LOCUS       NM_001318234            5593 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens syntaphilin (SNPH), transcript variant 1, mRNA.
ACCESSION   NM_001318234 XM_005260888
VERSION     NM_001318234.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5593)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 5593)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 5593)
  AUTHORS   Hwang,M.J., Bryant,K.G., Seo,J.H., Liu,Q., Humphrey,P.A.,
            Melnick,M.A.C., Altieri,D.C. and Robert,M.E.
  TITLE     Syntaphilin Is a Novel Biphasic Biomarker of Aggressive Prostate
            Cancer and a Metastasis Predictor
  JOURNAL   Am J Pathol 189 (6), 1180-1189 (2019)
   PUBMED   31079810
  REMARK    GeneRIF: These data suggest that SNPH is a novel marker of high
            Gleason grade prostate cancer, differentially expressed at the
            invasive front compared with the central tumor bulk, and is
            potentially down-regulated in metastatic disease.
REFERENCE   4  (bases 1 to 5593)
  AUTHORS   Seo,J.H., Agarwal,E., Bryant,K.G., Caino,M.C., Kim,E.T.,
            Kossenkov,A.V., Tang,H.Y., Languino,L.R., Gabrilovich,D.I.,
            Cohen,A.R., Speicher,D.W. and Altieri,D.C.
  TITLE     Syntaphilin Ubiquitination Regulates Mitochondrial Dynamics and
            Tumor Cell Movements
  JOURNAL   Cancer Res 78 (15), 4215-4228 (2018)
   PUBMED   29898993
  REMARK    GeneRIF: By establishing the role of SNPH ubiquitination.
REFERENCE   5  (bases 1 to 5593)
  AUTHORS   Caino,M.C., Seo,J.H., Wang,Y., Rivadeneira,D.B., Gabrilovich,D.I.,
            Kim,E.T., Weeraratna,A.T., Languino,L.R. and Altieri,D.C.
  TITLE     Syntaphilin controls a mitochondrial rheostat for
            proliferation-motility decisions in cancer
  JOURNAL   J Clin Invest 127 (10), 3755-3769 (2017)
   PUBMED   28891816
  REMARK    GeneRIF: SNPH is a stress-regulated mitochondrial switch of the
            cell proliferation-motility balance in cancer, and its pathway may
            represent a therapeutic target.
REFERENCE   6  (bases 1 to 5593)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5593)
  AUTHORS   Su,Q., Cai,Q., Gerwin,C., Smith,C.L. and Sheng,Z.H.
  TITLE     Syntabulin is a microtubule-associated protein implicated in
            syntaxin transport in neurons
  JOURNAL   Nat Cell Biol 6 (10), 941-953 (2004)
   PUBMED   15459722
REFERENCE   8  (bases 1 to 5593)
  AUTHORS   Das,S., Gerwin,C. and Sheng,Z.H.
  TITLE     Syntaphilin binds to dynamin-1 and inhibits dynamin-dependent
            endocytosis
  JOURNAL   J Biol Chem 278 (42), 41221-41226 (2003)
   PUBMED   12896979
  REMARK    GeneRIF: syntaphilin is an inhibitor of both SNARE-based fusion and
            dynamin-mediated endocytosis
REFERENCE   9  (bases 1 to 5593)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   10 (bases 1 to 5593)
  AUTHORS   Lao,G., Scheuss,V., Gerwin,C.M., Su,Q., Mochida,S., Rettig,J. and
            Sheng,Z.H.
  TITLE     Syntaphilin: a syntaxin-1 clamp that controls SNARE assembly
  JOURNAL   Neuron 25 (1), 191-201 (2000)
   PUBMED   10707983
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL136531.16.
            
            On Nov 23, 2018 this sequence version replaced NM_001318234.1.
