LOCUS       NM_003096                594 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens small nuclear ribonucleoprotein polypeptide G (SNRPG),
            transcript variant 1, mRNA.
ACCESSION   NM_003096
VERSION     NM_003096.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 594)
  AUTHORS   Yang,F., Bian,T., Zhan,X., Chen,Z., Xing,Z., Larsen,N.A., Zhang,X.
            and Shi,Y.
  TITLE     Mechanisms of the RNA helicases DDX42 and DDX46 in human U2 snRNP
            assembly
  JOURNAL   Nat Commun 14 (1), 897 (2023)
   PUBMED   36797247
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 594)
  AUTHORS   Campagne,S., de Vries,T., Malard,F., Afanasyev,P., Dorn,G.,
            Dedic,E., Kohlbrecher,J., Boehringer,D., Clery,A. and Allain,F.H.
  TITLE     An in vitro reconstituted U1 snRNP allows the study of the
            disordered regions of the particle and the interactions with
            proteins and ligands
  JOURNAL   Nucleic Acids Res 49 (11), e63 (2021)
   PUBMED   33677607
REFERENCE   3  (bases 1 to 594)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 594)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 594)
  AUTHORS   Zhang,Z., Will,C.L., Bertram,K., Dybkov,O., Hartmuth,K.,
            Agafonov,D.E., Hofele,R., Urlaub,H., Kastner,B., Luhrmann,R. and
            Stark,H.
  TITLE     Molecular architecture of the human 17S U2 snRNP
  JOURNAL   Nature 583 (7815), 310-313 (2020)
   PUBMED   32494006
REFERENCE   6  (bases 1 to 594)
  AUTHORS   Fury,M.G., Zhang,W., Christodoulopoulos,I. and Zieve,G.W.
  TITLE     Multiple protein: protein interactions between the snRNP common
            core proteins
  JOURNAL   Exp Cell Res 237 (1), 63-69 (1997)
   PUBMED   9417867
REFERENCE   7  (bases 1 to 594)
  AUTHORS   Liu,Q., Fischer,U., Wang,F. and Dreyfuss,G.
  TITLE     The spinal muscular atrophy disease gene product, SMN, and its
            associated protein SIP1 are in a complex with spliceosomal snRNP
            proteins
  JOURNAL   Cell 90 (6), 1013-1021 (1997)
   PUBMED   9323129
REFERENCE   8  (bases 1 to 594)
  AUTHORS   Plessel,G., Luhrmann,R. and Kastner,B.
  TITLE     Electron microscopy of assembly intermediates of the snRNP core:
            morphological similarities between the RNA-free (E.F.G) protein
            heteromer and the intact snRNP core
  JOURNAL   J Mol Biol 265 (2), 87-94 (1997)
   PUBMED   9020971
REFERENCE   9  (bases 1 to 594)
  AUTHORS   Hermann,H., Fabrizio,P., Raker,V.A., Foulaki,K., Hornig,H.,
            Brahms,H. and Luhrmann,R.
  TITLE     snRNP Sm proteins share two evolutionarily conserved sequence
            motifs which are involved in Sm protein-protein interactions
  JOURNAL   EMBO J 14 (9), 2076-2088 (1995)
   PUBMED   7744013
REFERENCE   10 (bases 1 to 594)
  AUTHORS   Heinrichs,V., Hackl,W. and Luhrmann,R.
  TITLE     Direct binding of small nuclear ribonucleoprotein G to the Sm site
            of small nuclear RNA. Ultraviolet light cross-linking of protein G
            to the AAU stretch within the Sm site (AAUUUGUGG) of U1 small
            nuclear ribonucleoprotein reconstituted in vitro
  JOURNAL   J Mol Biol 227 (1), 15-28 (1992)
   PUBMED   1387914
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DW428820.1, BC106055.1 and
            AI742299.1.
            
            On Nov 23, 2018 this sequence version replaced NM_003096.3.
            
