LOCUS       NM_198220               2311 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens small nuclear ribonucleoprotein polypeptide B2
            (SNRPB2), transcript variant 2, mRNA.
ACCESSION   NM_198220
VERSION     NM_198220.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2311)
  AUTHORS   Yang,F., Bian,T., Zhan,X., Chen,Z., Xing,Z., Larsen,N.A., Zhang,X.
            and Shi,Y.
  TITLE     Mechanisms of the RNA helicases DDX42 and DDX46 in human U2 snRNP
            assembly
  JOURNAL   Nat Commun 14 (1), 897 (2023)
   PUBMED   36797247
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2311)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 2311)
  AUTHORS   Qin,Y., Huttlin,E.L., Winsnes,C.F., Gosztyla,M.L., Wacheul,L.,
            Kelly,M.R., Blue,S.M., Zheng,F., Chen,M., Schaffer,L.V., Licon,K.,
            Backstrom,A., Vaites,L.P., Lee,J.J., Ouyang,W., Liu,S.N., Zhang,T.,
            Silva,E., Park,J., Pitea,A., Kreisberg,J.F., Gygi,S.P., Ma,J.,
            Harper,J.W., Yeo,G.W., Lafontaine,D.L.J., Lundberg,E. and Ideker,T.
  TITLE     A multi-scale map of cell structure fusing protein images and
            interactions
  JOURNAL   Nature 600 (7889), 536-542 (2021)
   PUBMED   34819669
REFERENCE   4  (bases 1 to 2311)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 2311)
  AUTHORS   Zhang,Z., Will,C.L., Bertram,K., Dybkov,O., Hartmuth,K.,
            Agafonov,D.E., Hofele,R., Urlaub,H., Kastner,B., Luhrmann,R. and
            Stark,H.
  TITLE     Molecular architecture of the human 17S U2 snRNP
  JOURNAL   Nature 583 (7815), 310-313 (2020)
   PUBMED   32494006
REFERENCE   6  (bases 1 to 2311)
  AUTHORS   Liu,Q., Fischer,U., Wang,F. and Dreyfuss,G.
  TITLE     The spinal muscular atrophy disease gene product, SMN, and its
            associated protein SIP1 are in a complex with spliceosomal snRNP
            proteins
  JOURNAL   Cell 90 (6), 1013-1021 (1997)
   PUBMED   9323129
REFERENCE   7  (bases 1 to 2311)
  AUTHORS   Hong,W., Bennett,M., Xiao,Y., Feld Kramer,R., Wang,C. and Reed,R.
  TITLE     Association of U2 snRNP with the spliceosomal complex E
  JOURNAL   Nucleic Acids Res 25 (2), 354-361 (1997)
   PUBMED   9016565
REFERENCE   8  (bases 1 to 2311)
  AUTHORS   Laitinen,J., Saris,P., Holtta,E. and Pettersson,I.
  TITLE     U2-snRNP B' protein gene is an early growth-inducible gene
  JOURNAL   J Cell Biochem 58 (4), 490-498 (1995)
   PUBMED   7593271
REFERENCE   9  (bases 1 to 2311)
  AUTHORS   Feeney,R.J. and Zieve,G.W.
  TITLE     Nuclear exchange of the U1 and U2 snRNP-specific proteins
  JOURNAL   J Cell Biol 110 (4), 871-881 (1990)
   PUBMED   2139037
REFERENCE   10 (bases 1 to 2311)
  AUTHORS   Habets,W.J., Sillekens,P.T., Hoet,M.H., Schalken,J.A.,
            Roebroek,A.J., Leunissen,J.A., van de Ven,W.J. and van
            Venrooij,W.J.
  TITLE     Analysis of a cDNA clone expressing a human autoimmune antigen:
            full-length sequence of the U2 small nuclear RNA-associated B'
            antigen
  JOURNAL   Proc Natl Acad Sci U S A 84 (8), 2421-2425 (1987)
   PUBMED   2951739
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA088017.1, BC036737.3,
            BM772256.1, AI741327.1 and AL034428.4.
            
            On May 31, 2019 this sequence version replaced NM_198220.2.
