LOCUS       NM_014014               7194 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens small nuclear ribonucleoprotein U5 subunit 200
            (SNRNP200), mRNA.
ACCESSION   NM_014014
VERSION     NM_014014.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7194)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7194)
  AUTHORS   Atkinson,R., Georgiou,M., Yang,C., Szymanska,K., Lahat,A.,
            Vasconcelos,E.J.R., Ji,Y., Moya Molina,M., Collin,J., Queen,R.,
            Dorgau,B., Watson,A., Kurzawa-Akanbi,M., Laws,R., Saxena,A., Shyan
            Beh,C., Siachisumo,C., Goertler,F., Karwatka,M., Davey,T.,
            Inglehearn,C.F., McKibbin,M., Luhrmann,R., Steel,D.H.,
            Elliott,D.J., Armstrong,L., Urlaub,H., Ali,R.R., Grellscheid,S.N.,
            Johnson,C.A., Mozaffari-Jovin,S. and Lako,M.
  TITLE     PRPF8-mediated dysregulation of hBrr2 helicase disrupts human
            spliceosome kinetics and 5 -splice-site selection causing
            tissue-specific defects
  JOURNAL   Nat Commun 15 (1), 3138 (2024)
   PUBMED   38605034
  REMARK    GeneRIF: PRPF8-mediated dysregulation of hBrr2 helicase disrupts
            human spliceosome kinetics and 5 -splice-site selection causing
            tissue-specific defects.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7194)
  AUTHORS   Guidarelli Mattioli,F., Saltalamacchia,A. and Magistrato,A.
  TITLE     Tracing Allostery in the Spliceosome Ski2-like RNA Helicase Brr2
  JOURNAL   J Phys Chem Lett 15 (13), 3502-3508 (2024)
   PUBMED   38517341
  REMARK    GeneRIF: Tracing Allostery in the Spliceosome Ski2-like RNA
            Helicase Brr2.
REFERENCE   4  (bases 1 to 7194)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 7194)
  AUTHORS   Bergfort,A., Preussner,M., Kuropka,B., Ilik,I.A., Hilal,T.,
            Weber,G., Freund,C., Aktas,T., Heyd,F. and Wahl,M.C.
  TITLE     A multi-factor trafficking site on the spliceosome remodeling
            enzyme BRR2 recruits C9ORF78 to regulate alternative splicing
  JOURNAL   Nat Commun 13 (1), 1132 (2022)
   PUBMED   35241646
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7194)
  AUTHORS   Achsel,T., Ahrens,K., Brahms,H., Teigelkamp,S. and Luhrmann,R.
  TITLE     The human U5-220kD protein (hPrp8) forms a stable RNA-free complex
            with several U5-specific proteins, including an RNA unwindase, a
            homologue of ribosomal elongation factor EF-2, and a novel WD-40
            protein
  JOURNAL   Mol Cell Biol 18 (11), 6756-6766 (1998)
   PUBMED   9774689
REFERENCE   7  (bases 1 to 7194)
  AUTHORS   Laggerbauer,B., Achsel,T. and Luhrmann,R.
  TITLE     The human U5-200kD DEXH-box protein unwinds U4/U6 RNA duplices in
            vitro
  JOURNAL   Proc Natl Acad Sci U S A 95 (8), 4188-4192 (1998)
   PUBMED   9539711
REFERENCE   8  (bases 1 to 7194)
  AUTHORS   Lauber,J., Fabrizio,P., Teigelkamp,S., Lane,W.S., Hartmann,E. and
            Luhrmann,R.
  TITLE     The HeLa 200 kDa U5 snRNP-specific protein and its homologue in
            Saccharomyces cerevisiae are members of the DEXH-box protein family
            of putative RNA helicases
  JOURNAL   EMBO J 15 (15), 4001-4015 (1996)
   PUBMED   8670905
REFERENCE   9  (bases 1 to 7194)
  AUTHORS   Laggerbauer,B., Lauber,J. and Luhrmann,R.
