LOCUS       NM_003082               2593 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens small nuclear RNA activating complex polypeptide 1
            (SNAPC1), mRNA.
ACCESSION   NM_003082
VERSION     NM_003082.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2593)
  AUTHORS   Sun,J., Li,X., Hou,X., Cao,S., Cao,W., Zhang,Y., Song,J., Wang,M.,
            Wang,H., Yan,X., Li,Z., Roeder,R.G. and Wang,W.
  TITLE     Structural basis of human SNAPc recognizing proximal sequence
            element of snRNA promoter
  JOURNAL   Nat Commun 13 (1), 6871 (2022)
   PUBMED   36369505
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2593)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2593)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2593)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 2593)
  AUTHORS   Hasegawa,Y., Taylor,D., Ovchinnikov,D.A., Wolvetang,E.J., de
            Torrente,L. and Mar,J.C.
  TITLE     Variability of Gene Expression Identifies Transcriptional
            Regulators of Early Human Embryonic Development
  JOURNAL   PLoS Genet 11 (8), e1005428 (2015)
   PUBMED   26288249
  REMARK    GeneRIF: Results from a study on gene expression variability
            markers in early-stage human embryos shows that is a putative
            expression variability marker as well as a differential gene
            expression marker for the 3-day, 8-cell embryo stage.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2593)
  AUTHORS   Maeng,J.H. and Yoon,J.B.
  TITLE     The human PTFgamma/SNAP43 gene: structure, chromosomal location,
            and identification of a VNTR in 5'-UTR
  JOURNAL   J Biochem 124 (1), 23-27 (1998)
   PUBMED   9644240
REFERENCE   7  (bases 1 to 2593)
  AUTHORS   Wong,M.W., Henry,R.W., Ma,B., Kobayashi,R., Klages,N., Matthias,P.,
            Strubin,M. and Hernandez,N.
  TITLE     The large subunit of basal transcription factor SNAPc is a Myb
            domain protein that interacts with Oct-1
  JOURNAL   Mol Cell Biol 18 (1), 368-377 (1998)
   PUBMED   9418884
REFERENCE   8  (bases 1 to 2593)
  AUTHORS   Henry,R.W., Ma,B., Sadowski,C.L., Kobayashi,R. and Hernandez,N.
  TITLE     Cloning and characterization of SNAP50, a subunit of the
            snRNA-activating protein complex SNAPc
  JOURNAL   EMBO J 15 (24), 7129-7136 (1996)
   PUBMED   9003788
REFERENCE   9  (bases 1 to 2593)
  AUTHORS   Yoon,J.B. and Roeder,R.G.
  TITLE     Cloning of two proximal sequence element-binding transcription
            factor subunits (gamma and delta) that are required for
            transcription of small nuclear RNA genes by RNA polymerases II and
            III and interact with the TATA-binding protein
  JOURNAL   Mol Cell Biol 16 (1), 1-9 (1996)
   PUBMED   8524284
REFERENCE   10 (bases 1 to 2593)
  AUTHORS   Henry,R.W., Sadowski,C.L., Kobayashi,R. and Hernandez,N.
  TITLE     A TBP-TAF complex required for transcription of human snRNA genes
            by RNA polymerase II and III
  JOURNAL   Nature 374 (6523), 653-656 (1995)
   PUBMED   7715707
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK314933.1 and BC014984.1.
