LOCUS       NM_001376684            4413 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens synaptosome associated protein 91 (SNAP91), transcript
            variant 18, mRNA.
ACCESSION   NM_001376684
VERSION     NM_001376684.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4413)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 4413)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4413)
  AUTHORS   Moshkanbaryans,L., Xue,J., Wark,J.R., Robinson,P.J. and Graham,M.E.
  TITLE     A Novel Sequence in AP180 and CALM Promotes Efficient Clathrin
            Binding and Assembly
  JOURNAL   PLoS One 11 (8), e0162050 (2016)
   PUBMED   27574975
  REMARK    GeneRIF: Study concludes that the novel clathrin interaction sites
            identified here in CALM and AP180 have a major role in how these
            proteins interface with clathrin. This work advances the case that
            AP180 and CALM are required to use a combination of standard
            clathrin N-terminal domain binding motifs and the sequence
            identified here for optimal binding and assembling clathrin.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4413)
  AUTHORS   Koo,S.J., Kochlamazashvili,G., Rost,B., Puchkov,D., Gimber,N.,
            Lehmann,M., Tadeus,G., Schmoranzer,J., Rosenmund,C., Haucke,V. and
            Maritzen,T.
  TITLE     Vesicular Synaptobrevin/VAMP2 Levels Guarded by AP180 Control
            Efficient Neurotransmission
  JOURNAL   Neuron 88 (2), 330-344 (2015)
   PUBMED   26412491
  REMARK    GeneRIF: To sustain efficient neurotransmission and synaptic
            vesicle formation, AP180 and VAMP2 are required.
REFERENCE   5  (bases 1 to 4413)
  AUTHORS   Busch,D.J., Houser,J.R., Hayden,C.C., Sherman,M.B., Lafer,E.M. and
            Stachowiak,J.C.
  TITLE     Intrinsically disordered proteins drive membrane curvature
  JOURNAL   Nat Commun 6, 7875 (2015)
   PUBMED   26204806
  REMARK    GeneRIF: intrinsically disordered domains are highly potent drivers
            of membrane curvature
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4413)
  AUTHORS   Slepnev,V.I., Ochoa,G.C., Butler,M.H. and De Camilli,P.
  TITLE     Tandem arrangement of the clathrin and AP-2 binding domains in
            amphiphysin 1 and disruption of clathrin coat function by
            amphiphysin fragments comprising these sites
  JOURNAL   J Biol Chem 275 (23), 17583-17589 (2000)
   PUBMED   10748223
REFERENCE   7  (bases 1 to 4413)
  AUTHORS   Traub,L.M., Downs,M.A., Westrich,J.L. and Fremont,D.H.
  TITLE     Crystal structure of the alpha appendage of AP-2 reveals a
            recruitment platform for clathrin-coat assembly
  JOURNAL   Proc Natl Acad Sci U S A 96 (16), 8907-8912 (1999)
   PUBMED   10430869
REFERENCE   8  (bases 1 to 4413)
  AUTHORS   Tebar,F., Bohlander,S.K. and Sorkin,A.
  TITLE     Clathrin assembly lymphoid myeloid leukemia (CALM) protein:
            localization in endocytic-coated pits, interactions with clathrin,
            and the impact of overexpression on clathrin-mediated traffic
  JOURNAL   Mol Biol Cell 10 (8), 2687-2702 (1999)
   PUBMED   10436022
REFERENCE   9  (bases 1 to 4413)
  AUTHORS   Yao,P.J., Morsch,R., Callahan,L.M. and Coleman,P.D.
  TITLE     Changes in synaptic expression of clathrin assembly protein AP180
            in Alzheimer's disease analysed by immunohistochemistry
  JOURNAL   Neuroscience 94 (2), 389-394 (1999)
   PUBMED   10579202
REFERENCE   10 (bases 1 to 4413)
  AUTHORS   Murphy,J.E., Hanover,J.A., Froehlich,M., DuBois,G. and Keen,J.H.
  TITLE     Clathrin assembly protein AP-3 is phosphorylated and glycosylated
            on the 50-kDa structural domain
  JOURNAL   J Biol Chem 269 (33), 21346-21352 (1994)
   PUBMED   8063760
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL109915.10.
