LOCUS       NM_001039697            3000 bp    mRNA    linear   PRI 13-DEC-2024
DEFINITION  Homo sapiens small nuclear RNA activating complex polypeptide 3
            (SNAPC3), transcript variant 1, mRNA.
ACCESSION   NM_001039697
VERSION     NM_001039697.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3000)
  AUTHORS   Sun,J., Li,X., Hou,X., Cao,S., Cao,W., Zhang,Y., Song,J., Wang,M.,
            Wang,H., Yan,X., Li,Z., Roeder,R.G. and Wang,W.
  TITLE     Structural basis of human SNAPc recognizing proximal sequence
            element of snRNA promoter
  JOURNAL   Nat Commun 13 (1), 6871 (2022)
   PUBMED   36369505
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3000)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3000)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 3000)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3000)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3000)
  AUTHORS   Ma,B. and Hernandez,N.
  TITLE     A map of protein-protein contacts within the small nuclear
            RNA-activating protein complex SNAPc
  JOURNAL   J Biol Chem 276 (7), 5027-5035 (2001)
   PUBMED   11056176
REFERENCE   7  (bases 1 to 3000)
  AUTHORS   Henry,R.W., Ma,B., Sadowski,C.L., Kobayashi,R. and Hernandez,N.
  TITLE     Cloning and characterization of SNAP50, a subunit of the
            snRNA-activating protein complex SNAPc
  JOURNAL   EMBO J 15 (24), 7129-7136 (1996)
   PUBMED   9003788
REFERENCE   8  (bases 1 to 3000)
  AUTHORS   Bai,L., Wang,Z., Yoon,J.B. and Roeder,R.G.
  TITLE     Cloning and characterization of the beta subunit of human proximal
            sequence element-binding transcription factor and its involvement
            in transcription of small nuclear RNA genes by RNA polymerases II
            and III
  JOURNAL   Mol Cell Biol 16 (10), 5419-5426 (1996)
   PUBMED   8816454
REFERENCE   9  (bases 1 to 3000)
  AUTHORS   Henry,R.W., Sadowski,C.L., Kobayashi,R. and Hernandez,N.
  TITLE     A TBP-TAF complex required for transcription of human snRNA genes
            by RNA polymerase II and III
  JOURNAL   Nature 374 (6523), 653-656 (1995)
   PUBMED   7715707
REFERENCE   10 (bases 1 to 3000)
  AUTHORS   Bagramian,E.R., Bogdanova,E.A., Krymskaia,M.L. and Sokovykh,S.I.
  TITLE     [Diagnostic importance of determining 17-ketosteroids in
            gynecology]
  JOURNAL   Akush Ginekol (Mosk) (2), 65-67 (1977)
   PUBMED   900378
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL441925.16.
            
            On Apr 8, 2021 this sequence version replaced NM_001039697.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.832476.1, BC108743.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380821.8/ ENSP00000370200.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-318               AL441925.16        12882-13199
            319-396             AL441925.16        13915-13992
            397-481             AL441925.16        23558-23642
            482-586             AL441925.16        34608-34712
            587-736             AL441925.16        37101-37250
            737-819             AL441925.16        41326-41408
            820-984             AL441925.16        43047-43211
            985-1092            AL441925.16        47966-48073
            1093-3000           AL441925.16        49725-51632
FEATURES             Location/Qualifiers
     source          1..3000
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p22.3"
     gene            1..3000
                     /gene="SNAPC3"
                     /gene_synonym="PTFbeta; SNAP50"
                     /note="small nuclear RNA activating complex polypeptide 3"
                     /db_xref="GeneID:6619"
