LOCUS       NM_003092               2411 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens small nuclear ribonucleoprotein polypeptide B2
            (SNRPB2), transcript variant 1, mRNA.
ACCESSION   NM_003092
VERSION     NM_003092.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2411)
  AUTHORS   Yang,F., Bian,T., Zhan,X., Chen,Z., Xing,Z., Larsen,N.A., Zhang,X.
            and Shi,Y.
  TITLE     Mechanisms of the RNA helicases DDX42 and DDX46 in human U2 snRNP
            assembly
  JOURNAL   Nat Commun 14 (1), 897 (2023)
   PUBMED   36797247
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2411)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 2411)
  AUTHORS   Qin,Y., Huttlin,E.L., Winsnes,C.F., Gosztyla,M.L., Wacheul,L.,
            Kelly,M.R., Blue,S.M., Zheng,F., Chen,M., Schaffer,L.V., Licon,K.,
            Backstrom,A., Vaites,L.P., Lee,J.J., Ouyang,W., Liu,S.N., Zhang,T.,
            Silva,E., Park,J., Pitea,A., Kreisberg,J.F., Gygi,S.P., Ma,J.,
            Harper,J.W., Yeo,G.W., Lafontaine,D.L.J., Lundberg,E. and Ideker,T.
  TITLE     A multi-scale map of cell structure fusing protein images and
            interactions
  JOURNAL   Nature 600 (7889), 536-542 (2021)
   PUBMED   34819669
REFERENCE   4  (bases 1 to 2411)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 2411)
  AUTHORS   Zhang,Z., Will,C.L., Bertram,K., Dybkov,O., Hartmuth,K.,
            Agafonov,D.E., Hofele,R., Urlaub,H., Kastner,B., Luhrmann,R. and
            Stark,H.
  TITLE     Molecular architecture of the human 17S U2 snRNP
  JOURNAL   Nature 583 (7815), 310-313 (2020)
   PUBMED   32494006
REFERENCE   6  (bases 1 to 2411)
  AUTHORS   Liu,Q., Fischer,U., Wang,F. and Dreyfuss,G.
  TITLE     The spinal muscular atrophy disease gene product, SMN, and its
            associated protein SIP1 are in a complex with spliceosomal snRNP
            proteins
  JOURNAL   Cell 90 (6), 1013-1021 (1997)
   PUBMED   9323129
REFERENCE   7  (bases 1 to 2411)
  AUTHORS   Hong,W., Bennett,M., Xiao,Y., Feld Kramer,R., Wang,C. and Reed,R.
  TITLE     Association of U2 snRNP with the spliceosomal complex E
  JOURNAL   Nucleic Acids Res 25 (2), 354-361 (1997)
   PUBMED   9016565
REFERENCE   8  (bases 1 to 2411)
  AUTHORS   Laitinen,J., Saris,P., Holtta,E. and Pettersson,I.
  TITLE     U2-snRNP B' protein gene is an early growth-inducible gene
  JOURNAL   J Cell Biochem 58 (4), 490-498 (1995)
   PUBMED   7593271
REFERENCE   9  (bases 1 to 2411)
  AUTHORS   Feeney,R.J. and Zieve,G.W.
  TITLE     Nuclear exchange of the U1 and U2 snRNP-specific proteins
  JOURNAL   J Cell Biol 110 (4), 871-881 (1990)
   PUBMED   2139037
REFERENCE   10 (bases 1 to 2411)
  AUTHORS   Habets,W.J., Sillekens,P.T., Hoet,M.H., Schalken,J.A.,
            Roebroek,A.J., Leunissen,J.A., van de Ven,W.J. and van
            Venrooij,W.J.
  TITLE     Analysis of a cDNA clone expressing a human autoimmune antigen:
            full-length sequence of the U2 small nuclear RNA-associated B'
            antigen
  JOURNAL   Proc Natl Acad Sci U S A 84 (8), 2421-2425 (1987)
   PUBMED   2951739
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC018022.1, BM772256.1,
            AI741327.1 and AL034428.4.
            
            On Nov 22, 2018 this sequence version replaced NM_003092.4.
            
            Summary: The protein encoded by this gene associates with stem loop
            IV of U2 small nuclear ribonucleoprotein (U2 snRNP) in the presence
            of snRNP-A'. The encoded protein may play a role in pre-mRNA
            splicing. Autoantibodies from patients with systemic lupus
            erythematosus frequently recognize epitopes on the encoded protein.
