LOCUS       NM_003083               1520 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens small nuclear RNA activating complex polypeptide 2
            (SNAPC2), transcript variant 1, mRNA.
ACCESSION   NM_003083
VERSION     NM_003083.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1520)
  AUTHORS   Harrigan,J.A., Belotserkovskaya,R., Coates,J., Dimitrova,D.S.,
            Polo,S.E., Bradshaw,C.R., Fraser,P. and Jackson,S.P.
  TITLE     Replication stress induces 53BP1-containing OPT domains in G1 cells
  JOURNAL   J Cell Biol 193 (1), 97-108 (2011)
   PUBMED   21444690
  REMARK    GeneRIF: The findings invoke a model wherein incomplete DNA
            synthesis during S phase leads to a DNA damage response and
            formation of 53BP1-OPT domains in the subsequent G1.
REFERENCE   2  (bases 1 to 1520)
  AUTHORS   Shanmugam,M. and Hernandez,N.
  TITLE     Mitotic functions for SNAP45, a subunit of the small nuclear
            RNA-activating protein complex SNAPc
  JOURNAL   J Biol Chem 283 (21), 14845-14856 (2008)
   PUBMED   18356157
  REMARK    GeneRIF: SNAP45 plays two roles in the cell, one as a subunit of
            the transcription factor SNAP(c) and another as a factor required
            for proper mitotic progression
REFERENCE   3  (bases 1 to 1520)
  AUTHORS   Emran,F., Florens,L., Ma,B., Swanson,S.K., Washburn,M.P. and
            Hernandez,N.
  TITLE     A role for Yin Yang-1 (YY1) in the assembly of snRNA transcription
            complexes
  JOURNAL   Gene 377, 96-108 (2006)
   PUBMED   16769183
REFERENCE   4  (bases 1 to 1520)
  AUTHORS   Hinkley,C.S., Hirsch,H.A., Gu,L., LaMere,B. and Henry,R.W.
  TITLE     The small nuclear RNA-activating protein 190 Myb DNA binding domain
            stimulates TATA box-binding protein-TATA box recognition
  JOURNAL   J Biol Chem 278 (20), 18649-18657 (2003)
   PUBMED   12621023
REFERENCE   5  (bases 1 to 1520)
  AUTHORS   Acierno,J.S. Jr., Kennedy,J.C., Falardeau,J.L., Leyne,M.,
            Bromley,M.C., Colman,M.W., Sun,M., Bove,C., Ashworth,L.K.,
            Chadwick,L.H., Schiripo,T., Ma,S., Goldin,E., Schiffmann,R. and
            Slaugenhaupt,S.A.
  TITLE     A physical and transcript map of the MCOLN1 gene region on human
            chromosome 19p13.3-p13.2
  JOURNAL   Genomics 73 (2), 203-210 (2001)
   PUBMED   11318610
REFERENCE   6  (bases 1 to 1520)
  AUTHORS   Wong,M.W., Henry,R.W., Ma,B., Kobayashi,R., Klages,N., Matthias,P.,
            Strubin,M. and Hernandez,N.
  TITLE     The large subunit of basal transcription factor SNAPc is a Myb
            domain protein that interacts with Oct-1
  JOURNAL   Mol Cell Biol 18 (1), 368-377 (1998)
   PUBMED   9418884
REFERENCE   7  (bases 1 to 1520)
  AUTHORS   Henry,R.W., Ma,B., Sadowski,C.L., Kobayashi,R. and Hernandez,N.
  TITLE     Cloning and characterization of SNAP50, a subunit of the
            snRNA-activating protein complex SNAPc
  JOURNAL   EMBO J 15 (24), 7129-7136 (1996)
   PUBMED   9003788
REFERENCE   8  (bases 1 to 1520)
  AUTHORS   Sadowski,C.L., Henry,R.W., Kobayashi,R. and Hernandez,N.
