LOCUS       NM_001080437            8394 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens sushi, nidogen and EGF like domains 1 (SNED1), mRNA.
ACCESSION   NM_001080437 XM_059482
VERSION     NM_001080437.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8394)
  AUTHORS   Vallet,S.D., Davis,M.N., Barque,A., Thahab,A.H., Ricard-Blum,S. and
            Naba,A.
  TITLE     Computational and experimental characterization of the novel ECM
            glycoprotein SNED1 and prediction of its interactome
  JOURNAL   Biochem J 478 (7), 1413-1434 (2021)
   PUBMED   33724335
REFERENCE   2  (bases 1 to 8394)
  AUTHORS   Leimeister,C., Schumacher,N., Diez,H. and Gessler,M.
  TITLE     Cloning and expression analysis of the mouse stroma marker Snep
            encoding a novel nidogen domain protein
  JOURNAL   Dev Dyn 230 (2), 371-377 (2004)
   PUBMED   15162516
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104809.5, AC093585.4, AC005237.2, KF510803.1 and AL050143.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001080437.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968189,
                              SAMEA1968540 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000310397.13/ ENSP00000308893.8
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-433               AC104809.5         6380-6812           c
            434-721             AC093585.4         3461-3748           c
            722-862             AC005237.2         1704-1844
            863-1025            AC005237.2         2537-2699
            1026-1151           AC005237.2         4759-4884
            1152-1265           AC005237.2         5209-5322
            1266-1379           AC005237.2         8044-8157
            1380-1493           AC005237.2         8269-8382
            1494-1619           AC005237.2         16284-16409
            1620-1724           AC005237.2         16631-16735
            1725-1838           AC005237.2         16991-17104
            1839-1955           AC005237.2         17786-17902
            1956-2072           AC005237.2         19713-19829
            2073-2189           AC005237.2         20010-20126
            2190-2303           AC005237.2         20324-20437
            2304-2477           AC005237.2         21122-21295
            2478-2591           AC005237.2         30760-30873
            2592-2705           AC005237.2         31556-31669
            2706-2819           AC005237.2         31981-32094
            2820-2861           KF510803.1         1-42                c
            2862-2933           AC005237.2         32854-32925
            2934-3230           AC005237.2         33267-33563
            3231-3414           AC005237.2         35731-35914
            3415-3527           AC005237.2         36878-36990
            3528-3809           AC005237.2         37887-38168
            3810-3954           AC005237.2         39543-39687
            3955-4037           AC005237.2         39763-39845
            4038-4136           AC005237.2         41233-41331
            4137-4253           AC005237.2         49644-49760
            4254-4341           AC005237.2         50244-50331
            4342-4425           AC005237.2         55359-55442
