LOCUS       NM_003498               3264 bp    mRNA    linear   PRI 11-DEC-2024
DEFINITION  Homo sapiens stannin (SNN), mRNA.
ACCESSION   NM_003498
VERSION     NM_003498.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3264)
  AUTHORS   Lipovsky,A., Erden,A., Kanaya,E., Zhang,W., Crite,M., Bradfield,C.,
            MacMicking,J., DiMaio,D., Schoggins,J.W. and Iwasaki,A.
  TITLE     The cellular endosomal protein stannin inhibits intracellular
            trafficking of human papillomavirus during virus entry
  JOURNAL   J Gen Virol 98 (11), 2821-2836 (2017)
   PUBMED   29058661
  REMARK    GeneRIF: The authors show that stannin interacts with human
            papillomavirus 16 L1 major capsid protein and impairs the
            interaction of the L2 minor capsid protein with retromer, which is
            required for virus trafficking to the trans-Golgi network.
REFERENCE   2  (bases 1 to 3264)
  AUTHORS   Newton-Cheh,C., Eijgelsheim,M., Rice,K.M., de Bakker,P.I., Yin,X.,
            Estrada,K., Bis,J.C., Marciante,K., Rivadeneira,F.,
            Noseworthy,P.A., Sotoodehnia,N., Smith,N.L., Rotter,J.I.,
            Kors,J.A., Witteman,J.C., Hofman,A., Heckbert,S.R., O'Donnell,C.J.,
            Uitterlinden,A.G., Psaty,B.M., Lumley,T., Larson,M.G. and
            Stricker,B.H.
  TITLE     Common variants at ten loci influence QT interval duration in the
            QTGEN Study
  JOURNAL   Nat Genet 41 (4), 399-406 (2009)
   PUBMED   19305408
REFERENCE   3  (bases 1 to 3264)
  AUTHORS   Buck-Koehntop,B.A., Mascioni,A., Buffy,J.J. and Veglia,G.
  TITLE     Structure, dynamics, and membrane topology of stannin: a mediator
            of neuronal cell apoptosis induced by trimethyltin chloride
  JOURNAL   J Mol Biol 354 (3), 652-665 (2005)
   PUBMED   16246365
REFERENCE   4  (bases 1 to 3264)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   5  (bases 1 to 3264)
  AUTHORS   Horrevoets,A.J., Fontijn,R.D., van Zonneveld,A.J., de Vries,C.J.,
            ten Cate,J.W. and Pannekoek,H.
  TITLE     Vascular endothelial genes that are responsive to tumor necrosis
            factor-alpha in vitro are expressed in atherosclerotic lesions,
            including inhibitor of apoptosis protein-1, stannin, and two novel
            genes
  JOURNAL   Blood 93 (10), 3418-3431 (1999)
   PUBMED   10233894
REFERENCE   6  (bases 1 to 3264)
  AUTHORS   Dejneka,N.S., Polavarapu,R., Deng,X., Martin-DeLeon,P.A. and
            Billingsley,M.L.
  TITLE     Chromosomal localization and characterization of the stannin (Snn)
            gene
  JOURNAL   Mamm Genome 9 (7), 556-564 (1998)
   PUBMED   9657854
REFERENCE   7  (bases 1 to 3264)
  AUTHORS   Dejneka,N.S., Patanow,C.M., Polavarapu,R., Toggas,S.M., Krady,J.K.
            and Billingsley,M.L.
  TITLE     Localization and characterization of stannin: relationship to
            cellular sensitivity to organotin compounds
  JOURNAL   Neurochem Int 31 (6), 801-815 (1997)
   PUBMED   9413842
REFERENCE   8  (bases 1 to 3264)
  AUTHORS   Toggas,S.M., Krady,J.K. and Billingsley,M.L.
  TITLE     Molecular neurotoxicology of trimethyltin: identification of
            stannin, a novel protein expressed in trimethyltin-sensitive cells
  JOURNAL   Mol Pharmacol 42 (1), 44-56 (1992)
   PUBMED   1635553
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL538273.3 and BC036443.1.
