LOCUS       NM_003090               1052 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens small nuclear ribonucleoprotein polypeptide A'
            (SNRPA1), transcript variant 1, mRNA.
ACCESSION   NM_003090
VERSION     NM_003090.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1052)
  AUTHORS   Yang,J.J., Yang,Y.J., Gu,Y.L., Tong,L., Liu,Y.F. and Zhang,J.G.
  TITLE     High SNRPA1 expression leads to poor prognosis in patients with
            lung adenocarcinoma
  JOURNAL   Clin Respir J 17 (8), 719-732 (2023)
   PUBMED   37277111
  REMARK    GeneRIF: High SNRPA1 expression leads to poor prognosis in patients
            with lung adenocarcinoma.
REFERENCE   2  (bases 1 to 1052)
  AUTHORS   Mo,Z., Li,R., Cao,C., Li,Y., Zheng,S., Wu,R., Xue,J., Hu,J.,
            Meng,H., Zhai,H., Huang,W., Zheng,F. and Zhou,B.
  TITLE     Splicing factor SNRPA associated with microvascular invasion
            promotes hepatocellular carcinoma metastasis through activating
            NOTCH1/Snail pathway and is mediated by circSEC62/miR-625-5p axis
  JOURNAL   Environ Toxicol 38 (5), 1022-1037 (2023)
   PUBMED   36715182
  REMARK    GeneRIF: Splicing factor SNRPA associated with microvascular
            invasion promotes hepatocellular carcinoma metastasis through
            activating NOTCH1/Snail pathway and is mediated by
            circSEC62/miR-625-5p axis.
REFERENCE   3  (bases 1 to 1052)
  AUTHORS   Yang,F., Bian,T., Zhan,X., Chen,Z., Xing,Z., Larsen,N.A., Zhang,X.
            and Shi,Y.
  TITLE     Mechanisms of the RNA helicases DDX42 and DDX46 in human U2 snRNP
            assembly
  JOURNAL   Nat Commun 14 (1), 897 (2023)
   PUBMED   36797247
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1052)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 1052)
  AUTHORS   Qin,Y., Huttlin,E.L., Winsnes,C.F., Gosztyla,M.L., Wacheul,L.,
            Kelly,M.R., Blue,S.M., Zheng,F., Chen,M., Schaffer,L.V., Licon,K.,
            Backstrom,A., Vaites,L.P., Lee,J.J., Ouyang,W., Liu,S.N., Zhang,T.,
            Silva,E., Park,J., Pitea,A., Kreisberg,J.F., Gygi,S.P., Ma,J.,
            Harper,J.W., Yeo,G.W., Lafontaine,D.L.J., Lundberg,E. and Ideker,T.
  TITLE     A multi-scale map of cell structure fusing protein images and
            interactions
  JOURNAL   Nature 600 (7889), 536-542 (2021)
   PUBMED   34819669
REFERENCE   6  (bases 1 to 1052)
  AUTHORS   Price,S.R., Evans,P.R. and Nagai,K.
  TITLE     Crystal structure of the spliceosomal U2B'-U2A' protein complex
            bound to a fragment of U2 small nuclear RNA
  JOURNAL   Nature 394 (6694), 645-650 (1998)
   PUBMED   9716128
REFERENCE   7  (bases 1 to 1052)
  AUTHORS   Blencowe,B.J., Issner,R., Nickerson,J.A. and Sharp,P.A.
  TITLE     A coactivator of pre-mRNA splicing
  JOURNAL   Genes Dev 12 (7), 996-1009 (1998)
   PUBMED   9531537
REFERENCE   8  (bases 1 to 1052)
  AUTHORS   Kjems,J. and Sharp,P.A.
  TITLE     The basic domain of Rev from human immunodeficiency virus type 1
            specifically blocks the entry of U4/U6.U5 small nuclear
            ribonucleoprotein in spliceosome assembly
  JOURNAL   J Virol 67 (8), 4769-4776 (1993)
   PUBMED   8331728
REFERENCE   9  (bases 1 to 1052)
  AUTHORS   Ohno,M., Kataoka,N. and Shimura,Y.
  TITLE     A nuclear cap binding protein from HeLa cells
  JOURNAL   Nucleic Acids Res 18 (23), 6989-6995 (1990)
   PUBMED   2148205
REFERENCE   10 (bases 1 to 1052)
  AUTHORS   Sillekens,P.T., Beijer,R.P., Habets,W.J. and van Verooij,W.J.
  TITLE     Molecular cloning of the cDNA for the human U2 snRNA-specific A'
            protein
  JOURNAL   Nucleic Acids Res 17 (5), 1893-1906 (1989)
   PUBMED   2928112
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC023024.6, AK312200.1 and BC022816.1.