            
            Transcript Variant: This variant (18), as well as variant 17,
            encodes isoform h.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-257               AL109915.10        166235-166491       c
            258-417             AL109915.10        165188-165347       c
            418-560             AL109915.10        122829-122971       c
            561-636             AL109915.10        119737-119812       c
            637-739             AL109915.10        118892-118994       c
            740-833             AL109915.10        116389-116482       c
            834-945             AL109915.10        114144-114255       c
            946-1052            AL109915.10        98486-98592         c
            1053-1094           AL109915.10        80691-80732         c
            1095-1165           AL109915.10        74359-74429         c
            1166-1193           AL109915.10        68040-68067         c
            1194-1303           AL109915.10        65089-65198         c
            1304-1422           AL109915.10        63075-63193         c
            1423-1437           AL109915.10        58975-58989         c
            1438-1605           AL109915.10        58661-58828         c
            1606-1713           AL109915.10        51764-51871         c
            1714-1974           AL109915.10        50871-51131         c
            1975-2052           AL109915.10        50572-50649         c
            2053-2124           AL109915.10        50336-50407         c
            2125-2208           AL109915.10        49845-49928         c
            2209-2292           AL109915.10        48601-48684         c
            2293-2427           AL109915.10        39612-39746         c
            2428-2577           AL109915.10        37840-37989         c
            2578-2608           AL109915.10        33413-33443         c
            2609-2720           AL109915.10        32400-32511         c
            2721-2804           AL109915.10        18254-18337         c
            2805-2909           AL109915.10        17494-17598         c
            2910-3012           AL109915.10        13533-13635         c
            3013-4413           AL109915.10        10275-11675         c
FEATURES             Location/Qualifiers
     source          1..4413
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q14.2"
     gene            1..4413
                     /gene="SNAP91"
                     /gene_synonym="AP180; CALM"
                     /note="synaptosome associated protein 91"
                     /db_xref="GeneID:9892"
                     /db_xref="HGNC:HGNC:14986"
                     /db_xref="MIM:607923"
     exon            1..257
                     /gene="SNAP91"
                     /gene_synonym="AP180; CALM"
                     /inference="alignment:Splign:2.1.0"
     exon            258..417
                     /gene="SNAP91"
                     /gene_synonym="AP180; CALM"
                     /inference="alignment:Splign:2.1.0"
     CDS             288..3002
                     /gene="SNAP91"
                     /gene_synonym="AP180; CALM"
                     /note="isoform h is encoded by transcript variant 18;
                     clathrin coat assembly protein AP180; assembly protein,
                     180kDa; phosphoprotein F1-20; synaptosome associated
                     protein 91kDa; 91 kDa synaptosomal-associated protein;
                     clathrin coat-associated protein AP180;
                     synaptosomal-associated protein, 91kDa homolog"
                     /codon_start=1
                     /product="clathrin coat assembly protein AP180 isoform h"
                     /protein_id="NP_001363613.1"
                     /db_xref="GeneID:9892"
                     /db_xref="HGNC:HGNC:14986"
