LOCUS       NM_006750               9754 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens syntrophin beta 2 (SNTB2), transcript variant 1, mRNA.
ACCESSION   NM_006750 XM_003118481
VERSION     NM_006750.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9754)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 9754)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 9754)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   4  (bases 1 to 9754)
  AUTHORS   Krautbauer,S., Neumeier,M., Rein-Fischboeck,L., Haberl,E.M.,
            Tilg,H., Eisinger,K. and Buechler,C.
  TITLE     Adipocyte Hypertrophy and Improved Postprandial Lipid Response in
            Beta 2 Syntrophin Deficient Mice
  JOURNAL   Cell Physiol Biochem 52 (5), 1151-1165 (2019)
   PUBMED   30990585
  REMARK    GeneRIF: Current study shows that high SNTB2 in obese adipose
            tissues restricts adipocyte growth and thereby may contribute to
            metabolic diseases.
REFERENCE   5  (bases 1 to 9754)
  AUTHORS   Schmidt,C., Wiedmann,F., El-Battrawy,I., Fritz,M., Ratte,A.,
            Beller,C.J., Lang,S., Rudic,B., Schimpf,R., Akin,I., Karck,M.,
            Borggrefe,M., Katus,H.A., Zhou,X.B. and Thomas,D.
  TITLE     Reduced Na+ Current in Native Cardiomyocytes of a Brugada Syndrome
            Patient Associated With beta-2-Syntrophin Mutation
  JOURNAL   Circ Genom Precis Med 11 (11), e002263 (2018)
   PUBMED   30571189
  REMARK    GeneRIF: Reduced Na(+) Current in Native Cardiomyocytes of a
            Brugada Syndrome Patient Associated With beta-2-Syntrophin
            Mutation.
REFERENCE   6  (bases 1 to 9754)
  AUTHORS   Garcia,R.A., Vasudevan,K. and Buonanno,A.
  TITLE     The neuregulin receptor ErbB-4 interacts with PDZ-containing
            proteins at neuronal synapses
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3596-3601 (2000)
   PUBMED   10725395
REFERENCE   7  (bases 1 to 9754)
  AUTHORS   Lumeng,C., Phelps,S., Crawford,G.E., Walden,P.D., Barald,K. and
            Chamberlain,J.S.
  TITLE     Interactions between beta 2-syntrophin and a family of
            microtubule-associated serine/threonine kinases
  JOURNAL   Nat Neurosci 2 (7), 611-617 (1999)
   PUBMED   10404183
REFERENCE   8  (bases 1 to 9754)
  AUTHORS   Gee,S.H., Madhavan,R., Levinson,S.R., Caldwell,J.H., Sealock,R. and
            Froehner,S.C.
  TITLE     Interaction of muscle and brain sodium channels with multiple
            members of the syntrophin family of dystrophin-associated proteins
  JOURNAL   J Neurosci 18 (1), 128-137 (1998)
   PUBMED   9412493
REFERENCE   9  (bases 1 to 9754)
  AUTHORS   Ahn,A.H., Freener,C.A., Gussoni,E., Yoshida,M., Ozawa,E. and
            Kunkel,L.M.
  TITLE     The three human syntrophin genes are expressed in diverse tissues,
            have distinct chromosomal locations, and each bind to dystrophin
            and its relatives
  JOURNAL   J Biol Chem 271 (5), 2724-2730 (1996)
   PUBMED   8576247
REFERENCE   10 (bases 1 to 9754)
  AUTHORS   Ahn,A.H., Yoshida,M., Anderson,M.S., Feener,C.A., Selig,S.,
            Hagiwara,Y., Ozawa,E. and Kunkel,L.M.
  TITLE     Cloning of human basic A1, a distinct 59-kDa dystrophin-associated
            protein encoded on chromosome 8q23-24
  JOURNAL   Proc Natl Acad Sci U S A 91 (10), 4446-4450 (1994)
   PUBMED   8183929
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC009131.6, AC026474.7 and
            AC026464.7.