            
            On Nov 23, 2018 this sequence version replaced NM_003090.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189658.21692.1,
                                           SRR1163658.513763.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000254193.11/ ENSP00000254193.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                AC023024.6         102604-102638       c
            36-838              AK312200.1         1-803
            839-1052            BC022816.1         826-1039
FEATURES             Location/Qualifiers
     source          1..1052
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q26.3"
     gene            1..1052
                     /gene="SNRPA1"
                     /gene_synonym="Lea1; U2A'"
                     /note="small nuclear ribonucleoprotein polypeptide A'"
                     /db_xref="GeneID:6627"
                     /db_xref="HGNC:HGNC:11152"
                     /db_xref="MIM:603521"
     exon            1..152
                     /gene="SNRPA1"
                     /gene_synonym="Lea1; U2A'"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..838
                     /gene="SNRPA1"
                     /gene_synonym="Lea1; U2A'"
                     /note="U2 small nuclear ribonucleoprotein polypeptide A';
                     U2 snRNP A'"
                     /codon_start=1
                     /product="U2 small nuclear ribonucleoprotein A'"
                     /protein_id="NP_003081.2"
                     /db_xref="CCDS:CCDS10391.1"
                     /db_xref="GeneID:6627"
                     /db_xref="HGNC:HGNC:11152"
                     /db_xref="MIM:603521"
                     /translation="MVKLTAELIEQAAQYTNAVRDRELDLRGYKIPVIENLGATLDQF
                     DAIDFSDNEIRKLDGFPLLRRLKTLLVNNNRICRIGEGLDQALPCLTELILTNNSLVE
                     LGDLDPLASLKSLTYLSILRNPVTNKKHYRLYVIYKVPQVRVLDFQKVKLKERQEAEK
                     MFKGKRGAQLAKDIARRSKTFNPGAGLPTDKKKGGPSPGDVEAIKNAIANASTLAEVE
                     RLKGLLQSGQIPGRERRSGPTDDGEEEMEEDTVTNGS"
     exon            153..300
                     /gene="SNRPA1"
                     /gene_synonym="Lea1; U2A'"
                     /inference="alignment:Splign:2.1.0"
     exon            301..379
                     /gene="SNRPA1"
                     /gene_synonym="Lea1; U2A'"
                     /inference="alignment:Splign:2.1.0"
     exon            380..426
                     /gene="SNRPA1"
                     /gene_synonym="Lea1; U2A'"
                     /inference="alignment:Splign:2.1.0"
     exon            427..529
                     /gene="SNRPA1"
                     /gene_synonym="Lea1; U2A'"
                     /inference="alignment:Splign:2.1.0"
     exon            530..609
                     /gene="SNRPA1"
                     /gene_synonym="Lea1; U2A'"
                     /inference="alignment:Splign:2.1.0"
     exon            610..685
                     /gene="SNRPA1"
                     /gene_synonym="Lea1; U2A'"
                     /inference="alignment:Splign:2.1.0"
     exon            686..779
                     /gene="SNRPA1"
                     /gene_synonym="Lea1; U2A'"
                     /inference="alignment:Splign:2.1.0"
     exon            780..1052
                     /gene="SNRPA1"
                     /gene_synonym="Lea1; U2A'"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1026..1031
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNRPA1"
                     /gene_synonym="Lea1; U2A'"
                     /note="hexamer: AATAAA"
     polyA_site      1052
                     /gene="SNRPA1"
                     /gene_synonym="Lea1; U2A'"
                     /note="major polyA site"
ORIGIN      
        1 gcacgctggg acgtctcgct ggcgggaggc cacgggcttt ccacagcgcg ggggaacggg
       61 aggctgcagg atggtcaagc tgacggcgga gctgatcgag caggcggcgc agtacaccaa
      121 cgcggtgcgc gaccgggagc tggacctccg ggggtataaa attcccgtca ttgaaaatct
      181 aggtgctacg ttagaccagt ttgatgctat tgatttttct gacaatgaga tcaggaaact
      241 ggatggtttt cctttgttga gaagactgaa aacattgtta gtgaacaaca acagaatatg
      301 ccgtataggt gagggacttg atcaggctct gccctgtctg acagaactca ttctcaccaa
      361 taatagtctc gtggaactgg gtgatctgga ccctctggca tctctcaaat cgctgactta
      421 cctaagtatc ctaagaaatc cggtaaccaa taagaagcat tacagattgt atgtgattta
      481 taaagttccg caagtcagag tactggattt ccagaaagtg aaactaaaag agcgtcagga
      541 agcagagaaa atgttcaagg gcaaacgggg tgcacagctt gcaaaggata ttgccaggag
      601 aagcaaaact tttaatccag gtgctggttt gccaactgac aaaaagaaag gtgggccatc
      661 tccaggggat gtagaagcaa tcaagaatgc catagcaaat gcttcaactc tggctgaagt
      721 ggagaggctg aaggggttgc tgcagtctgg tcagatccct ggcagagaac gcagatcagg
      781 gcccactgat gatggtgaag aagagatgga agaagacaca gtcacaaacg ggtcctgagc
      841 agtgaggcag atgtataata ataggccctc ttggaacaag tcttgctttt cgaacatggt
      901 ataatagcct tgtttgtgtt agcaaagtgg aatctatcag cattgttgaa atgcttaaga
      961 ctgctgctga taattttgta atataagttt tgaaatctaa atgtcaattt tctacaaatt
     1021 ataaaaataa actccactca ctatgctacc aa
//