            
            On Nov 22, 2018 this sequence version replaced NM_003082.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189652.221889.1,
                                           SRR3476690.931522.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000216294.5/ ENSP00000216294.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AK314933.1         64-92
            30-2497             BC014984.1         1-2468
            2498-2593           BC014984.1         2471-2566
FEATURES             Location/Qualifiers
     source          1..2593
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q23.2"
     gene            1..2593
                     /gene="SNAPC1"
                     /gene_synonym="PTFgamma; SNAP43"
                     /note="small nuclear RNA activating complex polypeptide 1"
                     /db_xref="GeneID:6617"
                     /db_xref="HGNC:HGNC:11134"
                     /db_xref="MIM:600591"
     exon            1..169
                     /gene="SNAPC1"
                     /gene_synonym="PTFgamma; SNAP43"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..1148
                     /gene="SNAPC1"
                     /gene_synonym="PTFgamma; SNAP43"
                     /note="PTF subunit gamma; SNAPc 43 kDa subunit;
                     PSE-binding factor subunit gamma; snRNA-activating protein
                     complex 43 kDa subunit; proximal sequence element-binding
                     transcription factor subunit gamma; SNAPc subunit 1; small
                     nuclear RNA activating complex, polypeptide 1, 43kD; small
                     nuclear RNA activating complex, polypeptide 1, 43kDa"
                     /codon_start=1
                     /product="snRNA-activating protein complex subunit 1"
                     /protein_id="NP_003073.1"
                     /db_xref="CCDS:CCDS9755.1"
                     /db_xref="GeneID:6617"
                     /db_xref="HGNC:HGNC:11134"
                     /db_xref="MIM:600591"
                     /translation="MGTPPGLQTDCEALLSRFQETDSVRFEDFTELWRNMKFGTIFCG
                     RMRNLEKNMFTKEALALAWRYFLPPYTFQIRVGALYLLYGLYNTQLCQPKQKIRVALK
                     DWDEVLKFQQDLVNAQHFDAAYIFRKLRLDRAFHFTAMPKLLSYRMKKKIHRAEVTEE
                     FKDPSDRVMKLITSDVLEEMLNVHDHYQNMKHVISVDKSKPDKALSLIKDDFFDNIKN
                     IVLEHQQWHKDRKNPSLKSKTNDGEEKMEGNSQETERCERAESLAKIKSKAFSVVIQA
                     SKSRRHRQVKLDSSDSDSASGQGQVKATRKKEKKERLKPAGRKMSLRNKGNVQNIHKE
                     DKPLSLSMPVITEEEENESLSGTEFTASKKRRKH"
     exon            170..329
                     /gene="SNAPC1"
                     /gene_synonym="PTFgamma; SNAP43"
                     /inference="alignment:Splign:2.1.0"
     exon            330..470
                     /gene="SNAPC1"
                     /gene_synonym="PTFgamma; SNAP43"
                     /inference="alignment:Splign:2.1.0"
     exon            471..575
                     /gene="SNAPC1"
                     /gene_synonym="PTFgamma; SNAP43"
                     /inference="alignment:Splign:2.1.0"
     exon            576..734
                     /gene="SNAPC1"
                     /gene_synonym="PTFgamma; SNAP43"
                     /inference="alignment:Splign:2.1.0"
     exon            735..803
                     /gene="SNAPC1"
                     /gene_synonym="PTFgamma; SNAP43"
                     /inference="alignment:Splign:2.1.0"
     exon            804..866
                     /gene="SNAPC1"
                     /gene_synonym="PTFgamma; SNAP43"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1017
                     /gene="SNAPC1"
                     /gene_synonym="PTFgamma; SNAP43"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1113
                     /gene="SNAPC1"
                     /gene_synonym="PTFgamma; SNAP43"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..2593
                     /gene="SNAPC1"
                     /gene_synonym="PTFgamma; SNAP43"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1611..1616
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNAPC1"
