LOCUS       NM_053052               1923 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens synaptosome associated protein 47 (SNAP47), transcript
            variant 1, mRNA.
ACCESSION   NM_053052
VERSION     NM_053052.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1923)
  AUTHORS   Jian,F., Wang,S., Tian,R., Wang,Y., Li,C., Li,Y., Wang,S., Fang,C.,
            Ma,C. and Rong,Y.
  TITLE     The STX17-SNAP47-VAMP7/VAMP8 complex is the default SNARE complex
            mediating autophagosome-lysosome fusion
  JOURNAL   Cell Res 34 (2), 151-168 (2024)
   PUBMED   38182888
  REMARK    GeneRIF: The STX17-SNAP47-VAMP7/VAMP8 complex is the default SNARE
            complex mediating autophagosome-lysosome fusion.
REFERENCE   2  (bases 1 to 1923)
  AUTHORS   Wang,Y., Wang,H., Zhang,L., Zhang,J., Liu,N. and Zhao,P.
  TITLE     A novel identified circular RNA, circSnap47, promotes heart failure
            progression via regulation of miR-223-3p/MAPK axis
  JOURNAL   Mol Cell Biochem 478 (3), 459-469 (2023)
   PUBMED   35900666
  REMARK    GeneRIF: A novel identified circular RNA, circSnap47, promotes
            heart failure progression via regulation of miR-223-3p/MAPK axis.
REFERENCE   3  (bases 1 to 1923)
  AUTHORS   Xiang,P., Mohamud,Y. and Luo,H.
  TITLE     SNAP47 Interacts with ATG14 to Promote VP1 Conjugation and CVB3
            Propagation
  JOURNAL   Cells 10 (8), 2141 (2021)
   PUBMED   34440910
  REMARK    GeneRIF: SNAP47 Interacts with ATG14 to Promote VP1 Conjugation and
            CVB3 Propagation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1923)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 1923)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1923)
  AUTHORS   Sun,W., Guo,C., Meng,X., Yu,Y., Jin,Y., Tong,D., Geng,J., Huang,Q.,
            Qi,J., Liu,A., Guan,R., Xu,L., Sun,D., Ji,W., Liu,P., Liu,F.,
            Sun,H., Ji,G., Fu,S. and Bai,J.
  TITLE     Differential expression of PAI-RBP1, C1orf142, and COTL1 in
            non-small cell lung cancer cell lines with different tumor
            metastatic potential
  JOURNAL   J Investig Med 60 (4), 689-694 (2012)
   PUBMED   22373659
  REMARK    GeneRIF: Three proteins are identified: PAI-RBP1, C1orf142, and
            COTL1, which are differentially expressed in non-small cell lung
            cancer cell lines with different metastatic potential.
REFERENCE   7  (bases 1 to 1923)
  AUTHORS   Pfefferle,S., Schopf,J., Kogl,M., Friedel,C.C., Muller,M.A.,
            Carbajo-Lozoya,J., Stellberger,T., von Dall'Armi,E., Herzog,P.,
            Kallies,S., Niemeyer,D., Ditt,V., Kuri,T., Zust,R., Pumpor,K.,
            Hilgenfeld,R., Schwarz,F., Zimmer,R., Steffen,I., Weber,F.,
            Thiel,V., Herrler,G., Thiel,H.J., Schwegmann-Wessels,C.,
            Pohlmann,S., Haas,J., Drosten,C. and von Brunn,A.
  TITLE     The SARS-coronavirus-host interactome: identification of
            cyclophilins as target for pan-coronavirus inhibitors
  JOURNAL   PLoS Pathog 7 (10), e1002331 (2011)
   PUBMED   22046132
REFERENCE   8  (bases 1 to 1923)
  AUTHORS   Ghiani,C.A., Starcevic,M., Rodriguez-Fernandez,I.A., Nazarian,R.,
            Cheli,V.T., Chan,L.N., Malvar,J.S., de Vellis,J., Sabatti,C. and
            Dell'Angelica,E.C.