                     /db_xref="HGNC:HGNC:11136"
                     /db_xref="MIM:602348"
     exon            1..318
                     /gene="SNAPC3"
                     /gene_synonym="PTFbeta; SNAP50"
                     /inference="alignment:Splign:2.1.0"
     CDS             5..1240
                     /gene="SNAPC3"
                     /gene_synonym="PTFbeta; SNAP50"
                     /note="isoform 1 is encoded by transcript variant 1;
                     snRNA-activating protein complex subunit 3; SNAPc subunit
                     3; PTF subunit beta; SNAPc 50 kDa subunit; PSE-binding
                     factor subunit beta; snRNA-activating protein complex 50
                     kDa subunit; proximal sequence element-binding
                     transcription factor subunit beta; small nuclear RNA
                     activating complex, polypeptide 3, 50kD; small nuclear RNA
                     activating complex, polypeptide 3, 50kDa"
                     /codon_start=1
                     /product="snRNA-activating protein complex subunit 3
                     isoform 1"
                     /protein_id="NP_001034786.1"
                     /db_xref="CCDS:CCDS6478.1"
                     /db_xref="GeneID:6619"
                     /db_xref="HGNC:HGNC:11136"
                     /db_xref="MIM:602348"
                     /translation="MAEGSRGGPTCSGVGGRQDPVSGSGGCNFPEYELPELNTRAFHV
                     GAFGELWRGRLRGAGDLSLREPPASALPGSQAADSDREDAAVARDLDCSLEAAAELRA
                     VCGLDKLKCLEDGEDPEVIPENTDLVTLGVRKRFLEHREETITIDRACRQETFVYEME
                     SHAIGKKPENSADMIEEGELILSVNILYPVIFHKHKEHKPYQTMLVLGSQKLTQLRDS
                     IRCVSDLQIGGEFSNTPDQAPEHISKDLYKSAFFYFEGTFYNDKRYPECRDLSRTIIE
                     WSESHDRGYGKFQTARMEDFTFNDLCIKLGFPYLYCHQGDCEHVIVITDIRLVHHDDC
                     LDRTLYPLLIKKHWLWTRKCFVCKMYTARWVTNNDSFAPEDPCFFCDVCFRMLHYDSE
                     GNKLGEFLAYPYVDPGTFN"
     exon            319..396
                     /gene="SNAPC3"
                     /gene_synonym="PTFbeta; SNAP50"
                     /inference="alignment:Splign:2.1.0"
     exon            397..481
                     /gene="SNAPC3"
                     /gene_synonym="PTFbeta; SNAP50"
                     /inference="alignment:Splign:2.1.0"
     exon            482..586
                     /gene="SNAPC3"
                     /gene_synonym="PTFbeta; SNAP50"
                     /inference="alignment:Splign:2.1.0"
     exon            587..736
                     /gene="SNAPC3"
                     /gene_synonym="PTFbeta; SNAP50"
                     /inference="alignment:Splign:2.1.0"
     exon            737..819
                     /gene="SNAPC3"
                     /gene_synonym="PTFbeta; SNAP50"
                     /inference="alignment:Splign:2.1.0"
     exon            820..984
                     /gene="SNAPC3"
                     /gene_synonym="PTFbeta; SNAP50"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1092
                     /gene="SNAPC3"
                     /gene_synonym="PTFbeta; SNAP50"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..3000
                     /gene="SNAPC3"
                     /gene_synonym="PTFbeta; SNAP50"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2979..2984
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNAPC3"
                     /gene_synonym="PTFbeta; SNAP50"
                     /note="hexamer: AATAAA"
     polyA_site      3000
                     /gene="SNAPC3"
                     /gene_synonym="PTFbeta; SNAP50"
                     /note="major polyA site"
ORIGIN      
        1 gaacatggct gaaggaagcc gaggtggccc tacgtgtagc ggggtgggtg gcaggcagga
