LOCUS       NM_004782               4259 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens synaptosome associated protein 29 (SNAP29), mRNA.
ACCESSION   NM_004782
VERSION     NM_004782.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4259)
  AUTHORS   Zheng,D., Tong,M., Zhang,S., Pan,Y., Zhao,Y., Zhong,Q. and Liu,X.
  TITLE     Human YKT6 forms priming complex with STX17 and SNAP29 to
            facilitate autophagosome-lysosome fusion
  JOURNAL   Cell Rep 43 (2), 113760 (2024)
   PUBMED   38340317
  REMARK    GeneRIF: Human YKT6 forms priming complex with STX17 and SNAP29 to
            facilitate autophagosome-lysosome fusion.
REFERENCE   2  (bases 1 to 4259)
  AUTHORS   Smeele,P.H. and Vaccari,T.
  TITLE     Snapshots from within the cell: Novel trafficking and non
            trafficking functions of Snap29 during tissue morphogenesis
  JOURNAL   Semin Cell Dev Biol 133, 42-52 (2023)
   PUBMED   35256275
  REMARK    GeneRIF: Snapshots from within the cell: Novel trafficking and non
            trafficking functions of Snap29 during tissue morphogenesis.
            Review article
REFERENCE   3  (bases 1 to 4259)
  AUTHORS   Matsui,K., Emoto,M., Fukuda,N., Nomiyama,R., Yamada,K. and
            Tanizawa,Y.
  TITLE     SNARE-binding protein synaptosomal-associated protein of 29 kDa
            (SNAP29) regulates the intracellular sequestration of glucose
            transporter 4 (GLUT4) vesicles in adipocytes
  JOURNAL   J Diabetes Investig 14 (1), 19-27 (2023)
   PUBMED   36181414
  REMARK    GeneRIF: SNARE-binding protein synaptosomal-associated protein of
            29 kDa (SNAP29) regulates the intracellular sequestration of
            glucose transporter 4 (GLUT4) vesicles in adipocytes.
REFERENCE   4  (bases 1 to 4259)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 4259)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   6  (bases 1 to 4259)
  AUTHORS   Rotem-Yehudar,R., Galperin,E. and Horowitz,M.
  TITLE     Association of insulin-like growth factor 1 receptor with EHD1 and
            SNAP29
  JOURNAL   J Biol Chem 276 (35), 33054-33060 (2001)
   PUBMED   11423532
REFERENCE   7  (bases 1 to 4259)
  AUTHORS   Saito,T., Guan,F., Papolos,D.F., Rajouria,N., Fann,C.S. and
            Lachman,H.M.
  TITLE     Polymorphism in SNAP29 gene promoter region associated with
            schizophrenia
  JOURNAL   Mol Psychiatry 6 (2), 193-201 (2001)
   PUBMED   11317222
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Erratum:[Mol Psychiatry 2001 Sep;6(5):605]
REFERENCE   8  (bases 1 to 4259)
  AUTHORS   Scales,S.J., Chen,Y.A., Yoo,B.Y., Patel,S.M., Doung,Y.C. and
            Scheller,R.H.
  TITLE     SNAREs contribute to the specificity of membrane fusion
  JOURNAL   Neuron 26 (2), 457-464 (2000)
   PUBMED   10839363
REFERENCE   9  (bases 1 to 4259)
  AUTHORS   Wong,S.H., Xu,Y., Zhang,T., Griffiths,G., Lowe,S.L.,
            Subramaniam,V.N., Seow,K.T. and Hong,W.
  TITLE     GS32, a novel Golgi SNARE of 32 kDa, interacts preferentially with
            syntaxin 6
  JOURNAL   Mol Biol Cell 10 (1), 119-134 (1999)
   PUBMED   9880331
REFERENCE   10 (bases 1 to 4259)
  AUTHORS   Steegmaier,M., Yang,B., Yoo,J.S., Huang,B., Shen,M., Yu,S., Luo,Y.
            and Scheller,R.H.
  TITLE     Three novel proteins of the syntaxin/SNAP-25 family
  JOURNAL   J Biol Chem 273 (51), 34171-34179 (1998)
   PUBMED   9852078
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG773022.1, AF115436.1,
            AC007308.13 and CA427899.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_004782.3.
