LOCUS       NM_024571               1087 bp    mRNA    linear   PRI 05-SEP-2024
DEFINITION  Homo sapiens small nuclear ribonucleoprotein U11/U12 subunit 25
            (SNRNP25), mRNA.
ACCESSION   NM_024571
VERSION     NM_024571.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1087)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1087)
  AUTHORS   Yang,J., Annala,M., Ji,P., Wang,G., Zheng,H., Codgell,D., Du,X.,
            Fang,Z., Sun,B., Nykter,M., Chen,K. and Zhang,W.
  TITLE     Recurrent LRP1-SNRNP25 and KCNMB4-CCND3 fusion genes promote tumor
            cell motility in human osteosarcoma
  JOURNAL   J Hematol Oncol 7, 76 (2014)
   PUBMED   25300797
  REMARK    GeneRIF: Two recurrent fusion genes associated with the 12q locus,
            LRP1-SNRNP25 and KCNMB4-CCND3, were by RT-PCR, Sanger sequencing
            and FISH, and were found to be osteosarcoma specific in a
            validation cohort of 240 other sarcomas.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1087)
  AUTHORS   Pessa,H.K., Will,C.L., Meng,X., Schneider,C., Watkins,N.J.,
            Perala,N., Nymark,M., Turunen,J.J., Luhrmann,R. and Frilander,M.J.
  TITLE     Minor spliceosome components are predominantly localized in the
            nucleus
  JOURNAL   Proc Natl Acad Sci U S A 105 (25), 8655-8660 (2008)
   PUBMED   18559850
REFERENCE   4  (bases 1 to 1087)
  AUTHORS   De Gobbi,M., Viprakasit,V., Hughes,J.R., Fisher,C., Buckle,V.J.,
            Ayyub,H., Gibbons,R.J., Vernimmen,D., Yoshinaga,Y., de Jong,P.,
            Cheng,J.F., Rubin,E.M., Wood,W.G., Bowden,D. and Higgs,D.R.
  TITLE     A regulatory SNP causes a human genetic disease by creating a new
            transcriptional promoter
  JOURNAL   Science 312 (5777), 1215-1217 (2006)
   PUBMED   16728641
REFERENCE   5  (bases 1 to 1087)
  AUTHORS   Martin,J., Han,C., Gordon,L.A., Terry,A., Prabhakar,S., She,X.,
            Xie,G., Hellsten,U., Chan,Y.M., Altherr,M., Couronne,O., Aerts,A.,
            Bajorek,E., Black,S., Blumer,H., Branscomb,E., Brown,N.C.,
            Bruno,W.J., Buckingham,J.M., Callen,D.F., Campbell,C.S.,
            Campbell,M.L., Campbell,E.W., Caoile,C., Challacombe,J.F.,
            Chasteen,L.A., Chertkov,O., Chi,H.C., Christensen,M., Clark,L.M.,
            Cohn,J.D., Denys,M., Detter,J.C., Dickson,M.,
            Dimitrijevic-Bussod,M., Escobar,J., Fawcett,J.J., Flowers,D.,
            Fotopulos,D., Glavina,T., Gomez,M., Gonzales,E., Goodstein,D.,
            Goodwin,L.A., Grady,D.L., Grigoriev,I., Groza,M., Hammon,N.,
            Hawkins,T., Haydu,L., Hildebrand,C.E., Huang,W., Israni,S.,
            Jett,J., Jewett,P.B., Kadner,K., Kimball,H., Kobayashi,A.,
            Krawczyk,M.C., Leyba,T., Longmire,J.L., Lopez,F., Lou,Y., Lowry,S.,
            Ludeman,T., Manohar,C.F., Mark,G.A., McMurray,K.L., Meincke,L.J.,
            Morgan,J., Moyzis,R.K., Mundt,M.O., Munk,A.C., Nandkeshwar,R.D.,
            Pitluck,S., Pollard,M., Predki,P., Parson-Quintana,B., Ramirez,L.,
            Rash,S., Retterer,J., Ricke,D.O., Robinson,D.L., Rodriguez,A.,
            Salamov,A., Saunders,E.H., Scott,D., Shough,T., Stallings,R.L.,
            Stalvey,M., Sutherland,R.D., Tapia,R., Tesmer,J.G., Thayer,N.,
            Thompson,L.S., Tice,H., Torney,D.C., Tran-Gyamfi,M., Tsai,M.,
            Ulanovsky,L.E., Ustaszewska,A., Vo,N., White,P.S., Williams,A.L.,
            Wills,P.L., Wu,J.R., Wu,K., Yang,J., Dejong,P., Bruce,D.,
            Doggett,N.A., Deaven,L., Schmutz,J., Grimwood,J., Richardson,P.,
            Rokhsar,D.S., Eichler,E.E., Gilna,P., Lucas,S.M., Myers,R.M.,
            Rubin,E.M. and Pennacchio,L.A.
  TITLE     The sequence and analysis of duplication-rich human chromosome 16
  JOURNAL   Nature 432 (7020), 988-994 (2004)
   PUBMED   15616553
REFERENCE   6  (bases 1 to 1087)
  AUTHORS   Will,C.L., Schneider,C., Hossbach,M., Urlaub,H., Rauhut,R.,
            Elbashir,S., Tuschl,T. and Luhrmann,R.
  TITLE     The human 18S U11/U12 snRNP contains a set of novel proteins not
            found in the U2-dependent spliceosome
  JOURNAL   RNA 10 (6), 929-941 (2004)
   PUBMED   15146077
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z69719.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jul 12, 2019 this sequence version replaced NM_024571.3.
