LOCUS       NM_001323933            2235 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens synaptosome associated protein 47 (SNAP47), transcript
            variant 5, mRNA.
ACCESSION   NM_001323933
VERSION     NM_001323933.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2235)
  AUTHORS   Jian,F., Wang,S., Tian,R., Wang,Y., Li,C., Li,Y., Wang,S., Fang,C.,
            Ma,C. and Rong,Y.
  TITLE     The STX17-SNAP47-VAMP7/VAMP8 complex is the default SNARE complex
            mediating autophagosome-lysosome fusion
  JOURNAL   Cell Res 34 (2), 151-168 (2024)
   PUBMED   38182888
  REMARK    GeneRIF: The STX17-SNAP47-VAMP7/VAMP8 complex is the default SNARE
            complex mediating autophagosome-lysosome fusion.
REFERENCE   2  (bases 1 to 2235)
  AUTHORS   Wang,Y., Wang,H., Zhang,L., Zhang,J., Liu,N. and Zhao,P.
  TITLE     A novel identified circular RNA, circSnap47, promotes heart failure
            progression via regulation of miR-223-3p/MAPK axis
  JOURNAL   Mol Cell Biochem 478 (3), 459-469 (2023)
   PUBMED   35900666
  REMARK    GeneRIF: A novel identified circular RNA, circSnap47, promotes
            heart failure progression via regulation of miR-223-3p/MAPK axis.
REFERENCE   3  (bases 1 to 2235)
  AUTHORS   Xiang,P., Mohamud,Y. and Luo,H.
  TITLE     SNAP47 Interacts with ATG14 to Promote VP1 Conjugation and CVB3
            Propagation
  JOURNAL   Cells 10 (8), 2141 (2021)
   PUBMED   34440910
  REMARK    GeneRIF: SNAP47 Interacts with ATG14 to Promote VP1 Conjugation and
            CVB3 Propagation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2235)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 2235)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 2235)
  AUTHORS   Sun,W., Guo,C., Meng,X., Yu,Y., Jin,Y., Tong,D., Geng,J., Huang,Q.,
            Qi,J., Liu,A., Guan,R., Xu,L., Sun,D., Ji,W., Liu,P., Liu,F.,
            Sun,H., Ji,G., Fu,S. and Bai,J.
  TITLE     Differential expression of PAI-RBP1, C1orf142, and COTL1 in
            non-small cell lung cancer cell lines with different tumor
            metastatic potential
  JOURNAL   J Investig Med 60 (4), 689-694 (2012)
   PUBMED   22373659
  REMARK    GeneRIF: Three proteins are identified: PAI-RBP1, C1orf142, and
            COTL1, which are differentially expressed in non-small cell lung
            cancer cell lines with different metastatic potential.
REFERENCE   7  (bases 1 to 2235)
  AUTHORS   Pfefferle,S., Schopf,J., Kogl,M., Friedel,C.C., Muller,M.A.,
            Carbajo-Lozoya,J., Stellberger,T., von Dall'Armi,E., Herzog,P.,
            Kallies,S., Niemeyer,D., Ditt,V., Kuri,T., Zust,R., Pumpor,K.,
            Hilgenfeld,R., Schwarz,F., Zimmer,R., Steffen,I., Weber,F.,
            Thiel,V., Herrler,G., Thiel,H.J., Schwegmann-Wessels,C.,
            Pohlmann,S., Haas,J., Drosten,C. and von Brunn,A.
  TITLE     The SARS-coronavirus-host interactome: identification of
            cyclophilins as target for pan-coronavirus inhibitors
  JOURNAL   PLoS Pathog 7 (10), e1002331 (2011)
   PUBMED   22046132
REFERENCE   8  (bases 1 to 2235)
  AUTHORS   Ghiani,C.A., Starcevic,M., Rodriguez-Fernandez,I.A., Nazarian,R.,
            Cheli,V.T., Chan,L.N., Malvar,J.S., de Vellis,J., Sabatti,C. and
            Dell'Angelica,E.C.
  TITLE     The dysbindin-containing complex (BLOC-1) in brain: developmental
            regulation, interaction with SNARE proteins and role in neurite
            outgrowth
  JOURNAL   Mol Psychiatry 15 (2), 115 (2010)
   PUBMED   19546860
REFERENCE   9  (bases 1 to 2235)
  AUTHORS   Holt,M., Varoqueaux,F., Wiederhold,K., Takamori,S., Urlaub,H.,
            Fasshauer,D. and Jahn,R.
