LOCUS       NM_004596               1277 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens small nuclear ribonucleoprotein polypeptide A (SNRPA),
            mRNA.
ACCESSION   NM_004596
VERSION     NM_004596.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1277)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1277)
  AUTHORS   Liu,J., Li,J., Su,Y., Ma,Z., Yu,S. and He,Y.
  TITLE     Circ_0009910 Serves as miR-361-3p Sponge to Promote the
            Proliferation, Metastasis, and Glycolysis of Gastric Cancer via
            Regulating SNRPA
  JOURNAL   Biochem Genet 60 (5), 1809-1824 (2022)
   PUBMED   35098410
  REMARK    GeneRIF: Circ_0009910 Serves as miR-361-3p Sponge to Promote the
            Proliferation, Metastasis, and Glycolysis of Gastric Cancer via
            Regulating SNRPA.
REFERENCE   3  (bases 1 to 1277)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 1277)
  AUTHORS   Campagne,S., de Vries,T., Malard,F., Afanasyev,P., Dorn,G.,
            Dedic,E., Kohlbrecher,J., Boehringer,D., Clery,A. and Allain,F.H.
  TITLE     An in vitro reconstituted U1 snRNP allows the study of the
            disordered regions of the particle and the interactions with
            proteins and ligands
  JOURNAL   Nucleic Acids Res 49 (11), e63 (2021)
   PUBMED   33677607
REFERENCE   5  (bases 1 to 1277)
  AUTHORS   Jessen,T.H., Oubridge,C., Teo,C.H., Pritchard,C. and Nagai,K.
  TITLE     Identification of molecular contacts between the U1 A small nuclear
            ribonucleoprotein and U1 RNA
  JOURNAL   EMBO J 10 (11), 3447-3456 (1991)
   PUBMED   1833186
REFERENCE   6  (bases 1 to 1277)
  AUTHORS   Nelissen,R.L., Sillekens,P.T., Beijer,R.P., Geurts van Kessel,A.H.
            and van Venrooij,W.J.
  TITLE     Structure, chromosomal localization and evolutionary conservation
            of the gene encoding human U1 snRNP-specific A protein
  JOURNAL   Gene 102 (2), 189-196 (1991)
   PUBMED   1831431
REFERENCE   7  (bases 1 to 1277)
  AUTHORS   Hoffman,D.W., Query,C.C., Golden,B.L., White,S.W. and Keene,J.D.
  TITLE     RNA-binding domain of the A protein component of the U1 small
            nuclear ribonucleoprotein analyzed by NMR spectroscopy is
            structurally similar to ribosomal proteins
  JOURNAL   Proc Natl Acad Sci U S A 88 (6), 2495-2499 (1991)
   PUBMED   1826055
REFERENCE   8  (bases 1 to 1277)
  AUTHORS   Lutz-Freyermuth,C., Query,C.C. and Keene,J.D.
  TITLE     Quantitative determination that one of two potential RNA-binding
            domains of the A protein component of the U1 small nuclear
            ribonucleoprotein complex binds with high affinity to stem-loop II
            of U1 RNA
  JOURNAL   Proc Natl Acad Sci U S A 87 (16), 6393-6397 (1990)
   PUBMED   1696729
REFERENCE   9  (bases 1 to 1277)
  AUTHORS   Schonk,D., van Dijk,P., Riegmann,P., Trapman,J., Holm,C.,
            Willcocks,T.C., Sillekens,P., van Venrooij,W., Wimmer,E., Geurts
            van Kessel,A. et al.
  TITLE     Assignment of seven genes to distinct intervals on the midportion
            of human chromosome 19q surrounding the myotonic dystrophy gene
            region
  JOURNAL   Cytogenet Cell Genet 54 (1-2), 15-19 (1990)
   PUBMED   1701111
REFERENCE   10 (bases 1 to 1277)
  AUTHORS   Sillekens,P.T., Habets,W.J., Beijer,R.P. and van Venrooij,W.J.
  TITLE     cDNA cloning of the human U1 snRNA-associated A protein: extensive
            homology between U1 and U2 snRNP-specific proteins
  JOURNAL   EMBO J 6 (12), 3841-3848 (1987)
   PUBMED   2962859
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC000405.2 and AC020945.6.
            
            On Nov 23, 2018 this sequence version replaced NM_004596.4.