  TITLE     Identification of an RNA-dependent ATPase activity in mammalian U5
            snRNPs
  JOURNAL   Nucleic Acids Res 24 (5), 868-875 (1996)
   PUBMED   8600454
REFERENCE   10 (bases 1 to 7194)
  AUTHORS   Fahim,A.T., Daiger,S.P. and Weleber,R.G.
  TITLE     Nonsyndromic Retinitis Pigmentosa Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301590
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB067751.1, AY572488.1,
            AB018331.2 and AW190145.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_014014.4.
            
            Summary: Pre-mRNA splicing is catalyzed by the spliceosome, a
            complex of specialized RNA and protein subunits that removes
            introns from a transcribed pre-mRNA segment. The spliceosome
            consists of small nuclear RNA proteins (snRNPs) U1, U2, U4, U5 and
            U6, together with approximately 80 conserved proteins. U5 snRNP
            contains nine specific proteins. This gene encodes one of the U5
            snRNP-specific proteins. This protein belongs to the DEXH-box
            family of putative RNA helicases. It is a core component of
            U4/U6-U5 snRNPs and appears to catalyze an ATP-dependent unwinding
            of U4/U6 RNA duplices. Mutations in this gene cause
            autosomal-dominant retinitis pigmentosa. Alternatively spliced
            transcript variants encoding different isoforms have been found,
            but the full-length nature of these variants has not been
            determined. [provided by RefSeq, Mar 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.187493.1,
                                           SRR1803611.60324.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000323853.10/ ENSP00000317123.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                DB067751.1         17-47
            32-3368             AY572488.1         1-3337
            3369-7193           AB018331.2         2930-6754
            7194-7194           AW190145.1         14-14               c
FEATURES             Location/Qualifiers
     source          1..7194
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q11.2"
     gene            1..7194
                     /gene="SNRNP200"
                     /gene_synonym="ASCC3L1; BRR2; HELIC2; RP33; U5-200KD"
                     /note="small nuclear ribonucleoprotein U5 subunit 200"
                     /db_xref="GeneID:23020"
                     /db_xref="HGNC:HGNC:30859"
                     /db_xref="MIM:601664"
     exon            1..154
                     /gene="SNRNP200"
                     /gene_synonym="ASCC3L1; BRR2; HELIC2; RP33; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..6520
                     /gene="SNRNP200"
                     /gene_synonym="ASCC3L1; BRR2; HELIC2; RP33; U5-200KD"
                     /EC_number="3.6.4.13"
                     /note="activating signal cointegrator 1 complex subunit
                     3-like 1; BRR2 homolog; U5 snRNP-specific 200 kDa protein;
                     small nuclear ribonucleoprotein, U5 200kDa subunit; small
                     nuclear ribonucleoprotein 200kDa (U5); bad response to
                     refrigeration 2 homolog"
                     /codon_start=1
                     /product="U5 small nuclear ribonucleoprotein 200 kDa
                     helicase"
                     /protein_id="NP_054733.2"