            
            Summary: Two types of spliceosomes catalyze splicing of pre-mRNAs.
            The major U2-type spliceosome is found in all eukaryotes and
            removes U2-type introns, which represent more than 99% of pre-mRNA
            introns. The minor U12-type spliceosome is found in some eukaryotes
            and removes U12-type introns, which are rare and have distinct
            splice consensus signals. The U12-type spliceosome consists of
            several small nuclear RNAs and associated proteins. This gene
            encodes a 25K protein that is a component of the U12-type
            spliceosome. [provided by RefSeq, Apr 2010].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK026593.1, BC001381.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000293861.8/
                                                ENSP00000293861.3
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-231               Z69719.1           16522-16752
            232-322             Z69719.1           18153-18243
            323-428             Z69719.1           18471-18576
            429-503             Z69719.1           19233-19307
            504-1087            Z69719.1           19780-20363
FEATURES             Location/Qualifiers
     source          1..1087
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..1087
                     /gene="SNRNP25"
                     /gene_synonym="C16orf33"
                     /note="small nuclear ribonucleoprotein U11/U12 subunit 25"
                     /db_xref="GeneID:79622"
                     /db_xref="HGNC:HGNC:14161"
     exon            1..231
                     /gene="SNRNP25"
                     /gene_synonym="C16orf33"
                     /inference="alignment:Splign:2.1.0"
     CDS             190..561
                     /gene="SNRNP25"
                     /gene_synonym="C16orf33"
                     /note="small nuclear ribonucleoprotein, U11/U12 25kDa
                     subunit; minus-99 protein; U11/U12 snRNP 25 kDa protein;
                     small nuclear ribonucleoprotein 25kDa (U11/U12); U11/U12
                     snRNP 25K"
                     /codon_start=1
                     /product="U11/U12 small nuclear ribonucleoprotein 25 kDa
                     protein"
                     /protein_id="NP_078847.2"
                     /db_xref="CCDS:CCDS10396.2"
                     /db_xref="GeneID:79622"
                     /db_xref="HGNC:HGNC:14161"
                     /translation="MVVQDPLLCDLPIQVTLEEVNSQIALEYGQAMTVRVCKMDGEVM
                     PVVVVQSATVLDLKKAIQRYVQLKQEREGGIQHISWSYVWRTYHLTSAGEKLTEDRKK
                     LRDYGIRNRDEVSFIKKLRQK"
     exon            232..322
                     /gene="SNRNP25"
                     /gene_synonym="C16orf33"
                     /inference="alignment:Splign:2.1.0"
     exon            323..428
                     /gene="SNRNP25"
                     /gene_synonym="C16orf33"
                     /inference="alignment:Splign:2.1.0"
     exon            429..503
                     /gene="SNRNP25"
                     /gene_synonym="C16orf33"
                     /inference="alignment:Splign:2.1.0"
     exon            504..1087
                     /gene="SNRNP25"
                     /gene_synonym="C16orf33"
                     /inference="alignment:Splign:2.1.0"
     regulatory      842..847
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNRNP25"
                     /gene_synonym="C16orf33"
                     /note="hexamer: AATAAA"
     polyA_site      871
                     /gene="SNRNP25"
                     /gene_synonym="C16orf33"
                     /note="major polyA site"
     regulatory      1058..1063
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNRNP25"
                     /gene_synonym="C16orf33"
                     /note="hexamer: AATAAA"
     polyA_site      1087
                     /gene="SNRNP25"
                     /gene_synonym="C16orf33"
ORIGIN      
        1 gcagttcctg cgcgtgcgcg cttggcctcc ctagtgcggg ctggcagtgc gggcagagcc
       61 cggctgagag gggcggccct ggaggagacg gaggccgcgg gtgggcccga ggcgcaagag
      121 gaagatgagg acgaagaaga ggcgctgccg cactccgagg ccatggacgt gttccaggag
      181 ggtctggcta tggtggtgca ggacccgctg ctctgcgatc tgccgatcca ggttactctg
      241 gaagaagtca actcccaaat agccctagaa tacggccagg caatgacggt ccgagtgtgc
      301 aagatggatg gagaagtaat gcccgtggtt gtagtgcaga gtgccacagt cctggacctg
      361 aagaaggcca tccagagata cgtgcagctc aagcaggagc gtgaaggggg cattcagcac
      421 atcagctggt cctacgtgtg gaggacgtac catctgacct ctgcaggaga gaaactcacg
      481 gaagacagaa agaagctccg agactacggc atccggaatc gagacgaggt ttccttcatc
      541 aaaaagctga ggcaaaagtg agcctccaga caggacaacc ctcttcatca ctggtggctg
      601 agctttttcc cagcaggaat gggtcctcga atcatcgtgc ctctttcaca gaaaggacgt
      661 tgtggtggcc tcaccccagg catgcccaac agtaactgtc agcataaacc tgggggccct
      721 caggactagg acagggtgag ccagtgctcc ctcctttcat gtacttggcc tgagactgac
      781 ctctccctag gtccaaatgc cctagtcaca tggcagaccc acggcctggc ccactgtata
      841 aaataaacct gtttgcttct tagtttgaaa agtagaaagc cacagtaacc tgggtagcaa
      901 agactgagat tgccccatca cagaggtgag ttaaggggag agaattggta caggcgagtc
      961 ctatagtcca agatggcgcc acaccaccaa agccttgagg ccacaccact ccccaaacca
     1021 cacaactgtg ttaccatgat ctccacagca aggaggaaat aaaagcagag cggctttagg
     1081 gtttgca
//