                     /db_xref="MIM:607923"
                     /translation="MSGQTLTDRIAAAQYSVTGSAVARAVCKATTHEVMGPKKKHLDY
                     LIQATNETNVNIPQMADTLFERATNSSWVVVFKALVTTHHLMVHGNERFIQYLASRNT
                     LFNLSNFLDKSGSHGYDMSTFIRRYSRYLNEKAFSYRQMAFDFARVKKGADGVMRTMA
                     PEKLLKSMPILQGQIDALLEFDVHPNELTNGVINAAFMLLFKDLIKLFACYNDGVINL
                     LEKFFEMKKGQCKDALEIYKRFLTRMTRVSEFLKVAEQVGIDKGDIPDLTQAPSSLME
                     TLEQHLNTLEGKKPGNKSGAPSPLSKSSPATTVTSPNSTPAKTIDTSPPVDLFATASA
                     AVPVSTSKPSSDLLDLQPDFSSGGAAAAAAPAPPPPAGGATAWGDLLGEDSLAALSSV
                     PSEAQISDPFAPEPTPPTTTAEIATASASASTTTTVTAVTAEVDLFGDAFAASPGEAP
                     AASEGAAAPATPTPVAAALDACSGNDPFAPSEGSAEAAPELDLFAMKPPETSVPVVTP
                     TASTAPPVPATAPSPAPAVAAAAAATTAATAAATTTTTTSAATATTAPPALDIFDLFE
                     STPEVAAAPKPDAAPSIDLFSTDAFSSPPQGASPVPESSLTADLLSVDAFAAPSPATT
                     ASPAKVDSSGVIDLFGDAFGSSASEPQPASQAASSSSASADLLAGFGGSFMAPSPSPV
                     TPAQNNLLQPNFEAAFGTTPSTSSSSSFDPSVFDGLGDLLMPTMAPAGQPAPVSMVPP
                     SPAMAASKALGSDLDSSLASLVGNLGISGTTTKKGDLQWNAGEKKLTGGANWQPKVAP
                     ATWSAGVPPSAPLQGAVPPTSSVPPVAGAPSVGQPGAGFGMPPAGTGMPMMPQQPVMF
                     AQPMMRPPFGAAAVPGTQLSPSPTPASQSPKKPPAKDPLADLNIKDFL"
     exon            418..560
                     /gene="SNAP91"
                     /gene_synonym="AP180; CALM"
                     /inference="alignment:Splign:2.1.0"
     exon            561..636
                     /gene="SNAP91"
                     /gene_synonym="AP180; CALM"
                     /inference="alignment:Splign:2.1.0"
     exon            637..739
                     /gene="SNAP91"
                     /gene_synonym="AP180; CALM"
                     /inference="alignment:Splign:2.1.0"
     exon            740..833
                     /gene="SNAP91"
                     /gene_synonym="AP180; CALM"
                     /inference="alignment:Splign:2.1.0"
     exon            834..945
                     /gene="SNAP91"
                     /gene_synonym="AP180; CALM"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1052
                     /gene="SNAP91"
                     /gene_synonym="AP180; CALM"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1094
                     /gene="SNAP91"
                     /gene_synonym="AP180; CALM"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1165
                     /gene="SNAP91"
                     /gene_synonym="AP180; CALM"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1193
                     /gene="SNAP91"
                     /gene_synonym="AP180; CALM"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1303
                     /gene="SNAP91"
                     /gene_synonym="AP180; CALM"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1422
                     /gene="SNAP91"
                     /gene_synonym="AP180; CALM"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1437
                     /gene="SNAP91"
                     /gene_synonym="AP180; CALM"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1605
                     /gene="SNAP91"
                     /gene_synonym="AP180; CALM"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1713
                     /gene="SNAP91"
                     /gene_synonym="AP180; CALM"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..1974
                     /gene="SNAP91"
                     /gene_synonym="AP180; CALM"
                     /inference="alignment:Splign:2.1.0"
     exon            1975..2052
                     /gene="SNAP91"
                     /gene_synonym="AP180; CALM"
                     /inference="alignment:Splign:2.1.0"
     exon            2053..2124
                     /gene="SNAP91"
                     /gene_synonym="AP180; CALM"
