LOCUS       NM_001384647             515 bp    mRNA    linear   PRI 13-OCT-2024
DEFINITION  Homo sapiens small nuclear ribonucleoprotein D2 polypeptide
            (SNRPD2), transcript variant 5, mRNA.
ACCESSION   NM_001384647
VERSION     NM_001384647.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 515)
  AUTHORS   Chang,C., Li,L., Su,L., Yang,F., Zha,Q., Sun,M., Tao,L., Wang,M.,
            Song,K., Jiang,L., Gao,H., Liang,Y., Xu,C., Yong,C., Wang,M.,
            Huang,J., Liu,J., Jin,W., Lv,W., Dong,H., Li,Q., Bu,F., Yan,S.,
            Qi,H., Zhao,S., Zhu,Y., Wang,Y., Shi,J., Qiao,Y., Xu,J., Chabot,B.
            and Chen,J.
  TITLE     Intron Retention of DDX39A Driven by SNRPD2 is a Crucial Splicing
            Axis for Oncogenic MYC/Spliceosome Program in Hepatocellular
            Carcinoma
  JOURNAL   Adv Sci (Weinh) 11 (35), e2403387 (2024)
   PUBMED   39018261
  REMARK    GeneRIF: Intron Retention of DDX39A Driven by SNRPD2 is a Crucial
            Splicing Axis for Oncogenic MYC/Spliceosome Program in
            Hepatocellular Carcinoma.
REFERENCE   2  (bases 1 to 515)
  AUTHORS   Yang,F., Bian,T., Zhan,X., Chen,Z., Xing,Z., Larsen,N.A., Zhang,X.
            and Shi,Y.
  TITLE     Mechanisms of the RNA helicases DDX42 and DDX46 in human U2 snRNP
            assembly
  JOURNAL   Nat Commun 14 (1), 897 (2023)
   PUBMED   36797247
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 515)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 515)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 515)
  AUTHORS   Kambach,C., Walke,S., Young,R., Avis,J.M., de la Fortelle,E.,
            Raker,V.A., Luhrmann,R., Li,J. and Nagai,K.
  TITLE     Crystal structures of two Sm protein complexes and their
            implications for the assembly of the spliceosomal snRNPs
  JOURNAL   Cell 96 (3), 375-387 (1999)
   PUBMED   10025403
REFERENCE   6  (bases 1 to 515)
  AUTHORS   Fury,M.G., Zhang,W., Christodoulopoulos,I. and Zieve,G.W.
  TITLE     Multiple protein: protein interactions between the snRNP common
            core proteins
  JOURNAL   Exp Cell Res 237 (1), 63-69 (1997)
   PUBMED   9417867
REFERENCE   7  (bases 1 to 515)
  AUTHORS   Liu,Q., Fischer,U., Wang,F. and Dreyfuss,G.
  TITLE     The spinal muscular atrophy disease gene product, SMN, and its
            associated protein SIP1 are in a complex with spliceosomal snRNP
            proteins
  JOURNAL   Cell 90 (6), 1013-1021 (1997)
   PUBMED   9323129
REFERENCE   8  (bases 1 to 515)
  AUTHORS   Lehmeier,T., Raker,V., Hermann,H. and Luhrmann,R.
  TITLE     cDNA cloning of the Sm proteins D2 and D3 from human small nuclear
            ribonucleoproteins: evidence for a direct D1-D2 interaction
  JOURNAL   Proc Natl Acad Sci U S A 91 (25), 12317-12321 (1994)
   PUBMED   7527560
REFERENCE   9  (bases 1 to 515)
  AUTHORS   Lehmeier,T., Foulaki,K. and Luhrmann,R.
  TITLE     Evidence for three distinct D proteins, which react differentially
            with anti-Sm autoantibodies, in the cores of the major snRNPs U1,
            U2, U4/U6 and U5
  JOURNAL   Nucleic Acids Res 18 (22), 6475-6484 (1990)
   PUBMED   1701240
REFERENCE   10 (bases 1 to 515)
  AUTHORS   Rokeach,L.A., Haselby,J.A. and Hoch,S.O.