                     /gene_synonym="PTFgamma; SNAP43"
                     /note="hexamer: AATAAA"
     polyA_site      1650
                     /gene="SNAPC1"
                     /gene_synonym="PTFgamma; SNAP43"
                     /note="major polyA site"
     regulatory      1810..1815
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNAPC1"
                     /gene_synonym="PTFgamma; SNAP43"
                     /note="hexamer: AATAAA"
     polyA_site      1832
                     /gene="SNAPC1"
                     /gene_synonym="PTFgamma; SNAP43"
     regulatory      2571..2576
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNAPC1"
                     /gene_synonym="PTFgamma; SNAP43"
                     /note="hexamer: AATAAA"
     polyA_site      2593
                     /gene="SNAPC1"
                     /gene_synonym="PTFgamma; SNAP43"
ORIGIN      
        1 agaggcgtgc gggcttcgga ggcgtgcggg cttcgggtgc catggggact cctcccggcc
       61 tgcagaccga ctgcgaggcg ctgctcagcc gcttccagga gacggacagt gtacgcttcg
      121 aggacttcac ggagctctgg agaaacatga agttcgggac tatcttctgt ggcagaatga
      181 gaaatttaga aaagaacatg tttacaaaag aagctttagc tttggcttgg cgatattttt
      241 tacctccata caccttccag atcagagttg gtgctttgta tctgctatat ggattatata
      301 atacccaact gtgtcaacca aaacaaaaga tcagagttgc cctgaaggat tgggatgaag
      361 ttttaaaatt tcagcaagat ttagtaaatg cacagcattt tgatgcagct tatattttta
      421 ggaagctacg actagacaga gcatttcact ttacagcaat gcccaaattg ctgtcatata
      481 ggatgaagaa aaaaattcac cgagctgaag ttacagaaga atttaaggac ccaagtgatc
      541 gtgtgatgaa acttatcact tctgatgtat tagaggaaat gctgaatgtt catgatcatt
      601 atcagaacat gaaacatgta atttcagttg ataagtccaa gccagataaa gccctcagct
      661 tgataaagga tgattttttt gacaatatta agaacatagt tttggagcat cagcagtggc
      721 acaaagacag aaagaatcca tccttaaagt caaaaactaa tgatggagaa gaaaaaatgg
      781 aaggaaattc acaagaaacg gagagatgtg aaagggcaga atcattagcg aaaataaaat
      841 caaaggcctt ttcagttgtc atacaggcat ccaaatcaag aaggcatcgt caagtcaaac
      901 tcgactcttc tgactctgat tctgcatctg gtcaagggca agtcaaagca actaggaaaa
      961 aagagaagaa agaaagattg aaaccagcag gaaggaagat gtctctcaga aacaaaggca
     1021 atgtgcagaa tatacacaag gaagataaac ctttaagtct gagtatgcct gtaattacag
     1081 aagaagaaga gaatgaaagt ttgagtggaa cagagttcac tgcatccaag aagaggagaa
     1141 aacactgaac aaagagcctg gtgtagtttt taattttgag ttttctgaca gaagaaaaga
     1201 ttgatatttt gtgtattgaa caggaagact gccagtatta aaaaaatcct tctgggaatc
     1261 tgtaggttat ttcttggaaa ttgcaatacg tagttctaga ataaaagtac aaaaaattag
     1321 aataagaatt ctttaacatt ttctttaatg atttgcataa atggagataa aacttgtatt
     1381 tagtatgtaa tagaaaaaat tctgttattc gcagattgtt actatttcct ataaggtttt
     1441 gtgatactat actgtcctaa tacagtctgg taatactatt ctattttatt taaaatattt
     1501 tttattgaaa tattaatgtt tattacatgc aaataactat tttgtatcta cagtcggata
     1561 atggattttt tattttgtat atttattcta ttttgtatat tgttaagtgc aataaagttt
     1621 ttgccttgct ttatttttta atacataaaa cttacattct cataacgtga ttgataactt
     1681 aggaagttca caatgtattt tctacttctg caattaaata ttctttagtg cttgtttatt
     1741 attactaaat actaattaag tactaacaag tacttaaata ctaatgtatt aagtatttaa
     1801 gtactttcta ataaaatctt taacaataat aatgtaaatt tcagaatgtg tctctggtac
     1861 agaatagttg atattaacag aaaaaaaaaa atctgtagct tcatgaatat gccactctgt
     1921 taatttcttg ttccagacat tttaatagag attgcttgag ccatgttgtt tgaattgctg
     1981 ccaatagcag accatatccc tatcatgttg ttggctcaac tgtttttttt ttttccctaa
     2041 tagagatgga gtatcgctat gttgctcagg ctggtcttga actcctgggc tcaagctatc
     2101 ctcctgcctc agcctcccaa agtactggga ttataggtgt gagctactgt acccagcctt
     2161 aacctgtttc acagttgatt atacttcatg ctgttttcca gcatggtatt attaagggat
     2221 ttaaagtttg ggttgcatgc ctgtaatccc agcattttgg gaggccgagg tgggcggatc
     2281 acgaggtcag gagatcgaga ccatcgtgac taacacagtg aaaccccgtc tctaataaaa
     2341 atacgaaaaa ttagccaggc gtggtggcgg gcgcctgtaa tcccagctac tcgggaagct
     2401 gaggcaggag aatggtgtga acccagtgag ccgagatcgt gccactgcac tccagcctgg
     2461 gcaacagagt gagacttcgt ctcaaaaaaa aaaaaaagtt tgggttgaag atcaaattcg
     2521 tgatatctct atatctaatc tttaaaaatc agaatgctaa tgctgacgca aataaaattt
     2581 tcatttatta gca
//