            
            On Apr 8, 2021 this sequence version replaced NM_006750.3.
            
            Summary: Dystrophin is a large, rod-like cytoskeletal protein found
            at the inner surface of muscle fibers. Dystrophin is missing in
            Duchenne Muscular Dystrophy patients and is present in reduced
            amounts in Becker Muscular Dystrophy patients. The protein encoded
            by this gene is a peripheral membrane protein found associated with
            dystrophin and dystrophin-related proteins. This gene is a member
            of the syntrophin gene family, which contains at least two other
            structurally-related genes. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the protein-coding
            transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14372080.434697.1,
                                           SRR14038192.3323882.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000336278.9/ ENSP00000338191.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-583               AC009131.6         36945-37527         c
            584-797             AC026474.7         172741-172954       c
            798-1008            AC026474.7         158296-158506       c
            1009-1151           AC026474.7         148271-148413       c
            1152-1348           AC026464.7         9168-9364
            1349-1533           AC026464.7         24710-24894
            1534-9754           AC026464.7         25952-34172
FEATURES             Location/Qualifiers
     source          1..9754
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..9754
                     /gene="SNTB2"
                     /gene_synonym="D16S2531E; EST25263; SNT2B2; SNT3; SNTL"
                     /note="syntrophin beta 2"
                     /db_xref="GeneID:6645"
                     /db_xref="HGNC:HGNC:11169"
                     /db_xref="MIM:600027"
     exon            1..583
                     /gene="SNTB2"
                     /gene_synonym="D16S2531E; EST25263; SNT2B2; SNT3; SNTL"
                     /inference="alignment:Splign:2.1.0"
     CDS             4..1626
                     /gene="SNTB2"
                     /gene_synonym="D16S2531E; EST25263; SNT2B2; SNT3; SNTL"
                     /note="syntrophin, beta 2 (dystrophin-associated protein
                     A1, 59kDa, basic component 2); dystrophin-associated
                     protein A1, 59kD, basic component 2; syntrophin-3; 59 kDa
                     dystrophin-associated protein A1 basic component 2"
                     /codon_start=1
                     /product="beta-2-syntrophin"
                     /protein_id="NP_006741.1"
                     /db_xref="CCDS:CCDS10873.1"
                     /db_xref="GeneID:6645"
                     /db_xref="HGNC:HGNC:11169"
                     /db_xref="MIM:600027"
                     /translation="MRVAAATAAAGAGPAMAVWTRATKAGLVELLLRERWVRVVAELS
