LOCUS       NM_014390               3448 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens staphylococcal nuclease and tudor domain containing 1
            (SND1), mRNA.
ACCESSION   NM_014390
VERSION     NM_014390.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3448)
  AUTHORS   Liu,S., Hao,X., Miao,D. and Zhang,Y.
  TITLE     A Study on the Binding Mechanism and the Impact of Key Residue
            Mutations between SND1 and MTDH Peptide through Molecular Dynamics
            Simulations
  JOURNAL   J Phys Chem B 128 (38), 9074-9085 (2024)
   PUBMED   39276108
  REMARK    GeneRIF: A Study on the Binding Mechanism and the Impact of Key
            Residue Mutations between SND1 and MTDH Peptide through Molecular
            Dynamics Simulations.
REFERENCE   2  (bases 1 to 3448)
  AUTHORS   Lai,Q., Wan,Y., Zhang,Y., Huang,Y., Tang,Q., Chen,M., Li,Q., Ma,K.,
            Xiao,P., Luo,C. and Zhuang,X.
  TITLE     Hypomethylation-associated LINC00987 downregulation induced lung
            adenocarcinoma progression by inhibiting the
            phosphorylation-mediated degradation of SND1
  JOURNAL   Mol Carcinog 63 (7), 1260-1274 (2024)
   PUBMED   38607240
  REMARK    GeneRIF: Hypomethylation-associated LINC00987 downregulation
            induced lung adenocarcinoma progression by inhibiting the
            phosphorylation-mediated degradation of SND1.
REFERENCE   3  (bases 1 to 3448)
  AUTHORS   Wang,S.T., Xu,S.J., Gui,P., Li,X.N., Sui,Y.H. and Li,Z.X.
  TITLE     [Effect of Staphylococcal Nuclease and Tudor Domain Containing
            1/SLC7A11 on the Occurrence and Development of Osteosarcoma by
            Inhibiting Ferroptosis]
  JOURNAL   Zhongguo Yi Xue Ke Xue Yuan Xue Bao 46 (1), 11-18 (2024)
   PUBMED   38433625
  REMARK    GeneRIF: [Effect of Staphylococcal Nuclease and Tudor Domain
            Containing 1/SLC7A11 on the Occurrence and Development of
            Osteosarcoma by Inhibiting Ferroptosis].
REFERENCE   4  (bases 1 to 3448)
  AUTHORS   Liu,C., Cong,Y., Chen,L., Lv,F., Cheng,L., Song,Y. and Xing,Y.
  TITLE     Hsa_circ_0001583 fuels bladder cancer metastasis by promoting
            staphylococcal nuclease and tudor domain containing 1-mediated
            MicroRNA decay
  JOURNAL   Neoplasia 47, 100963 (2024)
   PUBMED   38176295
  REMARK    GeneRIF: Hsa_circ_0001583 fuels bladder cancer metastasis by
            promoting staphylococcal nuclease and tudor domain containing
            1-mediated MicroRNA decay.
REFERENCE   5  (bases 1 to 3448)
  AUTHORS   Yang,J., Aittomaki,S., Pesu,M., Carter,K., Saarinen,J.,
            Kalkkinen,N., Kieff,E. and Silvennoinen,O.
  TITLE     Identification of p100 as a coactivator for STAT6 that bridges
            STAT6 with RNA polymerase II
  JOURNAL   EMBO J 21 (18), 4950-4958 (2002)
   PUBMED   12234934
  REMARK    GeneRIF: These findings identify p100 as a novel coactivator for
            STAT6 and suggest that p100 functions as a bridging factor between
            STAT6 and the basal transcription machinery.
REFERENCE   6  (bases 1 to 3448)
  AUTHORS   Broadhurst,M.K. and Wheeler,T.T.
  TITLE     The p100 coactivator is present in the nuclei of mammary epithelial
            cells and its abundance is increased in response to prolactin in
            culture and in mammary tissue during lactation
  JOURNAL   J Endocrinol 171 (2), 329-337 (2001)
   PUBMED   11691653
REFERENCE   7  (bases 1 to 3448)
  AUTHORS   Lienard,P., Riviere,M., Van Vooren,P., Szpirer,C. and Szpirer,J.
