LOCUS       NM_017719               5188 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens SNF related kinase (SNRK), transcript variant 1, mRNA.
ACCESSION   NM_017719
VERSION     NM_017719.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5188)
  AUTHORS   Xie,Z., Tang,J., Chen,Z., Wei,L., Chen,J. and Liu,Q.
  TITLE     Human bone marrow mesenchymal stem cell-derived extracellular
            vesicles reduce inflammation and pyroptosis in acute kidney injury
            via miR-223-3p/HDAC2/SNRK
  JOURNAL   Inflamm Res 72 (3), 553-576 (2023)
   PUBMED   36640195
  REMARK    GeneRIF: Human bone marrow mesenchymal stem cell-derived
            extracellular vesicles reduce inflammation and pyroptosis in acute
            kidney injury via miR-223-3p/HDAC2/SNRK.
REFERENCE   2  (bases 1 to 5188)
  AUTHORS   Wang,Y.L., Wang,J., Chen,X., Wang,Z.X. and Wu,J.W.
  TITLE     Crystal structure of the kinase and UBA domains of SNRK reveals a
            distinct UBA binding mode in the AMPK family
  JOURNAL   Biochem Biophys Res Commun 495 (1), 1-6 (2018)
   PUBMED   29061304
  REMARK    GeneRIF: Report the crystal structure of an N-terminal SNRK
            fragment containing kinase and adjacent ubiquitin-associated (UBA)
            domains. This structure shows that the UBA domain binds between the
            N- and C-lobes of the kinase domain. The mode of UBA binding in
            SNRK largely resembles that in AMPK and brain specific kinase
            (BRSK), however, unique interactions play vital roles in
            stabilizing the KD-UBA interface of SNRK.
REFERENCE   3  (bases 1 to 5188)
  AUTHORS   Hopp,E.E., Cossette,S.M., Kumar,S.N., Eastwood,D., Ramchandran,R.
            and Bishop,E.
  TITLE     Sucrose Non-Fermenting Related Kinase Expression in Ovarian Cancer
            and Correlation with Clinical Features
  JOURNAL   Cancer Invest 35 (7), 456-462 (2017)
   PUBMED   28722495
  REMARK    GeneRIF: Differential expression of SNRK in early versus late stage
            disease suggests specific roles for SNRK in ovarian cancer
            metastasis.
REFERENCE   4  (bases 1 to 5188)
  AUTHORS   Rines,A.K., Chang,H.C., Wu,R., Sato,T., Khechaduri,A., Kouzu,H.,
            Shapiro,J., Shang,M., Burke,M.A., Abdelwahid,E., Jiang,X., Chen,C.,
            Rawlings,T.A., Lopaschuk,G.D., Schumacker,P.T., Abel,E.D. and
            Ardehali,H.
  TITLE     Snf1-related kinase improves cardiac mitochondrial efficiency and
            decreases mitochondrial uncoupling
  JOURNAL   Nat Commun 8, 14095 (2017)
   PUBMED   28117339
  REMARK    GeneRIF: Study shows that TRIB3 binds to SNRK, and downregulates
            UCP3 through PPARalpha. SNRK is increased in cardiomyopathy
            patients, and SNRK reduces infarct size after
            ischaemia/reperfusion. SNRK also decreases cardiac cell death in a
            UCP3-dependent manner.
            Erratum:[Nat Commun. 2017 Aug 30;8:16155. doi:
            10.1038/ncomms16155.. PMID: 28853433]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5188)
  AUTHORS   Cossette,S.M., Bhute,V.J., Bao,X., Harmann,L.M., Horswill,M.A.,
            Sinha,I., Gastonguay,A., Pooya,S., Bordas,M., Kumar,S.N.,
            Mirza,S.P., Palecek,S.P., Strande,J.L. and Ramchandran,R.
  TITLE     Sucrose Nonfermenting-Related Kinase Enzyme-Mediated Rho-Associated
            Kinase Signaling is Responsible for Cardiac Function
  JOURNAL   Circ Cardiovasc Genet 9 (6), 474-486 (2016)
   PUBMED   27780848
  REMARK    GeneRIF: SNRK in cardiomyocytes is responsible for maintaining
            cardiac metabolic homeostasis, which is mediated in part by ROCK,
            and alteration of this homeostasis influences cardiac function in
            the adult heart.
