LOCUS       NM_018967               6344 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens syntrophin gamma 1 (SNTG1), transcript variant 1,
            mRNA.
ACCESSION   NM_018967
VERSION     NM_018967.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6344)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 6344)
  AUTHORS   Orvedahl,A., Sumpter,R. Jr., Xiao,G., Ng,A., Zou,Z., Tang,Y.,
            Narimatsu,M., Gilpin,C., Sun,Q., Roth,M., Forst,C.V., Wrana,J.L.,
            Zhang,Y.E., Luby-Phelps,K., Xavier,R.J., Xie,Y. and Levine,B.
  TITLE     Image-based genome-wide siRNA screen identifies selective autophagy
            factors
  JOURNAL   Nature 480 (7375), 113-117 (2011)
   PUBMED   22020285
REFERENCE   3  (bases 1 to 6344)
  AUTHORS   Eng,L., Ibrahim-zada,I., Jarjanazi,H., Savas,S., Meschian,M.,
            Pritchard,K.I. and Ozcelik,H.
  TITLE     Bioinformatic analyses identifies novel protein-coding
            pharmacogenomic markers associated with paclitaxel sensitivity in
            NCI60 cancer cell lines
  JOURNAL   BMC Med Genomics 4, 18 (2011)
   PUBMED   21314952
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6344)
  AUTHORS   Job,B., Bernheim,A., Beau-Faller,M., Camilleri-Broet,S., Girard,P.,
            Hofman,P., Mazieres,J., Toujani,S., Lacroix,L., Laffaire,J.,
            Dessen,P. and Fouret,P.
  CONSRTM   LG Investigators
  TITLE     Genomic aberrations in lung adenocarcinoma in never smokers
  JOURNAL   PLoS One 5 (12), e15145 (2010)
   PUBMED   21151896
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6344)
  AUTHORS   Hafner,A., Obermajer,N. and Kos,J.
  TITLE     gamma-1-syntrophin mediates trafficking of gamma-enolase towards
            the plasma membrane and enhances its neurotrophic activity
  JOURNAL   Neurosignals 18 (4), 246-258 (2010)
   PUBMED   21358174
  REMARK    GeneRIF: Brain-specific gamma1-syntrophin participates in
            gamma-enolase translocation towards the plasma membrane, a
            pre-requisite for its neurotrophic activity.
REFERENCE   6  (bases 1 to 6344)
  AUTHORS   Hogan,A., Yakubchyk,Y., Chabot,J., Obagi,C., Daher,E., Maekawa,K.
            and Gee,S.H.
  TITLE     The phosphoinositol 3,4-bisphosphate-binding protein TAPP1
            interacts with syntrophins and regulates actin cytoskeletal
            organization
  JOURNAL   J Biol Chem 279 (51), 53717-53724 (2004)
   PUBMED   15485858
REFERENCE   7  (bases 1 to 6344)
  AUTHORS   Bashiardes,S., Veile,R., Allen,M., Wise,C.A., Dobbs,M.,
            Morcuende,J.A., Szappanos,L., Herring,J.A., Bowcock,A.M. and
            Lovett,M.
  TITLE     SNTG1, the gene encoding gamma1-syntrophin: a candidate gene for
            idiopathic scoliosis
  JOURNAL   Hum Genet 115 (1), 81-89 (2004)
   PUBMED   15088139
  REMARK    GeneRIF: Observational study of genotype prevalence. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 6344)
  AUTHORS   Hogan,A., Shepherd,L., Chabot,J., Quenneville,S., Prescott,S.M.,
            Topham,M.K. and Gee,S.H.
  TITLE     Interaction of gamma 1-syntrophin with diacylglycerol kinase-zeta.
            Regulation of nuclear localization by PDZ interactions
  JOURNAL   J Biol Chem 276 (28), 26526-26533 (2001)
   PUBMED   11352924
REFERENCE   9  (bases 1 to 6344)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
REFERENCE   10 (bases 1 to 6344)
  AUTHORS   Piluso,G., Mirabella,M., Ricci,E., Belsito,A., Abbondanza,C.,
            Servidei,S., Puca,A.A., Tonali,P., Puca,G.A. and Nigro,V.
  TITLE     Gamma1- and gamma2-syntrophins, two novel dystrophin-binding
            proteins localized in neuronal cells
  JOURNAL   J Biol Chem 275 (21), 15851-15860 (2000)
   PUBMED   10747910
  REMARK    GeneRIF: suggests a differentiated role of a modified
            dystrophin-associated complex in the central nervous system
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC023762.8, DN995011.1,
            AL161971.1, AC087173.5 and AC090450.6.