  TITLE     Assignment of SND1, the gene encoding coactivator p100, to human
            chromosome 7q31.3 and rat chromosome 4q23 by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 90 (3-4), 253-254 (2000)
   PUBMED   11124528
REFERENCE   8  (bases 1 to 3448)
  AUTHORS   Leverson,J.D., Koskinen,P.J., Orrico,F.C., Rainio,E.M.,
            Jalkanen,K.J., Dash,A.B., Eisenman,R.N. and Ness,S.A.
  TITLE     Pim-1 kinase and p100 cooperate to enhance c-Myb activity
  JOURNAL   Mol Cell 2 (4), 417-425 (1998)
   PUBMED   9809063
REFERENCE   9  (bases 1 to 3448)
  AUTHORS   Callebaut,I. and Mornon,J.P.
  TITLE     The human EBNA-2 coactivator p100: multidomain organization and
            relationship to the staphylococcal nuclease fold and to the tudor
            protein involved in Drosophila melanogaster development
  JOURNAL   Biochem J 321 (Pt 1) (Pt 1), 125-132 (1997)
   PUBMED   9003410
REFERENCE   10 (bases 1 to 3448)
  AUTHORS   Tong,X., Drapkin,R., Yalamanchili,R., Mosialos,G. and Kieff,E.
  TITLE     The Epstein-Barr virus nuclear protein 2 acidic domain forms a
            complex with a novel cellular coactivator that can interact with
            TFIIE
  JOURNAL   Mol Cell Biol 15 (9), 4735-4744 (1995)
   PUBMED   7651391
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC017180.2, BE799345.1 and
            BQ217773.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_014390.3.
            
            Summary: This gene encodes a transcriptional co-activator that
            interacts with the acidic domain of Epstein-Barr virus nuclear
            antigen 2 (EBNA 2), a transcriptional activator that is required
            for B-lymphocyte transformation. Other transcription factors that
            interact with this protein are signal transducers and activators of
            transcription, STATs. This protein is also thought to be essential
            for normal cell growth. A similar protein in mammals and other
            organisms is a component of the RNA-induced silencing complex
            (RISC). [provided by RefSeq, Jul 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC017180.2, SRR1660809.165808.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000354725.8/ ENSP00000346762.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2243              BC017180.2         3-2245
            2244-2290           BE799345.1         626-672
            2291-2847           BC017180.2         2293-2849
            2848-3448           BQ217773.1         29-629              c
FEATURES             Location/Qualifiers
     source          1..3448
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q32.1"
     gene            1..3448
                     /gene="SND1"
                     /gene_synonym="p100; TDRD11; TSN; Tudor-SN"
                     /note="staphylococcal nuclease and tudor domain containing
                     1"
                     /db_xref="GeneID:27044"
                     /db_xref="HGNC:HGNC:30646"
                     /db_xref="MIM:602181"
     exon            1..258
                     /gene="SND1"
                     /gene_synonym="p100; TDRD11; TSN; Tudor-SN"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..2913
                     /gene="SND1"
                     /gene_synonym="p100; TDRD11; TSN; Tudor-SN"
                     /EC_number="3.1.31.1"
                     /note="EBNA2 coactivator p100; tudor domain-containing
                     protein 11; testis tissue sperm-binding protein Li 82P"