            
            Summary: Syntaxin-1, synaptobrevin/VAMP, and SNAP25 interact to
            form the SNARE complex, which is required for synaptic vesicle
            docking and fusion. The protein encoded by this gene is
            membrane-associated and inhibits SNARE complex formation by binding
            free syntaxin-1. Expression of this gene appears to be
            brain-specific. Alternative splicing results in multiple transcript
            variants encoding different isoforms. [provided by RefSeq, Dec
            2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB002372.1, AF187733.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381867.6/ ENSP00000371291.1
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-104               AL136531.16        8267-8370
            105-211             AL136531.16        8627-8733
            212-239             AL136531.16        36924-36951
            240-885             AL136531.16        37749-38394
            886-993             AL136531.16        39118-39225
            994-1143            AL136531.16        42535-42684
            1144-5593           AL136531.16        46851-51300
FEATURES             Location/Qualifiers
     source          1..5593
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p13"
     gene            1..5593
                     /gene="SNPH"
                     /note="syntaphilin"
                     /db_xref="GeneID:9751"
                     /db_xref="HGNC:HGNC:15931"
                     /db_xref="MIM:604942"
     exon            1..104
                     /gene="SNPH"
                     /inference="alignment:Splign:2.1.0"
     exon            105..211
                     /gene="SNPH"
                     /inference="alignment:Splign:2.1.0"
     exon            212..239
                     /gene="SNPH"
                     /inference="alignment:Splign:2.1.0"
     exon            240..885
                     /gene="SNPH"
                     /inference="alignment:Splign:2.1.0"
     CDS             704..2320
                     /gene="SNPH"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="syntaphilin isoform 1"
                     /protein_id="NP_001305163.1"
                     /db_xref="CCDS:CCDS82590.1"
                     /db_xref="GeneID:9751"
                     /db_xref="HGNC:HGNC:15931"
                     /db_xref="MIM:604942"
                     /translation="MPGSGPSERMTWPGPALSAGPPTRPLSSAPGIPPIPPLTRTHSL
                     MAMSLPGSRRTSAGSRRRTSPPVSVRDAYGTSSLSSSSNSGSYKGSDSSPTPRRSMKY
                     TLCSDNHGIKPPTPEQYLTPLQQKEVCIRHLKARLKDTQDRLQDRDTEIDDLKTQLSR
                     MQEDWIEEECHRVEAQLALKEARKEIKQLKQVIDTVKNNLIDKDKGLQKYFVDINIQN
                     KKLETLLHSMEVAQNGMAKEDGTGESAGGSPARSLTRSSTYTKLSDPAVCGDRQPGDP
                     SSGSAEDGADSGFAAADDTLSRTDALEASSLLSSGVDCGTEETSLHSSFGLGPRFPAS
                     NTYEKLLCGMEAGVQASCMQERAIQTDFVQYQPDLDTILEKVTQAQVCGTDPESGDRC
                     PELDAHPSGPRDPNSAVVVTVGDELEAPEPITRGPTPQRPGANPNPGQSVSVVCPMEE
                     EEEAAVAEKEPKSYWSRHYIVDLLAVVVPAVPTVAWLCRSQRRQGQPIYNISSLLRGC
                     CTVALHSIRRISCRSLSQPSPSPAGGGSQL"
     exon            886..993
                     /gene="SNPH"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1143
                     /gene="SNPH"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..5593
                     /gene="SNPH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5571..5576
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNPH"
                     /note="hexamer: ATTAAA"
