LOCUS       NM_024700               4554 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens Smad nuclear interacting protein 1 (SNIP1), mRNA.
ACCESSION   NM_024700
VERSION     NM_024700.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4554)
  AUTHORS   Chen,W., Xu,Z., Jiang,J., Chen,L., Chen,Y., Yu,T., Chen,H. and
            Shi,R.
  TITLE     LncRNA MSC-AS1 regulates SNIP1 SUMOylation-mediated EMT by binding
            to SENP1 to promote intestinal fibrosis in Crohn's disease
  JOURNAL   Int J Biol Macromol 262 (Pt 1), 129921 (2024)
   PUBMED   38309408
REFERENCE   2  (bases 1 to 4554)
  AUTHORS   Chen,Y., Guo,W., Lu,W., Guo,X., Gao,W. and Yin,Z.
  TITLE     SNIP1 reduces extracellular matrix degradation and inflammation via
            inhibiting the NF-kappaB signaling pathway in osteoarthritis
  JOURNAL   Arch Biochem Biophys 747, 109764 (2023)
   PUBMED   37739115
  REMARK    GeneRIF: SNIP1 reduces extracellular matrix degradation and
            inflammation via inhibiting the NF-kappaB signaling pathway in
            osteoarthritis.
REFERENCE   3  (bases 1 to 4554)
  AUTHORS   Zhang,Y., Li,Q.S., Liu,H.L., Tang,H.T., Yang,H.L., Wu,D.Q.,
            Huang,Y.Y., Li,L.C., Liu,L.H. and Li,M.X.
  TITLE     MKRN1 promotes colorectal cancer metastasis by activating the
            TGF-beta signalling pathway through SNIP1 protein degradation
  JOURNAL   J Exp Clin Cancer Res 42 (1), 219 (2023)
   PUBMED   37620897
  REMARK    GeneRIF: MKRN1 promotes colorectal cancer metastasis by activating
            the TGF-beta signalling pathway through SNIP1 protein degradation.
            Erratum:[J Exp Clin Cancer Res. 2023 Sep 15;42(1):240. doi:
            10.1186/s13046-023-02825-8.. PMID: 37710340]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4554)
  AUTHORS   Wu,J., Han,X., Yang,X., Li,Y., Liang,Y., Sun,G., Wang,R., Wang,P.,
            Xie,S., Feng,J. and Sun,H.
  TITLE     MiR-138-5p suppresses the progression of lung cancer by targeting
            SNIP1
  JOURNAL   Thorac Cancer 14 (6), 612-623 (2023)
   PUBMED   36597175
  REMARK    GeneRIF: MiR-138-5p suppresses the progression of lung cancer by
            targeting SNIP1.
REFERENCE   5  (bases 1 to 4554)
  AUTHORS   Puffenberger,E.G., Jinks,R.N., Sougnez,C., Cibulskis,K.,
            Willert,R.A., Achilly,N.P., Cassidy,R.P., Fiorentini,C.J.,
            Heiken,K.F., Lawrence,J.J., Mahoney,M.H., Miller,C.J., Nair,D.T.,
            Politi,K.A., Worcester,K.N., Setton,R.A., Dipiazza,R.,
            Sherman,E.A., Eastman,J.T., Francklyn,C., Robey-Bond,S.,
            Rider,N.L., Gabriel,S., Morton,D.H. and Strauss,K.A.
  TITLE     Genetic mapping and exome sequencing identify variants associated
            with five novel diseases
  JOURNAL   PLoS One 7 (1), e28936 (2012)
   PUBMED   22279524
  REMARK    GeneRIF: Study identified sequence variants in the known
            disease-causing genes SLC6A3 and FLVCR1, and present evidence to
            strongly support the pathogenicity of variants identified in
            TUBGCP6, BRAT1, SNIP1, CRADD, and HARS.
REFERENCE   6  (bases 1 to 4554)
  AUTHORS   Cui,Q., Lim,S.K., Zhao,B. and Hoffmann,F.M.
  TITLE     Selective inhibition of TGF-beta responsive genes by
            Smad-interacting peptide aptamers from FoxH1, Lef1 and CBP
  JOURNAL   Oncogene 24 (24), 3864-3874 (2005)
   PUBMED   15750622
  REMARK    GeneRIF: Smad-binding peptide aptamers can be developed to
            selectively inhibit TGF-beta-induced gene expression.
REFERENCE   7  (bases 1 to 4554)
  AUTHORS   Roche,K.C., Wiechens,N., Owen-Hughes,T. and Perkins,N.D.