REFERENCE   6  (bases 1 to 5188)
  AUTHORS   Bower,K.E., Zeller,R.W., Wachsman,W., Martinez,T. and McGuire,K.L.
  TITLE     Correlation of transcriptional repression by p21(SNFT) with changes
            in DNA.NF-AT complex interactions
  JOURNAL   J Biol Chem 277 (38), 34967-34977 (2002)
   PUBMED   12087103
REFERENCE   7  (bases 1 to 5188)
  AUTHORS   Kertesz,N., Samson,J., Debacker,C., Wu,H. and Labastie,M.C.
  TITLE     Cloning and characterization of human and mouse SNRK sucrose
            non-fermenting protein (SNF-1)-related kinases
  JOURNAL   Gene 294 (1-2), 13-24 (2002)
   PUBMED   12234663
REFERENCE   8  (bases 1 to 5188)
  AUTHORS   Yoshida,K., Yamada,M., Nishio,C., Konishi,A. and Hatanaka,H.
  TITLE     SNRK, a member of the SNF1 family, is related to low K(+)-induced
            apoptosis of cultured rat cerebellar granule neurons
  JOURNAL   Brain Res 873 (2), 274-282 (2000)
   PUBMED   10930554
REFERENCE   9  (bases 1 to 5188)
  AUTHORS   Iacobelli,M., Wachsman,W. and McGuire,K.L.
  TITLE     Repression of IL-2 promoter activity by the novel basic leucine
            zipper p21SNFT protein
  JOURNAL   J Immunol 165 (2), 860-868 (2000)
   PUBMED   10878360
REFERENCE   10 (bases 1 to 5188)
  AUTHORS   Becker,W., Heukelbach,J., Kentrup,H. and Joost,H.G.
  TITLE     Molecular cloning and characterization of a novel mammalian protein
            kinase harboring a homology domain that defines a subfamily of
            serine/threonine kinases
  JOURNAL   Eur J Biochem 235 (3), 736-743 (1996)
   PUBMED   8654423
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP281284.1, D43636.2, DB080037.1 and AK025449.1.
            
            On Nov 23, 2018 this sequence version replaced NM_017719.4.
            
            Summary: SNRK is a member of the sucrose nonfermenting
            (SNF)-related kinase family of serine/threonine kinases (Kertesz et
            al., 2002 [PubMed 12234663]).[supplied by OMIM, Apr 2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.140063.1,
                                           SRR1660809.65309.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296088.12/ ENSP00000296088.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-502               BP281284.1         1-502
            503-1791            D43636.2           203-1491
            1792-2344           DB080037.1         22-574
            2345-3509           D43636.2           2045-3209
            3510-4380           AK025449.1         1663-2533
            4381-5183           D43636.2           4080-4882
            5184-5188           AK025449.1         3337-3341
FEATURES             Location/Qualifiers
     source          1..5188
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p22.1"
     gene            1..5188
                     /gene="SNRK"
                     /gene_synonym="HSNFRK"
                     /note="SNF related kinase"
                     /db_xref="GeneID:54861"
                     /db_xref="HGNC:HGNC:30598"
                     /db_xref="MIM:612760"
     exon            1..136
                     /gene="SNRK"
                     /gene_synonym="HSNFRK"
                     /inference="alignment:Splign:2.1.0"