     polyA_site      5593
                     /gene="SNPH"
                     /note="major polyA site"
ORIGIN      
        1 agccccagcc ccggcgagca cccagctagc cgcctcctgc aggggctcgg gagagcaatt
       61 cggcggcccc tgcagggcag ctgaagccat ggaagcctcc gcaggtcgct gatcagggcc
      121 aggcggctgc agcagcgact gcagaggcgc tgcgccaagc cgggccggag tggtgcgagc
      181 cggcggggct gcggagggcc agtggactca gggttgttga gaggagtcaa tggcataata
      241 cgggaagccc cgaaccacgg gccaactggg aagttgatgg tcggcgagac cagcccatcc
      301 taatttgggg ttcctggtcc tgctccagga gtcctacagc ctgcagcccc taccagagag
      361 ggaggactga acagcaaggg ggtgtgtggg tctgagtatc agggtcctgg ggaagaagca
      421 ggcctggctc gtagagtaga agactcggtg ccggcagtca ggaggccctg ctcctgaagc
      481 ctctgtgacc ttgggcacgg ccttcactct gtctggggca cattcactca tctggagaac
      541 acagggttgg actgattact tttagccact cctgacagtt gtggttttaa gttgggtggt
      601 gggaacctgt gcaccagccc tattcaattc actggtggag gcagccgtgg tctgccaggc
      661 cctcgctcct ggggtgtcct gccgaagggt gagaagagaa gccatgccgg gcagcggccc
      721 cagcgagagg atgacgtggc ctggcccggc cctttctgcg ggccccccaa cccgccctct
      781 ctcctcagcc cccgggatac cgcccatccc accccttact cggacccaca gcctcatggc
      841 catgtccctg ccaggaagta gacggacctc tgctggatca cgcaggcgca cctctccacc
      901 tgtgagcgtg cgggatgcct acggcacctc ttcgctcagc agcagcagca attctggctc
      961 ctacaagggc agtgacagca gtcccacgcc aaggcgctcc atgaaataca cgctgtgcag
     1021 tgacaaccat ggcatcaagc ccccgacccc ggagcagtac ctgacccccc tgcagcagaa
     1081 ggaggtgtgc atccggcacc tgaaagcccg gctgaaggac acacaggacc ggctccagga
     1141 ccgggacaca gagattgatg acctgaagac gcagctgtca cgcatgcagg aggactggat
     1201 tgaggaggag tgccaccgcg tggaggccca gctggccctg aaggaggccc gaaaggagat
     1261 caagcagctc aagcaggtca tcgacactgt caagaacaac ctgattgaca aggacaaggg
     1321 gctgcagaag tacttcgtgg acatcaacat ccagaacaag aagctggaga cgctgctgca
     1381 cagcatggag gtggcccaga atggcatggc caaggaggat ggcactgggg agtcagccgg
     1441 tgggtcccct gcccgctccc tcacccgcag ctccacctac accaagctga gtgacccggc
     1501 tgtctgtggt gaccgccagc cgggtgatcc ctccagcggc tctgctgagg atggggcaga
     1561 cagtggcttt gcagcagccg atgacacact gagccggacg gacgcgctgg aagccagcag
     1621 cctgctgtcg tcgggggtgg actgtggcac cgaggagacc tcgctgcaca gctccttcgg
     1681 cctgggcccc cgcttccctg ccagcaacac ctatgagaag ctgctgtgtg gcatggaggc
     1741 tggtgtgcag gccagctgca tgcaggagcg tgccatccag acagacttcg tgcagtacca
     1801 gcctgacctt gacaccatcc tggagaaagt gacccaggcc caggtctgtg ggacagaccc
     1861 tgagtcaggg gacaggtgcc cagagctgga tgcccaccct tcagggccca gagaccccaa
     1921 ctcagcagtg gtggtgacag tgggtgatga gctagaggcc ccagagccca tcacccgtgg
     1981 acccacccca cagcggcctg gtgccaaccc caaccctggc cagtcggtga gcgtggtgtg
     2041 ccccatggaa gaggaggagg aggctgccgt ggctgagaag gagcccaaga gctactggag
     2101 ccgccactac atcgtggatc tgctggctgt ggtggtgccg gccgtgccca cggtggcctg
     2161 gctttgccgc tcccagcggc gccagggcca gcccatctac aacatcagct ccctgctgcg
     2221 gggctgctgc actgtggcct tgcactccat ccgcaggatc agctgccgct cgctgagcca
     2281 gccgagtccc agcccagcgg gcggcggctc ccagctctga gggggcccat tctggcagcg
     2341 gcgcctgcgg cctgaccact gattgtaggg atgccgttcc cccctccctt ctcccatggg
     2401 catcatctta tttatttagt tttgggtgtg gaactgtttc tttttttcaa gatgttaaaa
     2461 cagtcccgtg gaaggagcag gggttggaga aaggcatccc aaagcttcga tggagagcag
     2521 ggaaggggga cccaaggcag gaggtacacc agctggacaa attgcaggga ggggagggag
     2581 cgagggccaa cccggcccct ctgtcccctt ggctcttcag acagggccag ccctgctcag
     2641 gaagtctctg gctgtcttca tgtggggaag ccgggcttga gttgcccata ggcccctgcc
     2701 ctgcaccatc ctgtccagtg ccctgcgcac tccatgccgt ctcttccaag ccaccttgcc