            
            Summary: This gene, a member of the SNAP25 gene family, encodes a
            protein involved in multiple membrane trafficking steps. Two other
            members of this gene family, SNAP23 and SNAP25, encode proteins
            that bind a syntaxin protein and mediate synaptic vesicle membrane
            docking and fusion to the plasma membrane. The protein encoded by
            this gene binds tightly to multiple syntaxins and is localized to
            intracellular membrane structures rather than to the plasma
            membrane. While the protein is mostly membrane-bound, a significant
            fraction of it is found free in the cytoplasm. Use of multiple
            polyadenylation sites has been noted for this gene. [provided by
            RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.113951.1,
                                           SRR1660809.243742.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000215730.12/ ENSP00000215730.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                BG773022.1         7-91
            86-1003             AF115436.1         56-973
            1004-4142           AC007308.13        194821-197959
            4143-4259           CA427899.1         16-132              c
FEATURES             Location/Qualifiers
     source          1..4259
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.21"
     gene            1..4259
                     /gene="SNAP29"
                     /gene_synonym="CEDNIK; SNAP-29"
                     /note="synaptosome associated protein 29"
                     /db_xref="GeneID:9342"
                     /db_xref="HGNC:HGNC:11133"
                     /db_xref="MIM:604202"
     exon            1..341
                     /gene="SNAP29"
                     /gene_synonym="CEDNIK; SNAP-29"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..881
                     /gene="SNAP29"
                     /gene_synonym="CEDNIK; SNAP-29"
                     /note="vesicle-membrane fusion protein SNAP-29; soluble 29
                     kDa NSF attachment protein; synaptosome associated protein
                     29kDa; synaptosomal-associated protein, 29kD;
                     synaptosomal-associated protein, 29kDa; cerebral
                     dysgenesis, neuropathy, ichthyosis and keratoderma
                     syndrome"
                     /codon_start=1
                     /product="synaptosomal-associated protein 29"
                     /protein_id="NP_004773.1"
                     /db_xref="CCDS:CCDS13784.1"
                     /db_xref="GeneID:9342"
                     /db_xref="HGNC:HGNC:11133"
                     /db_xref="MIM:604202"
                     /translation="MSAYPKSYNPFDDDGEDEGARPAPWRDARDLPDGPDAPADRQQY
                     LRQEVLRRAEATAASTSRSLALMYESEKVGVASSEELARQRGVLERTEKMVDKMDQDL
                     KISQKHINSIKSVFGGLVNYFKSKPVETPPEQNGTLTSQPNNRLKEAISTSKEQEAKY
                     QASHPNLRKLDDTDPVPRGAGSAMSTDAYPKNPHLRAYHQKIDSNLDELSMGLGRLKD
                     IALGMQTEIEEQDDILDRLTTKVDKLDVNIKSTERKVRQL"
     exon            342..538
                     /gene="SNAP29"
                     /gene_synonym="CEDNIK; SNAP-29"
                     /inference="alignment:Splign:2.1.0"
     exon            539..624
                     /gene="SNAP29"
                     /gene_synonym="CEDNIK; SNAP-29"