            
            On Nov 22, 2018 this sequence version replaced NM_018967.4.
            
            Summary: The protein encoded by this gene is a member of the
            syntrophin family. Syntrophins are cytoplasmic peripheral membrane
            proteins that typically contain 2 pleckstrin homology (PH) domains,
            a PDZ domain that bisects the first PH domain, and a C-terminal
            domain that mediates dystrophin binding. This family member plays a
            role in mediating gamma-enolase trafficking to the plasma membrane
            and in enhancing its neurotrophic activity. Mutations in this gene
            are associated with idiopathic scoliosis. Alternatively spliced
            transcript variants have been found for this gene. [provided by
            RefSeq, Mar 2016].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1). Variants 1, 2 and 4 all encode isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.278654.1,
                                           SRR1660809.252032.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2146236
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000642720.2/ ENSP00000493900.1
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-266               AC023762.8         104383-104648
            267-499             DN995011.1         8-240
            500-500             AC023762.8         104882-104882
            501-1913            AL161971.1         130-1542
            1914-1914           AC087173.5         108176-108176       c
            1915-3770           AL161971.1         1544-3399
            3771-6344           AC090450.6         129416-131989
FEATURES             Location/Qualifiers
     source          1..6344
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q11.21"
     gene            1..6344
                     /gene="SNTG1"
                     /gene_synonym="G1SYN; SYN4"
                     /note="syntrophin gamma 1"
                     /db_xref="GeneID:54212"
                     /db_xref="HGNC:HGNC:13740"
                     /db_xref="MIM:608714"
     exon            1..825
                     /gene="SNTG1"
                     /gene_synonym="G1SYN; SYN4"
                     /inference="alignment:Splign:2.1.0"
     exon            826..900
                     /gene="SNTG1"
                     /gene_synonym="G1SYN; SYN4"
                     /inference="alignment:Splign:2.1.0"
     exon            901..954
                     /gene="SNTG1"
                     /gene_synonym="G1SYN; SYN4"
                     /inference="alignment:Splign:2.1.0"
     CDS             928..2481
                     /gene="SNTG1"
                     /gene_synonym="G1SYN; SYN4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     gamma1-syntrophin; syntrophin 4; gamma-1-syntrophin"
                     /codon_start=1
                     /product="gamma-1-syntrophin isoform 1"
                     /protein_id="NP_061840.1"
                     /db_xref="CCDS:CCDS6147.1"
                     /db_xref="GeneID:54212"
                     /db_xref="HGNC:HGNC:13740"
                     /db_xref="MIM:608714"
                     /translation="MDFRTACEETKTGICLLQDGNQEPFKVRLHLAKDILMIQEQDVI
                     CVSGEPFYSGERTVTIRRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIG
                     DAILQINGINVRKCRHEEVVQVLRNAGEEVTLTVSFLKRAPAFLKLPLNEDCACAPSD
                     QSSGTSSPLCDSGLHLNYHPNNTDTLSCSSWPTSPGLRWEKRWCDLRLIPLLHSRFSQ
                     YVPGTDLSRQNAFQVIAVDGVCTGIIQCLSAEDCVDWLQAIATNISNLTKHNIKKINR
                     NFPVNQQIVYMGWCEAREQDPLQDRVYSPTFLALRGSCLYKFLAPPVTTWDWTRAEKT