            Two transcript variants encoding the same protein have been found
            for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.193633.1,
                                           SRR3476690.249153.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000246071.8/ ENSP00000246071.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1065              BC018022.1         15-1079
            1066-1088           BM772256.1         421-443
            1089-1619           AI741327.1         12-542              c
            1620-2411           AL034428.4         35249-36040
FEATURES             Location/Qualifiers
     source          1..2411
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p12.1"
     gene            1..2411
                     /gene="SNRPB2"
                     /gene_synonym="Msl1; U2B''"
                     /note="small nuclear ribonucleoprotein polypeptide B2"
                     /db_xref="GeneID:6629"
                     /db_xref="HGNC:HGNC:11155"
                     /db_xref="MIM:603520"
     exon            1..139
                     /gene="SNRPB2"
                     /gene_synonym="Msl1; U2B''"
                     /inference="alignment:Splign:2.1.0"
     exon            140..238
                     /gene="SNRPB2"
                     /gene_synonym="Msl1; U2B''"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..852
                     /gene="SNRPB2"
                     /gene_synonym="Msl1; U2B''"
                     /note="U2 snRNP B''; small nuclear ribonucleoprotein
                     polypeptide B"
                     /codon_start=1
                     /product="U2 small nuclear ribonucleoprotein B''"
                     /protein_id="NP_003083.1"
                     /db_xref="CCDS:CCDS13123.1"
                     /db_xref="GeneID:6629"
                     /db_xref="HGNC:HGNC:11155"
                     /db_xref="MIM:603520"
                     /translation="MDIRPNHTIYINNMNDKIKKEELKRSLYALFSQFGHVVDIVALK
                     TMKMRGQAFVIFKELGSSTNALRQLQGFPFYGKPMRIQYAKTDSDIISKMRGTFADKE
                     KKKEKKKAKTVEQTATTTNKKPGQGTPNSANTQGNSTPNPQVPDYPPNYILFLNNLPE
                     ETNEMMLSMLFNQFPGFKEVRLVPGRHDIAFVEFENDGQAGAARDALQGFKITPSHAM
                     KITYAKK"
     exon            239..411
                     /gene="SNRPB2"
                     /gene_synonym="Msl1; U2B''"
                     /inference="alignment:Splign:2.1.0"
     exon            412..552
                     /gene="SNRPB2"
                     /gene_synonym="Msl1; U2B''"
                     /inference="alignment:Splign:2.1.0"
     exon            553..603
                     /gene="SNRPB2"
                     /gene_synonym="Msl1; U2B''"
                     /inference="alignment:Splign:2.1.0"
     exon            604..692
                     /gene="SNRPB2"
                     /gene_synonym="Msl1; U2B''"
                     /inference="alignment:Splign:2.1.0"
     exon            693..2411
                     /gene="SNRPB2"
                     /gene_synonym="Msl1; U2B''"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1041..1046
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNRPB2"
                     /gene_synonym="Msl1; U2B''"
                     /note="hexamer: AATAAA"
     polyA_site      1067
                     /gene="SNRPB2"
                     /gene_synonym="Msl1; U2B''"
                     /note="major polyA site"
     regulatory      1602..1607
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNRPB2"
                     /gene_synonym="Msl1; U2B''"
                     /note="hexamer: AATAAA"
     polyA_site      1623
                     /gene="SNRPB2"