                     /db_xref="CCDS:CCDS2020.1"
                     /db_xref="GeneID:23020"
                     /db_xref="HGNC:HGNC:30859"
                     /db_xref="MIM:601664"
                     /translation="MADVTARSLQYEYKANSNLVLQADRSLIDRTRRDEPTGEVLSLV
                     GKLEGTRMGDKAQRTKPQMQEERRAKRRKRDEDRHDINKMKGYTLLSEGIDEMVGIIY
                     KPKTKETRETYEVLLSFIQAALGDQPRDILCGAADEVLAVLKNEKLRDKERRKEIDLL
                     LGQTDDTRYHVLVNLGKKITDYGGDKEIQNMDDNIDETYGVNVQFESDEEEGDEDVYG
                     EVREEASDDDMEGDEAVVRCTLSANLVASGELMSSKKKDLHPRDIDAFWLQRQLSRFY
                     DDAIVSQKKADEVLEILKTASDDRECENQLVLLLGFNTFDFIKVLRQHRMMILYCTLL
                     ASAQSEAEKERIMGKMEADPELSKFLYQLHETEKEDLIREERSRRERVRQSRMDTDLE
                     TMDLDQGGEALAPRQVLDLEDLVFTQGSHFMANKRCQLPDGSFRRQRKGYEEVHVPAL
                     KPKPFGSEEQLLPVEKLPKYAQAGFEGFKTLNRIQSKLYRAALETDENLLLCAPTGAG
                     KTNVALMCMLREIGKHINMDGTINVDDFKIIYIAPMRSLVQEMVGSFGKRLATYGITV
                     AELTGDHQLCKEEISATQIIVCTPEKWDIITRKGGERTYTQLVRLIILDEIHLLHDDR
                     GPVLEALVARAIRNIEMTQEDVRLIGLSATLPNYEDVATFLRVDPAKGLFYFDNSFRP
                     VPLEQTYVGITEKKAIKRFQIMNEIVYEKIMEHAGKNQVLVFVHSRKETGKTARAIRD
                     MCLEKDTLGLFLREGSASTEVLRTEAEQCKNLELKDLLPYGFAIHHAGMTRVDRTLVE
                     DLFADKHIQVLVSTATLAWGVNLPAHTVIIKGTQVYSPEKGRWTELGALDILQMLGRA
                     GRPQYDTKGEGILITSHGELQYYLSLLNQQLPIESQMVSKLPDMLNAEIVLGNVQNAK
                     DAVNWLGYAYLYIRMLRSPTLYGISHDDLKGDPLLDQRRLDLVHTAALMLDKNNLVKY
                     DKKTGNFQVTELGRIASHYYITNDTVQTYNQLLKPTLSEIELFRVFSLSSEFKNITVR
                     EEEKLELQKLLERVPIPVKESIEEPSAKINVLLQAFISQLKLEGFALMADMVYVTQSA
                     GRLMRAIFEIVLNRGWAQLTDKTLNLCKMIDKRMWQSMCPLRQFRKLPEEVVKKIEKK
                     NFPFERLYDLNHNEIGELIRMPKMGKTIHKYVHLFPKLELSVHLQPITRSTLKVELTI
                     TPDFQWDEKVHGSSEAFWILVEDVDSEVILHHEYFLLKAKYAQDEHLITFFVPVFEPL
                     PPQYFIRVVSDRWLSCETQLPVSFRHLILPEKYPPPTELLDLQPLPVSALRNSAFESL
                     YQDKFPFFNPIQTQVFNTVYNSDDNVFVGAPTGSGKTICAEFAILRMLLQSSEGRCVY
                     ITPMEALAEQVYMDWYEKFQDRLNKKVVLLTGETSTDLKLLGKGNIIISTPEKWDILS
                     RRWKQRKNVQNINLFVVDEVHLIGGENGPVLEVICSRMRYISSQIERPIRIVALSSSL
                     SNAKDVAHWLGCSATSTFNFHPNVRPVPLELHIQGFNISHTQTRLLSMAKPVYHAITK
                     HSPKKPVIVFVPSRKQTRLTAIDILTTCAADIQRQRFLHCTEKDLIPYLEKLSDSTLK
                     ETLLNGVGYLHEGLSPMERRLVEQLFSSGAIQVVVASRSLCWGMNVAAHLVIIMDTQY
                     YNGKIHAYVDYPIYDVLQMVGHANRPLQDDEGRCVIMCQGSKKDFFKKFLYEPLPVES
                     HLDHCMHDHFNAEIVTKTIENKQDAVDYLTWTFLYRRMTQNPNYYNLQGISHRHLSDH
                     LSELVEQTLSDLEQSKCISIEDEMDVAPLNLGMIAAYYYINYTTIELFSMSLNAKTKV
                     RGLIEIISNAAEYENIPIRHHEDNLLRQLAQKVPHKLNNPKFNDPHVKTNLLLQAHLS
                     RMQLSAELQSDTEEILSKAIRLIQACVDVLSSNGWLSPALAAMELAQMVTQAMWSKDS
                     YLKQLPHFTSEHIKRCTDKGVESVFDIMEMEDEERNALLQLTDSQIADVARFCNRYPN
                     IELSYEVVDKDSIRSGGPVVVLVQLEREEEVTGPVIAPLFPQKREEGWWVVIGDAKSN
                     SLISIKRLTLQQKAKVKLDFVAPATGAHNYTLYFMSDAYMGCDQEYKFSVDVKEAETD
                     SDSD"
     exon            155..318
                     /gene="SNRNP200"
                     /gene_synonym="ASCC3L1; BRR2; HELIC2; RP33; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            319..490
                     /gene="SNRNP200"