     2761 cgcagcccag gctcctgggc cagtgctctc tcctcaaatg gaggcagcca tggcctgaag
     2821 tgcagatcac tgacccaggg ctcagagcag aggccagaac cactgggccg gccggcattc
     2881 cagcctcccc agactgctgc ccaccttggg actcaggagc tcagtcaagg ccacaggctg
     2941 gaggagagac ggggctgggc gcaaggtggc ggagggcagt gtgggttctg tgtctgtctg
     3001 ttcatcccag gctttcccgt catccctttc ctcttggcac ttctgggtgt gtcagtcatt
     3061 attcctgtga ggtagctaag cccggcaagc tcagtgctgg ggtaggaggg cctgcctgag
     3121 tcccagctcc cagctggaga atccaccagc acaagaagag gaggcagggg cagaaaccca
     3181 agggggctcc cccagccttc caaggtgagg ccatctcatc tgcaggctgg gaggcagggc
     3241 tggactcagg aacccacagc ttactgaaaa agccagaggc catgactgcc cccagaaact
     3301 tgccccgagt ttctctgggg ccctcgggcc caacttctgc tttgcactat gttcactttg
     3361 gggttggttc tcagccatcc aagggtctcc agtgaggtgg ctgcttgctg tctgagatga
     3421 gggttcctaa accttaaacc tctctgcctc tggaggaggg tggggtattc tggcaggatg
     3481 aatcgcagga tggcgcgtac tgaagccacg atgttcatcc aggccaaagc agggtgtcct
     3541 gggataggtt tcctaggcag gggcgtggca gagcaggtag gcgccctgca gcctccctgc
     3601 tcccagccca aggccagtcg gcctgggaag ttcactgccc caactctttt cccgggacca
     3661 tactgagtcc cccagccacg ctgctgacat taccattatt attttaccaa gtaaactcac
     3721 tccttttccc ccacaggggt tacacccatc tggttgtccc acccactctt cagaggctag
     3781 gccccacctc tgggggttgg agggaccctg tgtcttactc gcccctctgg cctaagggcc
     3841 actctggtta tctgccaagg ttgcttgccc tcaccccaat gctccaacag ccattgccta
     3901 actcatgggc tctgcccttc tgctcggtgc cctccacgtg aggcggggca cctgcatgca
     3961 ctgggagggg gcggctggcc cagccctcgg ggcaggagcc ccctctgcca cacgctttgt
     4021 gcctccaaag ctccccccgc cttggtcagg gcctcagacc agccaacctt tgtggaataa
     4081 gccccagccc agccaaacca aacccagatg cctgaggcct ggctggggct gcccccgcag
     4141 gacactgtgg ccatgccacg gagggggcag tggacaaaac caatccaaag ccaagccggg
     4201 actggctgcg gacccagcct cctgtgccgc gcactcacgg agctgcgtag tctcctcaga
     4261 catagtcaaa gctttgccga gaaaagaaat gtatgaacta tatttgacaa cataaaatct
     4321 ctctattttt caccactgga atttagtcaa gcttcaggcc cctctgctcc tgtctgtgtc
     4381 ttgcgtctgt ggccttccta ttgtgtcttg tgttttggtg gatgtgacag ggctggggcc
     4441 acagtctact ctgtctctgc tgctagagaa gccacctgtg gaggactggg ctgtggttgg
     4501 gcctgaggcc tgtggaggag gtgagtgtag ccagcagcgg ccgtctactc ctgttctggc
     4561 ctgagaccac cggtgtgggt cacgagggcc ctggcccaca gtgttgaggg tcctctcttt
     4621 cgggggctct cctggggcct tcgatgggct tttcttcttg tcagtggagg gagcagctcc
     4681 ccactcagcc ctgggacagg ccctgggact gtggtggccg gtggccctgg cccagctctg
     4741 gagtgcatgt gtgtgtgctc agatcccgca tctatgcaaa ggtgcaggct gcctgtgagg
     4801 ctccaggcgg tggaggtgcg gcagctgctg ctcaggtgcc atgccctgaa gaggcagggt
     4861 acacatgggg ctgggagggc aaagatgggg cggggcctcc ccctgagaga gctcaccctc
     4921 cacagtgacc cttttccttc ctgcctaata cctcctcccg ttgggctgtg acttttcctc
     4981 ctgccctcag cctctgaaac agaaatcttt ggggcctccc ctttccccag cgtctggcaa
     5041 gagctgatga ggtcctgagg aacagtgtcc ccaggaacca ccttctggag cctagcggcc
     5101 agacgtggct tctcctgagt tctagggctc gggccagagt ggcactactg cccggccagt
     5161 ccaggctcag gcaggaatcg gacgctgggg cccgggctct gcacagagag ctgggcttga
     5221 gtggagttta ttgtagattt ctcccaaggg gatcacttag cttctcactg acacaccctt
     5281 cccaattgcc acaagcgcag gggtatctta cagcactttg gggaggggtg ggacaaactg
     5341 caaggttctg gggccaaggc ctacccaggg gcctctgccc agagaactca caaccccctc
     5401 tctgacctgg gggacaatgc aaacaggtca cagtgcattc ccatattagg ccatcccctt
     5461 cacgaagaat tcaggggatg tgggaagtgg ggaggcgggg agggatcttg actcttgtct
     5521 cctttgtcct tttgttcaga cagagttgta cctgcagcag acaactctga attaaagcat
     5581 gaaaacacag caa
//
