LOCUS       NM_001080537            1574 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens sentan, cilia apical structure protein (SNTN),
            transcript variant 2, mRNA.
ACCESSION   NM_001080537 XM_930543
VERSION     NM_001080537.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1574)
  AUTHORS   Kubo,A., Yuba-Kubo,A., Tsukita,S., Tsukita,S. and Amagai,M.
  TITLE     Sentan: a novel specific component of the apical structure of
            vertebrate motile cilia
  JOURNAL   Mol Biol Cell 19 (12), 5338-5346 (2008)
   PUBMED   18829862
  REMARK    GeneRIF: Data suggest that sentan is the first molecular component
            of the ciliary tip to bridge the cell membrane and peripheral
            singlet microtubules, making the distal portion of the cilia narrow
            and stiff to allow for better airway clearance or ovum transport.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC136289.2.
            
            On May 17, 2019 this sequence version replaced NM_001080537.1.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon compared to variant 1. The resulting isoform (2) has the same
            N- and C-termini but is shorter compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138524.405607.1,
                                           DRR138524.493373.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000343837.8/ ENSP00000341442.3
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               AC136289.2         76280-76402
            124-158             AC136289.2         78367-78401
            159-298             AC136289.2         83330-83469
            299-1574            AC136289.2         87542-88817
FEATURES             Location/Qualifiers
     source          1..1574
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p14.2"
     gene            1..1574
                     /gene="SNTN"
                     /gene_synonym="S100A1L; S100AL; sentan"
                     /note="sentan, cilia apical structure protein"
                     /db_xref="GeneID:132203"
                     /db_xref="HGNC:HGNC:33706"
                     /db_xref="MIM:617832"
     exon            1..123
                     /gene="SNTN"
                     /gene_synonym="S100A1L; S100AL; sentan"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..457
                     /gene="SNTN"
                     /gene_synonym="S100A1L; S100AL; sentan"
                     /note="isoform 2 is encoded by transcript variant 2;
                     S100A-like protein"
                     /codon_start=1
                     /product="sentan isoform 2"
                     /protein_id="NP_001074006.1"
                     /db_xref="CCDS:CCDS33779.1"
                     /db_xref="GeneID:132203"
                     /db_xref="HGNC:HGNC:33706"
                     /db_xref="MIM:617832"
                     /translation="MGGCMHSTQDKSLHLEGDPNPSAAPTSTCAPRKMPKRISISKQL
                     ASVKALRKCSDLEKAIATTALIFRNSSDSDGKLEKAIAKDLLQTQFRNFAEGQETKPK
                     YREILSELDEHTENKLDFEDFMILLLSITVMSDLLQNIRNVKIMK"
     exon            124..158
                     /gene="SNTN"
                     /gene_synonym="S100A1L; S100AL; sentan"
                     /inference="alignment:Splign:2.1.0"
     exon            159..298
                     /gene="SNTN"
                     /gene_synonym="S100A1L; S100AL; sentan"
                     /inference="alignment:Splign:2.1.0"
     exon            299..1574
                     /gene="SNTN"
                     /gene_synonym="S100A1L; S100AL; sentan"
                     /inference="alignment:Splign:2.1.0"
     regulatory      694..699
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNTN"
                     /gene_synonym="S100A1L; S100AL; sentan"
                     /note="hexamer: AATAAA"
     polyA_site      729
                     /gene="SNTN"
                     /gene_synonym="S100A1L; S100AL; sentan"
                     /note="major polyA site"
ORIGIN      
        1 agaagatgag agaatgggtg gctgtatgca cagtacccag gacaaatctc tccacttgga
       61 aggagatccc aatccttctg cagccccaac atccacctgc gcacctagga aaatgcccaa
      121 aaggatttca atatccaaac aactggcttc agtgaaagct ctgaggaagt gctcagatct
      181 ggaaaaagct attgccacca ctgctctgat tttcagaaat tcttctgact ctgatggtaa
      241 acttgaaaaa gctattgcca aagatctgct gcaaacccaa tttaggaatt tcgcagaggg
      301 acaagaaacc aagccaaaat acagagagat cctttctgaa cttgatgagc acacagaaaa
      361 taagctagat tttgaagact tcatgatctt gctcttaagc atcactgtca tgtcagatct
      421 gctacaaaat atacggaatg taaaaattat gaaatgaaca gttttaaata tgctgtataa
      481 aataatggca aaagacagtg ttattaaaat gtttccatct tatttttgat taattgaata
      541 tatctatcat gcatctgaaa ttgcctagga tggttctgat tgctggtatt cagatccaat
      601 gtaactccaa atatttaccc atacacttca agaatgtttg aatgataagg tctctgtgtg
      661 ctttacaata ggatagattt gataccactg aataataaat ggcttttgct gagtcagtag
      721 cgacctagag cactctactt atagtcattg agtcactcat ttattcacta aacatttgtt
      781 gagcatctac ttgatggaac tgctgaggat acagtaatga attggccagg caattccttc
      841 cttcagacat gtttgcagaa gtctagcaga agagatagac attgaacaat ttttaaataa
      901 ttgcatacac agtataatta gaattgaaat aagggctata ggatgctaaa agagattatc
      961 acctgatcgg agttcaaagg tcagaaaagc tttactgaca ttctataaaa agcaaaaaaa
     1021 aaaaaattgg tccatggatg ccagggatat gggtgggaaa tggggctgtc cacaaatggc
     1081 acaaggggag ttttttattt tattttattt tattttattt tattttattt tgagacagag
     1141 ttttgctctt gttgcccagg ctggagtgca atggcacgat ctcagcttac tgcaacctcg
     1201 atctcccagg ttcaagtgat tctcctgcct cagcctcctg agtagctggg attacaggcg
     1261 tgtgccacga tgccaggcta attttttttg tatttttagt ggagacgggg tttcgccatg
     1321 tcggccaggc tggtctcgaa ctcctgacct caggtgatcc gcccacagcc tcccaaagtg
     1381 ctgggattac aggcttgagc caccaagtct ggccaagggg acttttaagg gggctggaaa
     1441 tggtctccat tttgattgtg aggtggtggc tacaagattg catgcatttg tcaaactcat
     1501 agaactgcac actgaaaaga gtgaattgta ctgtatgtca attataccta aataaatctg
     1561 acttaacaaa aaaa
//