                     GESLSLTGDAAAAELEPALGPAAAAFNGLPNGGGAGDSLPGSPSRGLGPPSPPAPPRG
                     PAGEAGASPPVRRVRVVKQEAGGLGISIKGGRENRMPILISKIFPGLAADQSRALRLG
                     DAILSVNGTDLRQATHDQAVQALKRAGKEVLLEVKFIREVTPYIKKPSLVSDLPWEGA
                     APQSPSFSGSEDSGSPKHQNSTKDRKIIPLKMCFAARNLSMPDLENRLIELHSPDSRN
                     TLILRCKDTATAHSWFVAIHTNIMALLPQVLAELNAMLGATSTAGGSKEVKHIAWLAE
                     QAKLDGGRQQWRPVLMAVTEKDLLLYDCMPWTRDAWASPCHSYPLVATRLVHSGSGCR
                     SPSLGSDLTFATRTGSRQGIEMHLFRVETHRDLSSWTRILVQGCHAAAELIKEVSLGC
                     MLNGQEVRLTIHYENGFTISRENGGSSSILYRYPFERLKMSADDGIRNLYLDFGGPEG
                     ELTMDLHSCPKPIVFVLHTFLSAKVTRMGLLV"
     exon            584..797
                     /gene="SNTB2"
                     /gene_synonym="D16S2531E; EST25263; SNT2B2; SNT3; SNTL"
                     /inference="alignment:Splign:2.1.0"
     exon            798..1008
                     /gene="SNTB2"
                     /gene_synonym="D16S2531E; EST25263; SNT2B2; SNT3; SNTL"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1151
                     /gene="SNTB2"
                     /gene_synonym="D16S2531E; EST25263; SNT2B2; SNT3; SNTL"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1348
                     /gene="SNTB2"
                     /gene_synonym="D16S2531E; EST25263; SNT2B2; SNT3; SNTL"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1533
                     /gene="SNTB2"
                     /gene_synonym="D16S2531E; EST25263; SNT2B2; SNT3; SNTL"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..9754
                     /gene="SNTB2"
                     /gene_synonym="D16S2531E; EST25263; SNT2B2; SNT3; SNTL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5963..5968
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNTB2"
                     /gene_synonym="D16S2531E; EST25263; SNT2B2; SNT3; SNTL"
                     /note="hexamer: ATTAAA"
     polyA_site      5990
                     /gene="SNTB2"
                     /gene_synonym="D16S2531E; EST25263; SNT2B2; SNT3; SNTL"
     regulatory      9733..9738
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNTB2"
                     /gene_synonym="D16S2531E; EST25263; SNT2B2; SNT3; SNTL"
                     /note="hexamer: AATAAA"
     polyA_site      9754
                     /gene="SNTB2"
                     /gene_synonym="D16S2531E; EST25263; SNT2B2; SNT3; SNTL"
                     /note="major polyA site"
ORIGIN      
        1 ggaatgaggg tagctgcggc gactgcggcg gctggagcgg ggccggccat ggcggtgtgg
       61 acgcgggcca ccaaagcggg gctggtggag ctgctcctga gggagcgctg ggtccgagtg
      121 gtggccgagc tgagcgggga gagcctgagc ctgacgggcg acgccgccgc ggccgagctg
      181 gagcccgctc tgggacccgc ggccgccgcc ttcaacggcc tcccaaacgg cggcggcgcg
      241 ggcgactcgc tgcccgggag cccaagccgc ggcctggggc ccccgagccc gccggcgccg
      301 cctcggggcc ccgcgggtga ggcgggcgcg tcgccgcccg tgcgccgggt gcgggtggtg