                     /gene_synonym="ASCC3L1; BRR2; HELIC2; RP33; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            491..683
                     /gene="SNRNP200"
                     /gene_synonym="ASCC3L1; BRR2; HELIC2; RP33; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            684..739
                     /gene="SNRNP200"
                     /gene_synonym="ASCC3L1; BRR2; HELIC2; RP33; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            740..838
                     /gene="SNRNP200"
                     /gene_synonym="ASCC3L1; BRR2; HELIC2; RP33; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            839..991
                     /gene="SNRNP200"
                     /gene_synonym="ASCC3L1; BRR2; HELIC2; RP33; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1091
                     /gene="SNRNP200"
                     /gene_synonym="ASCC3L1; BRR2; HELIC2; RP33; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1228
                     /gene="SNRNP200"
                     /gene_synonym="ASCC3L1; BRR2; HELIC2; RP33; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1312
                     /gene="SNRNP200"
                     /gene_synonym="ASCC3L1; BRR2; HELIC2; RP33; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1486
                     /gene="SNRNP200"
                     /gene_synonym="ASCC3L1; BRR2; HELIC2; RP33; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1624
                     /gene="SNRNP200"
                     /gene_synonym="ASCC3L1; BRR2; HELIC2; RP33; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1780
                     /gene="SNRNP200"
                     /gene_synonym="ASCC3L1; BRR2; HELIC2; RP33; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..1951
                     /gene="SNRNP200"
                     /gene_synonym="ASCC3L1; BRR2; HELIC2; RP33; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2145
                     /gene="SNRNP200"
                     /gene_synonym="ASCC3L1; BRR2; HELIC2; RP33; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            2146..2269
                     /gene="SNRNP200"
                     /gene_synonym="ASCC3L1; BRR2; HELIC2; RP33; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            2270..2419
                     /gene="SNRNP200"
                     /gene_synonym="ASCC3L1; BRR2; HELIC2; RP33; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            2420..2530
                     /gene="SNRNP200"
                     /gene_synonym="ASCC3L1; BRR2; HELIC2; RP33; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            2531..2662
                     /gene="SNRNP200"
                     /gene_synonym="ASCC3L1; BRR2; HELIC2; RP33; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            2663..2851
                     /gene="SNRNP200"
                     /gene_synonym="ASCC3L1; BRR2; HELIC2; RP33; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            2852..3049
                     /gene="SNRNP200"
                     /gene_synonym="ASCC3L1; BRR2; HELIC2; RP33; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            3050..3202
                     /gene="SNRNP200"
                     /gene_synonym="ASCC3L1; BRR2; HELIC2; RP33; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            3203..3283
                     /gene="SNRNP200"
                     /gene_synonym="ASCC3L1; BRR2; HELIC2; RP33; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            3284..3367
