NHPX; OTK27;
                     SNRNP15-5; SPAG12; SSFA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      560..565
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNU13"
                     /gene_synonym="15.5K; FA-1; FA1; NHP2L1; NHPX; OTK27;
                     SNRNP15-5; SPAG12; SSFA1"
                     /note="hexamer: TATAAA"
     polyA_site      583
                     /gene="SNU13"
                     /gene_synonym="15.5K; FA-1; FA1; NHP2L1; NHPX; OTK27;
                     SNRNP15-5; SPAG12; SSFA1"
                     /note="major polyA site"
     regulatory      1433..1438
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNU13"
                     /gene_synonym="15.5K; FA-1; FA1; NHP2L1; NHPX; OTK27;
                     SNRNP15-5; SPAG12; SSFA1"
                     /note="hexamer: AATAAA"
     polyA_site      1458
                     /gene="SNU13"
                     /gene_synonym="15.5K; FA-1; FA1; NHP2L1; NHPX; OTK27;
                     SNRNP15-5; SPAG12; SSFA1"
                     /note="major polyA site"
ORIGIN      
        1 cggtgcacgc gagtgcttct gaaacgtcag ctgcgctccc ctaggagtgc tgagcccgcg
       61 gaaccgcagc catgactgag gctgatgtga atccaaaggc ctatcccctt gccgatgccc
      121 acctcaccaa gaagctactg gacctcgttc agcagtcatg taactataag cagcttcgga
      181 aaggagccaa tgaggccacc aaaaccctca acaggggcat ctctgagttc atcgtgatgg
      241 ctgcagacgc cgagccactg gagatcattc tgcacctgcc gctgctgtgt gaagacaaga
      301 atgtgcccta cgtgtttgtg cgctccaagc aggccctggg gagagcctgt ggggtctcca
      361 ggcctgtcat cgcctgttct gtcaccatca aagaaggctc gcagctgaaa cagcagatcc
      421 aatccattca gcagtccatt gaaaggctct tagtctaaac ctgtggcctc tgccacgtgc
      481 tccctgccag cttcccccct gaggttgtgt atcatattat ctgtgttagc atgtagtatt
      541 ttcagctact ctctattgtt ataaaatgta gtactaaatc tggtttctgg atttttgtgt
      601 tgtttttgtt ctgttttaca gggttgctat cccccttcct ttcctccctc cctctgccat
      661 ccttcatcct tttatcctcc ctttttggaa caagtgttca gagcagacag aagcagggtg
      721 gtggcaccgt tgaaaggcag aaagagccag gagaaagctg atggagccag gacagagatc
      781 tggttccagc tttcagccac tagcttcctg ttgtgtgcgg ggtgtggtgg aattaaacag
      841 cattcattgt gtgtccctgt gcctggcaca cagaatcatt catacgtgtt caagtgatca
      901 aggggtttca tttgctcttg ggggattagg tatcatttgg ggaggaagca tgtgttctgt
      961 gaggttgttc ggctatgtcc aagtgtcgtt tactaatgta cccctgctgt ttgcttttgg
     1021 taatgtgatg ttgatgttct ccccctaccc acaaccatgc ccttgagggt agcagggcag
     1081 cagcatacca aagagatgtg ctgcaggact ccggaggcag cctgggtggg tgagccatgg
     1141 ggcagttgac ctgggtcttg aaagagtcgg gagtgacaag ctcagagagc atgaactgat
     1201 gctggcatga aggattccag gaagatcatg gagacctggc tggtagctgt aacagagatg
     1261 gtggagtcca aggaaacagc ctgtctctgg tgaatgggac tttctttggt ggacacttgg
     1321 caccagctct gagagccctt cccctgtgtc ctgccaccat gtgggtcaga tgtactctct
     1381 gtcacatgag gagagtgcta gttcatgtgt tctccattct tgtgagcatc ctaataaatc
     1441 tgttccattt tgatgaca
//