            4426-4463           AC005237.2         56332-56369
            4464-7901           AC005237.2         59605-63042
            7902-8389           AL050143.1         2232-2719
            8390-8394           AC005237.2         63531-63535
FEATURES             Location/Qualifiers
     source          1..8394
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.3"
     gene            1..8394
                     /gene="SNED1"
                     /gene_synonym="IRE-BP1; Snep; SST3"
                     /note="sushi, nidogen and EGF like domains 1"
                     /db_xref="GeneID:25992"
                     /db_xref="HGNC:HGNC:24696"
                     /db_xref="MIM:616634"
     exon            1..433
                     /gene="SNED1"
                     /gene_synonym="IRE-BP1; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     CDS             221..4462
                     /gene="SNED1"
                     /gene_synonym="IRE-BP1; Snep; SST3"
                     /note="sushi, nidogen and EGF-like domain-containing
                     protein 1; insulin responsive sequence DNA binding
                     protein-1"
                     /codon_start=1
                     /product="sushi, nidogen and EGF-like domain-containing
                     protein 1 precursor"
                     /protein_id="NP_001073906.1"
                     /db_xref="CCDS:CCDS46562.1"
                     /db_xref="GeneID:25992"
                     /db_xref="HGNC:HGNC:24696"
                     /db_xref="MIM:616634"
                     /translation="MRHGVAWALLVAAALGLGARGVRGAVALADFYPFGAERGDAVTP
                     KQDDGGSGLRPLSVPFPFFGAEHSGLYVNNNGIISFLKEVSQFTPVAFPIAKDRCVVA
                     AFWADVDNRRAGDVYYREATDPAMLRRATEDVRHYFPELLDFNATWVFVATWYRVTFF
                     GGSSSSPVNTFQTVLITDGKLSFTIFNYESIVWTTGTHASSGGNATGLGGIAAQAGFN
                     AGDGQRYFSIPGSRTADMAEVETTTNVGVPGRWAFRIDDAQVRVGGCGHTTSVCLALR
                     PCLNGGKCIDDCVTGNPSYTCSCLSGFTGRRCHLDVNECASQPCQNGGTCTHGINSFR
                     CQCPAGFGGPTCETAQSPCDTKECQHGGQCQVENGSAVCVCQAGYTGAACEMDVDDCS
                     PDPCLNGGSCVDLVGNYTCLCAEPFKGLRCETGDHPVPDACLSAPCHNGGTCVDADQG
                     YVCECPEGFMGLDCRERVPDDCECRNGGRCLGANTTLCQCPLGFFGLLCEFEITAMPC
                     NMNTQCPDGGYCMEHGGSYLCVCHTDHNASHSLPSPCDSDPCFNGGSCDAHDDSYTCE
                     CPRGFHGKHCEKARPHLCSSGPCRNGGTCKEAGGEYHCSCPYRFTGRHCEIGKPDSCA
                     SGPCHNGGTCFHYIGKYKCDCPPGFSGRHCEIAPSPCFRSPCVNGGTCEDRDTDFFCH
                     CQAGYMGRRCQAEVDCGPPEEVKHATLRFNGTRLGAVALYACDRGYSLSAPSRIRVCQ
                     PHGVWSEPPQCLEIDECRSQPCLHGGSCQDRVAGYLCLCSTGYEGAHCELERDECRAH
                     PCRNGGSCRNLPGAYVCRCPAGFVGVHCETEVDACDSSPCQHGGRCESGGGAYLCVCP
                     ESFFGYHCETVSDPCFSSPCGGRGYCLASNGSHSCTCKVGYTGEDCAKELFPPTALKM
                     ERVEESGVSISWNPPNGPAARQMLDGYAVTYVSSDGSYRRTDFVDRTRSSHQLQALAA
                     GRAYNISVFSVKRNSNNKNDISRPAVLLARTRPRPVEGFEVTNVTASTISVQWALHRI
                     RHATVSGVRVSIRHPEALRDQATDVDRSVDRFTFRALLPGKRYTIQLTTLSGLRGEEH
                     PTESLATAPTHVWTRPLPPANLTAARVTATSAHVVWDAPTPGSLLEAYVINVTTSQST
                     KSRYVPNGKLASYTVRDLLPGRRYQLSVIAVQSTELGPQHSEPAHLYIITSPRDGADR