  TITLE     The FHA domain protein SNIP1 is a regulator of the cell cycle and
            cyclin D1 expression
  JOURNAL   Oncogene 23 (50), 8185-8195 (2004)
   PUBMED   15378006
  REMARK    GeneRIF: define both a new function for SNIP1 and identify a
            previously unrecognized regulator of the cell cycle and cyclin D1
            expression
REFERENCE   8  (bases 1 to 4554)
  AUTHORS   Lin,Y., Martin,J., Gruendler,C., Farley,J., Meng,X., Li,B.Y.,
            Lechleider,R., Huff,C., Kim,R.H., Grasser,W.A., Paralkar,V. and
            Wang,T.
  TITLE     A novel link between the proteasome pathway and the signal
            transduction pathway of the bone morphogenetic proteins (BMPs)
  JOURNAL   BMC Cell Biol 3, 15 (2002)
   PUBMED   12097147
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 4554)
  AUTHORS   Kim,R.H., Flanders,K.C., Birkey Reffey,S., Anderson,L.A.,
            Duckett,C.S., Perkins,N.D. and Roberts,A.B.
  TITLE     SNIP1 inhibits NF-kappa B signaling by competing for its binding to
            the C/H1 domain of CBP/p300 transcriptional co-activators
  JOURNAL   J Biol Chem 276 (49), 46297-46304 (2001)
   PUBMED   11567019
REFERENCE   10 (bases 1 to 4554)
  AUTHORS   Kim,R.H., Wang,D., Tsang,M., Martin,J., Huff,C., de
            Caestecker,M.P., Parks,W.T., Meng,X., Lechleider,R.J., Wang,T. and
            Roberts,A.B.
  TITLE     A novel smad nuclear interacting protein, SNIP1, suppresses
            p300-dependent TGF-beta signal transduction
  JOURNAL   Genes Dev 14 (13), 1605-1616 (2000)
   PUBMED   10887155
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP364813.1, BC027040.1 and
            AL034379.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_024700.3.
            
            Summary: This gene encodes a protein that contains a coiled-coil
            motif and C-terminal forkhead-associated (FHA) domain. The encoded
            protein functions as a transcriptional coactivator that increases
            c-Myc activity and inhibits transforming growth factor beta
            (TGF-beta) and nuclear factor kappa-B (NF-kB) signaling. The
            encoded protein also regulates the stability of cyclin D1 mRNA, and
            may play a role in cell proliferation and cancer progression.
            Mutations in this gene are a cause of psychomotor retardation,
            epilepsy, and craniofacial dysmorphism (PMRED). [provided by
            RefSeq, Mar 2012].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.269461.1,
                                           SRR1803613.235319.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296215.8/ ENSP00000296215.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-148               BP364813.1         14-161
            149-2462            BC027040.1         158-2471
            2463-4554           AL034379.8         57893-59984         c
FEATURES             Location/Qualifiers
     source          1..4554
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.3"
     gene            1..4554
                     /gene="SNIP1"
                     /gene_synonym="NEDHCS; PML1; PMRED"
                     /note="Smad nuclear interacting protein 1"
                     /db_xref="GeneID:79753"
                     /db_xref="HGNC:HGNC:30587"
                     /db_xref="MIM:608241"
     exon            1..288
                     /gene="SNIP1"
                     /gene_synonym="NEDHCS; PML1; PMRED"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..1255
                     /gene="SNIP1"
                     /gene_synonym="NEDHCS; PML1; PMRED"
                     /note="PML1 homolog; FHA domain-containing protein SNIP1"
                     /codon_start=1
                     /product="smad nuclear-interacting protein 1"
                     /protein_id="NP_078976.2"