  TITLE     The dysbindin-containing complex (BLOC-1) in brain: developmental
            regulation, interaction with SNARE proteins and role in neurite
            outgrowth
  JOURNAL   Mol Psychiatry 15 (2), 115 (2010)
   PUBMED   19546860
REFERENCE   9  (bases 1 to 1923)
  AUTHORS   Holt,M., Varoqueaux,F., Wiederhold,K., Takamori,S., Urlaub,H.,
            Fasshauer,D. and Jahn,R.
  TITLE     Identification of SNAP-47, a novel Qbc-SNARE with ubiquitous
            expression
  JOURNAL   J Biol Chem 281 (25), 17076-17083 (2006)
   PUBMED   16621800
REFERENCE   10 (bases 1 to 1923)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL136378.14 and AL731702.12.
            
            On Jul 31, 2020 this sequence version replaced NM_053052.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY090635.2, BC018760.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000617596.5/ ENSP00000483253.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                AL136378.14        41473-41537
            66-607              AL136378.14        53730-54271
            608-1098            AL136378.14        65033-65523
            1099-1223           AL136378.14        72997-73121
            1224-1923           AL731702.12        3908-4607
FEATURES             Location/Qualifiers
     source          1..1923
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q42.13"
     gene            1..1923
                     /gene="SNAP47"
                     /gene_synonym="C1orf142; ESFI5812; HEL-S-290; HEL170;
                     SNAP-47; SVAP1"
                     /note="synaptosome associated protein 47"
                     /db_xref="GeneID:116841"
                     /db_xref="HGNC:HGNC:30669"
                     /db_xref="MIM:619659"
     exon            1..65
                     /gene="SNAP47"
                     /gene_synonym="C1orf142; ESFI5812; HEL-S-290; HEL170;
                     SNAP-47; SVAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            66..607
                     /gene="SNAP47"
                     /gene_synonym="C1orf142; ESFI5812; HEL-S-290; HEL170;
                     SNAP-47; SVAP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..1370
                     /gene="SNAP47"
                     /gene_synonym="C1orf142; ESFI5812; HEL-S-290; HEL170;
                     SNAP-47; SVAP1"
                     /note="isoform b is encoded by transcript variant 1;
                     synaptosomal-associated protein 47; epididymis luminal
                     protein 170; synaptosomal-associated 47 kDa protein;
                     epididymis secretory protein Li 290; synaptosome
                     associated protein 47kDa; synaptosomal-associated protein,
                     47kDa"
                     /codon_start=1
                     /product="synaptosomal-associated protein 47 isoform b"
                     /protein_id="NP_444280.3"
                     /db_xref="CCDS:CCDS81429.1"
                     /db_xref="GeneID:116841"
                     /db_xref="HGNC:HGNC:30669"
                     /db_xref="MIM:619659"
                     /translation="MSRDVCIHTWPCTYYLEPKRRWVTGQLSLTSLSLRFMTDSTGEI
                     LVSFPLSSIVEIKKEASHFIFSSITILEKGHAKHWFSSLRPSRNVVFSIIEHFWRELL
                     LSQPGAVADASVPRTRGEELTGLMAGSQKRLEDTARVLHHQGQQLDSVMRGLDKMESD
                     LEVADRLLTELESPAWWPFSSKLWKTPPETKPREDVSMTSCEPFGKEGILIKIPAVIS
                     HRTESHVKPGRLTVLVSGLEIHDSSSLLMHRFEREDVDDIKVHSPYEISIRQRFIGKP
                     DMAYRLISAKMPEVIPILEVQFSKKMELLEDALVLRSARTSSPAEKSCSVWHAASGLM
                     GRTLHREPPAGDQEGTALHLQTSLPALSEADTQELTQILRRMKGLALEAESELERQDE