                     /inference="alignment:Splign:2.1.0"
     exon            625..723
                     /gene="SNAP29"
                     /gene_synonym="CEDNIK; SNAP-29"
                     /inference="alignment:Splign:2.1.0"
     exon            724..4259
                     /gene="SNAP29"
                     /gene_synonym="CEDNIK; SNAP-29"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1000..1005
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNAP29"
                     /gene_synonym="CEDNIK; SNAP-29"
                     /note="hexamer: AATAGA"
     polyA_site      1020
                     /gene="SNAP29"
                     /gene_synonym="CEDNIK; SNAP-29"
                     /note="major polyA site"
     regulatory      2514..2519
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNAP29"
                     /gene_synonym="CEDNIK; SNAP-29"
                     /note="hexamer: ATTAAA"
     polyA_site      2534
                     /gene="SNAP29"
                     /gene_synonym="CEDNIK; SNAP-29"
     regulatory      4236..4241
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SNAP29"
                     /gene_synonym="CEDNIK; SNAP-29"
                     /note="hexamer: AATAAA"
     polyA_site      4259
                     /gene="SNAP29"
                     /gene_synonym="CEDNIK; SNAP-29"
                     /note="major polyA site"
ORIGIN      
        1 gttcgcgcga cgaccgcggg gtcggcgggc ggggcgaggc cctggacggc ggcggcagtg
       61 gggctcctcc ttctgtttcc cagaccgaga gccgcgccgg caccatgtca gcttacccta
      121 aaagctacaa tccgttcgac gacgacgggg aggacgaagg cgcccggccg gccccttgga
      181 gggacgcccg agacctcccc gacgggcccg acgcgcccgc ggacaggcag cagtacttgc
      241 ggcaggaggt cctccgcagg gctgaggcca cggccgccag caccagcagg tccctggccc
      301 tcatgtacga gtccgagaag gttggggtcg cctcttccga ggagctcgcc cgtcagcgag
      361 gagtcctgga gcgcacagag aagatggtgg acaagatgga ccaagatttg aagatcagcc
      421 agaaacacat caatagcatt aagagcgtgt ttggggggct ggtcaattac ttcaaatcca
      481 aaccagtaga gaccccacct gaacagaatg gcaccctcac ctcccagccc aacaacagat
      541 tgaaagaagc tataagtaca agtaaagaac aggaagcaaa gtaccaggcc agccacccaa
      601 accttagaaa gctggatgat acagaccctg tccccagagg ggctggttct gccatgagta
      661 ctgatgctta cccaaagaac ccacaccttc gagcctatca ccagaagatc gacagcaacc
      721 tagatgagct gtccatggga ctgggtcgtc tgaaggacat agccctgggg atgcagacag
      781 aaattgagga gcaagatgac attcttgacc ggctgacaac caaagtggac aagttagatg
      841 tcaacataaa aagcacagaa agaaaagttc gacaactctg aagacagacg gatttccact
      901 ctattgtgat gaaaagattt gaaagatctt tttttgaact tccaagaaat ttcatttact
      961 attttagtat gtaaattaat gtgtgtttgc aaatgttata atagagtagg tcttaagaca
     1021 tttttgctgt tataaggaag tgtttgtccc acattttcct agggttaaca cctcaccaag
     1081 ttcttccagc aaaatgctta ttagagtttt tgtctgagca cagtagcctg gccctgcata
     1141 tcttgggcgt ttgattacca tgctggaata agaagagttg catttctcat tttaatgagc
     1201 atatggaaag atgggaacag aatttcagtc ttgcagccat gagcctctat ttctcattcc
     1261 taagccttac catgagtcag agtgttaagg gggcctgtga accagtcgtt tggtggagga
     1321 gggtccttcc cacacctttg tttaggagtc atcattcaca cacacacaca cacacacaca
     1381 cacacacaca cacacacaca ctctctgagc acattatctg tgattctttc atcctcccag
     1441 aaaggatcag tgttagaatg ggaaatagag tgtgccatct tgctcttttg ttggcagatg
     1501 tccccgcttc cctccagccc cccatccttg gcatgtatat tagtaggagg gcttcacacc