                     /codon_start=1
                     /product="staphylococcal nuclease domain-containing
                     protein 1"
                     /protein_id="NP_055205.2"
                     /db_xref="CCDS:CCDS34747.1"
                     /db_xref="GeneID:27044"
                     /db_xref="HGNC:HGNC:30646"
                     /db_xref="MIM:602181"
                     /translation="MASSAQSGGSSGGPAVPTVQRGIIKMVLSGCAIIVRGQPRGGPP
                     PERQINLSNIRAGNLARRAAATQPDAKDTPDEPWAFPAREFLRKKLIGKEVCFTIENK
                     TPQGREYGMIYLGKDTNGENIAESLVAEGLATRREGMRANNPEQNRLSECEEQAKAAK
                     KGMWSEGNGSHTIRDLKYTIENPRHFVDSHHQKPVNAIIEHVRDGSVVRALLLPDYYL
                     VTVMLSGIKCPTFRREADGSETPEPFAAEAKFFTESRLLQRDVQIILESCHNQNILGT
                     ILHPNGNITELLLKEGFARCVDWSIAVYTRGAEKLRAAERFAKERRLRIWRDYVAPTA
                     NLDQKDKQFVAKVMQVLNADAIVVKLNSGDYKTIHLSSIRPPRLEGENTQDKNKKLRP
                     LYDIPYMFEAREFLRKKLIGKKVNVTVDYIRPASPATETVPAFSERTCATVTIGGINI
                     AEALVSKGLATVIRYRQDDDQRSSHYDELLAAEARAIKNGKGLHSKKEVPIHRVADIS
                     GDTQKAKQFLPFLQRAGRSEAVVEYVFSGSRLKLYLPKETCLITFLLAGIECPRGARN
                     LPGLVQEGEPFSEEATLFTKELVLQREVEVEVESMDKAGNFIGWLHIDGANLSVLLVE
                     HALSKVHFTAERSSYYKSLLSAEEAAKQKKEKVWAHYEEQPVEEVMPVLEEKERSASY
                     KPVFVTEITDDLHFYVQDVETGTQLEKLMENMRNDIASHPPVEGSYAPRRGEFCIAKF
                     VDGEWYRARVEKVESPAKIHVFYIDYGNREVLPSTRLGTLSPAFSTRVLPAQATEYAF
                     AFIQVPQDDDARTDAVDSVVRDIQNTQCLLNVEHLSAGCPHVTLQFADSKGDVGLGLV
                     KEGLVMVEVRKEKQFQKVITEYLNAQESAKSARLNLWRYGDFRADDADEFGYSR"
     exon            259..408
                     /gene="SND1"
                     /gene_synonym="p100; TDRD11; TSN; Tudor-SN"
                     /inference="alignment:Splign:2.1.0"
     exon            409..529
                     /gene="SND1"
                     /gene_synonym="p100; TDRD11; TSN; Tudor-SN"
                     /inference="alignment:Splign:2.1.0"
     exon            530..608
                     /gene="SND1"
                     /gene_synonym="p100; TDRD11; TSN; Tudor-SN"
                     /inference="alignment:Splign:2.1.0"
     exon            609..769
                     /gene="SND1"
                     /gene_synonym="p100; TDRD11; TSN; Tudor-SN"
                     /inference="alignment:Splign:2.1.0"
     exon            770..861
                     /gene="SND1"
                     /gene_synonym="p100; TDRD11; TSN; Tudor-SN"
                     /inference="alignment:Splign:2.1.0"
     exon            862..1020
                     /gene="SND1"
                     /gene_synonym="p100; TDRD11; TSN; Tudor-SN"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1127
                     /gene="SND1"
                     /gene_synonym="p100; TDRD11; TSN; Tudor-SN"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1218
                     /gene="SND1"
                     /gene_synonym="p100; TDRD11; TSN; Tudor-SN"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1332
                     /gene="SND1"
                     /gene_synonym="p100; TDRD11; TSN; Tudor-SN"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1422
                     /gene="SND1"
                     /gene_synonym="p100; TDRD11; TSN; Tudor-SN"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1523
                     /gene="SND1"