     exon            137..198
                     /gene="SNRK"
                     /gene_synonym="HSNFRK"
                     /inference="alignment:Splign:2.1.0"
     exon            199..893
                     /gene="SNRK"
                     /gene_synonym="HSNFRK"
                     /inference="alignment:Splign:2.1.0"
     CDS             305..2602
                     /gene="SNRK"
                     /gene_synonym="HSNFRK"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1; SNF-1
                     related kinase; SNF-related serine/threonine-protein
                     kinase; SNF1-related kinase"
                     /codon_start=1
                     /product="SNF-related serine/threonine-protein kinase
                     isoform 1"
                     /protein_id="NP_060189.3"
                     /db_xref="CCDS:CCDS43075.1"
                     /db_xref="GeneID:54861"
                     /db_xref="HGNC:HGNC:30598"
                     /db_xref="MIM:612760"
                     /translation="MAGFKRGYDGKIAGLYDLDKTLGRGHFAVVKLARHVFTGEKVAV
                     KVIDKTKLDTLATGHLFQEVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGGDMFD
                     YIMKHEEGLNEDLAKKYFAQIVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFG
                     FSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEA
                     NDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRDPKRRASLEEIENHPWLQGVDPSP
                     ATKYNIPLVSYKNLSEEEHNSIIQRMVLGDIADRDAIVEALETNRYNHITATYFLLAE
                     RILREKQEKEIQTRSASPSNIKAQFRQSWPTKIDVPQDLEDDLTATPLSHATVPQSPA
                     RAADSVLNGHRSKGLCDSAKKDDLPELAGPALSTVPPASLKPTASGRKCLFRVEEDEE
                     EDEEDKKPMSLSTQVVLRRKPSVTNRLTSRKSAPVLNQIFEEGESDDEFDMDENLPPK
                     LSRLKMNIASPGTVHKRYHRRKSQGRGSSCSSSETSDDDSESRRRLDKDSGFTYSWHR
                     RDSSEGPPGSEGDGGGQSKPSNASGGVDKASPSENNAGGGSPSSGSGGNPTNTSGTTR
                     RCAGPSNSMQLASRSAGELVESLKLMSLCLGSQLHGSTKYIIDPQNGLSFSSVKVQEK
                     STWKMCISSTGNAGQVPAVGGIKFFSDHMADTTTELERIKSKNLKNNVLQLPLCEKTI
                     SVNIQRNPKEGLLCASSPASCCHVI"
     exon            894..1035
                     /gene="SNRK"
                     /gene_synonym="HSNFRK"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1248
                     /gene="SNRK"
                     /gene_synonym="HSNFRK"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1383
                     /gene="SNRK"
                     /gene_synonym="HSNFRK"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..5188
                     /gene="SNRK"
                     /gene_synonym="HSNFRK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5155..5160
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNRK"
                     /gene_synonym="HSNFRK"
                     /note="hexamer: AATAAA"
     polyA_site      5188
                     /gene="SNRK"
                     /gene_synonym="HSNFRK"
                     /note="major polyA site"
ORIGIN      
        1 agctacccgg caccccctcc ccgcggccgg cagcccgctc ggtattatga ttagcgctgg
       61 gtgcggggtt tcggcggccg ggagggagtt gtcggcgccg cggccgctgc ggacggacgc