  TITLE     Identification of SNAP-47, a novel Qbc-SNARE with ubiquitous
            expression
  JOURNAL   J Biol Chem 281 (25), 17076-17083 (2006)
   PUBMED   16621800
REFERENCE   10 (bases 1 to 2235)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL136378.14 and AL731702.12.
            
            On Aug 13, 2020 this sequence version replaced NM_001323933.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.224395.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               AL136378.14        34206-34322
            118-214             AL136378.14        34728-34824
            215-377             AL136378.14        37623-37785
            378-919             AL136378.14        53730-54271
            920-1410            AL136378.14        65033-65523
            1411-1535           AL136378.14        72997-73121
            1536-2235           AL731702.12        3908-4607
FEATURES             Location/Qualifiers
     source          1..2235
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q42.13"
     gene            1..2235
                     /gene="SNAP47"
                     /gene_synonym="C1orf142; ESFI5812; HEL-S-290; HEL170;
                     SNAP-47; SVAP1"
                     /note="synaptosome associated protein 47"
                     /db_xref="GeneID:116841"
                     /db_xref="HGNC:HGNC:30669"
                     /db_xref="MIM:619659"
     exon            1..117
                     /gene="SNAP47"
                     /gene_synonym="C1orf142; ESFI5812; HEL-S-290; HEL170;
                     SNAP-47; SVAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            118..214
                     /gene="SNAP47"
                     /gene_synonym="C1orf142; ESFI5812; HEL-S-290; HEL170;
                     SNAP-47; SVAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            215..377
                     /gene="SNAP47"
                     /gene_synonym="C1orf142; ESFI5812; HEL-S-290; HEL170;
                     SNAP-47; SVAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            378..919
                     /gene="SNAP47"
                     /gene_synonym="C1orf142; ESFI5812; HEL-S-290; HEL170;
                     SNAP-47; SVAP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             423..1682
                     /gene="SNAP47"
                     /gene_synonym="C1orf142; ESFI5812; HEL-S-290; HEL170;
                     SNAP-47; SVAP1"
                     /note="isoform b is encoded by transcript variant 5;
                     synaptosomal-associated protein 47; epididymis luminal
                     protein 170; synaptosomal-associated 47 kDa protein;
                     epididymis secretory protein Li 290; synaptosome
                     associated protein 47kDa; synaptosomal-associated protein,
                     47kDa"
                     /codon_start=1
                     /product="synaptosomal-associated protein 47 isoform b"
                     /protein_id="NP_001310862.1"
                     /db_xref="CCDS:CCDS81429.1"
                     /db_xref="GeneID:116841"
                     /db_xref="HGNC:HGNC:30669"
                     /db_xref="MIM:619659"
                     /translation="MSRDVCIHTWPCTYYLEPKRRWVTGQLSLTSLSLRFMTDSTGEI
                     LVSFPLSSIVEIKKEASHFIFSSITILEKGHAKHWFSSLRPSRNVVFSIIEHFWRELL
                     LSQPGAVADASVPRTRGEELTGLMAGSQKRLEDTARVLHHQGQQLDSVMRGLDKMESD
                     LEVADRLLTELESPAWWPFSSKLWKTPPETKPREDVSMTSCEPFGKEGILIKIPAVIS
                     HRTESHVKPGRLTVLVSGLEIHDSSSLLMHRFEREDVDDIKVHSPYEISIRQRFIGKP
                     DMAYRLISAKMPEVIPILEVQFSKKMELLEDALVLRSARTSSPAEKSCSVWHAASGLM
                     GRTLHREPPAGDQEGTALHLQTSLPALSEADTQELTQILRRMKGLALEAESELERQDE
                     ALDGVAAAVDRATLTIDKHNRRMKRLT"
     exon            920..1410
                     /gene="SNAP47"