                     /gene="SNRNP200"
                     /gene_synonym="ASCC3L1; BRR2; HELIC2; RP33; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            3368..3474
                     /gene="SNRNP200"
                     /gene_synonym="ASCC3L1; BRR2; HELIC2; RP33; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            3475..3593
                     /gene="SNRNP200"
                     /gene_synonym="ASCC3L1; BRR2; HELIC2; RP33; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            3594..3748
                     /gene="SNRNP200"
                     /gene_synonym="ASCC3L1; BRR2; HELIC2; RP33; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            3749..3938
                     /gene="SNRNP200"
                     /gene_synonym="ASCC3L1; BRR2; HELIC2; RP33; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            3939..4112
                     /gene="SNRNP200"
                     /gene_synonym="ASCC3L1; BRR2; HELIC2; RP33; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            4113..4273
                     /gene="SNRNP200"
                     /gene_synonym="ASCC3L1; BRR2; HELIC2; RP33; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            4274..4501
                     /gene="SNRNP200"
                     /gene_synonym="ASCC3L1; BRR2; HELIC2; RP33; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            4502..4693
                     /gene="SNRNP200"
                     /gene_synonym="ASCC3L1; BRR2; HELIC2; RP33; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            4694..4872
                     /gene="SNRNP200"
                     /gene_synonym="ASCC3L1; BRR2; HELIC2; RP33; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            4873..5024
                     /gene="SNRNP200"
                     /gene_synonym="ASCC3L1; BRR2; HELIC2; RP33; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            5025..5133
                     /gene="SNRNP200"
                     /gene_synonym="ASCC3L1; BRR2; HELIC2; RP33; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            5134..5242
                     /gene="SNRNP200"
                     /gene_synonym="ASCC3L1; BRR2; HELIC2; RP33; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            5243..5432
                     /gene="SNRNP200"
                     /gene_synonym="ASCC3L1; BRR2; HELIC2; RP33; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            5433..5597
                     /gene="SNRNP200"
                     /gene_synonym="ASCC3L1; BRR2; HELIC2; RP33; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            5598..5719
                     /gene="SNRNP200"
                     /gene_synonym="ASCC3L1; BRR2; HELIC2; RP33; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            5720..5863
                     /gene="SNRNP200"
                     /gene_synonym="ASCC3L1; BRR2; HELIC2; RP33; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            5864..6040
                     /gene="SNRNP200"
                     /gene_synonym="ASCC3L1; BRR2; HELIC2; RP33; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            6041..6201
                     /gene="SNRNP200"
                     /gene_synonym="ASCC3L1; BRR2; HELIC2; RP33; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            6202..6283
                     /gene="SNRNP200"