                     RWHQGGHHPRVLKNRPPPARLPELRLLNDHSAPETPTQPPRFSELVDGRGRVSARFGG
                     SPSKAATVRSQPTASAQLENMEEAPKRVSLALQLPEHGSKDIGNVPGNCSENPCQNGG
                     TCVPGADAHSCDCGPGFKGRRCELACIKVSRPCTRLFSETKAFPVWEGGVCHHVYKRV
                     YRVHQDICFKESCESTSLKKTPNRKQSKSQTLEKS"
     exon            434..721
                     /gene="SNED1"
                     /gene_synonym="IRE-BP1; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            722..862
                     /gene="SNED1"
                     /gene_synonym="IRE-BP1; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            863..1025
                     /gene="SNED1"
                     /gene_synonym="IRE-BP1; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1151
                     /gene="SNED1"
                     /gene_synonym="IRE-BP1; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1265
                     /gene="SNED1"
                     /gene_synonym="IRE-BP1; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1379
                     /gene="SNED1"
                     /gene_synonym="IRE-BP1; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1493
                     /gene="SNED1"
                     /gene_synonym="IRE-BP1; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1619
                     /gene="SNED1"
                     /gene_synonym="IRE-BP1; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1724
                     /gene="SNED1"
                     /gene_synonym="IRE-BP1; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1838
                     /gene="SNED1"
                     /gene_synonym="IRE-BP1; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..1955
                     /gene="SNED1"
                     /gene_synonym="IRE-BP1; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            1956..2072
                     /gene="SNED1"
                     /gene_synonym="IRE-BP1; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            2073..2189
                     /gene="SNED1"
                     /gene_synonym="IRE-BP1; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            2190..2303
                     /gene="SNED1"
                     /gene_synonym="IRE-BP1; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            2304..2477
                     /gene="SNED1"
                     /gene_synonym="IRE-BP1; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            2478..2591
                     /gene="SNED1"
                     /gene_synonym="IRE-BP1; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            2592..2705
                     /gene="SNED1"
                     /gene_synonym="IRE-BP1; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            2706..2819
                     /gene="SNED1"
                     /gene_synonym="IRE-BP1; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            2820..2933
                     /gene="SNED1"
                     /gene_synonym="IRE-BP1; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            2934..3230
                     /gene="SNED1"
                     /gene_synonym="IRE-BP1; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            3231..3414
