LOCUS       NM_003095                452 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens small nuclear ribonucleoprotein polypeptide F (SNRPF),
            transcript variant 1, mRNA.
ACCESSION   NM_003095
VERSION     NM_003095.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 452)
  AUTHORS   Yang,F., Bian,T., Zhan,X., Chen,Z., Xing,Z., Larsen,N.A., Zhang,X.
            and Shi,Y.
  TITLE     Mechanisms of the RNA helicases DDX42 and DDX46 in human U2 snRNP
            assembly
  JOURNAL   Nat Commun 14 (1), 897 (2023)
   PUBMED   36797247
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 452)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 452)
  AUTHORS   Campagne,S., de Vries,T., Malard,F., Afanasyev,P., Dorn,G.,
            Dedic,E., Kohlbrecher,J., Boehringer,D., Clery,A. and Allain,F.H.
  TITLE     An in vitro reconstituted U1 snRNP allows the study of the
            disordered regions of the particle and the interactions with
            proteins and ligands
  JOURNAL   Nucleic Acids Res 49 (11), e63 (2021)
   PUBMED   33677607
REFERENCE   4  (bases 1 to 452)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 452)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 452)
  AUTHORS   Plessel,G., Luhrmann,R. and Kastner,B.
  TITLE     Electron microscopy of assembly intermediates of the snRNP core:
            morphological similarities between the RNA-free (E.F.G) protein
            heteromer and the intact snRNP core
  JOURNAL   J Mol Biol 265 (2), 87-94 (1997)
   PUBMED   9020971
REFERENCE   7  (bases 1 to 452)
  AUTHORS   Hermann,H., Fabrizio,P., Raker,V.A., Foulaki,K., Hornig,H.,
            Brahms,H. and Luhrmann,R.
  TITLE     snRNP Sm proteins share two evolutionarily conserved sequence
            motifs which are involved in Sm protein-protein interactions
  JOURNAL   EMBO J 14 (9), 2076-2088 (1995)
   PUBMED   7744013
REFERENCE   8  (bases 1 to 452)
  AUTHORS   Sauterer,R.A., Goyal,A. and Zieve,G.W.
  TITLE     Cytoplasmic assembly of small nuclear ribonucleoprotein particles
            from 6 S and 20 S RNA-free intermediates in L929 mouse fibroblasts
  JOURNAL   J Biol Chem 265 (2), 1048-1058 (1990)
   PUBMED   1688550
REFERENCE   9  (bases 1 to 452)
  AUTHORS   Feeney,R.J., Sauterer,R.A., Feeney,J.L. and Zieve,G.W.
  TITLE     Cytoplasmic assembly and nuclear accumulation of mature small
            nuclear ribonucleoprotein particles
  JOURNAL   J Biol Chem 264 (10), 5776-5783 (1989)
   PUBMED   2522439
REFERENCE   10 (bases 1 to 452)
  AUTHORS   Woppmann,A., Rinke,J. and Luhrmann,R.
  TITLE     Direct cross-linking of snRNP proteins F and 70K to snRNAs by
            ultra-violet radiation in situ
  JOURNAL   Nucleic Acids Res 16 (23), 10985-11004 (1988)
   PUBMED   2974540
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090001.19.
            
            On Apr 8, 2021 this sequence version replaced NM_003095.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002505.2, BM670308.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000266735.10/ ENSP00000266735.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               AC090001.19        171193-171317
            126-251             AC090001.19        173409-173534
            252-316             AC090001.19        177565-177629
            317-452             AC090001.19        178246-178381
FEATURES             Location/Qualifiers
     source          1..452
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q23.1"
     gene            1..452
                     /gene="SNRPF"
                     /gene_synonym="Sm-F; SMF; snRNP-F"
                     /note="small nuclear ribonucleoprotein polypeptide F"
                     /db_xref="GeneID:6636"
                     /db_xref="HGNC:HGNC:11162"
                     /db_xref="MIM:603541"
     exon            1..125
                     /gene="SNRPF"
                     /gene_synonym="Sm-F; SMF; snRNP-F"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..383
                     /gene="SNRPF"
                     /gene_synonym="Sm-F; SMF; snRNP-F"
                     /note="isoform 1 is encoded by transcript variant 1; small
                     nuclear ribonucleoprotein F; sm protein F"
                     /codon_start=1
                     /product="small nuclear ribonucleoprotein F isoform 1"
                     /protein_id="NP_003086.1"
                     /db_xref="CCDS:CCDS9055.1"
                     /db_xref="GeneID:6636"
                     /db_xref="HGNC:HGNC:11162"
                     /db_xref="MIM:603541"
                     /translation="MSLPLNPKPFLNGLTGKPVMVKLKWGMEYKGYLVSVDGYMNMQL
                     ANTEEYIDGALSGHLGEVLIRCNNVLYIRGVEEEEEDGEMRE"
     exon            126..251
                     /gene="SNRPF"
                     /gene_synonym="Sm-F; SMF; snRNP-F"
                     /inference="alignment:Splign:2.1.0"
     exon            252..316
                     /gene="SNRPF"
                     /gene_synonym="Sm-F; SMF; snRNP-F"
                     /inference="alignment:Splign:2.1.0"
     exon            317..452
                     /gene="SNRPF"
                     /gene_synonym="Sm-F; SMF; snRNP-F"
                     /inference="alignment:Splign:2.1.0"
     regulatory      424..429
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNRPF"
                     /gene_synonym="Sm-F; SMF; snRNP-F"
                     /note="hexamer: AATAAA"
     polyA_site      452
                     /gene="SNRPF"
                     /gene_synonym="Sm-F; SMF; snRNP-F"
                     /note="major polyA site"
ORIGIN      
        1 ctgtttggcg gccatttctc ttgaaactgc ggctcgggac ctgcggtacc tgctgtagtc
       61 acgagggacg ggcggcggcc tggtcggcag agagtagcct gcaacattcg gccgtggtta
      121 cgatgagttt acccctcaat cccaaacctt tcctcaatgg actaacagga aagccagtga
      181 tggtgaaact taagtgggga atggagtaca agggctatct ggtatctgta gatggctaca
      241 tgaacatgca gcttgcaaat acagaagaat acatagatgg agctttgtct ggacatctgg
      301 gtgaagtttt aataaggtgt aataatgtcc tttatatcag aggtgtggaa gaagaggaag
      361 aagatgggga aatgagagaa tagcatcttt tgtgggggat tttttttata tatatttcta
      421 gacaataaag atttgtttgt ttttcaactt ga
//