                     FSVYEIMCKILKDSDLLDRRKQCFTVQSESGEDLYFSVELESDLAQWERAFQTATFLE
                     VERIQCKTYACVLESHLMGLTIDFSTGFICFDAATKAVLWRYKFSQLKGSSDDGKSKI
                     KFLFQNPDTKQIEAKELEFSNLFAVLHCIHSFFAAKVACLDPLFLGNQATASTAASSA
                     TTSKAKYTT"
     exon            955..1089
                     /gene="SNTG1"
                     /gene_synonym="G1SYN; SYN4"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1146
                     /gene="SNTG1"
                     /gene_synonym="G1SYN; SYN4"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1204
                     /gene="SNTG1"
                     /gene_synonym="G1SYN; SYN4"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1248
                     /gene="SNTG1"
                     /gene_synonym="G1SYN; SYN4"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1290
                     /gene="SNTG1"
                     /gene_synonym="G1SYN; SYN4"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1393
                     /gene="SNTG1"
                     /gene_synonym="G1SYN; SYN4"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1476
                     /gene="SNTG1"
                     /gene_synonym="G1SYN; SYN4"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1607
                     /gene="SNTG1"
                     /gene_synonym="G1SYN; SYN4"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1737
                     /gene="SNTG1"
                     /gene_synonym="G1SYN; SYN4"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1776
                     /gene="SNTG1"
                     /gene_synonym="G1SYN; SYN4"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..1893
                     /gene="SNTG1"
                     /gene_synonym="G1SYN; SYN4"
                     /inference="alignment:Splign:2.1.0"
     exon            1894..1965
                     /gene="SNTG1"
                     /gene_synonym="G1SYN; SYN4"
                     /inference="alignment:Splign:2.1.0"
     exon            1966..2118
                     /gene="SNTG1"
                     /gene_synonym="G1SYN; SYN4"
                     /inference="alignment:Splign:2.1.0"
     exon            2119..2211
                     /gene="SNTG1"
                     /gene_synonym="G1SYN; SYN4"
                     /inference="alignment:Splign:2.1.0"
     exon            2212..2322
                     /gene="SNTG1"
                     /gene_synonym="G1SYN; SYN4"
                     /inference="alignment:Splign:2.1.0"
     exon            2323..6344
                     /gene="SNTG1"
                     /gene_synonym="G1SYN; SYN4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6319..6324
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNTG1"
                     /gene_synonym="G1SYN; SYN4"
                     /note="hexamer: AATAAA"
     polyA_site      6344
                     /gene="SNTG1"
                     /gene_synonym="G1SYN; SYN4"
                     /note="major polyA site"
ORIGIN      
        1 atttctggca ttaggaaact cgtgcagggc cactgaaaag tcaggggagg ctcagatgtt
       61 atttcccagg gattcctgtt tttccagaaa cgttgtcacc aaataagtat gagactgtta
      121 atttggagaa acaattagcc cctacaaaaa aaaaaaagaa agaaaaaaga aaaaaaaaag
      181 aaccggaggg gagaaggcta gggcggaaga caaggaagct gctgcttgga ttcgctggtg
      241 gaggaaagtg cgacctggac ctgcgcttag gggctcccgt ccccttactt cagcaccaga
      301 ggggatggac agcgtctccg gactgagctg cagccacagg gacggaacta cgctgccgcc
      361 gccgctgtcc ttgccgccac tgtcgtcgcc acgggcagct gggctacttg ctcctcgcag
      421 ctaaaaggcg gtgcctccta ttaccccctc gcctcccggc ccccttcctt aatggatgaa
      481 aagtacccct ccctctacac ctgctgtacc taaggacagg actctgagga gtactcttgc
