LOCUS       NM_006857               1425 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens small nuclear ribonucleoprotein U4/U6.U5 subunit 27
            (SNRNP27), transcript variant 1, mRNA.
ACCESSION   NM_006857
VERSION     NM_006857.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1425)
  AUTHORS   Charenton,C., Wilkinson,M.E. and Nagai,K.
  TITLE     Mechanism of 5' splice site transfer for human spliceosome
            activation
  JOURNAL   Science 364 (6438), 362-367 (2019)
   PUBMED   30975767
REFERENCE   2  (bases 1 to 1425)
  AUTHORS   Varjosalo,M., Keskitalo,S., Van Drogen,A., Nurkkala,H.,
            Vichalkovski,A., Aebersold,R. and Gstaiger,M.
  TITLE     The protein interaction landscape of the human CMGC kinase group
  JOURNAL   Cell Rep 3 (4), 1306-1320 (2013)
   PUBMED   23602568
REFERENCE   3  (bases 1 to 1425)
  AUTHORS   Hegele,A., Kamburov,A., Grossmann,A., Sourlis,C., Wowro,S.,
            Weimann,M., Will,C.L., Pena,V., Luhrmann,R. and Stelzl,U.
  TITLE     Dynamic protein-protein interaction wiring of the human spliceosome
  JOURNAL   Mol Cell 45 (4), 567-580 (2012)
   PUBMED   22365833
REFERENCE   4  (bases 1 to 1425)
  AUTHORS   Liu,S., Rauhut,R., Vornlocher,H.P. and Luhrmann,R.
  TITLE     The network of protein-protein interactions within the human
            U4/U6.U5 tri-snRNP
  JOURNAL   RNA 12 (7), 1418-1430 (2006)
   PUBMED   16723661
REFERENCE   5  (bases 1 to 1425)
  AUTHORS   Fetzer,S., Lauber,J., Will,C.L. and Luhrmann,R.
  TITLE     The [U4/U6.U5] tri-snRNP-specific 27K protein is a novel SR protein
            that can be phosphorylated by the snRNP-associated protein kinase
  JOURNAL   RNA 3 (4), 344-355 (1997)
   PUBMED   9085842
REFERENCE   6  (bases 1 to 1425)
  AUTHORS   Nakamura,Y., Moriuchi,R., Nakayama,D., Yamashita,I.,
            Higashiyama,Y., Yamamoto,T., Kusano,Y., Hino,S., Miyamoto,T. and
            Katamine,S.
  TITLE     Altered expression of a novel cellular gene as a consequence of
            integration of human T cell lymphotropic virus type 1
  JOURNAL   J Gen Virol 75 (Pt 10), 2625-2633 (1994)
   PUBMED   7931148
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC019206.4, BC017890.1,
            X76302.1 and AW452063.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006857.2.
            
            Summary: This gene encodes a serine/arginine-rich (SR) protein. SR
            proteins play important roles in pre-mRNA splicing by facilitating
            the recognition and selection of splice sites. The encoded protein
            associates with the 25S U4/U6.U5 tri-snRNP, a major component of
            the U2-type spiceosome. The expression of this gene may be altered
            in cells infected with the human T-cell lymphotropic virus type 1
            (HTLV-1) retrovirus. A pseudogene of this gene is located on the
            long arm of chromosome 5. Alternatively spliced transcript variants
            have been observed for this gene. [provided by RefSeq, Feb 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes a functional protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.893936.1,
                                           SRR3476690.554754.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000244227.8/ ENSP00000244227.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC019206.4         144739-144740
            3-1019              BC017890.1         1-1017
            1020-1405           X76302.1           1017-1402
            1406-1425           AW452063.1         15-34               c
FEATURES             Location/Qualifiers
     source          1..1425
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p13.3"
     gene            1..1425
                     /gene="SNRNP27"
                     /gene_synonym="27K; RY1"
                     /note="small nuclear ribonucleoprotein U4/U6.U5 subunit
                     27"
                     /db_xref="GeneID:11017"
                     /db_xref="HGNC:HGNC:30240"
                     /db_xref="MIM:619629"
     exon            1..63
                     /gene="SNRNP27"