                     /inference="alignment:Splign:2.1.0"
     exon            2125..2208
                     /gene="SNAP91"
                     /gene_synonym="AP180; CALM"
                     /inference="alignment:Splign:2.1.0"
     exon            2209..2292
                     /gene="SNAP91"
                     /gene_synonym="AP180; CALM"
                     /inference="alignment:Splign:2.1.0"
     exon            2293..2427
                     /gene="SNAP91"
                     /gene_synonym="AP180; CALM"
                     /inference="alignment:Splign:2.1.0"
     exon            2428..2577
                     /gene="SNAP91"
                     /gene_synonym="AP180; CALM"
                     /inference="alignment:Splign:2.1.0"
     exon            2578..2608
                     /gene="SNAP91"
                     /gene_synonym="AP180; CALM"
                     /inference="alignment:Splign:2.1.0"
     exon            2609..2720
                     /gene="SNAP91"
                     /gene_synonym="AP180; CALM"
                     /inference="alignment:Splign:2.1.0"
     exon            2721..2804
                     /gene="SNAP91"
                     /gene_synonym="AP180; CALM"
                     /inference="alignment:Splign:2.1.0"
     exon            2805..2909
                     /gene="SNAP91"
                     /gene_synonym="AP180; CALM"
                     /inference="alignment:Splign:2.1.0"
     exon            2910..3012
                     /gene="SNAP91"
                     /gene_synonym="AP180; CALM"
                     /inference="alignment:Splign:2.1.0"
     exon            3013..4413
                     /gene="SNAP91"
                     /gene_synonym="AP180; CALM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4385..4390
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNAP91"
                     /gene_synonym="AP180; CALM"
                     /note="hexamer: AATAAA"
     polyA_site      4413
                     /gene="SNAP91"
                     /gene_synonym="AP180; CALM"
                     /note="major polyA site"
ORIGIN      
        1 gcagctcgga gcgctagaga gacgcggcgg cgctggcaga agaggcggcg gcgggcgggt
       61 actggcttct ggggccaggg gccaggggcg gtgggcgccg ggaccgcgga gctgaggagc
      121 ggggcccggc cagggctgga gactttgcgc ccgggggcac cggggctacg cgcggtcgca
      181 cacatccacc ggcgcggctt ccctcggcgg cccgggctcc gctcatcctg cggcgggcgg
      241 cgccgctcag gggcgggaag aggaggcggt agacgcgacc acagaagatg tcgggccaaa
      301 cgctcacgga tcggatcgcc gccgctcagt acagcgttac aggctctgct gtagcaagag
      361 cggtctgcaa agccactact catgaagtaa tgggccccaa gaaaaagcac ctggactatt
      421 tgatccaggc taccaacgag accaatgtta atattcctca gatggccgac actctctttg
      481 agcgggcaac aaacagtagc tgggtggttg tgtttaaggc tttagtgaca acacatcatc
      541 tcatggtgca tggaaatgag agatttattc aatatttggc ttctagaaat acactattca
      601 atctcagcaa ttttttggac aaaagtggat cccatggtta tgatatgtct accttcataa
      661 ggcgctatag tagatatttg aatgaaaagg ctttttctta cagacagatg gcctttgatt
      721 ttgccagggt gaagaaaggg gccgatggtg taatgaggac aatggctccc gaaaagctgc
      781 taaagagtat gccaatacta cagggacaaa ttgatgcact gcttgaattt gatgtgcatc
      841 caaatgaact aacaaatggt gtcataaatg cagcatttat gcttcttttc aaagatctta
      901 tcaaactttt tgcttgctac aatgatggtg ttattaactt actcgaaaag ttttttgaaa
      961 tgaagaaagg acaatgtaaa gatgctctag aaatttacaa acgatttcta actagaatga
     1021 cacgagtgtc tgaatttctc aaggttgcag agcaagttgg tattgataaa ggtgacattc
     1081 ctgacctcac acaggctccc agcagtctta tggagacgct tgaacagcat ctaaatacat
     1141 tagaaggaaa gaaacctgga aacaaatctg gtgctccctc tccattaagt aagtcttctc
     1201 cagccacaac tgttacgtct cctaattcta caccagctaa aactattgac acatccccac
     1261 cggttgattt atttgcaact gcatctgcgg ctgtcccagt cagcacttct aaaccatcta
     1321 gtgatctcct ggacctccag ccagactttt cctctggagg ggcagcagca gccgcagcac