                     /gene_synonym="ASCC3L1; BRR2; HELIC2; RP33; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            6284..6376
                     /gene="SNRNP200"
                     /gene_synonym="ASCC3L1; BRR2; HELIC2; RP33; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     exon            6377..7194
                     /gene="SNRNP200"
                     /gene_synonym="ASCC3L1; BRR2; HELIC2; RP33; U5-200KD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6779..6784
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNRNP200"
                     /gene_synonym="ASCC3L1; BRR2; HELIC2; RP33; U5-200KD"
                     /note="hexamer: AATAAA"
     polyA_site      6798
                     /gene="SNRNP200"
                     /gene_synonym="ASCC3L1; BRR2; HELIC2; RP33; U5-200KD"
                     /note="major polyA site"
     regulatory      7173..7178
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNRNP200"
                     /gene_synonym="ASCC3L1; BRR2; HELIC2; RP33; U5-200KD"
                     /note="hexamer: AATAAA"
     polyA_site      7194
                     /gene="SNRNP200"
                     /gene_synonym="ASCC3L1; BRR2; HELIC2; RP33; U5-200KD"
ORIGIN      
        1 agtgcgtctt tcctgcgtcg ttccggcgcg gcgggagcag agatctgcgg ccgtttgcag
       61 cttgcggtag ggaggcgtgg tggtctgaag cctccgagca gccgcggcca tggcggatgt
      121 aaccgcccgt agtctgcaat acgagtacaa ggcgaactcg aatcttgtgc tccaagctga
      181 ccgttctctc attgaccgga cccgccggga tgaacccaca ggagaggtgc tgtcccttgt
      241 tgggaagctg gagggcaccc gtatgggaga caaggctcaa cggaccaaac cgcagatgca
      301 ggaggaaaga agagccaagc gaagaaagcg tgatgaggac cggcatgaca tcaacaagat
      361 gaagggttat actctgctgt cggagggcat tgatgagatg gtgggcatca tctacaagcc
      421 caaaactaaa gagactcggg agacctatga ggtgctactc agcttcatcc aggctgctct
      481 tggggaccag ccacgtgata tcctttgtgg ggcagctgat gaagttctag ctgttctaaa
      541 gaatgaaaag ctgcgggaca aggaaaggcg aaaggagatt gacctgctgc tgggtcaaac
      601 agatgatacc agataccatg tgctagtgaa cctgggcaaa aagatcacag actatggtgg
      661 agataaggaa atccaaaata tggatgacaa cattgatgag acatacggtg tgaatgtgca
      721 gtttgagtct gatgaggagg aaggtgatga agacgtatac ggggaggttc gagaagaggc
      781 atctgatgat gacatggaag gggacgaggc tgtcgtgcgc tgcaccctct cggctaatct
      841 cgtagcctca ggtgaactga tgagttccaa gaagaaggat ttgcaccctc gggatattga
      901 tgcattttgg ctgcagcggc agctcagtcg tttctatgat gatgccatcg tgtcgcagaa
      961 gaaggcagat gaagtattgg agattttgaa gacggccagt gatgatcggg aatgtgaaaa
     1021 tcagctggtt ctgctgcttg gtttcaacac ctttgatttc attaaagtgt tgcggcagca
     1081 caggatgatg attttatact gtaccttgct ggccagtgca caaagtgaag ctgaaaagga
     1141 aaggattatg ggaaagatgg aagctgaccc agagctatcc aagttcctct accagcttca
     1201 tgaaaccgag aaggaggatc tgatccgaga ggaaaggtcc cggagagagc gagtgcgtca
     1261 gtctcgaatg gacacagatc tggaaaccat ggatctcgac cagggtggag aggcactggc
     1321 tccacggcag gttctggact tggaggacct ggtttttacc caagggagcc actttatggc
     1381 caataaacgc tgtcagcttc ctgatggatc cttccgtcgc cagcgtaagg gctatgaaga
     1441 ggtgcatgtg cctgctctga agcccaagcc ctttggctca gaagaacaac tgcttccagt
     1501 ggaaaagctg ccaaagtatg cccaggctgg gtttgagggc ttcaaaacac tgaatcggat
     1561 ccagagtaag ctctaccgtg ctgcccttga gacggatgag aatctgctgc tgtgtgctcc
     1621 tactggtgct gggaagacca acgtggccct gatgtgcatg ctccgagaga ttgggaaaca
     1681 cataaacatg gacggcacca tcaatgtgga tgacttcaag attatctaca ttgcccccat