            Summary: The protein encoded by this gene is a component of the U1,
            U2, U4, and U5 small nuclear ribonucleoprotein complexes,
            precursors of the spliceosome. The encoded protein may also be a
            part of the U7 small nuclear ribonucleoprotein complex, which
            participates in the processing of the 3' end of histone
            transcripts. Several transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Nov
            2015].
            
            Transcript Variant: This variant (1) encodes the highly conserved
            isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BG772605.1, HX785413.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000272348.7/ ENSP00000272348.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                DW428820.1         37-63
            28-452              BC106055.1         42-466
            453-594             AI742299.1         6-147               c
FEATURES             Location/Qualifiers
     source          1..594
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p13.3"
     gene            1..594
                     /gene="SNRPG"
                     /gene_synonym="Sm-G; SMG"
                     /note="small nuclear ribonucleoprotein polypeptide G"
                     /db_xref="GeneID:6637"
                     /db_xref="HGNC:HGNC:11163"
                     /db_xref="MIM:603542"
     exon            1..123
                     /gene="SNRPG"
                     /gene_synonym="Sm-G; SMG"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..322
                     /gene="SNRPG"
                     /gene_synonym="Sm-G; SMG"
                     /EC_number="1.8.1.4"
                     /note="isoform a is encoded by transcript variant 1; small
                     nuclear ribonucleoprotein G; snRNP-G; sm protein G"
                     /codon_start=1
                     /product="small nuclear ribonucleoprotein G isoform a"
                     /protein_id="NP_003087.1"
                     /db_xref="CCDS:CCDS1903.1"
                     /db_xref="GeneID:6637"
                     /db_xref="HGNC:HGNC:11163"
                     /db_xref="MIM:603542"
                     /translation="MSKAHPPELKKFMDKKLSLKLNGGRHVQGILRGFDPFMNLVIDE
                     CVEMATSGQQNNIGMVVIRGNSIIMLEALERV"
     exon            124..146
                     /gene="SNRPG"
                     /gene_synonym="Sm-G; SMG"
                     /inference="alignment:Splign:2.1.0"
     exon            147..271
                     /gene="SNRPG"
                     /gene_synonym="Sm-G; SMG"
                     /inference="alignment:Splign:2.1.0"
     exon            272..594
                     /gene="SNRPG"
                     /gene_synonym="Sm-G; SMG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      552..557
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNRPG"
                     /gene_synonym="Sm-G; SMG"
                     /note="hexamer: ATTAAA"
     regulatory      571..576
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNRPG"
                     /gene_synonym="Sm-G; SMG"
                     /note="hexamer: ATTAAA"
     polyA_site      583
                     /gene="SNRPG"
                     /gene_synonym="Sm-G; SMG"
     polyA_site      594
                     /gene="SNRPG"
                     /gene_synonym="Sm-G; SMG"
                     /note="major polyA site"
ORIGIN      
        1 gccagacgca agacgccggg cctacagcgg gagcgtgagg aaagccgtgc gttgcgttcc
       61 aaggcatctg tgagcccgcg gagtatacac catgagcaaa gctcaccctc ccgagttgaa
      121 aaaatttatg gacaagaagt tatcattgaa attaaatggt ggcagacatg tccaaggaat
      181 attgcgggga tttgatccct ttatgaacct tgtgatagat gaatgtgtgg agatggcgac
      241 tagtggacaa cagaacaata ttggaatggt ggtaatacga ggaaatagta tcatcatgtt
      301 agaagccttg gaacgagtat aaataatggc tgttcagcag agaaacccat gtcctctctc
      361 catagggcct gttttactat gatgtaaaaa ttaggtcatg tacattttca tattagactt
      421 tttgttaaat aaacttttgt aatagtcaaa aatgctttct cagatgttct gaatatagaa
      481 tatcagctct cattccagtt ttttctaaca tgaattttcc tggttgacat tgatttcaaa
      541 gggttttatg cattaaagtg aaagaatctt attaaatgtg aaacatggca agga
//