      361 aagcaagagg cgggcggcct gggcatcagc atcaagggcg gccgcgagaa ccggatgccg
      421 atcctcatct ccaagatctt ccccgggctg gctgccgacc agagccgggc gctgcggctg
      481 ggcgacgcca tcctgtcggt gaacggcacc gacctgcgcc aggccaccca cgaccaggcc
      541 gtgcaggcgc tgaagcgcgc gggcaaggag gtgctgctgg aggtcaagtt catccgagaa
      601 gtaacaccat atatcaagaa gccatcatta gtatcagatc tgccgtggga aggtgcagcc
      661 ccccagtcac caagctttag tggcagtgag gactctggtt cgccaaaaca ccagaacagc
      721 accaaggaca ggaagatcat ccctctcaaa atgtgctttg ctgctagaaa cctaagcatg
      781 ccggatctgg aaaacagatt gatagagcta cattctcctg atagcaggaa cacgttgatc
      841 ctacgctgca aagatacagc cacagcacac tcctggttcg tagctatcca caccaacata
      901 atggctctcc tcccacaggt gttggctgaa ctcaacgcca tgcttggggc aaccagtaca
      961 gcaggaggca gtaaagaggt gaagcatatt gcctggctgg cagaacaggc aaaactagat
     1021 ggtggaagac agcaatggag acctgtcctc atggctgtga ctgagaagga tttgctgctc
     1081 tatgactgta tgccgtggac aagagatgcc tgggcgtcac catgccacag ctacccactt
     1141 gttgccacca ggttggttca ttctggctcc ggatgtcgat ccccctccct tggatctgac
     1201 cttacatttg ctaccaggac aggctctcga cagggcattg agatgcatct cttcagggtg
     1261 gagacacatc gggatctgtc atcctggacc aggatacttg ttcagggttg ccatgctgct
     1321 gctgagctga tcaaggaagt ctctctaggc tgcatgttaa atggccaaga ggtgaggctt
     1381 actattcact atgaaaatgg gttcaccatc tcaagggaaa atggaggctc cagcagcata
     1441 ttgtaccgct acccctttga aaggctgaag atgtctgctg atgatggcat ccgaaatcta
     1501 tacttggatt ttggtggtcc cgagggagaa ctgaccatgg acctgcactc ttgtccgaag
     1561 ccgattgtat ttgtgttgca cacgttttta tcggccaaag tcactcgtat gggactgctt
     1621 gtatgagcaa caaaaaatca gaaaagagcc ttgactgtca caagaaatat ttccacctca
     1681 aaaaaaaaaa agcacaaaaa gaaactcttt gctctccttc agcacagtgc cttcccaagg
     1741 acctgcaaat aactgctgaa ccataaccgt gtttaaagaa gagcctacct ttcacagtct
     1801 accttggcca gatattctag cactctaaaa ggctccaaaa tgaagctgtt gatttattct
     1861 catttcaaaa tatggtttat gagtaattag gtttatttct actgctaaaa agaatggctc
     1921 attgttttct ttttttttca ttgttttcat ttttagacat aatcaaatac ccaagcattg
     1981 ttttcttttt cttctccctg taggatttgt gttgtgctta gccttgatct cttgttcaga
     2041 acaattgtcc cttcccaggt gctagcttgc agcagcctgt tgcttcctga gcattccaga
     2101 taggtcgtat gtcttggaat ttactgtcct cactagctcc ttccaccata ggaagtcctt
     2161 gaattgtatc accaaagggt tgttccattt gccctggatc tccctctatc tcagcctggc
     2221 catcacttcc caccttatcc caagctttgc cactgtctct aggacttaga acttgtaaat
     2281 ttgatttgcc ttgccttcta cttcctttct agtggtgact gagttgaaaa gcaagttgga
     2341 agccactgct tttaaagaaa agttttgctt ggtttaggtt tttccaattt tatttttgtt
     2401 aggagccagg ggataagatt tattttaaat gaaaatcctc ttcctaggtt aagccatttt
     2461 ttttattgct taccaaatgt gcctttggtt agggttagtg gagctttatt agtcactatt
     2521 tgaataactg gaaatcactg ccatttccag gagatcacct atcctagttt tgaggaatag
     2581 tcattgaggt gggtttcctt aatggcatct cttctagtag gcagatctgt ttgaacaaga
     2641 taaatcctaa agagccagcc tgcttgagga gtagacttgg tgggtgaagc cagcaattcc