     1741 gcgctccttg gtgcaggaga tggtgggcag ctttggaaag cgcctggcca cttatggcat
     1801 cactgttgct gaactgactg gggaccacca gctgtgcaaa gaagagatca gtgccactca
     1861 gatcatcgtc tgcacccccg agaagtggga catcatcacc cgcaagggtg gtgagcgcac
     1921 ctacacccag ctggtgcggc tcatcattct ggatgagatt catcttctcc acgatgacag
     1981 aggtcctgtc ttagaagctt tagtggccag ggccatccga aacattgaga tgacccaaga
     2041 ggatgtccga ctcattggtc tcagtgccac cctacccaac tatgaagatg tagccacctt
     2101 tctacgtgtt gaccctgcca agggtctctt ttactttgac aacagcttcc gtccagtgcc
     2161 tctggaacag acatatgtgg gtatcacaga gaaaaaagct atcaagcgtt tccagatcat
     2221 gaatgaaatc gtctatgaaa aaatcatgga acatgctgga aaaaatcagg tgctggtgtt
     2281 tgtccactcc cggaaggaga ctggaaagac agccagggcc atccgggaca tgtgcctaga
     2341 aaaggacact ctgggtctgt ttctgaggga gggctcagcc tccacagaag tcctgcgaac
     2401 agaagctgag cagtgcaaga acctagagct gaaggatctt ctgccttatg gctttgctat
     2461 tcatcacgca ggcatgacca gggttgaccg aacactcgtg gaggatcttt ttgctgataa
     2521 acatattcag gttttagttt ccacagcaac tctagcttgg ggtgtgaatc tccctgcaca
     2581 tacagtcatc atcaaaggca cccaggtgta cagtccagag aaggggcgtt ggacagaact
     2641 gggagcactg gacattctgc agatgctggg acgtgccgga agaccccagt atgacaccaa
     2701 gggtgaaggc atactcatca catctcatgg ggagctacag tactacctgt ccctcctcaa
     2761 tcaacaactt cctattgaaa gccagatggt ttcaaagctt cctgacatgc tcaatgcaga
     2821 aatcgtgcta ggaaatgtcc agaatgccaa ggatgcggtg aactggctgg gctatgccta
     2881 cctctatatc cgaatgctgc gatccccaac cctctatggc atctctcatg atgacctcaa
     2941 gggagatccc ctgctggacc agcgccgact agatctggtt catacagctg ccctgatgct
     3001 ggacaagaac aatctggtca agtacgacaa gaagacgggc aacttccagg tgacagaact
     3061 gggccgtata gccagccact actacatcac caatgataca gtgcagactt acaaccagct
     3121 gctgaagccc accctgagtg agattgagct tttcagggtc ttctcattgt cctctgagtt
     3181 caagaacatc acagtgagag aggaggagaa gctggagctg cagaagttgc tggagagggt
     3241 gcctatccct gtaaaggaga gcattgagga acccagtgct aagatcaacg ttcttctgca
     3301 agccttcatc tcacagctga aattggaggg ctttgcactg atggctgaca tggtgtatgt
     3361 cacacagtcg gctggccggt tgatgcgagc gatatttgaa attgtcctga accgaggttg
     3421 ggcacagctt acagacaaga ccctgaacct ctgcaagatg atcgacaaac gcatgtggca
     3481 gtccatgtgt cctctgcgcc agttccggaa actccctgag gaagtagtga agaagattga
     3541 gaagaagaat ttcccctttg agcgtctgta cgacctgaat cataatgaga ttggggagct
     3601 tatccgcatg ccaaagatgg ggaagaccat ccacaaatat gtccatctgt ttcccaagtt
     3661 ggagttgtca gtgcacctgc agcctatcac acgctccacc ctgaaggtgg agctgaccat
     3721 cacgccagac ttccagtggg atgaaaaggt gcatggttca tccgaggctt tttggattct
     3781 ggtggaggat gtggacagcg aggtgattct gcaccatgag tattttctcc tcaaggccaa
     3841 gtacgcccag gacgagcacc tcattacatt cttcgtgcct gtctttgaac cgctgccccc
     3901 tcagtacttc atccgagtgg tgtctgaccg ctggctctct tgtgagaccc agctgcctgt
     3961 ctccttccgg cacctgatct tgccggagaa gtacccccct ccaaccgaac ttttggacct
     4021 gcagcccttg cccgtgtctg ctctgagaaa cagtgccttt gagagtcttt accaagataa
     4081 atttcctttc ttcaatccca tccagaccca ggtgtttaac actgtataca acagtgacga
     4141 caacgtgttt gtgggggccc ccacgggcag cgggaagact atttgtgcag agtttgccat
     4201 cctgcgaatg ctgctgcaga gctcggaggg gcgctgtgtg tacatcaccc ccatggaggc
     4261 cctggcagag caggtataca tggactggta cgagaagttc caggacaggc tcaacaagaa
     4321 ggtggtactc ctgacaggcg agaccagcac agacctgaag ctgctgggca aagggaacat
     4381 tatcatcagc acccctgaga agtgggacat actttcccgg cgatggaagc agcgcaagaa
     4441 cgtgcagaac atcaacctct tcgtggtgga tgaggtccac cttatcgggg gcgagaatgg
