LOCUS       NM_001317168            1260 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens small nuclear ribonucleoprotein polypeptide G (SNRPG),
            transcript variant 5, mRNA.
ACCESSION   NM_001317168
VERSION     NM_001317168.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1260)
  AUTHORS   Yang,F., Bian,T., Zhan,X., Chen,Z., Xing,Z., Larsen,N.A., Zhang,X.
            and Shi,Y.
  TITLE     Mechanisms of the RNA helicases DDX42 and DDX46 in human U2 snRNP
            assembly
  JOURNAL   Nat Commun 14 (1), 897 (2023)
   PUBMED   36797247
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1260)
  AUTHORS   Campagne,S., de Vries,T., Malard,F., Afanasyev,P., Dorn,G.,
            Dedic,E., Kohlbrecher,J., Boehringer,D., Clery,A. and Allain,F.H.
  TITLE     An in vitro reconstituted U1 snRNP allows the study of the
            disordered regions of the particle and the interactions with
            proteins and ligands
  JOURNAL   Nucleic Acids Res 49 (11), e63 (2021)
   PUBMED   33677607
REFERENCE   3  (bases 1 to 1260)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1260)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 1260)
  AUTHORS   Zhang,Z., Will,C.L., Bertram,K., Dybkov,O., Hartmuth,K.,
            Agafonov,D.E., Hofele,R., Urlaub,H., Kastner,B., Luhrmann,R. and
            Stark,H.
  TITLE     Molecular architecture of the human 17S U2 snRNP
  JOURNAL   Nature 583 (7815), 310-313 (2020)
   PUBMED   32494006
REFERENCE   6  (bases 1 to 1260)
  AUTHORS   Fury,M.G., Zhang,W., Christodoulopoulos,I. and Zieve,G.W.
  TITLE     Multiple protein: protein interactions between the snRNP common
            core proteins
  JOURNAL   Exp Cell Res 237 (1), 63-69 (1997)
   PUBMED   9417867
REFERENCE   7  (bases 1 to 1260)
  AUTHORS   Liu,Q., Fischer,U., Wang,F. and Dreyfuss,G.
  TITLE     The spinal muscular atrophy disease gene product, SMN, and its
            associated protein SIP1 are in a complex with spliceosomal snRNP
            proteins
  JOURNAL   Cell 90 (6), 1013-1021 (1997)
   PUBMED   9323129
REFERENCE   8  (bases 1 to 1260)
  AUTHORS   Plessel,G., Luhrmann,R. and Kastner,B.
  TITLE     Electron microscopy of assembly intermediates of the snRNP core:
            morphological similarities between the RNA-free (E.F.G) protein
            heteromer and the intact snRNP core
  JOURNAL   J Mol Biol 265 (2), 87-94 (1997)
   PUBMED   9020971
REFERENCE   9  (bases 1 to 1260)
  AUTHORS   Hermann,H., Fabrizio,P., Raker,V.A., Foulaki,K., Hornig,H.,
            Brahms,H. and Luhrmann,R.
  TITLE     snRNP Sm proteins share two evolutionarily conserved sequence
            motifs which are involved in Sm protein-protein interactions
  JOURNAL   EMBO J 14 (9), 2076-2088 (1995)
   PUBMED   7744013
REFERENCE   10 (bases 1 to 1260)
  AUTHORS   Heinrichs,V., Hackl,W. and Luhrmann,R.
  TITLE     Direct binding of small nuclear ribonucleoprotein G to the Sm site
            of small nuclear RNA. Ultraviolet light cross-linking of protein G
            to the AAU stretch within the Sm site (AAUUUGUGG) of U1 small
            nuclear ribonucleoprotein reconstituted in vitro
  JOURNAL   J Mol Biol 227 (1), 15-28 (1992)
   PUBMED   1387914
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY168189.1, BC035103.1 and
            AI742299.1.
            
            Summary: The protein encoded by this gene is a component of the U1,
            U2, U4, and U5 small nuclear ribonucleoprotein complexes,
            precursors of the spliceosome. The encoded protein may also be a
            part of the U7 small nuclear ribonucleoprotein complex, which
            participates in the processing of the 3' end of histone
            transcripts. Several transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Nov
            2015].
            
            Transcript Variant: This variant (5) uses an alternate exon in
            place of the first exon compared to variant 1. The resulting
            isoform (e) is shorter at the N-terminus compared to isoform a.