                     /gene="SNED1"
                     /gene_synonym="IRE-BP1; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            3415..3527
                     /gene="SNED1"
                     /gene_synonym="IRE-BP1; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            3528..3809
                     /gene="SNED1"
                     /gene_synonym="IRE-BP1; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            3810..3954
                     /gene="SNED1"
                     /gene_synonym="IRE-BP1; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            3955..4037
                     /gene="SNED1"
                     /gene_synonym="IRE-BP1; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            4038..4136
                     /gene="SNED1"
                     /gene_synonym="IRE-BP1; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            4137..4253
                     /gene="SNED1"
                     /gene_synonym="IRE-BP1; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            4254..4341
                     /gene="SNED1"
                     /gene_synonym="IRE-BP1; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            4342..4425
                     /gene="SNED1"
                     /gene_synonym="IRE-BP1; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            4426..4463
                     /gene="SNED1"
                     /gene_synonym="IRE-BP1; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     exon            4464..8394
                     /gene="SNED1"
                     /gene_synonym="IRE-BP1; Snep; SST3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5878..5883
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNED1"
                     /gene_synonym="IRE-BP1; Snep; SST3"
                     /note="hexamer: ATTAAA"
     polyA_site      5895
                     /gene="SNED1"
                     /gene_synonym="IRE-BP1; Snep; SST3"
                     /note="major polyA site"
     regulatory      8365..8370
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNED1"
                     /gene_synonym="IRE-BP1; Snep; SST3"
                     /note="hexamer: AATAAA"
     polyA_site      8394
                     /gene="SNED1"
                     /gene_synonym="IRE-BP1; Snep; SST3"
ORIGIN      
        1 ggccccgaac gcggtcccgc ccggcgcttt cctctgcgga gctgcggcga gagcgcggcc
       61 cggccgaacg ggcgcgggac gcggagcccc cgacggcgcg gccagcgggc gcgcccgcgc
      121 tccccgcacc ccgcctggcc ctgccggcca cccccgcgcg cagcctagtc ccccagcgcc
      181 ctgctccgcc agcgccccgt cccgcccgca cacctccgcg atgcggcacg gcgtcgcctg
      241 ggcgctgctg gtggccgcgg ccctggggct tggggcgcgc ggggtgcgcg gcgcggtggc
      301 ccttgccgac ttctacccgt tcggcgccga gcgcggcgac gccgtcaccc ccaagcagga
      361 cgacggcggc tcggggctgc ggccgctctc ggtgcccttc ccgttcttcg gtgccgagca
      421 ctccggactc tacgtgaaca acaacgggat catctccttc ctgaaggagg tttctcagtt
      481 caccccagtg gccttcccca ttgccaagga ccgctgcgtg gtggcagcct tctgggcaga
      541 tgtggacaac cggcgtgcag gcgacgtgta ctaccgggag gccaccgacc cagccatgct
      601 gcgccgagcc acggaggacg tcaggcacta cttccccgag ctcctggact tcaatgccac
      661 ctgggttttt gttgccacct ggtaccgagt gaccttcttt ggaggcagtt cctcatcccc