                     /db_xref="CCDS:CCDS419.1"
                     /db_xref="GeneID:79753"
                     /db_xref="HGNC:HGNC:30587"
                     /db_xref="MIM:608241"
                     /translation="MKAVKSERERGSRRRHRDGDVVLPAGVVVKQERLSPEVAPPAHR
                     RPDHSGGSPSPPTSEPARSGHRGNRARGVSRSPPKKKNKASGRRSKSPRSKRNRSPHH
                     STVKVKQEREDHPRRGREDRQHREPSEQEHRRARNSDRDRHRGHSHQRRTSNERPGSG
                     QGQGRDRDTQNLQAQEEEREFYNARRREHRQRNDVGGGGSESQELVPRPGGNNKEKEV
                     PAKEKPSFELSGALLEDTNTFRGVVIKYSEPPEARIPKKRWRLYPFKNDEVLPVMYIH
                     RQSAYLLGRHRRIADIPIDHPSCSKQHAVFQYRLVEYTRADGTVGRRVKPYIIDLGSG
                     NGTFLNNKRIEPQRYYELKEKDVLKFGFSSREYVLLHESSDTSEIDRKDDEDEEEEEE
                     VSDS"
     exon            289..391
                     /gene="SNIP1"
                     /gene_synonym="NEDHCS; PML1; PMRED"
                     /inference="alignment:Splign:2.1.0"
     exon            392..990
                     /gene="SNIP1"
                     /gene_synonym="NEDHCS; PML1; PMRED"
                     /inference="alignment:Splign:2.1.0"
     exon            991..4554
                     /gene="SNIP1"
                     /gene_synonym="NEDHCS; PML1; PMRED"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2444..2449
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNIP1"
                     /gene_synonym="NEDHCS; PML1; PMRED"
                     /note="hexamer: AATAAA"
     polyA_site      2462
                     /gene="SNIP1"
                     /gene_synonym="NEDHCS; PML1; PMRED"
                     /note="major polyA site"
     regulatory      4528..4533
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNIP1"
                     /gene_synonym="NEDHCS; PML1; PMRED"
                     /note="hexamer: ATTAAA"
     polyA_site      4554
                     /gene="SNIP1"
                     /gene_synonym="NEDHCS; PML1; PMRED"
ORIGIN      
        1 gtcatttcct ccagctagag gagctcaact gatctgtttt ctttcgccca gccaaaatca
       61 cagaatgaag gcggtgaaga gcgaacggga gcgagggagc cggcgaagac accgggacgg
      121 ggacgtggtg ctgccggcgg gggtggtggt gaagcaggag cgtctcagcc cagaagtcgc
      181 acctcccgcc caccgccgtc cggaccactc cggtggtagc ccgtctccgc cgaccagcga
      241 gccggcccgc tcgggccacc gcgggaaccg agcccgagga gttagccggt ccccacccaa
      301 aaagaaaaac aaggcctcag ggagaagaag caagtctcct cgcagtaaga gaaaccgaag
      361 tcctcaccac tcaacagtca aagtgaagca ggagcgtgag gatcatcccc ggagaggacg
      421 ggaggatcgg cagcacaggg aaccatcaga acaggaacac aggagagcta ggaacagtga
      481 ccgggacaga caccggggcc attcccacca aaggagaacg tctaacgaga ggcctgggag
      541 tgggcagggt cagggacggg atcgagacac tcagaacctg caggctcagg aagaagagcg
      601 ggagttttat aatgccaggc gacgggagca tcgccagagg aatgacgttg gtggtggcgg
      661 cagtgagtct caggagttgg ttcctcggcc tggtggcaac aacaaagaaa aagaggtgcc
      721 cgctaaagaa aaaccaagct ttgaactttc tggggcactt cttgaggaca ccaacacttt
      781 ccggggtgta gtcattaaat atagtgagcc cccagaagca cgtatcccca aaaaacggtg
      841 gcgtctctac ccatttaaaa atgatgaggt gcttccagtc atgtacatac atcgacagag
      901 tgcgtaccta ctgggtcgac accgccgcat tgcagacatt ccaattgatc acccgtcttg
      961 ttcaaagcag catgcggtct ttcaatatcg gcttgtggaa tatacccgtg ctgatggcac
     1021 agttggccga agagtgaagc cctacatcat tgaccttggc tcaggcaatg gaaccttctt
     1081 aaacaacaaa cgtattgagc cacagagata ctatgaacta aaagaaaagg atgtactcaa
     1141 atttggattc agtagcagag aatacgtctt gctccatgag tcgtcggaca cttctgaaat
     1201 agacaggaaa gatgacgagg atgaggagga ggaggaagaa gtgtctgaca gctagcaaac
     1261 taagaaccca aactattgat acacggtttc cttcttggaa gtctttgatt gactcagaga
     1321 gcactatggt ggtgggtcca gcactatggt gctctctgta atgcctctta ctgccttaag
     1381 tctttcctct gttgctgacc agattgtgtt accatttgaa tacactgact aatgtttgtt
     1441 aaactttttc tgtggcacct tggccacatg cctgcaggca tttgttttca gaacagtctc
