LOCUS       NM_003086               4693 bp    mRNA    linear   PRI 13-DEC-2024
DEFINITION  Homo sapiens small nuclear RNA activating complex polypeptide 4
            (SNAPC4), transcript variant 2, mRNA.
ACCESSION   NM_003086 XM_006717241
VERSION     NM_003086.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4693)
  AUTHORS   Frost,F.G., Morimoto,M., Sharma,P., Ruaud,L., Belnap,N.,
            Calame,D.G., Uchiyama,Y., Matsumoto,N., Oud,M.M., Ferreira,E.A.,
            Narayanan,V., Rangasamy,S., Huentelman,M., Emrick,L.T.,
            Sato-Shirai,I., Kumada,S., Wolf,N.I., Steinbach,P.J., Huang,Y.,
            Pusey,B.N., Passemard,S., Levy,J., Drunat,S., Vincent,M., Guet,A.,
            Agolini,E., Novelli,A., Digilio,M.C., Rosenfeld,J.A., Murphy,J.L.,
            Lupski,J.R., Vezina,G., Macnamara,E.F., Adams,D.R., Acosta,M.T.,
            Tifft,C.J., Gahl,W.A. and Malicdan,M.C.V.
  CONSRTM   Undiagnosed Diseases Network
  TITLE     Bi-allelic SNAPC4 variants dysregulate global alternative splicing
            and lead to neuroregression and progressive spastic paraparesis
  JOURNAL   Am J Hum Genet 110 (4), 663-680 (2023)
   PUBMED   36965478
  REMARK    GeneRIF: Bi-allelic SNAPC4 variants dysregulate global alternative
            splicing and lead to neuroregression and progressive spastic
            paraparesis.
REFERENCE   2  (bases 1 to 4693)
  AUTHORS   Sun,J., Li,X., Hou,X., Cao,S., Cao,W., Zhang,Y., Song,J., Wang,M.,
            Wang,H., Yan,X., Li,Z., Roeder,R.G. and Wang,W.
  TITLE     Structural basis of human SNAPc recognizing proximal sequence
            element of snRNA promoter
  JOURNAL   Nat Commun 13 (1), 6871 (2022)
   PUBMED   36369505
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4693)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 4693)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 4693)
  AUTHORS   Ma,X., Liu,Y., Zhang,H., Qiu,R., Zhao,H., Xin,Q., Shan,S., Dang,J.,
            Li,J., Yang,Z., Gong,Y. and Liu,Q.
  TITLE     Evidence for genetic association of CARD9 and SNAPC4 with
            ankylosing spondylitis in a Chinese Han population
  JOURNAL   J Rheumatol 41 (2), 318-324 (2014)
   PUBMED   24334645
  REMARK    GeneRIF: Our study confirmed that an SNP rs11145835 in 9q34.3 that
            harbors CARD9 and SNAPC4 is associated with ankylosing spondylitis
            in a Chinese Han population
REFERENCE   6  (bases 1 to 4693)
  AUTHORS   Hinkley,C.S., Hirsch,H.A., Gu,L., LaMere,B. and Henry,R.W.
  TITLE     The small nuclear RNA-activating protein 190 Myb DNA binding domain
            stimulates TATA box-binding protein-TATA box recognition
  JOURNAL   J Biol Chem 278 (20), 18649-18657 (2003)
   PUBMED   12621023
REFERENCE   7  (bases 1 to 4693)
  AUTHORS   Hovde,S., Brooks,A., Strong,K. and Geiger,J.H.
  TITLE     Crystallization of the Oct-1/SNAP190 peptide/DNA complex
  JOURNAL   Acta Crystallogr D Biol Crystallogr 58 (Pt 3), 511-512 (2002)
   PUBMED   11856838
REFERENCE   8  (bases 1 to 4693)
  AUTHORS   Ma,B. and Hernandez,N.
  TITLE     A map of protein-protein contacts within the small nuclear
            RNA-activating protein complex SNAPc
  JOURNAL   J Biol Chem 276 (7), 5027-5035 (2001)
   PUBMED   11056176
REFERENCE   9  (bases 1 to 4693)
  AUTHORS   Wong,M.W., Henry,R.W., Ma,B., Kobayashi,R., Klages,N., Matthias,P.,
            Strubin,M. and Hernandez,N.