                     ALDGVAAAVDRATLTIDKHNRRMKRLT"
     exon            608..1098
                     /gene="SNAP47"
                     /gene_synonym="C1orf142; ESFI5812; HEL-S-290; HEL170;
                     SNAP-47; SVAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1223
                     /gene="SNAP47"
                     /gene_synonym="C1orf142; ESFI5812; HEL-S-290; HEL170;
                     SNAP-47; SVAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1923
                     /gene="SNAP47"
                     /gene_synonym="C1orf142; ESFI5812; HEL-S-290; HEL170;
                     SNAP-47; SVAP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1901..1906
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNAP47"
                     /gene_synonym="C1orf142; ESFI5812; HEL-S-290; HEL170;
                     SNAP-47; SVAP1"
                     /note="hexamer: AATAAA"
     polyA_site      1923
                     /gene="SNAP47"
                     /gene_synonym="C1orf142; ESFI5812; HEL-S-290; HEL170;
                     SNAP-47; SVAP1"
                     /note="major polyA site"
ORIGIN      
        1 actgcgcagg cgccgagcgg ccgaggcgcc gcggtcggct ctgggactcg tctggcgtcc
       61 ctcagaggca gaagaggcct ggaccttggc gcacacagac ccaggaacag atgagcaggg
      121 atgtctgcat ccacacctgg ccgtgcacct actacctgga gcccaagagg cgatgggtta
      181 ctggacagct gtccttaaca tcgctgtcgc tcaggttcat gactgacagc actggagaga
      241 ttctggtcag cttccccctc tccagcatag ttgagatcaa gaaggaggct tcacatttta
      301 tcttcagctc catcaccatc ctggagaagg gccatgccaa gcactggttc agctccctgc
      361 ggccaagtcg aaatgtggtc ttcagcatca tcgagcattt ctggagggag ctgctgctgt
      421 ctcagcctgg agccgtggca gacgcatctg tcccaaggac ccggggcgag gagctgacgg
      481 gactcatggc tggatcccag aaacgcctgg aggacacggc gagggtcctg caccaccagg
      541 gccagcagct ggacagcgtc atgagaggcc tggacaagat ggagtcagac ctggaggtgg
      601 cggacagatt gctgacagaa ctggaatctc ctgcttggtg gccctttagc tccaagcttt
      661 ggaagacacc accggaaaca aagcccaggg aagatgtctc catgaccagt tgtgaaccct
      721 ttgggaaaga agggatactg ataaaaattc ctgctgttat ttcccacaga acagagtctc
      781 acgttaaacc agggaggctc accgtccttg tgtctgggtt ggaaatacat gactccagtt
      841 ctttgctcat gcacaggttt gaaagagaag acgtggacga catcaaggtc cactcacctt
      901 acgaaattag catccgccag cggtttattg gaaagccaga catggcctat cgtttgatat
      961 ctgccaagat gccagaggtt atccccattt tagaagtgca gttcagcaag aagatggagc
     1021 tgttagaaga tgcattggtg ctcagaagcg caagaacctc ttcccccgca gagaagagct
     1081 gctcagtctg gcatgcagca tctgggctga tgggccgtac cctgcaccgt gagccacccg
     1141 caggagacca ggagggcaca gcactgcacc tgcagacaag cctgccagcc ctttctgagg
     1201 cagataccca ggaactaacc cagatcctga ggaggatgaa ggggctggcc ctggaggccg
     1261 agagtgagct ggagagacaa gacgaagccc tggatggcgt tgcagcagct gtggacaggg
     1321 caaccttgac catcgacaag cacaacaggc ggatgaagag gctgacctag gggcagaacg
     1381 tccctgcatt cctgtctcac cctgcacatc ccgctgagat ggagggctgg gcggcagtgc
     1441 cagggctgca gaggcctgtg gccctccgga gtggtcttcc tctggatggg gctgctactg
     1501 tggggctgct tctgcaccag gggcctcccc aggtgtgcac catgcctgcc tcccacttgg
     1561 ctgtccctgc tgctgggcag gacccggcca catgttctgc ggatgctgca gaagtgtgga
     1621 ccatggcggg accccaagga cacttggcac aggcctggaa gaggccgccc tcgtcttgtc
     1681 tcggctccct ttcatggaca gactggcctt cttagctgta ctataaattt gtgagtgaag
     1741 ttagagccca gctcacttag ccagctcact ttgagggcat cctataaaca cccaactgtt
     1801 cttttatcgt ctcggtttta gccaaaagtg aaattagcat gactgcatct ttcaaacaaa
     1861 aatattgatt tctgctttta gggccccgtt tccatccaga aataaaggga aatgctggct
     1921 tca
//