                     /gene_synonym="C1orf142; ESFI5812; HEL-S-290; HEL170;
                     SNAP-47; SVAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1535
                     /gene="SNAP47"
                     /gene_synonym="C1orf142; ESFI5812; HEL-S-290; HEL170;
                     SNAP-47; SVAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..2235
                     /gene="SNAP47"
                     /gene_synonym="C1orf142; ESFI5812; HEL-S-290; HEL170;
                     SNAP-47; SVAP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2213..2218
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNAP47"
                     /gene_synonym="C1orf142; ESFI5812; HEL-S-290; HEL170;
                     SNAP-47; SVAP1"
                     /note="hexamer: AATAAA"
     polyA_site      2235
                     /gene="SNAP47"
                     /gene_synonym="C1orf142; ESFI5812; HEL-S-290; HEL170;
                     SNAP-47; SVAP1"
                     /note="major polyA site"
ORIGIN      
        1 acaggcggtg agtcaacggg cacctccggg ctaggaggtt ttcccaggct cgcctcattg
       61 ctcctgcacc tgcagggttc gctggaccct gggcgtcccg ctgcccggaa cacaaggggt
      121 cccagaagca agggcagtga ggacctggcc cacgtccctg gcacgggctg tctgattctc
      181 cttcgctgtg gcgggaagat ggccggattt gaaggcctcc gctgctcact gctgtgcctt
      241 gatcggcctg gacgagcccg cccacacctc catcataccc agtgtgaaga ggggctgggg
      301 acccaccact cctgagaaca gcatccttgg gaagacccag ctgtgagtgc acagcaggca
      361 cagtccctca ggcccagagg cagaagaggc ctggaccttg gcgcacacag acccaggaac
      421 agatgagcag ggatgtctgc atccacacct ggccgtgcac ctactacctg gagcccaaga
      481 ggcgatgggt tactggacag ctgtccttaa catcgctgtc gctcaggttc atgactgaca
      541 gcactggaga gattctggtc agcttccccc tctccagcat agttgagatc aagaaggagg
      601 cttcacattt tatcttcagc tccatcacca tcctggagaa gggccatgcc aagcactggt
      661 tcagctccct gcggccaagt cgaaatgtgg tcttcagcat catcgagcat ttctggaggg
      721 agctgctgct gtctcagcct ggagccgtgg cagacgcatc tgtcccaagg acccggggcg
      781 aggagctgac gggactcatg gctggatccc agaaacgcct ggaggacacg gcgagggtcc
      841 tgcaccacca gggccagcag ctggacagcg tcatgagagg cctggacaag atggagtcag
      901 acctggaggt ggcggacaga ttgctgacag aactggaatc tcctgcttgg tggcccttta
      961 gctccaagct ttggaagaca ccaccggaaa caaagcccag ggaagatgtc tccatgacca
     1021 gttgtgaacc ctttgggaaa gaagggatac tgataaaaat tcctgctgtt atttcccaca
     1081 gaacagagtc tcacgttaaa ccagggaggc tcaccgtcct tgtgtctggg ttggaaatac
     1141 atgactccag ttctttgctc atgcacaggt ttgaaagaga agacgtggac gacatcaagg
     1201 tccactcacc ttacgaaatt agcatccgcc agcggtttat tggaaagcca gacatggcct
     1261 atcgtttgat atctgccaag atgccagagg ttatccccat tttagaagtg cagttcagca
     1321 agaagatgga gctgttagaa gatgcattgg tgctcagaag cgcaagaacc tcttcccccg
     1381 cagagaagag ctgctcagtc tggcatgcag catctgggct gatgggccgt accctgcacc
     1441 gtgagccacc cgcaggagac caggagggca cagcactgca cctgcagaca agcctgccag
     1501 ccctttctga ggcagatacc caggaactaa cccagatcct gaggaggatg aaggggctgg
     1561 ccctggaggc cgagagtgag ctggagagac aagacgaagc cctggatggc gttgcagcag
     1621 ctgtggacag ggcaaccttg accatcgaca agcacaacag gcggatgaag aggctgacct
     1681 aggggcagaa cgtccctgca ttcctgtctc accctgcaca tcccgctgag atggagggct
     1741 gggcggcagt gccagggctg cagaggcctg tggccctccg gagtggtctt cctctggatg
     1801 gggctgctac tgtggggctg cttctgcacc aggggcctcc ccaggtgtgc accatgcctg
     1861 cctcccactt ggctgtccct gctgctgggc aggacccggc cacatgttct gcggatgctg
     1921 cagaagtgtg gaccatggcg ggaccccaag gacacttggc acaggcctgg aagaggccgc
     1981 cctcgtcttg tctcggctcc ctttcatgga cagactggcc ttcttagctg tactataaat
     2041 ttgtgagtga agttagagcc cagctcactt agccagctca ctttgagggc atcctataaa
     2101 cacccaactg ttcttttatc gtctcggttt tagccaaaag tgaaattagc atgactgcat
     2161 ctttcaaaca aaaatattga tttctgcttt tagggccccg tttccatcca gaaataaagg
     2221 gaaatgctgg cttca
//