  TITLE     The large subunit of basal transcription factor SNAPc is a Myb
            domain protein that interacts with Oct-1
  JOURNAL   Mol Cell Biol 18 (1), 368-377 (1998)
   PUBMED   9418884
REFERENCE   10 (bases 1 to 4693)
  AUTHORS   Henry,R.W., Sadowski,C.L., Kobayashi,R. and Hernandez,N.
  TITLE     A TBP-TAF complex required for transcription of human snRNA genes
            by RNA polymerase II and III
  JOURNAL   Nature 374 (6523), 653-656 (1995)
   PUBMED   7715707
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL592301.14.
            This sequence is a reference standard in the RefSeqGene project.
            
            On or before Apr 6, 2021 this sequence version replaced
            XM_006717241.3, NM_003086.3.
            
            Summary: This gene encodes the largest subunit of the small nuclear
            RNA-activating protein (SNAP) complex. The encoded protein contains
            a Myb DNA-binding domain, and is essential for RNA polymerase II
            and III polymerase transcription from small nuclear RNA promoters.
            A mutation in this gene is associated with ankylosing spondylitis.
            [provided by RefSeq, Jul 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853558.24479.1,
                                           SRR11853563.34225.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000684778.1/ ENSP00000510559.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                AL592301.14        43758-43794         c
            38-176              AL592301.14        41923-42061         c
            177-223             AL592301.14        40601-40647         c
            224-391             AL592301.14        39227-39394         c
            392-517             AL592301.14        38922-39047         c
            518-596             AL592301.14        38424-38502         c
            597-678             AL592301.14        37873-37954         c
            679-783             AL592301.14        36297-36401         c
            784-856             AL592301.14        36146-36218         c
            857-1021            AL592301.14        35566-35730         c
            1022-1169           AL592301.14        32068-32215         c
            1170-1276           AL592301.14        31366-31472         c
            1277-1371           AL592301.14        31109-31203         c
            1372-1466           AL592301.14        28344-28438         c
            1467-1546           AL592301.14        27577-27656         c
            1547-2029           AL592301.14        26810-27292         c
            2030-2113           AL592301.14        25877-25960         c
            2114-2363           AL592301.14        25448-25697         c
            2364-2434           AL592301.14        24946-25016         c
            2435-2545           AL592301.14        24364-24474         c
            2546-2573           AL592301.14        23461-23488         c
            2574-4330           AL592301.14        21167-22923         c
            4331-4463           AL592301.14        19973-20105         c
            4464-4693           AL592301.14        19195-19424         c
FEATURES             Location/Qualifiers
     source          1..4693
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..4693
                     /gene="SNAPC4"
                     /gene_synonym="NEDRSO; PTFalpha; SNAP190"