            
            On Nov 23, 2018 this sequence version replaced NM_003498.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.49238.1,
                                           SRR1803615.23526.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000329565.6/ ENSP00000329287.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AL538273.3         23-34
            13-3264             BC036443.1         7-3258
FEATURES             Location/Qualifiers
     source          1..3264
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.13"
     gene            1..3264
                     /gene="SNN"
                     /note="stannin"
                     /db_xref="GeneID:8303"
                     /db_xref="HGNC:HGNC:11149"
                     /db_xref="MIM:603032"
     exon            1..86
                     /gene="SNN"
                     /inference="alignment:Splign:2.1.0"
     exon            87..3264
                     /gene="SNN"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..438
                     /gene="SNN"
                     /note="AG8_1; hemotin"
                     /codon_start=1
                     /product="stannin"
                     /protein_id="NP_003489.1"
                     /db_xref="CCDS:CCDS10549.1"
                     /db_xref="GeneID:8303"
                     /db_xref="HGNC:HGNC:11149"
                     /db_xref="MIM:603032"
                     /translation="MSIMDHSPTTGVVTVIVILIAIAALGALILGCWCYLRLQRISQS
                     EDEESIVGDGETKEPFLLVQYSAKGPCVERKAKLMTPNGPEVHG"
     regulatory      3237..3242
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNN"
                     /note="hexamer: AATAAA"
     regulatory      3248..3253
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNN"
                     /note="hexamer: CATAAA"
     polyA_site      3257
                     /gene="SNN"
                     /note="major polyA site"
     polyA_site      3264
                     /gene="SNN"
                     /note="major polyA site"
ORIGIN      
        1 gagtgcgcgg cggccggacc gggcgggcgg agccgggccc gcggggctgc tgcggggcga
       61 tcgggccggg ccgctgccgc gccatggact cccgtgtcca gcctgagttc cagcctcact
      121 gagtggccac ccccaaagtg ctgccagccg aggaagcccc cagcactgac catgtctatt
      181 atggaccaca gccccaccac gggcgtggtc acagtcatcg tcatcctcat tgccatcgcg
      241 gccctggggg ccttgatcct gggctgctgg tgctacctgc ggctgcagcg catcagccag
      301 tcagaggacg aggagagcat cgtgggggat ggggagacca aggaaccctt cctgctggtg
      361 cagtattcgg ccaagggacc gtgcgtggag agaaaggcca agctgatgac tcccaacggc
      421 ccggaagtcc acggctgagc caggatgcaa ggctcctggt cctgtttgca gccggccaag
      481 aggcgctggg aggggcaaaa ccatacggat gcgctgctgt ctgagaggaa gggctgacac
      541 ttgctggcat ggcctctgcg ggcttcgtca tcgcatgcac tgatgcccgg ggacctggct
      601 gtcctgggct tcccctcggc ctccaggtga ggctgcccat tgcaggcact gggcaggcct
      661 gaccttgctg gggctcatgg ccctgtagcg cttttgttac ttgaatgtct agctgagcct
      721 gtttttgatg gagctactac tgtaatgcgt gaactaacaa acctgtgaac tgtaaatagg
      781 cccctggaag cacgtgctta agcccttttg ctgattttta aaaatatcat ctagcgcaca