      121 tcgcctgccg gctgaggaaa aagaagcaac taacaaaaca ctgtgataat aaggattatt
      181 cagtatgcag tttgcaggat atccatgacg acattgaaaa tgaatttttt gtattcacca
      241 gatattctta tatgagaaga tctattttaa acagtctaaa tattttttct tctgttggac
      301 cagcatggca ggatttaagc gagggtatga tggaaagatt gctggattat atgatctgga
      361 taaaaccttg ggtcgaggcc attttgccgt ggttaaactt gccaggcatg tctttacggg
      421 tgaaaaggtg gcagtaaaag ttattgacaa gacaaaactg gacactctag ctactggtca
      481 tcttttccag gaagtgagat gcatgaaact agtgcagcat cctaacatcg tccgccttta
      541 tgaagttatt gacacccaga ccaaactata tcttattcta gaacttgggg atggaggaga
      601 tatgtttgat tatataatga aacatgagga gggtcttaat gaagacttgg ccaagaagta
      661 ttttgctcag atagttcatg ctatatctta ttgccataaa ctccatgtgg ttcacagaga
      721 cttaaaacca gagaatgtag tcttctttga aaaacaaggt cttgtaaagt tgacagactt
      781 tgggttcagc aacaaatttc aaccagggaa gaagctcact acaagctgtg gatctcttgc
      841 atattccgct ccagaaattc tgcttggtga tgagtatgat gcacctgcag tagatatttg
      901 gagtctggga gtgatccttt tcatgttggt gtgtgggcag ccgccctttc aagaagccaa
      961 tgacagtgaa acactgacaa tgatcatgga ttgcaaatat acagtaccat cccatgtgtc
     1021 taaagagtgt aaagacctaa tcacacggat gctacagaga gatcccaaga gaagggcttc
     1081 tttagaagag attgaaaatc atccttggct tcagggagtg gacccttcac cagctacaaa
     1141 gtataacatt ccccttgtgt catacaaaaa tctctcggaa gaggagcaca acagcatcat
     1201 tcagcgcatg gtgcttgggg acatagcgga tcgagacgcc attgtagaag ccctggaaac
     1261 caacaggtat aaccatatca cagccacata cttcctgctg gctgaaagga tcctgagaga
     1321 aaagcaagag aaagaaatac agaccagatc tgcaagcccg agcaatatca aggcccagtt
     1381 taggcagtca tggccaacca aaattgatgt accccaggac cttgaggatg acctcacggc
     1441 cactcctttg tcccacgcga ctgtccctca gtctcctgct cgggctgctg acagtgtcct
     1501 caatggccac aggagcaaag gcctgtgtga ctcagctaag aaagatgacc tccctgagtt
     1561 ggctggacca gcactctcta cggtgccacc cgcaagctta aaacccacag ccagtgggcg
     1621 gaagtgtctg ttcagggtgg aagaagatga agaggaagat gaggaggaca agaaacccat
     1681 gtccctctca acacaagtgg ttttgcgccg gaagccatct gtaaccaacc gcctgacatc
     1741 caggaagagt gcgcccgtcc tcaaccagat ctttgaggaa ggggaatctg acgatgagtt
     1801 tgacatggat gagaatctgc ctcccaagtt gagcaggtta aagatgaata tagcttctcc
     1861 aggtacagtt cacaaacgct accaccggag gaaaagtcag ggccggggct ccagctgcag
     1921 tagttcggag accagtgatg atgattctga aagccggcgg cggctcgata aagatagcgg
     1981 gttcacctac tcctggcacc gacgggatag cagcgagggg ccccctggca gtgaggggga
     2041 tggcgggggc cagagcaagc caagcaatgc cagtggaggg gtggacaagg ccagccccag
     2101 tgagaacaat gctggtgggg gcagtccctc cagcggctcg ggtggcaacc ccaccaatac
     2161 atcgggtacc acacgccgct gtgccggccc cagcaactcc atgcagctgg cctctcgcag
     2221 tgctggggag ctcgttgaga gcctcaaact catgagcctc tgcctcggct cccagcttca
     2281 tgggagcacc aagtacatta ttgatccaca gaatggcttg tcattttcca gtgtgaaagt
     2341 ccaagagaaa tctacgtgga aaatgtgcat tagctccaca gggaatgcag ggcaggtccc
     2401 tgcagtgggc ggcataaagt ttttctctga ccacatggca gataccacca ctgaattgga
     2461 acggataaag agcaagaacc tgaaaaataa cgtgctgcag ctacctctgt gcgaaaagac
     2521 catctctgtg aacatccagc ggaaccctaa ggaggggctg ctgtgcgcat ccagcccagc
     2581 cagctgttgc catgtcatct gactgtggcc ccatctggcc gctagcacgc ttcctgctca