     2701 gcacaaacgt catgttgaat tgttttgggc tgcccaaaaa caacaggatg cagcatcctg
     2761 gctgtggcct ggccctttgt ggcagcagtg gcatggacaa gcaactgcta attcgagact
     2821 tactattggc ttcacagcac accctacagt gagcagggtg atgagaccgt ggaacagcta
     2881 cctgcttttg gttaagattg ccagatatca ttaggacaca gtagcagcaa gaatgctgat
     2941 tttgtagtgt tagaaaatga actcagcttg tttttcctaa ttttgaaggt ggtatatatc
     3001 tgcaaacatt taaaatggta taatatcata taaaatgtca aaattagcac agtccctgga
     3061 tctcaaagaa taggtaatat tgacttggat gttctttatg ctctctgaag aaaggtctag
     3121 ggaaagttct tgtttgcttg attgatcaag agtgccacgg aagaatgtga gcgctgtgga
     3181 gggtggagga gggtgtcact tcagatgggg caggcacagg gggagaaaag aagagaaaaa
     3241 cacacctgtg tgcaaaatga gctatttggt ttcagtgcgg cctgaccgat ggggaggacc
     3301 catgagcaga gagagttcta ggtcaacatt gtaactccat tgtcctcctt cacccataag
     3361 tcagtcctcc ttcctcatta cagtgaaacc aacaatatgc agaggttggg gagagatgcc
     3421 tgttcttccc ccagcttcat ataattgtca aagttccaaa aatgaattat ctgaactgct
     3481 taaaactgga aattaaaatc tagacaagaa tatgtctttc aagagctttt tatgttttga
     3541 aagttcataa acctaagatt ggctccatct gagataaatt ttcttttctt tttttttttg
     3601 agacggagtc tcgttctgtc tcccaggctg gagtgcagtg gcatgatctc ggctcactgc
     3661 aacctccacc tcctaggttc aagtgattct cctgagtagc tggggttata gctacccacc
     3721 accacaccca gctaattttt gtatttttag tagaggcagg ttttcaccat gttggctagg
     3781 ctggtcttga actcccgacc tcaagtgatc cacctgcctt ggcctcccaa agtgctggga
     3841 ttataggtgt gagcccccgt gcctggccca caataaattt tcatttcaga gaaggaaaaa
     3901 aatctcttga acgtccagaa atgatttctg gaatcagaat ttcaatatgt aataccctca
     3961 ggtaggcaat cttgaaccct ctatgcagtg agagcattat taatatgaga tgttgaatga
     4021 tgcctttaca gacttcagca gcaaagccat ttggttgagg ttttctgtgt taatgtgaaa
     4081 agctaagcca ctgagatttg caggggagct tctgagccac cctgcttgtt ggttatatga
     4141 ggatgtaaaa taggtggaat taaaatgtga gcaggaaagg caaggcatgt gtgcattttc
     4201 actcattttg gtcaaggtta aactgacatg tatagcactg aggtctgtag ggttcttaat
     4261 atcttttgag tcttgctgtg aaatgaaagt gtgggaggtt tcctttgtcc attagcagcc
     4321 ccaagaacca gaaccctttt gctgcttttc ttacatacct aacagctctc cagtcatgat
     4381 gaccaaggtt gttcttcaat caaatgtgtt tgtgggattt tcagtccgca aatgaagtgc
     4441 tctctaatga atgggacacc atgataaata tgtatttata tttagatgcc aaagtatggc
     4501 aaattatttc caaatgataa ctacaaatgg gaattttcga tattctacct tttttataga
     4561 accagctcac ttttcatttc tttttcattt tgaattaaga aaattgttga ggatgtggtg
     4621 ggttccagtg tgtggaatgg aaaggaaact gcagaatagt gtctgctccc cattcagagg
     4681 gactgcttcc tgtgcccccc agacccgggg cttcgacagc ttctccacat tccacacaga
     4741 tgcctaggag cagcgagttg gtatatgaaa agtctcccac cttttctcct aaaacttctc
     4801 tcctttctct ccataaaaag aaaaggaaag gaacaaaaga aaaacattca gtttttcttt
     4861 ttctgaaaaa ggtaagtcct ttcctgaagt catcaaatga aacattatct ggaaattagt
     4921 ttctaatgtt gtatatgaag aaatacttaa atataagttc ctgcagtatt tattagatag
     4981 ttgtaactgt aaactcacct ccctagtaga taagagtttc aggttaaata ctggaacata