                     /note="small nuclear RNA activating complex polypeptide 4"
                     /db_xref="GeneID:6621"
                     /db_xref="HGNC:HGNC:11137"
                     /db_xref="MIM:602777"
     exon            1..37
                     /gene="SNAPC4"
                     /gene_synonym="NEDRSO; PTFalpha; SNAP190"
                     /inference="alignment:Splign:2.1.0"
     exon            38..176
                     /gene="SNAPC4"
                     /gene_synonym="NEDRSO; PTFalpha; SNAP190"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..4456
                     /gene="SNAPC4"
                     /gene_synonym="NEDRSO; PTFalpha; SNAP190"
                     /note="isoform a is encoded by transcript variant 2;
                     snRNA-activating protein complex subunit 4; SNAPc subunit
                     4; PTF subunit alpha; SNAPc 190 kDa subunit; PSE-binding
                     factor subunit alpha; snRNA-activating protein complex 190
                     kDa subunit; proximal sequence element-binding
                     transcription factor subunit alpha"
                     /codon_start=1
                     /product="snRNA-activating protein complex subunit 4
                     isoform a"
                     /protein_id="NP_003077.2"
                     /db_xref="CCDS:CCDS6998.1"
                     /db_xref="GeneID:6621"
                     /db_xref="HGNC:HGNC:11137"
                     /db_xref="MIM:602777"
                     /translation="MDVDAEREKITQEIKELERILDPGSSGSHVEISESSLESDSEAD
                     SLPSEDLDPADPPISEEERWGEASNDEDDPKDKTLPEDPETCLQLNMVYQEVIQEKLA
                     EANLLLAQNREQQEELMRDLAGSKGTKVKDGKSLPPSTYMGHFMKPYFKDKVTGVGPP
                     ANEDTREKAAQGIKAFEELLVTKWKNWEKALLRKSVVSDRLQRLLQPKLLKLEYLHQK
                     QSKVSSELERQALEKQGREAEKEIQDINQLPEEALLGNRLDSHDWEKISNINFEGSRS
                     AEEIRKFWQNSEHPSINKQEWSREEEERLQAIAAAHGHLEWQKIAEELGTSRSAFQCL
                     QKFQQHNKALKRKEWTEEEDRMLTQLVQEMRVGSHIPYRRIVYYMEGRDSMQLIYRWT
                     KSLDPGLKKGYWAPEEDAKLLQAVAKYGEQDWFKIREEVPGRSDAQCRDRYLRRLHFS
                     LKKGRWNLKEEEQLIELIEKYGVGHWAKIASELPHRSGSQCLSKWKIMMGKKQGLRRR
                     RRRARHSVRWSSTSSSGSSSGSSGGSSSSSSSSSEEDEPEQAQAGEGDRALLSPQYMV
                     PDMDLWVPARQSTSQPWRGGAGAWLGGPAASLSPPKGSSASQGGSKEASTTAAAPGEE
                     TSPVQVPARAHGPVPRSAQASHSADTRPAGAEKQALEGGRRLLTVPVETVLRVLRANT
                     AARSCTQKEQLRQPPLPTSSPGVSSGDSVARSHVQWLRHRATQSGQRRWRHALHRRLL
                     NRRLLLAVTPWVGDVVVPCTQASQRPAVVQTQADGLREQLQQARLASTPVFTLFTQLF
                     HIDTAGCLEVVRERKALPPRLPQAGARDPPVHLLQASSSAQSTPGHLFPNVPAQEASK
                     SASHKGSRRLASSRVERTLPQASLLASTGPRPKPKTVSELLQEKRLQEARAREATRGP
                     VVLPSQLLVSSSVILQPPLPHTPHGRPAPGPTVLNVPLSGPGAPAAAKPGTSGSWQEA
                     GTSAKDKRLSTMQALPLAPVFSEAEGTAPAASQAPALGPGQISVSCPESGLGQSQAPA
                     ASRKQGLPEAPPFLPAAPSPTPLPVQPLSLTHIGGPHVATSVPLPVTWVLTAQGLLPV
                     PVPAVVSLPRPAGTPGPAGLLATLLPPLTETRAAQGPRAPALSSSWQPPANMNREPEP
                     SCRTDTPAPPTHALSQSPAEADGSVAFVPGEAQVAREIPEPRTSSHADPPEAEPPWSG
                     RLPAFGGVIPATEPRGTPGSPSGTQEPRGPLGLEKLPLRQPGPEKGALDLEKPPLPQP
                     GPEKGALDLGLLSQEGEAATQQWLGGQRGVRVPLLGSRLPYQPPALCSLRALSGLLLH
                     KKALEHKATSLVVGGEAERPAGALQASLGLVRGQLQDNPAYLLLRARFLAAFTLPALL
                     ATLAPQGVRTTLSVPSRVGSESEDEDLLSELELADRDGQPGCTTATCPIQGAPDSGKC