  TITLE     Molecular cloning of a cDNA encoding the human Sm-D autoantigen
  JOURNAL   Proc Natl Acad Sci U S A 85 (13), 4832-4836 (1988)
   PUBMED   3260384
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CD175580.1.
            
            Summary: The protein encoded by this gene belongs to the small
            nuclear ribonucleoprotein core protein family. It is required for
            pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis.
            Multiple transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, May 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BU600696.1, BG113313.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000342669.8/ ENSP00000342374.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-515               CD175580.1         31-545
FEATURES             Location/Qualifiers
     source          1..515
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.32"
     gene            1..515
                     /gene="SNRPD2"
                     /gene_synonym="Sm-D2; SMD2; SNRPD1"
                     /note="small nuclear ribonucleoprotein D2 polypeptide"
                     /db_xref="GeneID:6633"
                     /db_xref="HGNC:HGNC:11159"
                     /db_xref="MIM:601061"
     exon            1..67
                     /gene="SNRPD2"
                     /gene_synonym="Sm-D2; SMD2; SNRPD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..422
                     /gene="SNRPD2"
                     /gene_synonym="Sm-D2; SMD2; SNRPD1"
                     /note="isoform 1 is encoded by transcript variant 5; snRNP
                     core protein D2; small nuclear ribonucleoprotein Sm D2;
                     small nuclear ribonucleoprotein D2 polypeptide 16.5kDa"
                     /codon_start=1
                     /product="small nuclear ribonucleoprotein Sm D2 isoform 1"
                     /protein_id="NP_001371576.1"
                     /db_xref="CCDS:CCDS33053.1"
                     /db_xref="GeneID:6633"
                     /db_xref="HGNC:HGNC:11159"
                     /db_xref="MIM:601061"
                     /translation="MSLLNKPKSEMTPEELQKREEEEFNTGPLSVLTQSVKNNTQVLI
                     NCRNNKKLLGRVKAFDRHCNMVLENVKEMWTEVPKSGKGKKKSKPVNKDRYISKMFLR
                     GDSVIVVLRNPLIAGK"
     exon            68..247
                     /gene="SNRPD2"
                     /gene_synonym="Sm-D2; SMD2; SNRPD1"
                     /inference="alignment:Splign:2.1.0"
     exon            248..515
                     /gene="SNRPD2"
                     /gene_synonym="Sm-D2; SMD2; SNRPD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      492..497
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNRPD2"
                     /gene_synonym="Sm-D2; SMD2; SNRPD1"
                     /note="hexamer: AATAAA"
     polyA_site      515
                     /gene="SNRPD2"
                     /gene_synonym="Sm-D2; SMD2; SNRPD1"
                     /note="major polyA site"
ORIGIN      
        1 ctctctctcc tcaggcagca gcaacgcgga ggaaacggga gtgaacggag agcgtagtga
       61 ccatcatgag cctcctcaac aagcccaaga gtgagatgac cccagaggag ctgcagaagc
      121 gagaggagga ggaatttaac accggtccac tctctgtgct cacacagtca gtcaagaaca
      181 atacccaagt gctcatcaac tgccgcaaca ataagaaact cctgggccgc gtgaaggcct
      241 tcgataggca ctgcaacatg gtgctggaga acgtgaagga gatgtggact gaggtaccca
      301 agagtggcaa gggcaagaag aagtccaagc cagtcaacaa agaccgctac atctccaaga
      361 tgttcctgcg cggggactca gtcatcgtgg tcctgcggaa cccgctcatc gccggcaagt
      421 aggggccgcc tgtctgttga cagaactcac tcctctgtcc tatgaagacc gctgccattg
      481 gtgttgagaa taataaagct ctgtgttttt ttcta
//