      541 tccacagatt aaactctcag cagcaacttc aagaatcatt tttctatagg ggtctgggag
      601 gaattctgga ggagagtaaa gtcgaagttc ttagaagctc tgagaaatca tgggccgtgc
      661 ggtaggggtt gaaatgctca aaggtccaca cttcttgaaa taaacagaat ggtcttgagt
      721 ggattgcaac tgttttggaa atagctttgt gaaaagaggg tggagagcta ctcaaaattc
      781 tacgttagag agactgaaaa gacatctaat ttcattgctc ggcagactgc tctccagaat
      841 gttgagattg cccgagaagt gaccccagca aaagaaaaat attgctgtac ctaaattcaa
      901 acgacatcct ttgtggtgcc acagcacatg gatttcagaa ccgcctgtga ggagacaaag
      961 acaggaattt gtttgctgca ggatggtaac caggagcctt tcaaagtgcg gctgcaccta
     1021 gccaaagaca ttttgatgat ccaggaacag gatgtgatat gtgtgtctgg tgagcctttc
     1081 tattctggtg aaagaacggt gaccatcaga agacaaacag taggaggatt tggattaagc
     1141 ataaagggag gagcagaaca taacattcca gttgtcgttt caaaaatctc caaggaacaa
     1201 agagcggaac tttcaggact actttttatt ggagatgcaa ttctacagat aaatggcatt
     1261 aatgtgagaa aatgtagaca tgaagaagtg gttcaggttc ttcggaatgc tggagaagaa
     1321 gtgactctaa cagtgtcatt tttaaaaaga gcacctgctt tcctcaaact cccattgaat
     1381 gaagattgtg catgtgctcc aagtgaccag agcagtggca cctcctctcc tctctgtgac
     1441 agtggcttac atctcaacta ccatcccaac aatacagaca cattatcatg ctcgtcgtgg
     1501 ccgacgtctc caggcttgag gtgggagaag cgatggtgcg acctcagact gatccctcta
     1561 cttcattcgc gcttctctca gtatgtgccc ggcacagatt tgagtcggca gaatgccttt
     1621 caagtcattg ctgtggatgg ggtctgcact gggattattc agtgcctctc tgctgaagac
     1681 tgcgttgact ggctacaagc aatagcaact aacatttcaa atctcacaaa gcacaatatt
     1741 aaaaaaatca acagaaactt tcctgtaaac cagcagattg tctacatggg ctggtgtgaa
     1801 gcccgggagc aagaccccct ccaggacaga gtgtactccc cgaccttcct ggccctgagg
     1861 ggctcatgtc tctacaagtt tctggcacct ccagtgacca cctgggactg gacgagagca
     1921 gagaaaacat tctcagttta tgagattatg tgcaagatcc tcaaggacag tgacctgctg
     1981 gaccgacgga aacagtgctt caccgtgcag tctgagtctg gggaggacct gtacttctca
     2041 gtggagctgg aaagtgacct cgcccagtgg gaaagagcct tccagacagc aacctttcta
     2101 gaagtagaac ggatacagtg caagacctat gcatgtgtgc tagaaagtca tctaatggga
     2161 ctcacaattg atttcagcac aggatttatc tgctttgatg ctgcaacaaa ggctgtcctt
     2221 tggaggtata aattctctca gcttaaaggt tcttcagatg atggcaagag caaaatcaaa
     2281 tttttgtttc agaatccaga tactaaacag attgaagcaa aggagttgga attttctaat
     2341 ttatttgctg ttcttcactg cattcattcc ttctttgctg ccaaggtagc ttgtttggac
     2401 cctctatttt taggcaatca agctactgct tctactgctg ccagctctgc taccacgagc
     2461 aaagcaaagt atacaacttg acatactgaa ctcttcattg acacacccca tgactgtata
     2521 agcaggacac atttactcat cattttagac cctagagaaa ccataacatc accaagtcga
     2581 cagtggaggc aaatcaaaat ttcggcagaa aaagaaggtc atgtggaacc tcaaaaacac
     2641 ttctattctg gatgacatct gtgaaatata ctacatgaac agaacagctt gttctcactc
     2701 agttgctttg taccagtaag tgtattgctt tcaccaaaag tggagacaaa agaataaatt
     2761 atttgaagaa gtatgtaaat aacataaaaa tagtaagcta cctatgaata aaaatactta
     2821 ttaaatgatt acttctgtat tttagattat tttgtatgac tagtacatgt tgggcagagt
     2881 cataggaaaa caaatgccct atcttgtatt atgagggaca taaaagagtt aaaaaccata
     2941 aatcagcaag gagcatgcaa aaaaatctca tcaaagaagg atgcacttta atttgctgat
     3001 gtaaatttgc ccttgtgttc tcatcccatg atttgacact ggcattccaa ttgtttttat
     3061 cttattgtaa atattccgaa gaacttccaa aggataatta cattgaccca tgatagatac
     3121 aatgtgaaat ggactattct cccttggatc actgttattg aaatgtctta ttagctgcca
     3181 aagtcaatca aatatgccaa cagtgtatta atttaattat gagtgatgga aaatttcatg
     3241 aacctctcat ttcttccttg gtttgaaaga gatttgtatt ttacctaata agatttatta
     3301 tcaaattaaa gtttcataaa ttttcagtga acccaaaacc ttttgtagag aaaataatat
     3361 aaacaaatat ggtgtgagaa acaattcttt gtaatccgaa gtctactagt taatcatgaa