                     SASSCLDTSNDPDDLDVLRTRHARHTRKRRRLV"
     exon            177..223
                     /gene="SNAPC4"
                     /gene_synonym="NEDRSO; PTFalpha; SNAP190"
                     /inference="alignment:Splign:2.1.0"
     exon            224..391
                     /gene="SNAPC4"
                     /gene_synonym="NEDRSO; PTFalpha; SNAP190"
                     /inference="alignment:Splign:2.1.0"
     exon            392..517
                     /gene="SNAPC4"
                     /gene_synonym="NEDRSO; PTFalpha; SNAP190"
                     /inference="alignment:Splign:2.1.0"
     exon            518..596
                     /gene="SNAPC4"
                     /gene_synonym="NEDRSO; PTFalpha; SNAP190"
                     /inference="alignment:Splign:2.1.0"
     exon            597..678
                     /gene="SNAPC4"
                     /gene_synonym="NEDRSO; PTFalpha; SNAP190"
                     /inference="alignment:Splign:2.1.0"
     exon            679..783
                     /gene="SNAPC4"
                     /gene_synonym="NEDRSO; PTFalpha; SNAP190"
                     /inference="alignment:Splign:2.1.0"
     exon            784..856
                     /gene="SNAPC4"
                     /gene_synonym="NEDRSO; PTFalpha; SNAP190"
                     /inference="alignment:Splign:2.1.0"
     exon            857..1021
                     /gene="SNAPC4"
                     /gene_synonym="NEDRSO; PTFalpha; SNAP190"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1169
                     /gene="SNAPC4"
                     /gene_synonym="NEDRSO; PTFalpha; SNAP190"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1276
                     /gene="SNAPC4"
                     /gene_synonym="NEDRSO; PTFalpha; SNAP190"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1371
                     /gene="SNAPC4"
                     /gene_synonym="NEDRSO; PTFalpha; SNAP190"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1466
                     /gene="SNAPC4"
                     /gene_synonym="NEDRSO; PTFalpha; SNAP190"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1546
                     /gene="SNAPC4"
                     /gene_synonym="NEDRSO; PTFalpha; SNAP190"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..2029
                     /gene="SNAPC4"
                     /gene_synonym="NEDRSO; PTFalpha; SNAP190"
                     /inference="alignment:Splign:2.1.0"
     exon            2030..2113
                     /gene="SNAPC4"
                     /gene_synonym="NEDRSO; PTFalpha; SNAP190"
                     /inference="alignment:Splign:2.1.0"
     exon            2114..2363
                     /gene="SNAPC4"
                     /gene_synonym="NEDRSO; PTFalpha; SNAP190"
                     /inference="alignment:Splign:2.1.0"
     exon            2364..2434
                     /gene="SNAPC4"
                     /gene_synonym="NEDRSO; PTFalpha; SNAP190"
                     /inference="alignment:Splign:2.1.0"
     exon            2435..2545
                     /gene="SNAPC4"
                     /gene_synonym="NEDRSO; PTFalpha; SNAP190"
                     /inference="alignment:Splign:2.1.0"
     exon            2546..2573
                     /gene="SNAPC4"
                     /gene_synonym="NEDRSO; PTFalpha; SNAP190"
                     /inference="alignment:Splign:2.1.0"
