LOCUS       NP_001371576             118 aa            linear   PRI 30-APR-2025
DEFINITION  small nuclear ribonucleoprotein Sm D2 isoform 1 [Homo sapiens].
ACCESSION   NP_001371576
VERSION     NP_001371576.1
DBSOURCE    REFSEQ: accession NM_001384647.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 118)
  AUTHORS   Chang,C., Li,L., Su,L., Yang,F., Zha,Q., Sun,M., Tao,L., Wang,M.,
            Song,K., Jiang,L., Gao,H., Liang,Y., Xu,C., Yong,C., Wang,M.,
            Huang,J., Liu,J., Jin,W., Lv,W., Dong,H., Li,Q., Bu,F., Yan,S.,
            Qi,H., Zhao,S., Zhu,Y., Wang,Y., Shi,J., Qiao,Y., Xu,J., Chabot,B.
            and Chen,J.
  TITLE     Intron Retention of DDX39A Driven by SNRPD2 is a Crucial Splicing
            Axis for Oncogenic MYC/Spliceosome Program in Hepatocellular
            Carcinoma
  JOURNAL   Adv Sci (Weinh) 11 (35), e2403387 (2024)
   PUBMED   39018261
  REMARK    GeneRIF: Intron Retention of DDX39A Driven by SNRPD2 is a Crucial
            Splicing Axis for Oncogenic MYC/Spliceosome Program in
            Hepatocellular Carcinoma.
REFERENCE   2  (residues 1 to 118)
  AUTHORS   Yang,F., Bian,T., Zhan,X., Chen,Z., Xing,Z., Larsen,N.A., Zhang,X.
            and Shi,Y.
  TITLE     Mechanisms of the RNA helicases DDX42 and DDX46 in human U2 snRNP
            assembly
  JOURNAL   Nat Commun 14 (1), 897 (2023)
   PUBMED   36797247
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 118)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (residues 1 to 118)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (residues 1 to 118)
  AUTHORS   Kambach,C., Walke,S., Young,R., Avis,J.M., de la Fortelle,E.,
            Raker,V.A., Luhrmann,R., Li,J. and Nagai,K.
  TITLE     Crystal structures of two Sm protein complexes and their
            implications for the assembly of the spliceosomal snRNPs
  JOURNAL   Cell 96 (3), 375-387 (1999)
   PUBMED   10025403
REFERENCE   6  (residues 1 to 118)
  AUTHORS   Fury,M.G., Zhang,W., Christodoulopoulos,I. and Zieve,G.W.
  TITLE     Multiple protein: protein interactions between the snRNP common
            core proteins
  JOURNAL   Exp Cell Res 237 (1), 63-69 (1997)
   PUBMED   9417867
REFERENCE   7  (residues 1 to 118)
  AUTHORS   Liu,Q., Fischer,U., Wang,F. and Dreyfuss,G.
  TITLE     The spinal muscular atrophy disease gene product, SMN, and its
            associated protein SIP1 are in a complex with spliceosomal snRNP
            proteins
  JOURNAL   Cell 90 (6), 1013-1021 (1997)
   PUBMED   9323129
REFERENCE   8  (residues 1 to 118)
  AUTHORS   Lehmeier,T., Raker,V., Hermann,H. and Luhrmann,R.
  TITLE     cDNA cloning of the Sm proteins D2 and D3 from human small nuclear
            ribonucleoproteins: evidence for a direct D1-D2 interaction
  JOURNAL   Proc Natl Acad Sci U S A 91 (25), 12317-12321 (1994)
   PUBMED   7527560
REFERENCE   9  (residues 1 to 118)
  AUTHORS   Lehmeier,T., Foulaki,K. and Luhrmann,R.
  TITLE     Evidence for three distinct D proteins, which react differentially
            with anti-Sm autoantibodies, in the cores of the major snRNPs U1,
            U2, U4/U6 and U5
  JOURNAL   Nucleic Acids Res 18 (22), 6475-6484 (1990)
   PUBMED   1701240
REFERENCE   10 (residues 1 to 118)
  AUTHORS   Rokeach,L.A., Haselby,J.A. and Hoch,S.O.
  TITLE     Molecular cloning of a cDNA encoding the human Sm-D autoantigen
  JOURNAL   Proc Natl Acad Sci U S A 85 (13), 4832-4836 (1988)
   PUBMED   3260384
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CD175580.1.
            
            Summary: The protein encoded by this gene belongs to the small
            nuclear ribonucleoprotein core protein family. It is required for
            pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis.
            Multiple transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, May 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BU600696.1, BG113313.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000342669.8/ ENSP00000342374.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..118
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.32"
     Protein         1..118
                     /product="small nuclear ribonucleoprotein Sm D2 isoform 1"
                     /note="snRNP core protein D2; small nuclear
                     ribonucleoprotein Sm D2; small nuclear ribonucleoprotein
                     D2 polypeptide 16.5kDa"
                     /calculated_mol_wt=13396
     Region          1..31
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P62316.1)"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylserine. /evidence=ECO:0000269|Ref.6,
                     ECO:0007744|PubMed:22814378, ECO:0007744|PubMed:25944712;
                     propagated from UniProtKB/Swiss-Prot (P62316.1)"
     Site            9
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (P62316.1)"
     Site            12
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:20068231,
                     ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (P62316.1)"
     Region          24..113
                     /region_name="Sm_D2"
                     /note="Sm protein D2; cd01720"
                     /db_xref="CDD:212467"
     Site            order(25,28..29,47..49,61..62,64,102,104)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:212467"
     Site            order(31,39,45..49,56..57,60..64,68..69,72..73,92..94,96,
                     98..104,106..112)
                     /site_type="other"
                     /note="heptamer interface [polypeptide binding]"
                     /db_xref="CDD:212467"
     Site            order(42..48,50..62,64..68)
                     /site_type="other"
                     /note="Sm1 motif"
                     /db_xref="CDD:212467"
     Site            98..109
                     /site_type="other"
                     /note="Sm2 motif"
                     /db_xref="CDD:212467"
     CDS             1..118
                     /gene="SNRPD2"
                     /gene_synonym="Sm-D2; SMD2; SNRPD1"
                     /coded_by="NM_001384647.1:66..422"
                     /note="isoform 1 is encoded by transcript variant 5"
                     /db_xref="CCDS:CCDS33053.1"
                     /db_xref="GeneID:6633"
                     /db_xref="HGNC:HGNC:11159"
                     /db_xref="MIM:601061"
ORIGIN      
        1 msllnkpkse mtpeelqkre eeefntgpls vltqsvknnt qvlincrnnk kllgrvkafd
       61 rhcnmvlenv kemwtevpks gkgkkkskpv nkdryiskmf lrgdsvivvl rnpliagk
//