      721 tgtcaacaca ttccagactg tgctcatcac agacggcaag ctctccttca ccatcttcaa
      781 ctatgagtcc atcgtgtgga ccacaggcac acacgccagc agcgggggca acgccactgg
      841 cctcgggggc atcgcagccc aggctggctt caacgcaggc gatgggcagc gttacttcag
      901 tatccccggc tcgcgcacag cagacatggc cgaggtggag accaccacca acgtgggtgt
      961 gcccgggcgc tgggcgttca gaatcgatga tgcccaggtg cgcgtggggg gctgcggcca
     1021 tacaacgtcc gtgtgcctgg ccctgcgccc ctgcctcaac ggcggcaagt gcatcgacga
     1081 ctgcgtcacg ggcaacccct cctacacctg ctcctgcctc tcgggcttca cggggcggag
     1141 gtgccacctg gacgtgaacg aatgtgcctc ccagccctgt cagaatggtg ggacctgtac
     1201 tcacggcatc aacagtttcc gctgccagtg cccggctggc tttgggggac ccacctgtga
     1261 gacagcccaa tccccctgtg acaccaaaga gtgtcaacat ggtggccagt gccaggtgga
     1321 gaatggctct gcggtgtgtg tgtgccaggc cggatacacc ggagcagcct gcgagatgga
     1381 tgtggacgac tgcagccctg acccctgcct gaatggaggc tcttgtgttg acctagtggg
     1441 gaattacacc tgcttgtgtg ccgagccctt caagggactt cgctgtgaga caggagacca
     1501 tccagtgcca gacgcctgcc tctcggcccc ttgccacaat gggggcacct gtgtggatgc
     1561 ggaccagggc tacgtgtgcg agtgccccga aggcttcatg ggcctggact gcagggagag
     1621 agtccccgat gactgtgagt gccgcaacgg aggcagatgc ctgggcgcca acaccaccct
     1681 ctgccagtgc cccctgggat tctttgggct tctctgtgaa tttgaaatca cagccatgcc
     1741 ctgcaacatg aacacacagt gcccagatgg gggctactgc atggagcacg gcgggagcta
     1801 cctctgcgtc tgccacaccg accacaatgc cagccactcc ctgccatcac cctgcgactc
     1861 ggacccctgc ttcaacggag gctcctgcga tgcccatgac gactcctaca cctgcgagtg
     1921 cccgcgcggg ttccacggca agcactgcga gaaagcccgg ccacacctgt gcagctcagg
     1981 gccctgccgg aacgggggca cgtgcaagga ggcgggcggc gagtaccact gcagctgccc
     2041 ctaccgcttc actgggaggc actgtgagat cgggaagcca gactcgtgtg cctctggccc
     2101 ctgtcacaac ggcggcacct gcttccacta cattggcaaa tacaagtgtg actgtccccc
     2161 aggcttctcc gggcggcact gcgagatagc cccctccccc tgcttccgga gcccgtgtgt
     2221 gaatgggggc acctgcgagg accgggacac ggatttcttc tgccactgcc aagcagggta
     2281 catgggacgc cggtgccagg cagaggtgga ctgcggcccc ccggaggagg tgaagcacgc
     2341 cacactgcgc ttcaacggca cgcggctggg cgcggtggcc ctgtatgcat gtgaccgtgg
     2401 ctacagcctg agcgccccca gccgcatccg ggtctgccag ccacacggtg tctggagtga
     2461 gcctccccag tgccttgaaa tcgatgagtg ccggtctcag ccgtgcctgc atgggggctc
     2521 ttgtcaggac cgcgttgctg ggtacctgtg cctctgcagc acaggctatg agggcgccca
     2581 ctgtgagctg gagagggatg agtgccgagc tcacccgtgc agaaatggag ggtcctgcag
     2641 gaacctccca ggggcctatg tctgccggtg ccctgcaggc ttcgttggag tccactgtga
     2701 gacagaggtg gacgcctgcg actccagccc ctgccagcat ggaggccggt gtgagagcgg
     2761 cggcggggcc tacctgtgcg tctgcccaga gagcttcttc ggctaccact gcgagacagt
     2821 gagtgacccc tgcttctcca gcccctgtgg gggccgtggc tattgcctgg ccagcaacgg
     2881 ctcccacagc tgcacctgca aagtgggcta cacgggcgag gactgcgcca aagagctctt
     2941 cccaccgacg gccctcaaga tggagagagt ggaggagagt ggggtctcta tctcctggaa
     3001 cccgcccaat ggtccagccg ccaggcagat gcttgatggc tacgcggtca cctacgtctc
     3061 ctccgacggc tcctaccgcc gcacagactt tgtggacagg acccgctcct cgcaccagct
     3121 ccaggccctg gcggccggca gggcctacaa catctccgtc ttctcagtga agcgaaacag
     3181 taacaacaag aatgacatca gcaggcctgc cgtgctgctg gcccgcacgc gaccccgccc