                     /gene_synonym="27K; RY1"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..497
                     /gene="SNRNP27"
                     /gene_synonym="27K; RY1"
                     /note="putative nucleic acid binding protein RY-1; small
                     nuclear ribonucleoprotein, U4/U6.U5 27kDa subunit;
                     U4/U6.U5-27K; U4/U6.U5 tri-snRNP-associated protein 3;
                     U4/U6.U5 tri-snRNP-associated 27 kDa protein; small
                     nuclear ribonucleoprotein 27kDa (U4/U6.U5)"
                     /codon_start=1
                     /product="U4/U6.U5 small nuclear ribonucleoprotein 27 kDa
                     protein"
                     /protein_id="NP_006848.1"
                     /db_xref="CCDS:CCDS33219.1"
                     /db_xref="GeneID:11017"
                     /db_xref="HGNC:HGNC:30240"
                     /db_xref="MIM:619629"
                     /translation="MGRSRSRSPRRERRRSRSTSRERERRRRERSRSRERDRRRSRSR
                     SPHRRRSRSPRRHRSTSPSPSRLKERRDEEKKETKETKSKERQITEEDLEGKTEEEIE
                     MMKLMGFASFDSTKGKKVDGSVNAYAINVSQKRKYRQYMNRKGGFNRPLDFIA"
     exon            64..184
                     /gene="SNRNP27"
                     /gene_synonym="27K; RY1"
                     /inference="alignment:Splign:2.1.0"
     exon            185..297
                     /gene="SNRNP27"
                     /gene_synonym="27K; RY1"
                     /inference="alignment:Splign:2.1.0"
     exon            298..377
                     /gene="SNRNP27"
                     /gene_synonym="27K; RY1"
                     /inference="alignment:Splign:2.1.0"
     exon            378..442
                     /gene="SNRNP27"
                     /gene_synonym="27K; RY1"
                     /inference="alignment:Splign:2.1.0"
     exon            443..1425
                     /gene="SNRNP27"
                     /gene_synonym="27K; RY1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1388..1393
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNRNP27"
                     /gene_synonym="27K; RY1"
                     /note="hexamer: ATTAAA"
     polyA_site      1425
                     /gene="SNRNP27"
                     /gene_synonym="27K; RY1"
                     /note="major polyA site"
ORIGIN      
        1 acagttgttt ccgggaagcg ggactccaaa tgggtcgcag tcgcagccgc tctccacgga
       61 gggaacgtag gcgttcccgg tccacatccc gggagagaga acgcaggcgc cgagaaaggt
      121 ccaggtctcg ggagagagat cggagaagga gccgctcgcg atccccgcac cgaagacgct
      181 cccgatctcc aagacgacat agatccacat ctccttcccc ttctcgactg aaagaaagaa
      241 gagatgagga aaagaaagaa acaaaagaaa caaagagcaa agaacggcag attactgagg
      301 aagacttaga gggcaaaaca gaggaagaaa tagaaatgat gaagttaatg ggatttgcct
      361 cctttgactc cacaaaaggt aagaaggtgg atggctctgt aaatgcctat gccataaatg
      421 tctctcagaa gaggaagtac aggcagtaca tgaatcgaaa aggtggattc aacagacctt
      481 tggatttcat tgcatgagaa ttgaagtgtt gaaggatgat tttttttccc ctcatcttgg
      541 tcagagagtg gattttgtat tttgtattta acttgcattc aaaaaacagg atctcagttc
      601 tcctttcttg taaagtaaga aaatcttatt tatgatatat gcagttaact taccttgcct
      661 caacagaaga aaggttaaat attacatttt tttcttttag gaaatatcat ttgtggcagg
      721 cgtcaacccc attttatttg tccttattcc tgtggaagca gtatatgttt tcttcctgaa
      781 tgctcattag gacttcttaa aaaacatgaa agtaatttgg aagtaagttt atccaataaa
      841 gcagtatttc taccctttta gatttgataa atatttttat tactaaagaa tctccccaga
      901 cattttcttt tttttttcac acatagattt aagtatcttg attgttagta gtctaaaaat
      961 gggaagaatg aaaaagcata actagatttt tctatcttct gtggtcgccc gccccccccc
     1021 aaaaaaatac catttatggt tctctccgca agtataaaag cattacatgc aaaaaaaaga
     1081 tctcagagaa aacaaaagta aaagaaaagc agaaaatcac ctgttatcta ctcccagaaa
     1141 taatcaattt caacattttg gtatatgttt ttccaggctt ctttgggttg atcccaccta
     1201 tgagatcaga atatgtatgc agttctttct ttaacccttt tttctcctat gtactgtgaa
     1261 catttaaaaa gtacttttaa atattctttg gaaacttagc ttttagtaac tacttggttg
     1321 tatcataatt tattaactaa tgttttattg gtaaacattg gcttgcctcc catgacttgc
     1381 cattataatt aaaactgtga ctactatctg tctccattac ataca
//