  TITLE     The SNAP45 subunit of the small nuclear RNA (snRNA) activating
            protein complex is required for RNA polymerase II and III snRNA
            gene transcription and interacts with the TATA box binding protein
  JOURNAL   Proc Natl Acad Sci U S A 93 (9), 4289-4293 (1996)
   PUBMED   8633057
REFERENCE   9  (bases 1 to 1520)
  AUTHORS   Yoon,J.B. and Roeder,R.G.
  TITLE     Cloning of two proximal sequence element-binding transcription
            factor subunits (gamma and delta) that are required for
            transcription of small nuclear RNA genes by RNA polymerases II and
            III and interact with the TATA-binding protein
  JOURNAL   Mol Cell Biol 16 (1), 1-9 (1996)
   PUBMED   8524284
REFERENCE   10 (bases 1 to 1520)
  AUTHORS   Henry,R.W., Sadowski,C.L., Kobayashi,R. and Hernandez,N.
  TITLE     A TBP-TAF complex required for transcription of human snRNA genes
            by RNA polymerase II and III
  JOURNAL   Nature 374 (6523), 653-656 (1995)
   PUBMED   7715707
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U44755.1 and AC010336.8.
            
            On Nov 23, 2018 this sequence version replaced NM_003083.3.
            
            Summary: This gene encodes a subunit of the snRNA-activating
            protein complex which is associated with the TATA box-binding
            protein. The encoded protein is necessary for RNA polymerase II and
            III dependent small-nuclear RNA gene transcription. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Nov 2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the functional protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U44755.1, SRR3476690.130996.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000221573.11/ ENSP00000221573.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-380               U44755.1           14-393
            381-381             AC010336.8         102964-102964
            382-1092            U44755.1           395-1105
            1093-1093           AC010336.8         104034-104034
            1094-1347           U44755.1           1107-1360
            1348-1348           AC010336.8         104289-104289
            1349-1520           U44755.1           1361-1532
FEATURES             Location/Qualifiers
     source          1..1520
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..1520
                     /gene="SNAPC2"
                     /gene_synonym="PTFDELTA; SNAP45"
                     /note="small nuclear RNA activating complex polypeptide 2"
                     /db_xref="GeneID:6618"
                     /db_xref="HGNC:HGNC:11135"
                     /db_xref="MIM:605076"
     exon            1..212
                     /gene="SNAPC2"
                     /gene_synonym="PTFDELTA; SNAP45"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..1034
                     /gene="SNAPC2"
                     /gene_synonym="PTFDELTA; SNAP45"
                     /note="proximal sequence element-binding transcription
                     factor subunit delta; PSE-binding factor subunit delta;
                     PTF subunit delta; SNAPC 45 kDa subunit; SNAPc subunit 2;
                     snRNA-activating protein complex 45 kDa subunit; small
                     nuclear RNA activating complex, polypeptide 2, 45kD; small
                     nuclear RNA activating complex, polypeptide 2, 45kDa"
                     /codon_start=1
                     /product="snRNA-activating protein complex subunit 2"
                     /protein_id="NP_003074.1"
                     /db_xref="CCDS:CCDS12190.1"