     3241 tgtggaaggc ttcgaggtca ccaatgtgac ggctagcacc atctcagtgc agtgggccct
     3301 gcacaggatc cgccatgcca ccgtcagtgg ggtccgtgtg tccatccgcc accctgaggc
     3361 cctcagggac caggccaccg atgtggacag gagtgtggac aggttcacct ttagggccct
     3421 gctgcctggg aagaggtaca ccatccagct gaccaccctc agtgggctca ggggagagga
     3481 gcaccccaca gagagcctgg ccaccgcgcc gacgcacgtg tggacccggc ccctgcctcc
     3541 agcaaacctg accgccgccc gagtcactgc cacctctgcc cacgtggtct gggatgcccc
     3601 gactccaggc agcttgctgg aggcttatgt catcaatgtg accaccagcc agagcaccaa
     3661 gagccgctat gtccccaacg ggaagctggc gtcctacacg gtgcgcgacc tgctgccggg
     3721 acggcggtac cagctctctg tgatagcagt gcagagcacg gagctcgggc cgcagcacag
     3781 cgagcccgcc cacctctaca tcatcacctc ccccagggat ggcgctgaca gacgctggca
     3841 ccagggagga caccaccctc gggtgctcaa gaacagaccg cccccggcgc gcctgccgga
     3901 gctgcgcctg ctcaatgacc acagcgcccc cgagaccccc acccagcccc ccaggttctc
     3961 ggagcttgtg gacggcagag gaagagtgag cgccaggttc ggtggctcac ccagcaaagc
     4021 agccaccgtg agatcacaac ccacagcctc ggcgcagctc gagaacatgg aggaagcccc
     4081 caagcgggtc agcctggccc tccagctccc tgaacacggc agcaaggaca tcggaaacgt
     4141 ccctggcaac tgttcagaaa acccctgtca gaacggaggc acttgtgtgc cgggcgcaga
     4201 cgcccacagc tgtgactgcg ggccagggtt caaaggcaga cgctgcgagc tcgcctgtat
     4261 aaaggtgtcc cgcccctgca caaggctgtt ctccgagaca aaggcctttc cagtctggga
     4321 gggaggcgtc tgtcaccacg tgtataaaag agtctaccga gttcaccaag acatctgctt
     4381 caaagagagc tgtgaaagca caagcctcaa gaagacccca aacaggaaac aaagtaagag
     4441 tcagacactg gagaaatctt aaggatttaa gacgttcttg ttacactcca ccaacctcac
     4501 gagtttctaa cacccaggaa gatgaggtct aaaaactgga tgaaaaagga caccctgaga
     4561 aaaggtccta gctggagtca gtcccctctg tgacctctct cctcaggcct ctagaggaca
     4621 gatggccagg cctgtgcaca caccagccca ccctgagaga cccctctggg accaaccacc
     4681 tgtgagtcct gcgatgcgtt taagcagcct gtgccctcac ccaagctgca gttcctgaag
     4741 gtgtagtctg tgtctctgcg gatgagatga cagctcgcca ttccccggaa tcagtgaggc
     4801 tgtcagtcag ccacgcttct gcagtatgca gaaacctgtt cttagactcc aaagccagag
     4861 aaagaattct cccttcgagg cccaacaaat tgagaaggaa ctgtgatgga ccacttccaa
     4921 aacagagacg ggggcagggg ctgaagggca gagaccaggt gatgtcagaa ggaaagccgg
     4981 gttgcagaca cagccgcccc tgctctggtc ctccagcgtg tttatgacgc tcgtgcaggt
     5041 cgacgagcca tcctatggac tagttaacac taaggtggag ttcagacttt tttagacaac
     5101 ggcgcgactg gcagcctttc tctatcaagg gtcagacggt aaacgttttc agctttgcag
     5161 accagaggtc cctgtggcta cagtagcgca gacacagcca caggcatgtc attgaatggc
     5221 tgcggctatg ttccaataaa aacttattta caataacagg tggtggccaa attggcccat
     5281 gggccttatt tggtgaaccc tgttctatga gatcacctag gcttcagcct taaacagtgg
     5341 aagccatccc ctgaatgaca agtcacaagg gtatcaaaga aagacccctg aattttcatg
     5401 gaaaaagcta ttcagacccc tgcttggaaa gctaaggcac actgccacga agcagcaagg
     5461 acgccttaca agtctcagtg caacagagat ggacacctgg gctgggctgg acaatgttta
     5521 aggttccttt tagtccatga ctcaagtgat actgttttag gctatcaggt agtaaacacg
     5581 atcttagaca tccccatctt tgtaagcaga acagtacggc acttcaccac atctgcttcc
     5641 caccatgctt ctaagcagct gtcttccccc tgctaatgtt acaaccaaag cagccacccc
     5701 acctcctctc gtgttgagcc tcacgaccgc tgacccagct ggaaagccag cgccctgccg
     5761 cgtcaccctg actctgctca gagccagcat tccagccaca aagagggcct ccttcctttc