     1501 accaattaca acacaccgtg ttttagtaga agtgttgtgg ttttagttgg tgctttcaga
     1561 actgctgcct aggaaactat aaacccttgg ttaaggggaa atcatggctt gttctctttg
     1621 tacagttact ttatttatat aggtgttaag ctttgtggac caggtgtttt tcttttgggg
     1681 cgaacccctg agcagagaat cttactaggc tttggttatc accaaaacaa cctccagtat
     1741 ataccaaagc tttgacttgt ttgagctctt gagcttagaa gttgattttg cacttatttt
     1801 tttggggggt gggaatgtac tgcagtcagt aaacattatt gactgtttaa cttaaacaga
     1861 tgctttatgg cacctgctca agcccgtgac tgtacagaag gatcctggtt gctaccagtg
     1921 ggtgctgatt cagcatcaca agtgactgaa attggctgtg gatctgttct ttgtgaaaga
     1981 attcctgatt tctccatgga gcatgtacac aacaattttg atcatattaa ctgtacttca
     2041 gttttgcatt tttattcaaa tgttatctct ttttttcttt gagaaataaa ctgtcactga
     2101 tgtgacagcg ttctttcttt attctaataa catgtataga tctaaagcag gttgtgttgt
     2161 ttacatgttt ctacacattt catcctttaa aaagttgttg agagaggttg tatttacctt
     2221 cccaaggttg gaaagcaggg gaatttccca gtgtcctagt tttccaccag aggaatatgt
     2281 gtaagtagca aagtatttgc tgcttacata tagtgtgtat gtatgtatat atgtaaattg
     2341 tgtgttaaag agctgatact gattttcata tgacaatgtt aggcaaaggc ctccctgcat
     2401 ttgaagagca ggttttcatt tatatgtatt tttgggataa aaaaataaaa tttgtaaata
     2461 tagccccatt tcaaagagta atgctttcct agcgtagagg accttgtgtt cataggtctg
     2521 tttgctgcta atggagcctt ctgtcagtac ttttgagata aaagtaggta gctgttttag
     2581 agtgttgtgg ggcaggttat atcgttggcc tccaagtcag tggaatagca gatggtgaca
     2641 tggaggtggg ttgtggggaa aggtggtgaa gcagctcaat cagtgttact actaattgtt
     2701 cctcttgggt tgagacttag gatactatta aatttgattg ttttccattg tttttatacc
     2761 catgtgtgct cagggctaaa gattggctag tgggaggggc agctgactaa tgttcattca
     2821 gaagaagtta aaagatcctt tgaaaagtga acacttaata aggtcattag atgaaacgta
     2881 agttgggccg ggcatgggca cagtggctca tgcctgtaat cccaacactt tcggaggctg
     2941 aggtgggcag atcatctgag gtcaggagtt caagaccaac ctggccaaca tggtgaaacc
     3001 ccatctctac taaaaataca aaaattagct gggcgtggtg gcacatgcct gttttaatcc
     3061 cagctactcg ggaggctgag gcaggagaat cgcttgaacc cgggaggtgg aggttgcagc
     3121 gagctgagat tgtgccactg cactccagcc tgggtgacag cgagactctg tctcagaaaa
     3181 aaaaaaaaaa ggtaagttga agaatgtgtt ctacattggc cactgtaact gctattttct
     3241 tcattttggt atgtgccata gatcatatat atgtgcttgt ctgaaaagta ggtttgtttg
     3301 gatgaacttt tctcttgatc cagactgacg gttttctctt gagggtttaa gcactaatct
     3361 ggtatcttac tctaggatct ccttgttcag tctgtgctgc agtagcacta ctttgtggta
     3421 gccttgagtt ttgctacaaa cttcatcctg gtgggcactg tgatagatga ccactttgcc
     3481 tacatttttc agtaagaagt cctaattgtt tagtcagttt ttattttagt agaggaataa
     3541 cgtcctggat taagaaattc tttatgccac atatctgaga aggtgggttt ttttgttggt
     3601 ttgtttgttt tgagatggcg tctcactctg tcgcccaggc tggagtgcag tggcaccatc
     3661 ttggctcact gcaacctccg cctcccagtt tcaagcgatt ctcctgcctc agcctcccaa
     3721 gtagctggga ctacaggcac ctgtcaccaa gcctggctaa tttatatata taatttttat
     3781 tttttatttt tttttagtag agatggggtt tcaccatatt ggccaggctg gtctcgaact
     3841 cctgaccttg tgatccgccc ctctcagcct cccaaagtgc tgggattaca ggtgttagcc
     3901 accaggcctg gcctgagaag gtgttttttt ttttttttgg tcttgttttc ccttacccct
     3961 ttctttgaag aaagggtgtc aaaagacatt acctgcctct aaagccagat atcaccagca
     4021 gacttcttaa agtggacata atcctagagc tttcattctg tttagaagtt catgttcatc
     4081 ttagccattt ggaacttctt cattctctat cttttctcca cggtggctgg gcttgtctgc
     4141 aaatcattgt gtcaaaatca aactattttc aaaacagccc tttgcttctg agcccctccc
     4201 ctaagtcctc tgtgggggtc catgattctg cagaggtatg ggacagaatc ttcagatttt
     4261 accccttgag tctcttccta gtcatatcct ggttccctca ttctaatatt gacaaaggat
     4321 gactcattaa gtgcaactgg ttatgtaact ttcaaatact ttcattgtgt atgtcaggat
     4381 ctgaggaaca aaatgatgtc atttaatcgg aatctaaacg tgacacaaac aacgtgccag
     4441 caatacctgc ttgtgaaata atgttctgag cccacagtgt tcctgggtat gtgagtttat
     4501 atcaagtgaa aaggctgctt aattgacatt aaagttttgg aatgtaaagc ttca
//