     3421 ctaaaatgtc ccccgaaaac agtcccaaag ctattataga tgttaattaa atgacatttt
     3481 ttcattttag tactatttta tgagaaacaa aggtgatatt taaagataaa agttaaaatt
     3541 ctttaacctc ccttgtcatg gaaagtgatt aagtaatgcc aactatgcag gttgttttag
     3601 gtattttgtc ctaagaatgt aaatgtgaaa ggctgggaaa tttgaaagcc ttagaggtgt
     3661 gcaatttact cagattccag gtattattca actagttgta taacatggaa cacagtctct
     3721 gtccttcagt acagcttttt tgagatattt taaaaagtca gctgtgtatg taaaaaaaaa
     3781 aaaaaatttt tattgataca catgctccca ggtaaaccaa gtattatgtg tgtccttgtg
     3841 gagataacca agtatctaat aaattgattc aatttttttt ttcaaatatg tttttaaaaa
     3901 tcactcaaga aggaaacaaa gtgatttcta taaaggacag atttactaat ttaaaaaatt
     3961 aatatcaagt tgtttttata ctcatgattc attaatttat tttgcatcag attaatttgt
     4021 aaatacatca aattgaaaag aaaaagtgag ggtttataat tgtccctggg aaaatgttaa
     4081 actgaatcta acatacctta cccaaagaac tgtggcaaat tacaataaac agtttcagtg
     4141 taatgtattt tgaccgtaaa actaagtaca catttgtaat taggatagaa ctttagaatt
     4201 attgcacact atattgatca aatacaacag tcattgtaaa attgaaaccc accaaaagca
     4261 gccttcagta gtaggccact tctgaactta tggagaaaaa gcagtgggat acatcgaact
     4321 tagaattttc agctgtggca agtggttcat tatggaactt ctgcttccaa ccagagctga
     4381 atctcagtgt gccccatatt ggggttacat gaatgtgtcc acaatctgga aggcaatatg
     4441 acatgggcta attatccata agcaaaagaa aaacgtttca acagtttacc tacctgtaat
     4501 agaatgattt aaaaattgtg aaattttgta aacgttccat tttagaattt aaaaaaccta
     4561 ttaaccatta gctatctttt tagtgttatt atgaaaattt agcctatgct catgtgtgtt
     4621 acgaaggaaa aggtgcacaa tgagatatgt ataaatatat atctcctcag agaatacaca
     4681 cacacctaca tatgtattta tatgcataca tgggtgtata tatatataaa tataatgaaa
     4741 tgctgaccat taattatatt agaagaatgt tttgtgtaca tacatttaat atactttaaa
     4801 ttacgttgta aaatgtagct tgattaaaaa cttatgacaa taccattatg aatatttttg
     4861 atactattga taaaaaacat aagccgtgat ttttatttaa catgattagt acaacagcca
     4921 aaaagtaaca aaatactatt ctcgttttca tcagtttaac aattagtatt taatgttttc
     4981 tttacaatgt ggtgattagt cattggcatt tgttataact tggactactt gaatgagaaa
     5041 gctttgaaat gaacaaaaac acttaaaaat ttctatctct catataattt aggtttacat
     5101 gtaagagatt tattcataaa atcctagttt gtacattaag cacattttaa cagcaaaatg
     5161 ctaatgtgtt aacccctcca gtgccttggt atgtgtgagc gtgtatgtgt gtttgggtgt
     5221 gtgtctgtgt atgtgtgtga gtgtgtaagt gttatcatta aagggttcat tacagtgtac
     5281 ataacacaag cttaatggag aatattgtag gtatttaggt cagagaatga agttcaaagt
     5341 catttgaaaa ctgctaacta ctataataat gtcttttgcc tgataaagaa taacaattca
     5401 tctaagtcga agtatattac agaaagggca tttataattt gttaaaatgc aacaagtatt
     5461 tatttaaaaa atagtttaat agatagtgta agtgtaatgt atatctgaac acttatccag
     5521 cttttttaaa atgggaggat aatcaggtaa ttatttcttg cccatatttc aggcatgtac
     5581 caacttataa ttttgaaatc ttcgctcata aagctgtcat tcagcaagaa aaagaaagca
     5641 attacttgaa aataaatgtc aagtccatat tagccatgca aagagagaaa ttttcctttg
     5701 ggtgcattag tttatagatc aacatttccc tcatttacag tgctgaagct tgatcatgaa
     5761 ctttgtctat gttgaatgct ggatttaaga aaagcttgat ttattactga gaaaaattaa
     5821 taatcctaac gataatttag aattactgct agaaatcagc agtgtggaga agctttaaaa
     5881 gcacaaggat gatcttgtgc ttaacttttt aaggtaagtg tagatgttcg gatactaata
     5941 acaaagattt tgctactatt aatattgctg tgctcataat ttctccttat gaaattgctt
     6001 tattcatact tctaaaattg ttctttattg tttattctta ctaccgaata ctttaaaatc
     6061 ataatgccac ttatttgcac atttgaattt gcttttgaaa ataaaatatt ataaatgtta
     6121 tatattttat acatgttaaa atgcagtgaa aagacaagaa atataaaatg taaatatatt
     6181 tatttcattt ttaattgttt tggtggatgt ttgtaaaatg taaattaata tctgtgacaa
     6241 aaatttgtca cttcattctt tcagttcatt aatgtactac taatgaaacc atactttttt
     6301 aaatgaagca tactggaaaa taaaaacaaa tactttttac taga
//