     5821 ctctttcata aaaatgtttt ttgaagagtt agagtatatt ttaggctttt tatctttatt
     5881 aaaatttcat gtgcatgtgt ctgtgtattc tgcaatttgt cattttcaga aagaaggaac
     5941 aggcaattcg cgaagtttca cctgtactcc cgagctgttc cccaggctcc agacccactt
     6001 gagagcagaa ggtggagctc aatgaagggt ctcgagctca gcgaagggtc actgggtgaa
     6061 ctgagagaaa ccacgttcac aaacgcgtac tgcggacttc ctgccgccct gggacctgtc
     6121 actgtttgtc catgtaagct acagcattac tagcagatgc taagatcgag tgatatcact
     6181 ggaaaagtag gtgaatccta ctaggaaact ttctactccc tactaggacc tcaagcccct
     6241 cagccacaca gcaaatgcta atatgctcca gtgttagctt agaagccttg tgtcaacaag
     6301 aactggctcc tgagtcccaa gcttggtgcc acacagcaaa tgctaatatg ctccagtgtt
     6361 agcttagaag ccttgtgtca acaagaactg gctcctgagt cccaagcttg gtgccacaca
     6421 gcaaatgcta atatgctcca gtgttagctt agaagccttg tgtcaacaag aactggctcc
     6481 tgagtcccaa gtgctgtcac aggacttgcc cattgggatg ttttccacat taaatatcaa
     6541 gtaaaaagac ttcctggtgc tcaggaatta cagttcgttc ttgaaacatt ccaaagaggc
     6601 caccacagct tttcccatgt ggcttctttt aaaaactcaa atggcttcct tgaaaatact
     6661 caaagtccac ccaaggaaat tagtaataat agaatcagaa aactgtcagg agcataaaga
     6721 tttctgtatc aaaatgaaag aagcaatcct gagttgctga attacccatc tgctaatgaa
     6781 accgggatgg actgatcatc taaccaagtg cagactgagg attctactta gtcctccgac
     6841 tgggtacaac aacagcctag gttctaggga gggtggcagt gaccgggatg ccacaatgga
     6901 agagaaaatg aaaacactgg cacagtgaaa tgtctcattt ccaaacagtt ttgcctatgg
     6961 ccaagcaagg caataaagac aaactctccc ttttccccat tgcgtgtggg ctgccaggta
     7021 caagtaaggg aatctttgct gtgcccactg tcctccagta gagaacccaa caggcaaggg
     7081 ccccactcag gtatcagctc acctcctgca cctcccctta gcaggaactc cttccactgg
     7141 caaaggactg ccactgccat ctgactcaac tgtggcgatg tggacggagt caccgagctg
     7201 cttttctttt gcaaaacaaa agtctttttc tttgcagtca cgctgtaaga cgaggctgct
     7261 ggagaaaaca aaagcaccta gatttcagtg ctgaatcccc acaattgcat gcagctcaca
     7321 cctaccaggg gtattccagt gcatagggga aaggaacccg gctgaaaaac cagctcctta
     7381 tttttctttt aaataaaata atacgatcct aagtccattt accatctgaa gttgtcacga
     7441 gtgaacagtc acattactgt tgtggaccag gccttagatg agtttctcag gctcagcact
     7501 gacattctgg gccggatcat cctctcttgt gggaccatcc tgtgcactgc aggatgtttc
     7561 acagcacccc tggcctctac ccactagaat cctacaatct accagatcct aggatctagt
     7621 tgatcctaga atgctaccaa ggagacttga attttggtcc catcatcaaa aatgccttct
     7681 gcatcaatcc tatgccagtt tcccctaaaa gagggctaac tggaatgttc taggatgtac
     7741 caatcctcca ggaccctctt agagctcatg ccatcagaga caggcctcta tctcagggat
     7801 caccccggct gacatcaaat tcctcttctc ttttcccaac atttcaaatt gttcttcgga
     7861 ctcattgagt tccctaaggt gacacgcccc cccccccccc cacacccacc ttggggggtc
     7921 acggattgct ccctgtggcc ctggcttcag cccacctgct ccatgaccct atgctcttct
     7981 cctctggttc tcgaagctgt ctgtaaccag ggcaggggag ataactgtat gggaccattc
     8041 cctggcctcc acctgcccca gcactctcca ggccagcaca gtctggcact acagactaca
     8101 gggccggaga caccaggctt ggaagtgacc actggccaag agctgacata aaagccaact
     8161 tccccaaaca ggaagggcct gttcttcaca aagataaaga aaactgccag cattttgctg
     8221 gccttaagaa gccatgcaaa attaaccagt acatcatgaa ttaacttctt ttactctgct
     8281 gtgcactgaa taccattatg aagcaatata cttttggatt aaaaataagc atttttgtgg
     8341 aaaatctgct acatgttttc ataaaataaa gtgctatgat gtactaaaac ctca
//