     5041 tataggcagt caaaaatact actttaaatg tcattcacct attttaaagc catgttttag
     5101 cactttttag gccaaagaag gtctgatagt gcctgttttt atgttctgta ctctcacaaa
     5161 ctttgttact caaaattatt gcatggcagg agagattgga ttatttattt cttatatttt
     5221 tataagtaaa aaaatctttc taaacaacaa atacctaaca ttattactga ttgttttcct
     5281 aatttatcct cctaagttga atggtaacaa agcttttcca gctgaatgaa tgcacttagc
     5341 tgataaacca gaatttgttc ttttttttcc ttcttttttt tttgagacag gttctcactc
     5401 tgtcaccgag gttggagtgc agtggtatga tcatagctga ctgcagcctc aaccttctgg
     5461 gctcaaatga tcctttcacc tcagcctcct gagtagctgg gaccacaggt gtgtgccacc
     5521 acacctggct aatttttatg gatttttttt tctttttttt ttttcgccat gttgcccagg
     5581 ctggtcttga actcttggca ctcaagcagt ccttctgcct cagcctccca aagtgctggg
     5641 attacagatg tgagccactg cacctggccc cagaaattat gcttaaaaaa aaaattaagc
     5701 tgtgtggaat ctggacaagg ctatgtttct cctagaaaca ggttttgctg taaatggttt
     5761 tgatgggcga aagtgtgaga aaaggttata atagattctt ttttttaatt ttgtgagaaa
     5821 ttccaggtct tcttgcttaa cttatatgca tgtggatata tttgttttca aagccatgga
     5881 agaatctctg ttcatatatt ttaatgcaaa ttaccttgta tgctgctatg caaattctat
     5941 taaaaggcct acctgcttaa gaattaaaca tttttgaaac tttcagggaa gacctgtaga
     6001 ctcaagcact ttctctgctt ttttgtatct tatcttggac acttatgctg aattatgttc
     6061 ttattatttt cactggttat aagctattcc ttgtacataa tatttaaact atccaaatat
     6121 ccagcataca tttccatgtg gctgccatcg gctgttgatg ccatgaatga aatggctggt
     6181 tagaaagcca aaggtcttct tttttcaatt cctaatgaat aagtaaaatg ccagatctct
     6241 ttggtctcaa agcaaattgc tctgatcaga tcaaatatct atgtaatgaa aagagactta
     6301 cttaaatttg ggattctgct taaactttaa gttgaatttg actgtagtca ttcattcttt
     6361 ttatatatct ctgtcaggta tgacattaat taccaggtgg tattatactc tactttgagt
     6421 ttggacatca ctttcagtta aatttctgtt gttattgtgg cttttttttt tttttaaccc
     6481 cactgaagat ggaagtagag cagtctgcca tctcctgctg ttctttctct gtgcccccta
     6541 attgcttggt aatctaaaat tattctgact ttccacatac tgtctttaaa aaccaattgt
     6601 agcaatctgc ccgcctccac cctttaagct aaatctttca ctgtgctgga tacatagaca
     6661 ctcgataaat gtgtgatgat agttctaaaa taattatgct atatatcagg gttctgtatt
     6721 tttgagcaat atcattattc ctatgctgtg atgttaaatg gaatttattt tacactagta
     6781 atagactgct taagtggctg atttgaaacc tttctctaaa aaaacaaaaa catctggcag
     6841 atgagtgaca caaattcatt ctcttaaagg atagaatttc aagttaagga taaggcacaa
     6901 taaataggca catagaggac atctgttttt gtttttggtt ttggttttgt ttttttttgt
     6961 ctctctgact agctaaactg ccaactagaa gaatggttgt tatgtagtaa ctcagaagaa
     7021 tcttttaata agtttcttct tttgtttcaa aacaaacttg agcttcattt cttgccacct
     7081 ctattctttc ttcccacgtt gggtgactga actgatgctt attctagttt tagaagagga
     7141 tccacattta atgtaaggca taaatatgcc ttttgcaaat tattgcttgt tctccagtga
     7201 acatttgatc atattcaaca gaaatccacc atataaacca taatccttga attgcccctt
     7261 ttaaaataga ttggttaaaa ccaaaaacct ataagagaga aatgatattt cattgtattg
     7321 taggtttggg aatcctggtt agatttataa tttctggccg ggtgcggtgg ctcatgcctg
     7381 tattcccagt actttgggag cccaaggtgg gtggatcacc tgaggtaagg agtttgagac