       61 cccagtctcc ggcagtggcg gctgcaactt tccagagtat gagcttcccg agctaaatac
      121 gcgcgctttc catgtgggcg cctttgggga gctgtggcgg ggccgtctgc gcggggccgg
      181 ggacttgtcg ctgagggagc cgccggcatc cgctctgcct gggagccagg cagctgactc
      241 cgaccgggag gatgccgcgg tggccaggga tctggactgc agcctggagg cggcggctga
      301 gctgagggcg gtgtgcggcc ttgataaact gaaatgcctt gaggacggtg aggatccaga
      361 agtcattccg gagaatactg acctggtgac tttgggggtt agaaaaaggt tcttggaaca
      421 tcgggaagaa accattacaa tagatcgagc ctgcagacaa gaaacattcg tttatgagat
      481 ggagtcacat gccataggaa aaaagcctga aaattcagca gacatgattg aagaagggga
      541 gcttatccta tctgtgaata tcttgtaccc tgttatattt cataagcaca aagaacacaa
      601 accataccaa acaatgctgg tgttgggcag tcaaaaactc acacaactga gggattcaat
      661 tcgatgtgtc agtgacctcc agattggtgg tgaattcagc aacactcctg accaagcccc
      721 tgagcacatc agcaaagacc tatacaaatc agccttcttt tattttgaag gaacatttta
      781 taatgataaa agatacccag aatgcagaga tttgagcaga actatcattg agtggtcaga
      841 gtcccatgat agaggctatg gaaagtttca gactgctaga atggaagatt tcaccttcaa
      901 tgacttgtgt attaaactgg gttttcctta cttatactgt catcagggag actgtgaaca
      961 tgtcattgtc attactgaca taaggcttgt gcatcatgat gactgcttgg ataggacatt
     1021 gtatcccctc cttatcaaga agcattggct atggaccaga aaatgttttg tttgtaaaat
     1081 gtatacagcc agatgggtga cgaacaatga cagttttgca ccagaggacc catgcttctt
     1141 ttgtgatgtt tgcttccgaa tgctgcacta tgattcagaa ggcaacaaac tgggggaatt
     1201 ccttgcttat ccttatgttg atcctggaac ctttaattaa gaatagctac actcacaaaa
     1261 ataccccctc atgaaataac tgttctcttg gatggttacc ttatttctaa gaaacgccac
     1321 tgaggaacag gatccacttt gaacagtccg ctaaagctat caaaaaaaag tccaaatgac
     1381 agattttctt ataatgatag tatttaaatg tttataacat agtttaattt tatatttatt
     1441 ccagatagta tttaatttag tgctttttac ccattttgag ttgagttgta gtactttata
     1501 tattctgact ttaaatcctt tgtcagacac acatattctt tctcccaatc catgccttcc
     1561 ctattcattc tctgtccaga gttttttgct aaagatagaa ttattaatga tacatcaagt
     1621 agtggaagtg ttttgaaaat tctttgaaga atgtgagagc tacaccttct accatgaggc
     1681 ttccaaggta aagatccttc aaataactgt aatggaaact agggagaatg aattatttac
     1741 aaataagaca aaattaatag ctttgggatt atttattttt tgagacaaaa tctcgctctt
     1801 gttgcccagg ctggaataca gtggcgcaat ctcagctcac tgcagcctcc gcctcccgga
     1861 ttcaagtgat tctcctgcca cagcctcctg agtagctggg attgcaggca cctggcacca
     1921 tgcctggcta atttttgtat ttttagtaga gacggggttt caccatgttg gccaggctgg
     1981 tctcaaactc ctaacctcag gcgatccacc cgcctaagcc tcccaaaatt ttgggatcac
     2041 aggcgtgagc caccgcgccc ggctgctttg ggggaattta atcttagtgt gctgtttagt
     2101 aatgttaggt tttgttttgg aggaaactag gcatacaaga catgttaata agactatgtg
     2161 aataatgaat ttaaaaagat cttgagtata tactcataac tccagaaata acattaactt
     2221 gaagctttat ttcttgacaa aagctttatg aatgttatga gtttaaaata tgtcaattta
     2281 atactatgat ttaaaaaaca atagcagatt tcgtatgact gtggggacat ggaaaaatca
     2341 agatcctatt gattgctagc tctggctcac ttattctccg gtaatgatac tattggatat
     2401 ataccaaaat tatataagca aaaagaaaaa aaataagttt tcctggccca ggtcttccat
     2461 tcttctggtc cccttactat agtaattcta gttactctca tcttattctg aggaaaaaaa
     2521 aaaaaaccaa aactttttaa acttattttt tgacataggg tcttactgtg tcacccaggc
     2581 tggagtacag tggcgtgatc ttggctcact ggagccctga cctccctagg ctcaggtgat
     2641 cctcccacct cagcctaccg agtagctgag acatggtggc acaggccacc atggcgggct
     2701 aattttttta tttcttgtag atacagggtt tcactatgtt gcgcagaata gtctcgaact
     2761 cctgacctca agtgatccat ccgccttggc ctcccagagt gctgcgatta caggcatgaa
     2821 ccacagcgcc cagcaaaata aactttcttt attttcaggt ctagaccatc agatagattt
     2881 attcaaatat tttctgggaa cctttatggg tagaacattt aatactgttt agaagacttt
     2941 taggaatact atagatttca aatgcatcat ttaaaataaa taaattccac tttctctctc
//