                     /db_xref="GeneID:6618"
                     /db_xref="HGNC:HGNC:11135"
                     /db_xref="MIM:605076"
                     /translation="MKPPPRRRAAPARYLGEVTGPATWSAREKRQLVRLLQARQGQPE
                     PDATELARELRGRSEAEIRVFLQQLKGRVAREAIQKVHPGGLQGPRRREAQPPAPIEV
                     WTDLAEKITGPLEEALAVAFSQVLTIAATEPVTLLHSKPPKPTQARGKPLLLSAPGGQ
                     EDPAPEIPSSAPAAPSSAPRTPDPAPEKPSESSAGPSTEEDFAVDFEKIYKYLSSVSR
                     SGRSPELSAAESAVVLDLLMSLPEELPLLPCTALVEHMTETYLRLTAPQPIPAGGSLG
                     PAAEGDGAGSKAPEETPPATEKAEHSELKSPWQAAGICPLNPFLVPLELLGRAATPAR
                     "
     exon            213..332
                     /gene="SNAPC2"
                     /gene_synonym="PTFDELTA; SNAP45"
                     /inference="alignment:Splign:2.1.0"
     exon            333..401
                     /gene="SNAPC2"
                     /gene_synonym="PTFDELTA; SNAP45"
                     /inference="alignment:Splign:2.1.0"
     exon            402..714
                     /gene="SNAPC2"
                     /gene_synonym="PTFDELTA; SNAP45"
                     /inference="alignment:Splign:2.1.0"
     exon            715..1520
                     /gene="SNAPC2"
                     /gene_synonym="PTFDELTA; SNAP45"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1492..1497
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNAPC2"
                     /gene_synonym="PTFDELTA; SNAP45"
                     /note="hexamer: AATAAA"
     polyA_site      1520
                     /gene="SNAPC2"
                     /gene_synonym="PTFDELTA; SNAP45"
                     /note="major polyA site"
ORIGIN      
        1 cttacagcgc ctgcctcttt ctgagcggca tgaagccacc tcccaggcgg cgagcggccc
       61 cggcgcgcta tctgggcgag gtgaccggtc ccgcgacctg gagcgctcgc gagaagcggc
      121 agctagtgcg actcctgcag gcgcggcagg gccagccgga gccggacgcc accgagctgg
      181 cccgggagct gcggggccgg agcgaggctg agatccgggt cttcctccag cagctcaagg
      241 gccgcgtagc ccgggaggcc attcagaaag tgcatccggg tggccttcag ggaccaaggc
      301 gccgggaggc acagccccca gcccccatag aggtctggac ggatctggct gagaagataa
      361 cagggccact ggaagaagcc ctggcagtgg ctttctcgca ggtgctcacc atcgcggcca
      421 cggaaccggt caccctcctg cactccaagc cccccaagcc cacgcaggcc cgtggaaagc
      481 ctttgctcct gagcgcccct ggaggacagg aagaccccgc ccctgaaata cctagctctg
      541 cccctgctgc acctagctcc gcacccagga ctcctgaccc tgcccctgag aaaccttctg
      601 agtcgtcggc tggtccctcc actgaagaag actttgctgt ggactttgag aagatctaca
      661 agtacttgtc ctctgtctcc cgaagtggcc gcagccccga gctctcagca gctgagtccg
      721 ctgtggtcct cgacctgctc atgtcacttc cagaggagct gccactcctg ccctgcacag
      781 ccctggttga gcatatgacg gagacgtacc tacgcctgac agccccccag cccattcccg
      841 ctggagggag cctggggcct gcagcagaag gggatggggc tggctccaag gcaccagagg
      901 agaccccccc agccaccgag aaggccgagc acagcgaact gaaatcgcct tggcaagcag
      961 ctgggatctg tcccctgaac ccgttcctgg tgcccctgga gcttctgggt cgggcagcca
     1021 cccctgccag gtgaggggca tggcgggcag gaggccacac caggcccccc gccctgcccc
     1081 tcggttctgc tcggctggcc ctggctcttt ctgaggatcc cgtcatgggg gaaggtcctt
     1141 gagatgatgc tcagctgtgg ggcgggcctc taagatgccc catactttgg gggtctcaga
     1201 aatggaaccc ccgttgtaca ggggttgggt gggggttgca ggactccact cacaagcctc
     1261 ctgatgtcaa ggacaggcgg acagggctgg cctcccccag tccccaagcc ccactgtgcc
     1321 ttgttgtctg ctggggggcc atagctggca ctgcccaccg taaaggccct cgcacatttt
     1381 cccccttcct gtacacctcg gggccagcat cctcaccttc ttcaactgac cagtcgtggt
     1441 tactccctgc tgccaggtcc ttccccttcc cgggggtatt ctgtgaccat gaataaagtt
     1501 atcattctct ttctctttca
//