                     /gene_synonym="p100; TDRD11; TSN; Tudor-SN"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1634
                     /gene="SND1"
                     /gene_synonym="p100; TDRD11; TSN; Tudor-SN"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1707
                     /gene="SND1"
                     /gene_synonym="p100; TDRD11; TSN; Tudor-SN"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..1849
                     /gene="SND1"
                     /gene_synonym="p100; TDRD11; TSN; Tudor-SN"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..1959
                     /gene="SND1"
                     /gene_synonym="p100; TDRD11; TSN; Tudor-SN"
                     /inference="alignment:Splign:2.1.0"
     exon            1960..2148
                     /gene="SND1"
                     /gene_synonym="p100; TDRD11; TSN; Tudor-SN"
                     /inference="alignment:Splign:2.1.0"
     exon            2149..2290
                     /gene="SND1"
                     /gene_synonym="p100; TDRD11; TSN; Tudor-SN"
                     /inference="alignment:Splign:2.1.0"
     exon            2291..2414
                     /gene="SND1"
                     /gene_synonym="p100; TDRD11; TSN; Tudor-SN"
                     /inference="alignment:Splign:2.1.0"
     exon            2415..2484
                     /gene="SND1"
                     /gene_synonym="p100; TDRD11; TSN; Tudor-SN"
                     /inference="alignment:Splign:2.1.0"
     exon            2485..2598
                     /gene="SND1"
                     /gene_synonym="p100; TDRD11; TSN; Tudor-SN"
                     /inference="alignment:Splign:2.1.0"
     exon            2599..2802
                     /gene="SND1"
                     /gene_synonym="p100; TDRD11; TSN; Tudor-SN"
                     /inference="alignment:Splign:2.1.0"
     exon            2803..2847
                     /gene="SND1"
                     /gene_synonym="p100; TDRD11; TSN; Tudor-SN"
                     /inference="alignment:Splign:2.1.0"
     exon            2848..3448
                     /gene="SND1"
                     /gene_synonym="p100; TDRD11; TSN; Tudor-SN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3424..3429
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SND1"
                     /gene_synonym="p100; TDRD11; TSN; Tudor-SN"
                     /note="hexamer: AATAAA"
     polyA_site      3448
                     /gene="SND1"
                     /gene_synonym="p100; TDRD11; TSN; Tudor-SN"
                     /note="major polyA site"
ORIGIN      
        1 ctctttcgct ccgtgtcccg ctgctgctcc tgtgagcgcc cggcgagtcc gtcccgtcca
       61 ccgtccgcag ctggtagcca gcctgcccct cgcctcgact ccctttcacc aacaccgaca
      121 cccacattga cacctccagt ccggccagcc gctccactcg ttgcctttgc atctccacac
      181 atggcgtcct ccgcgcagag cggcggctcc tccgggggac ccgcggtccc caccgtgcag
      241 cggggcatca tcaagatggt cctctcaggg tgcgccatca ttgtccgagg tcagcctcgt
      301 ggtgggcctc ctcctgagcg gcagatcaac ctcagcaaca ttcgtgctgg aaatcttgct
      361 cgccgggcag ccgccacaca acctgatgca aaggataccc ctgatgagcc ctgggcattt
      421 ccagctcgag agttccttcg aaagaagctg attgggaagg aagtctgttt cacgatagaa
      481 aacaagactc cccaggggcg agagtatggc atgatctacc ttggaaaaga taccaatggg
      541 gaaaacattg cagaatcact ggttgcagag ggcttagcca cccggagaga aggcatgaga
      601 gctaataatc ctgagcagaa ccggctttca gaatgtgaag aacaagcaaa ggcagccaag
      661 aaagggatgt ggagtgaggg gaacggttca catactatcc gggatctcaa gtataccatt