            
            Summary: The protein encoded by this gene associates with stem loop
            IV of U2 small nuclear ribonucleoprotein (U2 snRNP) in the presence
            of snRNP-A'. The encoded protein may play a role in pre-mRNA
            splicing. Autoantibodies from patients with systemic lupus
            erythematosus frequently recognize epitopes on the encoded protein.
            Two transcript variants encoding the same protein have been found
            for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.164376.1,
                                           SRR3476690.1176981.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 DA088017.1         63-64
            3-967               BC036737.3         1-965
            968-988             BM772256.1         423-443
            989-1519            AI741327.1         12-542              c
            1520-2311           AL034428.4         35249-36040
FEATURES             Location/Qualifiers
     source          1..2311
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p12.1"
     gene            1..2311
                     /gene="SNRPB2"
                     /gene_synonym="Msl1; U2B''"
                     /note="small nuclear ribonucleoprotein polypeptide B2"
                     /db_xref="GeneID:6629"
                     /db_xref="HGNC:HGNC:11155"
                     /db_xref="MIM:603520"
     exon            1..39
                     /gene="SNRPB2"
                     /gene_synonym="Msl1; U2B''"
                     /inference="alignment:Splign:2.1.0"
     exon            40..138
                     /gene="SNRPB2"
                     /gene_synonym="Msl1; U2B''"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..752
                     /gene="SNRPB2"
                     /gene_synonym="Msl1; U2B''"
                     /note="U2 snRNP B''; small nuclear ribonucleoprotein
                     polypeptide B"
                     /codon_start=1
                     /product="U2 small nuclear ribonucleoprotein B''"
                     /protein_id="NP_937863.1"
                     /db_xref="CCDS:CCDS13123.1"
                     /db_xref="GeneID:6629"
                     /db_xref="HGNC:HGNC:11155"
                     /db_xref="MIM:603520"
                     /translation="MDIRPNHTIYINNMNDKIKKEELKRSLYALFSQFGHVVDIVALK
                     TMKMRGQAFVIFKELGSSTNALRQLQGFPFYGKPMRIQYAKTDSDIISKMRGTFADKE
                     KKKEKKKAKTVEQTATTTNKKPGQGTPNSANTQGNSTPNPQVPDYPPNYILFLNNLPE
                     ETNEMMLSMLFNQFPGFKEVRLVPGRHDIAFVEFENDGQAGAARDALQGFKITPSHAM
                     KITYAKK"
     exon            139..311
                     /gene="SNRPB2"
                     /gene_synonym="Msl1; U2B''"
                     /inference="alignment:Splign:2.1.0"
     exon            312..452
                     /gene="SNRPB2"
                     /gene_synonym="Msl1; U2B''"
                     /inference="alignment:Splign:2.1.0"
     exon            453..503
                     /gene="SNRPB2"
                     /gene_synonym="Msl1; U2B''"
                     /inference="alignment:Splign:2.1.0"
     exon            504..592
                     /gene="SNRPB2"
                     /gene_synonym="Msl1; U2B''"
                     /inference="alignment:Splign:2.1.0"
     exon            593..2311
                     /gene="SNRPB2"
                     /gene_synonym="Msl1; U2B''"
                     /inference="alignment:Splign:2.1.0"
     regulatory      941..946
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNRPB2"
                     /gene_synonym="Msl1; U2B''"
                     /note="hexamer: AATAAA"
     polyA_site      967
                     /gene="SNRPB2"
                     /gene_synonym="Msl1; U2B''"
                     /note="major polyA site"