                     /gene_synonym="Msl1; U2B''"
     regulatory      2118..2123
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNRPB2"
                     /gene_synonym="Msl1; U2B''"
                     /note="hexamer: GATAAA"
     polyA_site      2146
                     /gene="SNRPB2"
                     /gene_synonym="Msl1; U2B''"
     regulatory      2384..2389
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNRPB2"
                     /gene_synonym="Msl1; U2B''"
                     /note="hexamer: AATAAA"
     polyA_site      2411
                     /gene="SNRPB2"
                     /gene_synonym="Msl1; U2B''"
ORIGIN      
        1 cctgcttttg gttcttacag tagtcggcgt aggccttagg tgggttcgtg cgccttctac
       61 ctcgctgttt cggttttcct ggctcctcgg cccttttctc ccctgttgca gctgggagcg
      121 gacgaagcgc gaagctggga ttttttactg tctcctgaag aatttaacac aaacatggat
      181 atcagaccaa atcatacaat ttatatcaac aatatgaatg acaaaattaa aaaggaagaa
      241 ttgaagagat ccctatatgc cctgttttct cagtttggtc atgtggtgga cattgtggct
      301 ttaaagacca tgaagatgag ggggcaggcc tttgtcatat ttaaggaact gggctcatcc
      361 acaaatgcct tgagacagct acaaggattt ccattttatg gtaaaccaat gcgaatacag
      421 tatgcaaaaa cagattcgga tataatatca aaaatgcgtg gaacttttgc tgacaaagaa
      481 aagaaaaaag aaaagaaaaa agccaaaact gtggaacaga ctgcaacaac cacaaacaaa
      541 aagcctggcc agggaactcc aaattcagct aatacccaag gaaattcaac accaaatcct
      601 caggtccctg attaccctcc aaactatatt ttattcctta ataacttacc agaagagact
      661 aatgagatga tgttatccat gctgtttaat cagttccctg gcttcaagga agtacgtctg
      721 gtaccaggga ggcatgacat tgcttttgtt gaatttgaaa atgatgggca ggctggagct
      781 gccagggatg ctttacaggg atttaagatc acaccgtccc atgctatgaa gatcacctat
      841 gccaagaaat aacatttggg atagtcgtct ttaaaagact tggtgttatt tacagtgttt
      901 gttttgataa catttggctg ggtcatttta atagttagag atgaggagga gtaaaagtga
      961 aatttttgtg aaggacttaa attatccagt gtttctttag ccttggtgaa ctatgaaata
     1021 cgaaggcctt aattttgtac aataaacttt tatttgtatt ctgtgtatat aatgctttct
     1081 tgattgaccc atctccctat catcaaatga cttctagtct agaacacact taaggtttat
     1141 aaacttgtgt aataggatgc ttttctagtg ttactttgga ggagctaatt atacaacatc
     1201 attgaaccat tcaataaaag ttaagtaaaa ttagatcaca gaagctagta gatgactgtt
     1261 gtattaatgg taacaatgat tgttctgggt attagaagaa aatgagaccc aggcaggatc
     1321 taaatttgat ctttgtatcc ttttaagaaa tgaatatatt attttgctgc tagtagggat
     1381 tccacaagtt ttcttcattc agtattaaat aaaggctgtt cttactgttt actgagaaaa
     1441 cagaaaggga atgctatctt cacactttgc atttaatgct gtttccttca tgaggcagga
     1501 ctgttctaag gttaatatgc aatctcttta ttgaaagacc tccagggtaa aaattttttg
     1561 atctatagtc tcttttcccc cttaagacaa atagactgat taataaagag ttgccagtgc
     1621 taagcttgct acttctttgt aattcttaaa caccaatgtt caaatatttc caaagcccat
     1681 tttctttagc ttttgattta tgtttaaggc tattgattca gtcctctgct gagtaaacca
     1741 tgggtatctc cagaagtgga caatttgttt ttacaagtat ggtacatatt aatagtaaca
     1801 acaacaaaaa agaaaacagt acttattttt ctggtgttcc tgttttagta ttccttgaac
     1861 aaaaccttta tcacttggaa tttttattgt ctacttatgg aaagactttt agacttacgt
     1921 agacagtatc acatcactct tatgcataca taaagaggaa aaaaatgttt cctataactt
     1981 tgtcacagtt agtctgactc ttctgaataa cttttttaat cccagtagtc aagctcctgt
     2041 acttttgtaa aatatattaa cagtgaatta ctagaaaatg ggccatgttc ttgtatatta
     2101 cagtgatgtc aattgctgat aaattttcta actgcttact ctcggatacc gtacttgtct
     2161 aagaactgaa aataattcac agactgatcc catgcccagt cctggccatg ctttgagtgg
     2221 ctgtattgga gcagaaaagc cagggtggct cacctggggt gagaatgagg ggggtgaata
     2281 gtaagagggg tcgtgtaggt cttcttcagg atttgcttat actctgagtg aaatggggga
     2341 ctattttaga gaattttttt aaagtgggtt agaatttacg tacaataaag ttcacccatg
     2401 ttagtgttcc a
//