     1381 cagcaccacc accacctgct ggaggagcca ctgcatgggg agaccttttg ggagaggatt
     1441 ctttggctgc actttcctct gttccctctg aagcacagat ttcagatcca tttgcaccag
     1501 aacctacccc tcctactaca actgctgaaa ttgcaactgc ctcagcttct gcctccacta
     1561 ctacaactgt tactgctgtc actgctgaag tggatctctt tggagatgcc tttgcagctt
     1621 ctcctgggga ggcccctgca gcatccgaag gggccgccgc accagctacc ccaacccctg
     1681 tagcagcagc acttgatgca tgttcaggaa atgacccctt tgccccgtct gaaggtagtg
     1741 cagaggctgc acctgagctg gacctctttg caatgaagcc acctgagacc agtgttcctg
     1801 tagttacccc tacagctagc acagcccctc cagttcccgc aactgctcct tctcctgctc
     1861 ctgccgttgc agctgctgct gctgccacta ctgctgccac cgccgctgcc accaccacta
     1921 ccaccacctc cgctgccacc gccaccactg ctcctcctgc tctagatatc tttgatttat
     1981 ttgagtccac tcctgaagtt gctgcagcgc ctaagccaga tgctgctcct agcatagacc
     2041 tgtttagtac agatgctttc tcctctccac cacaaggggc ctctcctgtg cctgagagtt
     2101 ctctcactgc tgacctctta tctgtggatg catttgcagc accatctcct gcaaccactg
     2161 cctcgccagc aaaggtggat tcttcaggtg tcatagacct ttttggggat gcatttggaa
     2221 gtagtgcttc tgaaccccaa cctgcatctc aggctgcttc tagttcatca gcatcggcag
     2281 acctactagc tggatttggg ggttctttca tggcgccttc cccatctcca gtgactccag
     2341 ctcagaataa cctgctacag cccaattttg aggcagcttt tgggacaacg ccttcaactt
     2401 ccagcagcag ctcctttgat ccatcagtgt ttgatggtct aggtgatctt ttgatgccaa
     2461 ccatggcacc agctgggcag cctgcacctg tctcaatggt accacccagt cctgcaatgg
     2521 cagccagcaa agcccttgga agtgatcttg attcatctct tgccagctta gtaggcaatc
     2581 ttggaatttc tggtaccaca acaaaaaagg gagatcttca gtggaatgct ggagagaaaa
     2641 agttgactgg tggagccaac tggcagccta aagtagctcc agcaacctgg tcagcaggcg
     2701 ttccaccaag tgcacctttg caaggagctg tacctccaac cagttcagtt cctcctgttg
     2761 ccggggcccc atcggttgga caacctggag caggatttgg aatgcctcct gctgggacag
     2821 gcatgcccat gatgcctcag cagccggtca tgtttgcaca gcccatgatg aggcccccct
     2881 ttggagctgc cgctgtacct ggcacgcagc tttctccaag ccctacacct gccagtcaga
     2941 gtcccaagaa acctccagca aaggacccat tagcggatct taacatcaag gatttcttgt
     3001 aaacaattta agctgcaata tttgtgactg aataggaaaa taaatgagtt tggagacttc
     3061 aaataagatt gatgctgagt ttcaaaggga gccaccagta ccaaacccaa tacttactca
     3121 taacttctct tccaaaatgt gtaacacagc cgtgaaagtg aacattagga atatgtacta
     3181 ccttagctgt tatccctact cttgaaattg tagtgtattt ggattatttg tgtattgtac
     3241 gatgtaaaca atgaatggat gttactgatg ccgttagtgc ttttttggac ttcacctgag
     3301 gacagatgat gcagctgttg tgtggcgagc tatttggaaa gacgtctgtg tttttgaagg
     3361 tttcaatgta catataactt ttgaacaaac cccaaactct tcccataaat tatcttttct
     3421 tctgtatctc tgttacaagc gtagtgtgat aataccagat aataaggaaa acactcataa
     3481 atatacaaaa ctttttcagt gtggagtaca tttttccaat cacaggaact tcaactgttg
     3541 tgagaaatgt ttatttttgt ggcactgtat atgttaagaa attttatttt aaaaaatata
     3601 aaggttaacg tccataataa atacttctct ttgaagctac cttatcaaga acgaaaaatc
     3661 gtatgggaag aatcccctat ttatcactgc tatattaaaa tatatatatt ttaattatat
     3721 ttgacaggtt ttgcatctaa attgacctat ttattcattc ttgattaaat gcactgaaaa
     3781 gtaaagggtc tgtttgtgtc atgttcatga aaatgcggtt agagaggtgc tattcaagtg
     3841 attctgaagg caccccaagg tatatctgta atttaaagat tactgcaaat atctttactt
     3901 tactgtgggt ttttagtaca tctgttaatt tagtgtttct ttgtgtgttt tgtagactag
     3961 tgttcttcca tccttcaact gagctcaaag taggttttgt tgtaacattg tgattaggat
     4021 ttaaactaat tcagagaatt gtatctttta ctgtacatac tgtattcttt aagttttaat
     4081 ttgttgtcat actgtctgtg ctgatggctt ggcttaagat tttgatgcat aaatgaggtc
     4141 actgttgatc agtgttgcta gtagcttggc agctcttcat aaaagcatat tgggttggaa
     4201 aggtgtttgc ctatttttca aattatttaa tagatgtatg gtaccattta aaagtggttg
     4261 tatctgaatt tactgtgggg ataacataca ctgtaatggg gaaaaattac ctaaaaccaa
     4321 tttcaaaatg gctttctttg tatttcagtt taaaaaccca gtgcatgtac gccctctgag
     4381 atgcaataaa caccttgaac aaagaaatgc aaa
//