     regulatory      1502..1507
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNRPB2"
                     /gene_synonym="Msl1; U2B''"
                     /note="hexamer: AATAAA"
     polyA_site      1523
                     /gene="SNRPB2"
                     /gene_synonym="Msl1; U2B''"
     regulatory      2018..2023
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNRPB2"
                     /gene_synonym="Msl1; U2B''"
                     /note="hexamer: GATAAA"
     polyA_site      2046
                     /gene="SNRPB2"
                     /gene_synonym="Msl1; U2B''"
     regulatory      2284..2289
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNRPB2"
                     /gene_synonym="Msl1; U2B''"
                     /note="hexamer: AATAAA"
     polyA_site      2311
                     /gene="SNRPB2"
                     /gene_synonym="Msl1; U2B''"
ORIGIN      
        1 cctgcttttg gttcttacag tagtcggcgt aggccttaga ttttttactg tctcctgaag
       61 aatttaacac aaacatggat atcagaccaa atcatacaat ttatatcaac aatatgaatg
      121 acaaaattaa aaaggaagaa ttgaagagat ccctatatgc cctgttttct cagtttggtc
      181 atgtggtgga cattgtggct ttaaagacca tgaagatgag ggggcaggcc tttgtcatat
      241 ttaaggaact gggctcatcc acaaatgcct tgagacagct acaaggattt ccattttatg
      301 gtaaaccaat gcgaatacag tatgcaaaaa cagattcgga tataatatca aaaatgcgtg
      361 gaacttttgc tgacaaagaa aagaaaaaag aaaagaaaaa agccaaaact gtggaacaga
      421 ctgcaacaac cacaaacaaa aagcctggcc agggaactcc aaattcagct aatacccaag
      481 gaaattcaac accaaatcct caggtccctg attaccctcc aaactatatt ttattcctta
      541 ataacttacc agaagagact aatgagatga tgttatccat gctgtttaat cagttccctg
      601 gcttcaagga agtacgtctg gtaccaggga ggcatgacat tgcttttgtt gaatttgaaa
      661 atgatgggca ggctggagct gccagggatg ctttacaggg atttaagatc acaccgtccc
      721 atgctatgaa gatcacctat gccaagaaat aacatttggg atagtcgtct ttaaaagact
      781 tggtgttatt tacagtgttt gttttgataa catttggctg ggtcatttta atagttagag
      841 atgaggagga gtaaaagtga aatttttgtg aaggacttaa attatccagt gtttctttag
      901 ccttggtgaa ctatgaaata cgaaggcctt aattttgtac aataaacttt tatttgtatt
      961 ctgtgtatat aatgctttct tgattgaccc atctccctat catcaaatga cttctagtct
     1021 agaacacact taaggtttat aaacttgtgt aataggatgc ttttctagtg ttactttgga
     1081 ggagctaatt atacaacatc attgaaccat tcaataaaag ttaagtaaaa ttagatcaca
     1141 gaagctagta gatgactgtt gtattaatgg taacaatgat tgttctgggt attagaagaa
     1201 aatgagaccc aggcaggatc taaatttgat ctttgtatcc ttttaagaaa tgaatatatt
     1261 attttgctgc tagtagggat tccacaagtt ttcttcattc agtattaaat aaaggctgtt
     1321 cttactgttt actgagaaaa cagaaaggga atgctatctt cacactttgc atttaatgct
     1381 gtttccttca tgaggcagga ctgttctaag gttaatatgc aatctcttta ttgaaagacc
     1441 tccagggtaa aaattttttg atctatagtc tcttttcccc cttaagacaa atagactgat
     1501 taataaagag ttgccagtgc taagcttgct acttctttgt aattcttaaa caccaatgtt
     1561 caaatatttc caaagcccat tttctttagc ttttgattta tgtttaaggc tattgattca
     1621 gtcctctgct gagtaaacca tgggtatctc cagaagtgga caatttgttt ttacaagtat
     1681 ggtacatatt aatagtaaca acaacaaaaa agaaaacagt acttattttt ctggtgttcc
     1741 tgttttagta ttccttgaac aaaaccttta tcacttggaa tttttattgt ctacttatgg
     1801 aaagactttt agacttacgt agacagtatc acatcactct tatgcataca taaagaggaa
     1861 aaaaatgttt cctataactt tgtcacagtt agtctgactc ttctgaataa cttttttaat
     1921 cccagtagtc aagctcctgt acttttgtaa aatatattaa cagtgaatta ctagaaaatg
     1981 ggccatgttc ttgtatatta cagtgatgtc aattgctgat aaattttcta actgcttact
     2041 ctcggatacc gtacttgtct aagaactgaa aataattcac agactgatcc catgcccagt
     2101 cctggccatg ctttgagtgg ctgtattgga gcagaaaagc cagggtggct cacctggggt
     2161 gagaatgagg ggggtgaata gtaagagggg tcgtgtaggt cttcttcagg atttgcttat
     2221 actctgagtg aaatggggga ctattttaga gaattttttt aaagtgggtt agaatttacg
     2281 tacaataaag ttcacccatg ttagtgttcc a
//