            
            Summary: The protein encoded by this gene associates with stem loop
            II of the U1 small nuclear ribonucleoprotein, which binds the 5'
            splice site of precursor mRNAs and is required for splicing. The
            encoded protein autoregulates itself by polyadenylation inhibition
            of its own pre-mRNA via dimerization and has been implicated in the
            coupling of splicing and polyadenylation. [provided by RefSeq, Oct
            2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC000405.2, SRR1163657.318416.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000243563.8/ ENSP00000243563.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                BC000405.2         330-397
            69-69               AC020945.6         24823-24823         c
            70-1277             BC000405.2         399-1606
FEATURES             Location/Qualifiers
     source          1..1277
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..1277
                     /gene="SNRPA"
                     /gene_synonym="Mud1; U1-A; U1A"
                     /note="small nuclear ribonucleoprotein polypeptide A"
                     /db_xref="GeneID:6626"
                     /db_xref="HGNC:HGNC:11151"
                     /db_xref="MIM:182285"
     exon            1..279
                     /gene="SNRPA"
                     /gene_synonym="Mud1; U1-A; U1A"
                     /inference="alignment:Splign:2.1.0"
     CDS             207..1055
                     /gene="SNRPA"
                     /gene_synonym="Mud1; U1-A; U1A"
                     /note="U1 snRNP-specific protein A; U1 small nuclear
                     RNP-specific A; U1 snRNP A"
                     /codon_start=1
                     /product="U1 small nuclear ribonucleoprotein A"
                     /protein_id="NP_004587.1"
                     /db_xref="CCDS:CCDS12565.1"
                     /db_xref="GeneID:6626"
                     /db_xref="HGNC:HGNC:11151"
                     /db_xref="MIM:182285"
                     /translation="MAVPETRPNHTIYINNLNEKIKKDELKKSLYAIFSQFGQILDIL
                     VSRSLKMRGQAFVIFKEVSSATNALRSMQGFPFYDKPMRIQYAKTDSDIIAKMKGTFV
                     ERDRKREKRKPKSQETPATKKAVQGGGATPVVGAVQGPVPGMPPMTQAPRIMHHMPGQ
                     PPYMPPPGMIPPPGLAPGQIPPGAMPPQQLMPGQMPPAQPLSENPPNHILFLTNLPEE
                     TNELMLSMLFNQFPGFKEVRLVPGRHDIAFVEFDNEVQAGAARDALQGFKITQNNAMK
                     ISFAKK"
     exon            280..452
                     /gene="SNRPA"
                     /gene_synonym="Mud1; U1-A; U1A"
                     /inference="alignment:Splign:2.1.0"
     exon            453..632
                     /gene="SNRPA"
                     /gene_synonym="Mud1; U1-A; U1A"
                     /inference="alignment:Splign:2.1.0"
     exon            633..806
                     /gene="SNRPA"
                     /gene_synonym="Mud1; U1-A; U1A"
                     /inference="alignment:Splign:2.1.0"
     exon            807..895
                     /gene="SNRPA"
                     /gene_synonym="Mud1; U1-A; U1A"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1277
                     /gene="SNRPA"
                     /gene_synonym="Mud1; U1-A; U1A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1243..1248
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNRPA"
                     /gene_synonym="Mud1; U1-A; U1A"
                     /note="hexamer: ATTAAA"
     polyA_site      1277
                     /gene="SNRPA"
                     /gene_synonym="Mud1; U1-A; U1A"
                     /note="major polyA site"
ORIGIN      
        1 ctctccgcac gcgggctgga gaagcgggtc ctacgcacgc tttgttgtcg cgctttgcct
       61 ccgtccttgc ccctactccc gccttacctg acttcctttt cggaggaaga tccttgagca
      121 gccgacgttg ggacaaagga tttggagaaa cccagggcta aagtcacgtt tttcctcctt
      181 taagacttac ctcaacactt cactccatgg cagttcccga gacccgccct aaccacacta
      241 tttatatcaa caacctcaat gagaagatca agaaggatga gctaaaaaag tccctgtacg
      301 ccatcttctc ccagtttggc cagatcctgg atatcctggt atcacggagc ctgaagatga
      361 ggggccaggc ctttgtcatc ttcaaggagg tcagcagcgc caccaacgcc ctgcgctcca
      421 tgcagggttt ccctttctat gacaaaccta tgcgtatcca gtatgccaag accgactcag
      481 atatcattgc caagatgaaa ggcaccttcg tggagcggga ccgcaagcgg gagaagagga
      541 agcccaagag ccaggagacc ccggccacca agaaggctgt gcaaggcggg ggagccaccc
      601 ccgtggtggg ggctgtccag gggcctgtcc cgggcatgcc gccgatgact caggcgcccc
      661 gcattatgca ccacatgccg ggccagccgc cctacatgcc gccccctggt atgatccccc
      721 cgccaggcct tgcacctggc cagatcccac caggggccat gcccccgcag cagcttatgc
      781 caggacagat gccccctgcc cagcctcttt ctgagaatcc accgaatcac atcttgttcc
      841 tcaccaacct gccagaggag accaacgagc tcatgctgtc catgcttttc aatcagttcc
      901 ctggcttcaa ggaggtccgt ctggtacccg ggcggcatga catcgccttc gtggagtttg
      961 acaatgaggt acaggcaggg gcagctcgcg atgccctgca gggctttaag atcacgcaga
     1021 acaacgccat gaagatctcc tttgccaaga agtagcacct tttcccccca tgcctgcccc
     1081 ttcccctgtt ctggggccac ccctttcccc cttggctcag ccccctgaag gtaagtcccc
     1141 ccttgggggc cttcttggag ccgtgtgtga gtgagtggtc gccacacagc attgtaccca
     1201 gagtctgtcc ccagacattg cacctggcgc tgttaggccg gaattaaagt ggctttttga
     1261 ggtttggttt ttcacaa
//
