LOCUS       NM_001329615            1296 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens small nuclear RNA activating complex polypeptide 5
            (SNAPC5), transcript variant 4, mRNA.
ACCESSION   NM_001329615
VERSION     NM_001329615.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1296)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1296)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1296)
  AUTHORS   Gao,Y.F., Mao,X.Y., Zhu,T., Mao,C.X., Liu,Z.X., Wang,Z.B., Li,L.,
            Li,X., Yin,J.Y., Zhang,W., Zhou,H.H. and Liu,Z.Q.
  TITLE     COL3A1 and SNAP91: novel glioblastoma markers with diagnostic and
            prognostic value
  JOURNAL   Oncotarget 7 (43), 70494-70503 (2016)
   PUBMED   27655637
  REMARK    GeneRIF: Kaplan-Meir analysis of GSE7696 indicate that COL3A1 and
            SNAP91 correlated with survival.
REFERENCE   4  (bases 1 to 1296)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   5  (bases 1 to 1296)
  AUTHORS   Ma,B. and Hernandez,N.
  TITLE     A map of protein-protein contacts within the small nuclear
            RNA-activating protein complex SNAPc
  JOURNAL   J Biol Chem 276 (7), 5027-5035 (2001)
   PUBMED   11056176
REFERENCE   6  (bases 1 to 1296)
  AUTHORS   Henry,R.W., Mittal,V., Ma,B., Kobayashi,R. and Hernandez,N.
  TITLE     SNAP19 mediates the assembly of a functional core promoter complex
            (SNAPc) shared by RNA polymerases II and III
  JOURNAL   Genes Dev 12 (17), 2664-2672 (1998)
   PUBMED   9732265
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG764762.1, AC116913.6 and
            AK024763.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001329615.1.
            
            Summary: This gene encodes a subunit of the small nuclear RNA
            (snRNA)-activating protein complex that plays a role in the
            transcription of snRNA genes. This complex binds to the promoters
            of snRNA genes transcribed by either RNA polymerase II or III and
            recruits other regulatory factors to activate snRNA gene
            transcription. The encoded protein may play a role in stabilizing
            this complex. A pseudogene of this gene has been identified on
            chromosome 6. [provided by RefSeq, Jul 2016].
            
            Transcript Variant: This variant (4) differs in the 3' UTR compared
            to variant 1. Both variants 1 and 4 encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AV715338.1, SRR1660807.340971.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000316634.6/ ENSP00000319597.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-550               BG764762.1         5-554
            551-1109            AC116913.6         64323-64881         c
            1110-1296           AK024763.1         1549-1735
FEATURES             Location/Qualifiers
     source          1..1296
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q22.31"
     gene            1..1296
                     /gene="SNAPC5"
                     /gene_synonym="SNAP19"
                     /note="small nuclear RNA activating complex polypeptide 5"
                     /db_xref="GeneID:10302"
                     /db_xref="HGNC:HGNC:15484"
                     /db_xref="MIM:605979"
     exon            1..121
                     /gene="SNAPC5"
                     /gene_synonym="SNAP19"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..328
                     /gene="SNAPC5"
                     /gene_synonym="SNAP19"
                     /note="isoform 1 is encoded by transcript variant 4;
                     snRNA-activating protein complex subunit 5; SNAPc subunit
                     5; SNAPc 19 kDa subunit; snRNA-activating protein complex
                     19 kDa subunit"
                     /codon_start=1
                     /product="snRNA-activating protein complex subunit 5
                     isoform 1"
                     /protein_id="NP_001316544.1"
                     /db_xref="CCDS:CCDS10217.1"
                     /db_xref="GeneID:10302"
                     /db_xref="HGNC:HGNC:15484"
                     /db_xref="MIM:605979"
                     /translation="MLSRLQELRKEEETLLRLKAALHDQLNRLKVEELALQSMISSRR
                     GDEMLSSHTVPEQSHDMLVHVDNEASINQTTLELSTKSHVTEEEEEEEEEESDS"
     exon            122..211
                     /gene="SNAPC5"
                     /gene_synonym="SNAP19"
                     /inference="alignment:Splign:2.1.0"
     exon            212..1296
                     /gene="SNAPC5"
                     /gene_synonym="SNAP19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      603..608
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNAPC5"
                     /gene_synonym="SNAP19"
                     /note="hexamer: AACAAA"
     polyA_site      621
                     /gene="SNAPC5"
                     /gene_synonym="SNAP19"
                     /note="major polyA site"
     regulatory      665..670
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNAPC5"
                     /gene_synonym="SNAP19"
                     /note="hexamer: AATACA"
     polyA_site      689
                     /gene="SNAPC5"
                     /gene_synonym="SNAP19"
     regulatory      925..930
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNAPC5"
                     /gene_synonym="SNAP19"
                     /note="hexamer: AATAAA"
     polyA_site      947
                     /gene="SNAPC5"
                     /gene_synonym="SNAP19"
                     /note="major polyA site"
     regulatory      1272..1277
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNAPC5"
                     /gene_synonym="SNAP19"
                     /note="hexamer: AGTAAA"
     polyA_site      1296
                     /gene="SNAPC5"
                     /gene_synonym="SNAP19"
ORIGIN      
        1 agcccggagg ttggctatgt gaccaggcaa catgctgagc cggcttcagg aactgcgcaa
       61 ggaggaggag acgctgctgc ggttgaaggc agccctgcac gaccagctga accgcctcaa
      121 ggttgaagaa ttagccctcc aatcaatgat cagttctaga agaggggatg agatgctgtc
      181 ttctcacact gtacctgaac agtcacatga tatgttggtg catgtagaca atgaagcatc
      241 aatcaaccaa acaaccctgg agctgagcac aaagagtcat gtgacggaag aggaggagga
      301 ggaagaggaa gaagaatcag attcctaaag gagggggaaa gccaggctgg tcagttatac
      361 aaattgcatt tctaaggctc aggctacttc tcctcaagga aatcatcttg ccctgggccc
      421 tgtgatctgc ttgaaaggaa agcaagaact ataaggagga tgtgtagttg caaaaatggc
      481 tccatcggta actcaagctt cagaatgtta tgacatacag aaaatcaaag atgctgtgtc
      541 ttagcattga gtaatatggg tggtgctgtc tgtaatctgg tcagattcag ttaactgttc
      601 agaacaaaat ttcctctgaa atactgttga gaaagtctgt catttgcaaa aagagcagag
      661 tttaaataca agccagtctt tccagtcaac aatgcctctt tgaagaaaac caattaaaga
      721 ctgtttgcat gccgctgaac ccttgtgagc agttaggaca cagtctagga cagaaagatg
      781 acaaggggaa ggactgaggg ccgtctgaga gcacaagctg tttctacctc tcagaggcat
      841 tgaaatattg catgctataa actgctttgt gtatctgtta ccacctctca cttgagacat
      901 cactcactgg taaaatgttt tataaataaa tttataagta gccatcatgg agcctgctgg
      961 tttctagata gcgacagaga gaagcagcag ttccttctct gaggaaaaga tacaacagga
     1021 tggtttgaaa tccatttctg gtccttaaga gagatgtgcc atgcttggaa gactggattt
     1081 tttgttttgt tttttgtttt gttttgtttg agacggagtt tcactcttat tgcccaggct
     1141 ggagtgcaat ggcgcgattt tggctcactg caacctcccc ttctcgggtt caagtgattc
     1201 ttctgcctca gcctccagag tagctaggat tacaggcatg caccaccaca cccggctaat
     1261 tttgtatttt tagtaaagat gggatttttc catgtt
//