     7441 cagcctggcc aacatggtga aaccccatct ctactaaaaa tacaaaaagt tagctgggca
     7501 tggtggtgcg cgcctgtggt cccagctact cgggaggctg aggtgggaga atcccttgaa
     7561 cccaggaggc agaagttgca gtgagctgag atcatgccat tgcactccag cctgggcaac
     7621 agagcgagac ttcatctcca aaaaaagaaa aagaagaaaa agatttataa tttctgagtc
     7681 ccctaagtcc ctttctcagt ttgcaataat cttacgtcca tgctattgac actaattttg
     7741 aaactggaaa gctaattaat gacatattca tgtgttcttt catctaataa acatttatta
     7801 atgtatagtt ctacaccagg cattctgaag ggtccaaaag aaagttcctg ccctctagta
     7861 gcacataatc cgttatttct cagcacacca tgccatctgt ttatcattca gcagttaagt
     7921 aattcatcac ttcatatttt taccaaagta tatttacaag tctgtttatc tggatctggc
     7981 aaactggaaa atgtttgaag ggatactcag gctttgatcc atgccaacat gaaaggactc
     8041 caagcacatt taagtaggct ggtcttttca tcatgcatga tttttttttt agtgcaaatt
     8101 tagactttag tttgggaaag agaacagtat acagtatcct ttgtaagata aatcacaaca
     8161 acaaaaatta agttttattg cacaaagtag ataaatgaga aagtctttct taaaaaatgc
     8221 ttctttaact gtaacagcaa aactaaatgc atattttatc aaccccttat ttctaattgc
     8281 tgtattcatt tccaccctta aactatttaa gcatttcatc tgctgaaagt ccttatatac
     8341 atggtagacg gaatatttct ccattaatga tagatcaaaa tgaagatatt taaaaattaa
     8401 caaaatcagg ccaaggcagg aggatcactt tagcccagga ggtccagacc agcctgggca
     8461 acacagcggg accccgactc catttaaaaa attaaaaaaa aaaaaaaaac ttttaacatt
     8521 taaaaaataa aaattaacaa aatttcactt attccaggac acgctggcat ttggactcaa
     8581 tgaaaagggc acctaaagaa aataaggctg actgaatgtt ttccataatt ttcacacaat
     8641 aacagtccct ttctatccag cttgccttcc atttatctct agggttagct tttcaggcaa
     8701 catccttggt cattgcccag aaagtacctg agctatcagt gattggaatg gcacaggaaa
     8761 ccgaatcaca tgggtgccct ccccttggtt ttcaagtatc ttggagttgt gcacaaaaat
     8821 taggtcatgc cttcagtgtc ttgttcttta aacctaccct ttgacaatca ggtgctaatg
     8881 attgtatact attaaaacca gcacataagt attgtaaatg tgtgttcctc ctaggttgga
     8941 agaaatgtct ttccttctat ctgggtcctg ttaaagcggg tgtcagttgt gtcttttcac
     9001 ctcgatttgt gaattaatag aattgggggg agaggaaatg atgatgtcaa ttaagtttca
     9061 ggtttggcat gatcatcatt ctcgatgata ttctcacttt gtcgcaaatc tgcccttatc
     9121 gtaagaacaa gtttcagaat tttccctcca ctatacgact ccagtattat gtttacaatc
     9181 cattggatga gtgcagcatt ataagacctt ggtgcccaga aaaatctgtc ctttttggta
     9241 ccaaacctga ggtcttttgg aagataatgt agaaaaccac tacctattga aggcctgttt
     9301 tggctaatct gtgcaaactc tgatgatacc tgcttatgtg gattcttttc cacactgctt
     9361 tcatttttaa gtataaagac ttagaaaact agaataatgc ttttacaaat aattaaaagt
     9421 atgtgatgtt ctgggttttt tccttctttt tagaaccctg tatttaaaca agccttcttt
     9481 ttaagtcttg tttgaaattt aagtctcaga tcttctggat accaaatcaa aaacccaacg
     9541 cgtaaaacag ggcagtattt gtgttcctaa ttttaaaaag ctttatgtat actctataaa
     9601 tatagatgca taaacaacac ttccccttga gtagcacatc aacatacagc attgtacatt
     9661 acaatgaaaa tgtgtaactt aagggtatta tatatataaa tacatatata cctttgtaac
     9721 ctttatactg taaataaaaa agttgcttta gtca
//