      841 cgggactggt attctggctg tactaatgac aagctgagtc aagaccctgg agggtcatag
      901 gcttgtaaag gcccacgcca cactcggcag gggtctctca tgtgtgtcca tctgcgtgta
      961 tgtcaaggaa gtgagatgcc aatttggggt cttgaggctg accagttggg gtgcttgggt
     1021 gatctctgct tcattagtca tgggtggaag aaaaaccaca ccccccgcac ccctccgttc
     1081 tttctgcata gactcacttg ttaaatagca gttctgttga gagtggagtt actgcaggga
     1141 agctaccgga cctgcctggg agccagtgaa gggcgagtca gggcacgcgt cctggaggct
     1201 gccagcgtcc ttgtagcaga gcagtttctt gccgcttggg tcttcagcac gccaagcccc
     1261 ccaccaaccc tccaccccga gtgaaggctt cgctgaaatt gctttggtcc tcatagagcc
     1321 tgtggtggct acttttggtc tgaaacccac ttggcccagg aaagagaaaa ggttgtatgt
     1381 tttgtgttgg tgtttcctat tttctgcact ggaggggagg ggactgttga ggttctgtct
     1441 tttttcttct tttcctcttc cctcttcaca tcacttggct tcctttcctc tctgatgacc
     1501 gtccgcctat ggggttctga cttcactttc ctcagcgggt ctccagtccc ctgacccagc
     1561 tctaaaggca cttaggaccc agggaacatt tctcacgtgc acattcccct aagagccacc
     1621 agactgcttc ctgccagcct gtgcttgcgg cagggagccg gggcagggca gaggtgaact
     1681 tgaagttcag gacttgactc tcccacaggt ggtgagctgg tggctctctg gtgagctagt
     1741 gtctccacag cctgtctcca aggcctcccc tatgtacatt tcagtgagct cactttgatt
     1801 tttaatccca ccacaagcac atactaattt tatttatgat tcaaatgtga ctcgtgcctg
     1861 cccatccctg taatagatgg aaggtcagcc ccggcttaac cacagagcac tggcccttca
     1921 tggctgagct cagagctctg gcctcctgct cagactaaag gcacctcctc tggcctcacc
     1981 caagcctctt ctaaaaacca tgttgaatga atccacgttc tggaaccccg aggcgggaga
     2041 agtagggagc tgttcgttta agcagcatac acctaaattg ggggtttaaa cattaagtag
     2101 gagcttgggg tggaagaggg acagccggct gggccacctg agcagaaggt ggtaatgaaa
     2161 cacctcagct gggctcttgg gagaccttag gaagcaggag aggcaacacc tctggctact
     2221 gatggtgtgg caagttcaga agaggtggtg gtggggtagg cgtgatgtca gcagaagccc
     2281 tgcaggctgg gtgggcagga cacgtggtgg gggccactga aaccaggcct aggagggaga
     2341 acaagttcca aaggtgccga ctggaagaag ggggtaaaag tttgctttgg tgagtgagaa
     2401 aaggctgggg cgtgtgatcc atcccctcac gtttcagaac ttccaggctt tctacctcga
     2461 ctctcaccac agccagcaca tacacctagg ctgtttttcc ttcctccaca cctgagggac
     2521 gcagcaacag ctaggatctg cattttcagg ttccgagcct gacccctgga actgaccagc
     2581 gctcgattgt cagccttggc ctggggtttt gaccttgcca gtgaagtttc ggttttgaag
     2641 tgattaaatg tcacttcctc atcagtttca cttctggagg ttttcttatc ctactccctg
     2701 gtgccaggga cgtacctggg agtttgaatc aggcccattt gagcgtggca gccgtgttgg
     2761 gtgaaggtcc ggggctcggt gaggcactgg gggggttttc gggaggaaaa tgaaaatgct
     2821 tctagaatga gtgaaccaca tcatagctct cactgttttt tcaatagcta ctttttttag
     2881 cagacaccag agccacactc aaatggctaa gtaggttatg acctctctgg attatttttg
     2941 aatgcccaac tgttgcattc aagttttctg actaataaga aattaagcat tcatccttcg
     3001 tatcactgca gaagcaacag tgggggcaca gggagggaac tcttgacact gagccactaa
     3061 aatatggact aattttttgg acaaatcttc aaacggactg tgctactgta tttgtctcaa
     3121 agctaccaag tttgtgcaat aagtggaagg gatgtcatcc ttcttcaata aatgctgaat
     3181 gacattcaag ctgattttct agaccactga gaaaatcttt atttacaata aatttcaata
     3241 aaatttgcat aaatatattc ccaa
//