     exon            2574..4330
                     /gene="SNAPC4"
                     /gene_synonym="NEDRSO; PTFalpha; SNAP190"
                     /inference="alignment:Splign:2.1.0"
     exon            4331..4463
                     /gene="SNAPC4"
                     /gene_synonym="NEDRSO; PTFalpha; SNAP190"
                     /inference="alignment:Splign:2.1.0"
     exon            4464..4693
                     /gene="SNAPC4"
                     /gene_synonym="NEDRSO; PTFalpha; SNAP190"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4662..4667
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNAPC4"
                     /gene_synonym="NEDRSO; PTFalpha; SNAP190"
                     /note="hexamer: AATAAA"
     polyA_site      4693
                     /gene="SNAPC4"
                     /gene_synonym="NEDRSO; PTFalpha; SNAP190"
                     /note="major polyA site"
ORIGIN      
        1 gcagtcgccc gggcgacggc ggggtccgcg cggccaggcg ggagtcatgg atgtagatgc
       61 tgaaagagag aagataacac aggagatcaa ggagctggaa aggattttgg atcccggctc
      121 ctcgggctcc cacgtggaga tctcagaatc aagtctcgag tcagattctg aagcagattc
      181 actgccttct gaggacttgg atcctgccga tcccccgatc tcggaagaag aaaggtgggg
      241 cgaagccagc aatgacgagg acgatcccaa ggataaaacc ctccctgaag acccagaaac
      301 ctgcctgcag ctgaacatgg tctaccagga ggtcatccag gagaagctgg ctgaggccaa
      361 cctgctgctg gcccagaacc gggagcagca ggaggaactc atgagggatc tggctgggtc
      421 caaaggcacc aaggtgaaag atggcaaaag cctgccccca agcacataca tggggcactt
      481 catgaagccg tatttcaagg acaaggtcac gggcgtgggg ccacctgcca acgaggacac
      541 acgagagaag gctgcccagg ggatcaaggc tttcgaggag ctccttgtga ccaaatggaa
      601 aaactgggaa aaggccttgc tccgaaagtc agtggtgagt gaccgcctgc agcgattgct
      661 tcagcccaag ttactgaagc tcgagtactt gcaccagaag cagagcaaag tctccagtga
      721 gctggagagg caagccctgg agaagcaggg cagggaagcc gagaaggaga tccaggacat
      781 caaccagctt ccagaagagg ccttgctggg aaacaggctg gacagccacg actgggagaa
      841 gatttccaat attaactttg aaggcagccg cagtgcagag gagatccgga agttctggca
      901 gaactcggag caccccagca tcaacaagca ggagtggagc agggaggagg aggagcggct
      961 gcaggcgatc gcggctgcac acggccacct ggagtggcag aagattgcag aggagctggg
     1021 gaccagccgc agcgccttcc agtgcctgca gaaattccag cagcacaaca aagctctgaa
     1081 acgcaaggag tggacagagg aggaggaccg catgctcacg cagctggtgc aggagatgcg
     1141 cgtcggcagc cacatcccct accgcagaat tgtctactat atggaaggga gagactccat
     1201 gcagctgatc taccgatgga ccaagagctt ggatcctggt ctgaagaagg gttactgggc
     1261 cccggaggaa gatgctaagt tgcttcaagc tgttgccaaa tacggggagc aggattggtt
     1321 taaaatccgg gaagaggtgc caggtaggag cgatgcccag tgccgagatc ggtatctcag
     1381 gagattacat ttcagcttga aaaagggtcg gtggaattta aaagaagagg aacagttaat
     1441 tgaattaata gaaaaatatg gtgtcggtca ctgggcaaaa atagcttctg agctgcccca
     1501 tcggtctggc tcccagtgtc tgagcaagtg gaagatcatg atggggaaga agcagggtct
     1561 ccggaggcgg cggcggaggg cccgtcacag cgtccggtgg agctctacca gcagcagcgg
     1621 cagcagcagt ggcagcagtg gagggagcag cagcagcagc agcagcagca gcgaggagga
     1681 cgagccagag caggcgcagg ccggggaggg tgacagagcg ctgctgtccc cacagtacat
     1741 ggtcccggac atggacctgt gggttcctgc caggcagagc accagccagc catggagagg
     1801 aggggcaggg gcctggctgg gaggccccgc tgcctccctc agccctccca aggggtccag
     1861 tgccagccag ggcggcagca aggaagcttc caccacagcc gcggctcctg gagaggagac
     1921 gagtccggtg caggtccctg ccagggccca cggccctgtc ccgaggtctg cccaggcctc