      721 gaaaacccaa ggcactttgt ggactcacac caccagaagc ctgttaatgc tatcatcgag
      781 catgtgcggg acggcagtgt ggtcagggcc ctgctcctcc cagattacta cctggttaca
      841 gtcatgctgt caggcatcaa gtgcccaact tttcgacggg aagcagatgg cagtgaaact
      901 ccagagcctt ttgctgcaga agccaaattt ttcactgagt cgcgactgct tcagagagat
      961 gttcagatca ttctggagag ctgccacaac cagaacattc tgggtaccat ccttcatcca
     1021 aatggcaaca tcacagagct cctcctgaag gaaggtttcg cacgctgtgt ggactggtcg
     1081 attgcagttt acacccgggg cgcagaaaag ctgagggcgg cagagaggtt tgccaaagag
     1141 cgcaggctga gaatatggag agactatgtg gctcccacag ctaatttgga ccaaaaggac
     1201 aagcagtttg ttgccaaggt gatgcaggtt ctgaatgctg atgccattgt tgtgaagctg
     1261 aactcaggcg attacaagac gattcacctg tccagcatcc gaccaccgag gctggagggg
     1321 gagaacaccc aggataagaa caagaaactg cgtcccctgt atgacattcc ttacatgttt
     1381 gaggcccggg aatttcttcg aaaaaagctt attgggaaga aggtcaatgt gacggtggac
     1441 tacattagac cagccagccc agccacagag acagtgcctg ccttttcaga gcgtacctgt
     1501 gccactgtca ccattggagg aataaacatt gctgaggctc ttgtcagcaa aggtctagcc
     1561 acagtgatca gataccggca ggatgatgac cagagatcat cacactacga tgaactgctt
     1621 gctgcagagg ccagagctat taagaatggc aaaggattgc atagcaagaa ggaagtgcct
     1681 atccaccgtg ttgcagatat atctggggat acccaaaaag caaagcagtt cctgcctttt
     1741 cttcagcggg caggtcgttc tgaagctgtg gtggaatacg tcttcagtgg ttctcgtctc
     1801 aaactctatt tgccaaagga aacttgcctt atcaccttct tgcttgcagg cattgaatgc
     1861 cccagaggag cccgaaacct cccaggcttg gtgcaggaag gagagccctt cagcgaggaa
     1921 gctacacttt tcaccaagga actggtgctg cagcgagagg tggaggtgga ggtggagagc
     1981 atggacaagg ccggcaactt tatcggctgg ctgcacatcg acggtgccaa cctgtccgtc
     2041 ctgctggtgg agcacgcgct ctccaaggtc cacttcaccg ccgaacgcag ctcctactac
     2101 aagtccctgc tgtctgccga ggaggccgca aagcagaaga aagagaaggt ctgggcccac
     2161 tatgaggagc agcccgtgga ggaggtgatg ccagtgctgg aggagaagga gcgatctgct
     2221 agctacaagc ccgtgtttgt gactgagatc actgatgacc tgcacttcta cgtgcaggat
     2281 gtggagaccg gcacccagtt ggagaagctg atggagaaca tgcgcaatga cattgccagt
     2341 cacccccctg tagagggctc ctatgccccc cgcaggggag agttctgcat tgccaaattt
     2401 gtagatggag aatggtaccg tgcccgagta gagaaagtcg agtctcctgc caaaatacat
     2461 gtcttctaca ttgactacgg caacagagag gtcctgccat ccacccgcct gggtacccta
     2521 tcacctgcct tcagcactcg ggtgctgcca gctcaagcca cggagtatgc cttcgccttc
     2581 atccaggtgc cccaagatga tgatgcccgc acggacgccg tggacagcgt agttcgggat
     2641 atccagaaca ctcagtgcct gctcaacgtg gaacacctga gtgccggctg cccccatgtc
     2701 accctgcagt ttgcagattc caagggcgat gtggggctgg gcttggtgaa ggaagggctg
     2761 gtcatggtgg aggtgcgcaa ggagaaacag ttccagaaag tgatcacaga atacctgaat
     2821 gcccaagagt cagccaagag cgccaggctg aacctgtggc gctatggaga ctttcgagct
     2881 gatgatgcag acgaatttgg ctacagccgc taaggagggg atcgggtttg gcccccagcc
     2941 ccgctcacgc cagtccctct tcctctgccg ggagggtgtt ttcaactcca aaccccagag
     3001 aggggttgta gattgggtcc agctttgctt cagtgtgtgg aaatgtctcg tggggtggca
     3061 tcggggctgc ggggtgggga ccccaaggct ttctggggca gacccttgtc ctctgggatg
     3121 atgggcactg ctatccacag tctctgccag ttggttttat ttggaggttt gtgggctttt
     3181 tttaaaaaaa aaaagtcctc aaatcaggaa gaaacatcaa agactatgtc ctagtggagg
     3241 gagtaatcct aacacccagg ctggccgcca gctggcacct gcctctatcc cagactgccc
     3301 tcgtcccagc tctctgtcca actgttgatt atgtgatttt tctgatacgt ccattctcaa
     3361 atgccagtgt gttcacatct tcgctctggc cagcccattc tgtatttaaa gcttttgagg
     3421 cccaataaaa tagtacgtgc tgtctgca
//