     2641 gagcagtgaa gaccggctca cttcactgtt ccatttggtt ttactatttt aaagtgggcg
     2701 ttaggagcaa ttatttatta cctttccatt tgttcgcctg atgatgtgac aatgcatggt
     2761 ctttgtgcat gctgctagac acttttcttt cccagccgaa aagcctatta tgtaattttt
     2821 acattcataa ttttaatgtg gatgatcagg attaaatcaa gatatatatc tggaacctct
     2881 tataaatgga gcacttagaa atttgttgtt ctgcacttaa cctagagaga gaaaaaatgc
     2941 ttttctttgt gaaaaatctg aattcctgtc ctgaccttct gtgatgtgga aaccctaggc
     3001 tctgagacac actctctggt gtctgagaca gaaccaaagc aataacgttg tgatgcccac
     3061 aggcctggag ccagctagcg accttgtgcc gcccagctgt ccatggcccg tgcagagcag
     3121 aggacagtga gtgtctgcac tgagaacctt aaaccacagt tgaacatacc cacacctgtt
     3181 tgtcttaagc tatagtgtaa aaacaaagtt tgggctctga aaatttaact gaaaaagatt
     3241 tccttgtttt tgtaataggt gagataaagt acttagattt ataaggcagc ttcccctgta
     3301 gtgataaatt acaagcagac aatcttattt tgtaatgtga tgaagtgatg atgtcttaac
     3361 tctacttaga gagtgtatgt ctgtctaaca gaacaaaaag atgctctgtg taaattcctt
     3421 cctgtagggc acactgcagg atttccatgt agatagaaga actatagggc ctagtacaga
     3481 aggtgcacac aaatgttggc aaagtcaaaa ccccatgaat taaaacctac tggaatttgg
     3541 tttttaggag tttggtaatt agattatctc ttttgttatt ttcattcagt tatatccttt
     3601 ggctcagcta gctttgaaat tggctgatga aaaaatatac ataaaagggt aaaattcaca
     3661 catacagcaa acaaaaatgc acaaagcctg cttcgtaact tttttttctg gaattgtttt
     3721 tcactttgcc tttttctgcc aaaacaataa tcaaagaact cttgctttaa cctattcctg
     3781 tacaaagact gtttttgacc agataatcat ctgttgtggc attctatctt gtaggacact
     3841 gtatattgca aattgctgat tatggaaggg gccagttgct gttttttcat gcagtgccct
     3901 gggagtctta aaagcagtgc ttagcaacat tggtgatagc atgtggctgg gacccagggc
     3961 ccttccccac tcttcagccc cgagtcatgt gtctgaggtg acggactgag acgcatctgg
     4021 tcctgtaatt cagagagtgg gcacatcacc aaagaactgc attgctgtgg tcactgtttc
     4081 ttcaagtaca cactgactct gctactttag gataaatata ttttactcag aactctgaat
     4141 ttcacagtat acttactaaa ctaagtaaaa atgatactta aaatacttat tttactttct
     4201 agacctaggc tagatgtttt aagctacagc tctagttcat tgtgatattt ataatttgaa
     4261 agctatgaga atagatgtgt gggtgaagcc atagaacata tttgcttgaa attcttgagc
     4321 agggatctta taaagggcca gaaataagat gtgtggttca catagatagt gagcgtaaca
     4381 tctgtattaa acataggaga gaagtttata aagggcattg gcaataaact ctttgttgca
     4441 gctgttttcc aagcagtgta aatacttttt cctgtgatta tgtatagcct tggaatggca
     4501 ccttttaact aacccatatg tgtttggttt caatggtttt ttatattcag atgtatatat
     4561 ggtgctcact ttaggatcag cagtgttgac catttatgct gcatagctgt attatagcct
     4621 tattagttgt gtggttgacc cttggggtat acaaatgtca gtctgagtgg tgtcttactc
     4681 ctttgtttat aagtgaatga ttgtgcatgt tttgtatgtc atagtatgtc gtcacataaa
     4741 agggagggag cgaaaaacca ttacattaag ataatattgg accaaactac ttacttgctc
     4801 taaacagtta cttgtacccc ttaacctgtc ttcaaaagtt gcatatagtt acagtagtgt
     4861 ataaattaaa tattgtggaa aaacagtctt gtatttttct gtatgtgtgt atatatatat
     4921 aattatgtac ttctggcaat tctatctgta tttaaagatg tgacaatctt gacaccaatt
     4981 ttaagaatag ctgtgagacc gaattaaaga taatccctac caagtgaaaa ttgatgtgtg
     5041 ttaagagggt acagaattat caactgattt ggtcagttgc ttccaatgct ggttgatttc
     5101 cctcattgtg taaacattga caggtatgtg acaaatggga aaaaaaatcc aaataataaa
     5161 gtgacatatt ggtgttcagc aatataaa
//