     1981 ccactcagca gacactcgcc cggcgggcgc agagaagcag gccctggagg gtgggaggcg
     2041 tctgctgaca gtgcctgtgg agaccgtgct gagggtgctc agggccaaca cggctgctcg
     2101 gagctgcaca cagaaagagc agctgaggca gccacccctg cccacctcat ccccaggggt
     2161 cagctctggt gacagcgtgg cccgatccca tgtgcagtgg ctacggcaca gagccaccca
     2221 gagtgggcag cggcgctgga gacacgctct gcaccggagg ctcctgaacc gcaggctgct
     2281 gctggctgtg accccttggg taggggacgt tgtcgtgccc tgcacacagg cttcccagag
     2341 acccgccgta gtgcagactc aagcggatgg cctcagggag cagctgcagc aggcccgcct
     2401 ggccagcacc cctgtgttta ccctgtttac ccagctgttc cacatcgata ctgccggctg
     2461 cttggaggtc gtccgagaga ggaaggccct gccacccagg ctgccccagg ctggtgctcg
     2521 ggacccacca gttcatcttc tgcaggcatc ctcaagtgcc cagagcaccc caggccacct
     2581 cttcccaaac gtgccggctc aagaagcctc aaagagtgcc agccacaaag ggagccgaag
     2641 actggcgtcc agccgggtgg agcgcaccct accccaggcg tccctgctgg cttcaaccgg
     2701 cccccggccc aagcccaaga ctgtgtcgga gctgcttcag gagaagcggc ttcaggaggc
     2761 ccgtgccagg gaggccaccc ggggcccggt ggtgctcccg tcccagctgc tggtctcctc
     2821 gtctgtgatc ctccagcccc ctctaccaca caccccacac ggccgcccag ccccgggtcc
     2881 caccgtctta aatgtaccgc tctctgggcc tggggccccc gcggcagcca aacctggcac
     2941 ttctggctcc tggcaggagg ctgggacttc agccaaggac aagagactct ccaccatgca
     3001 agccctgccc ctcgctcctg tcttctcaga ggccgagggc acagcccctg ctgcttccca
     3061 agcccctgcc ctgggccccg gccagatctc tgtgagctgc cccgagagtg gtctcggaca
     3121 gtctcaggcc cccgctgcat cccggaagca gggcctgcct gaggcgccac cctttctccc
     3181 cgcagccccc agccccaccc cactgcccgt ccagcccctc agcctgacgc acataggagg
     3241 gccacatgtg gcgaccagtg tccccctgcc tgtcacctgg gtgctcacag cccaggggct
     3301 tctccctgtt cctgtaccag ctgtggtgag ccttcccagg ccagcaggga cccctggccc
     3361 cgcagggctg ctggccactc tgctgcctcc cctgactgag actcgggcgg cccagggccc
     3421 cagggcccca gcgttgagca gctcttggca gcccccagcc aatatgaaca gggaaccgga
     3481 gccttcctgc aggacagaca ccccagctcc tcccacacac gccctctccc aaagtcctgc
     3541 agaagcggat ggcagtgtgg cctttgtccc tggagaggcc caggtggcca gggagatacc
     3601 tgagcccagg acgtcctccc acgctgaccc tcctgaagca gaaccccctt ggtccgggag
     3661 gctgccagcc ttcggtggtg tcatcccagc aactgagcca agggggacgc cggggtcccc
     3721 ctcagggaca caggagccca gggggcctct gggcctggag aagctgcccc tgcgccagcc
     3781 tgggcctgag aagggggccc tggacctgga gaagccgccc ctaccccagc ctgggcctga
     3841 gaagggggcc ctggacctgg gcctgctgtc ccaggagggc gaggcggcca cacagcagtg
     3901 gctggggggc cagcgggggg tgcgtgtgcc tcttctgggc agcagactgc cctatcagcc
     3961 cccagccctg tgcagcctgc gagctctgtc cggtctccta ctccacaaga aggccctgga
     4021 gcacaaggcc acctccctgg tggtgggggg cgaggctgag cggccggccg gagcactgca
     4081 agcctcactg gggctggtgc gggggcagct ccaggacaac ccggcctacc tcctgttgcg
     4141 ggcgcggttc ctggcagcct tcaccctccc tgcgctcctg gccaccctgg ccccccaagg
     4201 cgtccgcacc accctctcag taccttcgag ggtgggctct gagagtgagg atgaagacct
     4261 cctgagtgag ctggaacttg cagacaggga cgggcagccg ggctgcacga cagccacatg
     4321 ccccattcag ggagccccag actctggtaa atgctctgct tcctcctgcc tggatacttc
     4381 taatgaccct gacgacctgg acgtgctcag aacccggcat gccaggcaca cccggaagcg
     4441 gaggcggctg gtgtgagcag caggacaagc actttctcag aagcccgtgg ccctgctgac
     4501 gagagacagc ccacccccag cctgcaagag aggcagccag aggccaggta tctgctggcc
     4561 gctgactgac caggtccgca gtgaacagag gcgggcctgc cgactgactg tgtggcatgg
     4621 agcatggctg ttccccaagt gcacacctga acacttggag gaataaagtt ctgtttttaa
     4681 ttgtggagct gga
//