     4501 gcctgtctta gaagtgatct gctcccgaat gcgctacatc tcctcccaga ttgagcggcc
     4561 cattcgcatt gtggcactca gctcttcgct ctccaatgcc aaggatgtgg cccactggct
     4621 gggctgcagt gccacctcca ccttcaactt ccatcccaat gtgcgtcccg tccccttgga
     4681 gctgcacatc cagggcttca acatcagcca tacacaaacc cgcctgctct ccatggccaa
     4741 gcctgtgtac catgctatca ccaagcactc gcccaagaag cctgtcattg tctttgtgcc
     4801 gtctcgcaag cagacccgcc tcactgccat tgacatcctc accacctgtg cagcagacat
     4861 ccaacggcag aggttcttgc actgcaccga gaaggatctg attccgtacc tggagaagct
     4921 aagtgacagc acgctcaagg aaacgctgct aaatggggtg ggctacctgc atgaggggct
     4981 cagccccatg gagcgacgcc tggtggagca gctcttcagc tcaggggcta tccaggtggt
     5041 ggtggcttct cggagtctct gctggggcat gaacgtggct gcccacctgg taatcatcat
     5101 ggatacccag tactacaatg gcaagatcca cgcctatgtg gattacccca tctatgacgt
     5161 gcttcagatg gtgggccacg ccaaccgccc tttgcaggac gatgaggggc gctgtgtcat
     5221 catgtgtcag ggctccaaga aggatttctt caagaagttc ttatatgagc cattgccagt
     5281 agaatctcac ctggaccact gtatgcatga ccacttcaat gctgagatcg tcaccaagac
     5341 cattgagaac aagcaggatg ctgtggacta cctcacctgg acctttctgt accgccgcat
     5401 gacacagaac cccaattact acaacctgca gggcatctcc catcgtcact tgtcggacca
     5461 cttgtcagag ctggtggagc agaccctgag tgacctggag cagtccaagt gcatcagcat
     5521 cgaggacgag atggacgtgg cgcctctgaa cctaggcatg atcgccgcct actattacat
     5581 caactacacc accattgagc tcttcagcat gtccctcaat gccaagacca aggtgcgagg
     5641 gcttatcgag atcatctcca atgcagcaga gtatgagaac attcccatcc ggcaccatga
     5701 agacaatctc ctgaggcagt tggctcagaa ggtcccccac aagctgaata accctaagtt
     5761 caatgatccg cacgtcaaga ccaacctgct cctgcaggct cacttgtctc gcatgcagct
     5821 gagtgctgag ttgcagtcag atacggagga aatccttagt aaggcaatcc ggctcatcca
     5881 ggcctgcgtg gatgtccttt ccagcaatgg gtggctcagc cctgctctgg cagctatgga
     5941 actggcccag atggtcaccc aagccatgtg gtccaaggac tcatacctga agcagctgcc
     6001 acacttcacc tctgagcata tcaaacgttg cacagacaag ggagtggaga gtgttttcga
     6061 catcatggag atggaggatg aagaacggaa cgcgttgctt cagctgactg acagccagat
     6121 tgcagatgtg gctcgctttt gtaaccgcta ccctaatatc gaactatctt atgaggtggt
     6181 agataaggac agcatccgca gtggcgggcc agttgtggtg ctggtgcagc tggagcgaga
     6241 ggaggaagtc acaggccctg tcattgcgcc tctcttcccg cagaaacgtg aagagggctg
     6301 gtgggtggtg attggagatg ccaagtccaa tagcctcatc tccatcaaga ggctgacctt
     6361 gcagcagaag gccaaggtga agttggactt tgtggcccca gccactggtg cccacaacta
     6421 cactctgtac ttcatgagtg acgcttacat gggatgtgac caggagtaca aattcagcgt
     6481 ggatgtgaaa gaagctgaga cagacagtga ttcagattga gtcctgaggc atttactttt
     6541 gggtaaagga gagttgagcc tgaattagga atgtgtacat tgtaggaatc ctggttgtgg
     6601 ggaccaggtc tgtgggcctc aggtctggcc agccagggct ggtgctgtcc ccgcctacct
     6661 ccacttcctt tcccttgctc actctggatc cagtgacagc aggtgtcatg ggtcaagcat
     6721 aaatcatata tagcattttc aggcatgttc ctggtagttc ttttgagtct gacattctaa
     6781 taaaataatt tgtagaaacc atttgtcttt gtagtgattc caaattaaaa gttttctttc
     6841 tccaacctga gggcacggcc aaaaagatct ggttattttt tagccaggaa cgtgcttgtt
     6901 aatgagtatg tctggaggac agacctgctc attaggtgtg ctgtcccctg tagcctcgtg
     6961 agtcagccca gaggagggta catgcgactg tggcctggcc tcagtggtac ccacacatca
     7021 gcactaccac aagaaccaac actgagcctc ggaagctaga tcacaggtta ggggtttctc
     7081 tagatggggg ttctgaaatt tgcagtgtct gctcctggga ggcagcacca gaaagggcac
     7141 tgaaatgtac tagctggatg tgacccagtc ttaataaaca ggttttctaa tcca
//