            Variants 5 and 6 both encode the same isoform (e).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC035103.1, AI268598.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                HY168189.1         2-27
            27-1113             BC035103.1         8-1094
            1114-1260           AI742299.1         1-147               c
FEATURES             Location/Qualifiers
     source          1..1260
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p13.3"
     gene            1..1260
                     /gene="SNRPG"
                     /gene_synonym="Sm-G; SMG"
                     /note="small nuclear ribonucleoprotein polypeptide G"
                     /db_xref="GeneID:6637"
                     /db_xref="HGNC:HGNC:11163"
                     /db_xref="MIM:603542"
     exon            1..784
                     /gene="SNRPG"
                     /gene_synonym="Sm-G; SMG"
                     /inference="alignment:Splign:2.1.0"
     exon            785..807
                     /gene="SNRPG"
                     /gene_synonym="Sm-G; SMG"
                     /inference="alignment:Splign:2.1.0"
     CDS             789..983
                     /gene="SNRPG"
                     /gene_synonym="Sm-G; SMG"
                     /EC_number="1.8.1.4"
                     /note="isoform e is encoded by transcript variant 5; small
                     nuclear ribonucleoprotein G; snRNP-G; sm protein G"
                     /codon_start=1
                     /product="small nuclear ribonucleoprotein G isoform e"
                     /protein_id="NP_001304097.1"
                     /db_xref="CCDS:CCDS82461.1"
                     /db_xref="GeneID:6637"
                     /db_xref="HGNC:HGNC:11163"
                     /db_xref="MIM:603542"
                     /translation="MDKKLSLKLNGGRHVQGILRGFDPFMNLVIDECVEMATSGQQNN
                     IGMVVIRGNSIIMLEALERV"
     exon            808..932
                     /gene="SNRPG"
                     /gene_synonym="Sm-G; SMG"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1255
                     /gene="SNRPG"
                     /gene_synonym="Sm-G; SMG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1213..1218
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNRPG"
                     /gene_synonym="Sm-G; SMG"
                     /note="hexamer: ATTAAA"
     regulatory      1232..1237
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNRPG"
                     /gene_synonym="Sm-G; SMG"
                     /note="hexamer: ATTAAA"
     polyA_site      1244
                     /gene="SNRPG"
                     /gene_synonym="Sm-G; SMG"
     polyA_site      1255
                     /gene="SNRPG"
                     /gene_synonym="Sm-G; SMG"
                     /note="major polyA site"
ORIGIN      
        1 gtgaagcccg cgcagagctc gcgcgtcggt gtggttacag ccggcagcca cggcacctcc
       61 ttccggccga ctagtctcca ggtcccgcgg tctggcccct ggtcacccgg cgctgtccct
      121 cgttccttga agatctccag tgctaccttt tgttgaacat ctcgaatagt atcatgttct
      181 agatagacgg ctagaggggg aaattctctg aaggaactaa ggaggggctg gaagggaagg
      241 aagtgttttt aaaactacgt gaggcatcag aatccgaaag ccactttagt cttagcaaat
      301 gtgtttgtag gtgtttgagc ttttacttag aaacctcatt cctttttctt gccttctttt
      361 acgttaagct tgaatgtcat gtgttatctt gctctgatgt tgaaactata taagaacatt
      421 catttttctt tttttttaag aacattaatt ttttctagtc agagaaggct aattttttga
      481 agttttttct acacacccag taaagtcaaa caactttaag taggagagcc ttactttagg
      541 taggactcaa cgtaaagctt tgaattcctc aaatactttt tgagtggact taacaggtta
      601 tgtgtttcct gactacgttt ctgttttgct tatacttcct gatgctggaa ttctacatgt
      661 attagttgga ttgcacaaag gatgcaaaat ttttacaggg atcagttttt tctggcgtag
      721 catgtggttg gctttgtgta tagttagttc atttattacc aggcccatgg aagtcagaca
      781 aaagatttat ggacaagaag ttatcattga aattaaatgg tggcagacat gtccaaggaa
      841 tattgcgggg atttgatccc tttatgaacc ttgtgataga tgaatgtgtg gagatggcga
      901 ctagtggaca acagaacaat attggaatgg tggtaatacg aggaaatagt atcatcatgt
      961 tagaagcctt ggaacgagta taaataatgg ctgttcagca gagaaaccca tgtcctctct
     1021 ccatagggcc tgttttacta tgatgtaaaa attaggtcat gtacattttc atattagact
     1081 ttttgttaaa taaacttttg taatagtcaa aaatgctttc tcagatgttc tgaatataga
     1141 atatcagctc tcattccagt tttttctaac atgaattttc ctggttgaca ttgatttcaa
     1201 agggttttat gcattaaagt gaaagaatct tattaaatgt gaaacatggc aaggaaaaaa
//