     1561 agcactgctc actgcgactc ctggaaatgt gtggggaatt gggtgagccc ctcttcccca
     1621 cgtgctccca tctgtaactc tccatctgtg atttgcaaca ggtcttccac tggctcgagg
     1681 ctgcgaggct gaccgacagg ggcgcccaat agagtttgtg ggaatggagt attgcacaga
     1741 tgcagctgca caatggtctt cctccacccc tctgggaatc accattaggc aggcctcagt
     1801 agggcaaaat gtttatttgg taccgggggt ctcctgacct gtctagcatt cccacccact
     1861 cttctgcact tcttgcaagg taacttgaat catcacttat ttctctgcca cctggtttta
     1921 ggactggcac tctataaatg acgctgactt tgtatagaag gattttgcta agggggcaaa
     1981 aagcccagat accattttaa ctggcccagt tcattttctc ctttcatttt acaaaagaaa
     2041 tcatgcagaa gcatcaatta aaactgattt atttatgttg gtacatccaa caaaatagtt
     2101 ggagccacaa ggcccttgtc tttttaaaaa aacaaaatat tttgaagatg gtgaaagtga
     2161 ctgattttaa taatgagata ggtcacttaa aataacagtg cctttgacct taaaacatgg
     2221 cactggccca tgtgaccttt gccatttccc agtacttccc tttacagtct gcagcctata
     2281 aacagtggtg tctcaaagca aaggaaacct ccacaagtgc tgcaacagtg cattagtttt
     2341 tatgtagcaa tttgtttata aaaattccca tcccataatg catgaccttc ctaaaaatat
     2401 ccacagcctc cataggcaag gtgagctttc tgtgctaccc acttgttaga ttccagccac
     2461 ctcagggatt ctgatccatg tcattaacga ccatcccagg gtgtgagggc ctgattaaag
     2521 cttatcgaac tagacatttg tttattagat gagctcggca ttattatttt ctcaataact
     2581 ggtagaaggg aaattttaaa cataacactc aacccaaaca aaactacttc gtgaggcttt
     2641 cagcaaaaag gctgcttaaa agcatgaacc cgggatgcag agcagctttt gtgcacggtt
     2701 ccacttactg taattgtttc tggttctttc ctctaacacc ttccatgtat gtcaactttt
     2761 tatcaccgtc aggcatagac tcgtggagat tagtcattat agctcagacc taagctaatt
     2821 atttaaaata aatacatgta aaggccactg ccacattctc agcagacttc cacttgccta
     2881 atgagattag tgattcaact gacttgaagc acagtaacat cttattttat gcacattccc
     2941 tgtcttttgc tggactgatg aagccagtca cccgcccttc tctgtttttt ggtttttttt
     3001 ttcttaaccc caggtatatg gaaggggagt tgccttcact tttctggaaa tttgtcttcg
     3061 tctgacatat tagagggcct cgttttgtcc tgttcttgtt cagaccctct cgttctacgt
     3121 cctgtgctga ggggactgtc cgtaagctac aggacagcga gctggtcctt tctgccactt
     3181 cttccccact cccatgccca ggaaggcctg gttgctgatg ctactttata aatgagttgc
     3241 ttgcattttc acagagaatg aaggaagacg taacatggct ccagaaactt ttcacatgat
     3301 gattgggatc gacaaaaaaa tgctaccctc tagactagac acatttcatg gagacaagca
     3361 aaatggtgcc agggctgggc tgactgtggg atgggatttg gtactgcaga cagattttga
     3421 tttccacagt tgagctggaa acaaactgtg ccttcaaaaa atgacttttc taacttaagg
     3481 ttggttatat gttaagtgtg ctactaactt aaaaaatagt ggctgggcgc ggtggctcat
     3541 gcctgtaatc ccagtgcttt gggaggccaa ggcgggggga tcacgaggtc aggagatcga
     3601 gaccatcctg gctaacacgg tgaaacccca tctctactaa aaacacacaa aaaattagct
     3661 gggcgtggtg gtgggcgcct gtagtcccag ctactcagga ggctgaggca ggagaatggc
     3721 atgaacctgg gaggcagagc ttgcagtgag ccgagacagc gccattgcac tccagcctgg
     3781 gcaacagagc aagactccgt ctcaaaaaaa aaaaaaaaaa aaaaatagtg cactctctgg
     3841 ctggtcacgg tggctcacgc ctgtaatctc agcactttgg aaggccaagg caggcggatc
     3901 acgaggtcag aagatcgaga ccatcctggc taacacagtg aaaccccgtc tctactaaaa
     3961 atataaaaaa ttagtcgggc atggtggcgg gcgcctgtag tcccaactac tcgggagact
     4021 gaggcagaag aatggcgtga actcaggagg cggagcttgc agtgagccaa ggcgacagag
     4081 caagactctg tctcaaaaaa taaaaaatag tgcactgtcc ttcgagaaag ttttctaaca
     4141 tctagtaatt tgtaacttag aagtggagtt gccttgtgga tgtctttttt gcattctgta
     4201 ggaaatgaaa cgtgaattta actcgggttg caagaaataa aaatgtcagt gcatttaaa
//
